Protein: PEN2
Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2)

Gene: PEN2, PSENEN
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q9NZ42

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

834358

PSN1
Presenilin-1

10

7

Small-scale

0.971

High

1266767

NICA
Nicastrin

6

3

Small-scale

0.931

High

835012

PSN2
Presenilin-2

3

7

Small-scale

0.827

High

1285543

APH1A
Gamma-secretase subunit APH-1A

7

3

Small-scale

0.740

High

1020079

NTCP2
Ileal sodium/bile acid cotransporter

2

1

High-throughput

0.606

High

1108651

SOAT
Sodium-dependent organic anion transporter

2

1

High-throughput

0.606

High

1312852

CRUM3
Protein crumbs homolog 3

2

0

High-throughput

0.580

High

821063

PRC2A
Protein PRRC2A

1

2

High-throughput

0.536

High

990947

ZO1
Tight junction protein ZO-1

1

1

High-throughput

0.536

High

1256907

PARD3
Partitioning defective 3 homolog

1

1

High-throughput

0.536

High

1268343

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

1

High-throughput

0.536

High

1348825

ZO2
Tight junction protein ZO-2

1

1

High-throughput

0.536

High

422675

TRBM
Thrombomodulin

1

0

High-throughput

0.518

High

216977

KIF1C
Kinesin-like protein KIF1C

1

0

High-throughput

0.513

High

254638

CLAP2
CLIP-associating protein 2

1

0

High-throughput

0.513

High

833666

NUMB
Protein numb homolog

1

0

High-throughput

0.513

High

1034037

PPIG
Peptidyl-prolyl cis-trans isomerase G

1

0

High-throughput

0.513

High

1039901

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1122704

ESCO2
N-acetyltransferase ESCO2

1

0

High-throughput

0.513

High

1199438

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

1234263

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

0

High-throughput

0.513

High

1264250

CTR3
Cationic amino acid transporter 3

1

0

High-throughput

0.513

High

1317910

GTPB4
GTP-binding protein 4

1

0

High-throughput

0.513

High

1327319

LSG1
Large subunit GTPase 1 homolog

1

0

High-throughput

0.513

High

833359

TMEDA
Transmembrane emp24 domain-containing protein 10

1

1

Small-scale

0.500

High

395926

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.493

High

412382

FYN
Tyrosine-protein kinase Fyn

1

0

High-throughput

0.493

High

1074117

CYH1
Cytohesin-1

1

0

High-throughput

0.493

High

224855

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

1

High-throughput

0.489

High

304667

SCAF4
SR-related and CTD-associated factor 4

1

1

High-throughput

0.489

High

1049536

SAFB2
Scaffold attachment factor B2

1

1

High-throughput

0.489

High

1127711

PRC2B
Protein PRRC2B

1

1

High-throughput

0.489

High

1312005

DIDO1
Death-inducer obliterator 1

1

1

High-throughput

0.489

High

1347210

SLTM
SAFB-like transcription modulator

1

1

High-throughput

0.489

High

216854

CREB3
Cyclic AMP-responsive element-binding protein 3

1

0

High-throughput

0.486

High

365091

FRIL
Ferritin light chain

1

0

Small-scale

0.484

High

300001

ERLN2
Erlin-2

1

1

Small-scale

0.479

High

1262271

APH1B
Gamma-secretase subunit APH-1B

1

3

Small-scale

0.479

High

59533

GSAP
Gamma-secretase-activating protein

1

1

Small-scale

0.437

High

230437

ZC3H1
Zinc finger C3H1 domain-containing protein

1

0

High-throughput

0.279

Low

328976

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.279

Low

534148

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.279

Low

558541

GCFC2
Intron Large complex component GCFC2

1

0

High-throughput

0.279

Low

596828

CD11B
Cyclin-dependent kinase 11B

1

0

High-throughput

0.279

Low

722653

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.279

Low

875756

MFAP1
Microfibrillar-associated protein 1

1

0

High-throughput

0.279

Low

966662

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.279

Low

1052036

ELOA1
Elongin-A

1

0

High-throughput

0.279

Low

1052167

MAP7
Ensconsin

1

0

High-throughput

0.279

Low

1115857

MAP9
Microtubule-associated protein 9

1

0

High-throughput

0.279

Low

1128552

HABP4
Intracellular hyaluronan-binding protein 4

1

0

High-throughput

0.279

Low

1129797

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

High-throughput

0.279

Low

1132755

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.279

Low

1135229

RBM26
RNA-binding protein 26

1

0

High-throughput

0.279

Low

1138156

PR38B
Pre-mRNA-splicing factor 38B

1

0

High-throughput

0.279

Low

1138976

FOCAD
Focadhesin

1

0

High-throughput

0.279

Low

1148825

VIR
Protein virilizer homolog

1

0

High-throughput

0.279

Low

1174488

F10C1
Protein FRA10AC1

1

0

High-throughput

0.279

Low

1183368

DDX46
Probable ATP-dependent RNA helicase DDX46

1

0

High-throughput

0.279

Low

1184581

RSRC2
Arginine/serine-rich coiled-coil protein 2

1

0

High-throughput

0.279

Low

1200067

EST1A
Telomerase-binding protein EST1A

1

0

High-throughput

0.279

Low

1204042

ERIC1
Glutamate-rich protein 1

1

0

High-throughput

0.279

Low

1239284

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.279

Low

1242579

RB15B
Putative RNA-binding protein 15B

1

0

High-throughput

0.279

Low

1251053

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.279

Low

1261502

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.279

Low

1289261

RMXL1
RNA binding motif protein, X-linked-like-1

1

0

High-throughput

0.279

Low

1290346

RRP36
Ribosomal RNA processing protein 36 homolog

1

0

High-throughput

0.279

Low

1299396

RBM14
RNA-binding protein 14

1

0

High-throughput

0.279

Low

1304765

SCAFB
Protein SCAF11

1

0

High-throughput

0.279

Low

1327744

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.279

Low

1331853

ESF1
ESF1 homolog

1

0

High-throughput

0.279

Low

1345578

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

High-throughput

0.279

Low

1346276

DCA13
DDB1- and CUL4-associated factor 13

1

0

High-throughput

0.279

Low

1347172

ARGL1
Arginine and glutamate-rich protein 1

1

0

High-throughput

0.279

Low

1348571

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

0

High-throughput

0.279

Low

1348824

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.279

Low

1348826

NOB1
RNA-binding protein NOB1

1

0

High-throughput

0.279

Low

1348827

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

0

High-throughput

0.279

Low

1348828

WBP11
WW domain-binding protein 11

1

0

High-throughput

0.279

Low

1348829

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.279

Low

1348830

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

1

0

High-throughput

0.279

Low

236515

NEMF
Ribosome quality control complex subunit NEMF

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024