Protein: PTN2
Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP)

Gene: PTN2, PTPN2
Organism: Homo sapiens
Interactions: 187
UniProt ID: P17706

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0004725 - protein tyrosine phosphatase activity
GO:0004726 - non-membrane spanning protein tyrosine phosphatase activity
GO:0005178 - integrin binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

570489

STAT3
Signal transducer and activator of transcription 3

7

18

Small-scale

0.959

High

337897

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.806

High

570474

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

18

High-throughput

0.776

High

570492

STAT1
Signal transducer and activator of transcription 1-alpha/beta

2

17

Small-scale

0.776

High

570493

STAT6
Signal transducer and activator of transcription 6

1

17

Small-scale

0.747

High

522754

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.724

High

570484

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.724

High

276138

PSD10
26S proteasome non-ATPase regulatory subunit 10

3

10

High-throughput

0.667

High

570515

PRS4
26S proteasome regulatory subunit 4

3

5

High-throughput

0.667

High

570516

PRS8
26S proteasome regulatory subunit 8

3

6

High-throughput

0.667

High

570545

S39A4
Zinc transporter ZIP4

3

7

High-throughput

0.667

High

570476

CO5A1

3

2

High-throughput

0.657

High

238629

IMA7
Importin subunit alpha-7

3

2

High-throughput

0.656

High

570508

IMA5
Importin subunit alpha-5

3

2

High-throughput

0.656

High

570509

PSMD4
26S proteasome non-ATPase regulatory subunit 4

3

3

High-throughput

0.656

High

426766

ASGR1
Asialoglycoprotein receptor 1

2

10

High-throughput

0.628

High

570486

TNFL8
Tumor necrosis factor ligand superfamily member 8

2

1

High-throughput

0.628

High

570539

C3AR
C3a anaphylatoxin chemotactic receptor

2

11

High-throughput

0.628

High

570604

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

13

High-throughput

0.628

High

411290

INSR
Insulin receptor

1

20

Small-scale

0.618

High

570543

PTN20
Tyrosine-protein phosphatase non-receptor type 20

1

17

High-throughput

0.618

High

570563

CSKI1
Caskin-1

1

14

High-throughput

0.618

High

130729

PSDE
26S proteasome non-ATPase regulatory subunit 14

2

4

High-throughput

0.611

High

570487

PRS7
26S proteasome regulatory subunit 7

2

5

High-throughput

0.611

High

570497

PRS6B
26S proteasome regulatory subunit 6B

2

5

High-throughput

0.611

High

570517

PRS10
26S proteasome regulatory subunit 10B

2

6

High-throughput

0.611

High

570525

APLP2
Amyloid beta precursor like protein 2

2

4

High-throughput

0.611

High

570530

PSMD2
26S proteasome non-ATPase regulatory subunit 2

2

8

High-throughput

0.611

High

570536

PSMD6
26S proteasome non-ATPase regulatory subunit 6

2

6

High-throughput

0.611

High

570578

PSMD1
26S proteasome non-ATPase regulatory subunit 1

2

8

High-throughput

0.611

High

570608

NUP50
Nuclear pore complex protein Nup50

2

1

High-throughput

0.611

High

500942

GHR
Growth hormone receptor

1

20

Small-scale

0.608

High

306931

CSPG5
Chondroitin sulfate proteoglycan 5

2

0

High-throughput

0.602

High

570528

TRAF2
TNF receptor-associated factor 2

2

8

Small-scale

0.601

High

168615

IMA6
Importin subunit alpha-6

2

2

High-throughput

0.584

High

570498

PSMD8
26S proteasome non-ATPase regulatory subunit 8

2

1

High-throughput

0.584

High

570512

SC61B
Protein transport protein Sec61 subunit beta

2

3

High-throughput

0.584

High

570564

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

2

4

High-throughput

0.584

High

570611

PSD13
26S proteasome non-ATPase regulatory subunit 13

2

4

High-throughput

0.584

High

570534

IMB1
Importin subunit beta-1

1

8

Small-scale

0.578

High

206457

B4GA1
Beta-1,4-glucuronyltransferase 1

2

1

High-throughput

0.574

High

570546

S39A5
Zinc transporter ZIP5

2

7

High-throughput

0.574

High

570501

TMEDA
Transmembrane emp24 domain-containing protein 10

1

3

Small-scale

0.573

High

570582

TMED9
Transmembrane emp24 domain-containing protein 9

1

3

Small-scale

0.573

High

570511

STX17
Syntaxin-17

1

0

Small-scale

0.549

High

570548

F220A
Protein FAM220A

1

0

Small-scale

0.537

High

117581

MYO1C
Unconventional myosin-Ic

1

1

High-throughput

0.536

High

134359

ACKR2
Atypical chemokine receptor 2

1

8

High-throughput

0.536

High

216169

CALU
Calumenin

1

6

High-throughput

0.536

High

394077

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.536

High

560036

CTLA4
Cytotoxic T-lymphocyte protein 4

1

2

High-throughput

0.536

High

570519

IF5A1
Eukaryotic translation initiation factor 5A-1

1

2

High-throughput

0.536

High

570520

TPM4
Tropomyosin alpha-4 chain

1

2

High-throughput

0.536

High

570529

TSN31
Tetraspanin-31

1

1

High-throughput

0.536

High

570541

DREB
Drebrin

1

1

High-throughput

0.536

High

570560

SETD7
Histone-lysine N-methyltransferase SETD7

1

2

High-throughput

0.536

High

570562

SPRY4
SPRY domain-containing protein 4

1

3

High-throughput

0.536

High

570585

STRA6
Receptor for retinol uptake STRA6

1

1

High-throughput

0.536

High

570610

TNF18
Tumor necrosis factor ligand superfamily member 18

1

1

High-throughput

0.536

High

434810

CXB1
Gap junction beta-1 protein

1

6

Small-scale

0.519

High

570485

1433S
14-3-3 protein sigma

1

16

High-throughput

0.515

High

570615

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

1

High-throughput

0.515

High

517869

HARS1
Histidine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.513

High

570488

COIL
Coilin

1

0

High-throughput

0.513

High

570522

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

449529

HMGB1
High mobility group protein B1

1

1

Small-scale

0.508

High

126912

WASL
Actin nucleation-promoting factor WASL

1

9

Small-scale

0.501

High

358710

CRYAA
Alpha-crystallin A chain

1

4

High-throughput

0.501

High

475317

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

570540

OCLN
Occludin

1

1

Small-scale

0.501

High

570507

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

High-throughput

0.493

High

129370

GOLI4
Golgi integral membrane protein 4

1

10

High-throughput

0.489

High

570490

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

1

High-throughput

0.489

High

570544

GOLM2
Protein GOLM2

1

1

High-throughput

0.489

High

570601

TMOD3
Tropomodulin-3

1

1

High-throughput

0.489

High

570609

COR1C
Coronin-1C

1

7

High-throughput

0.489

High

121675

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

11

High-throughput

0.479

High

121927

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

11

High-throughput

0.479

High

163741

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

8

High-throughput

0.479

High

198538

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.479

High

202588

TXNL1
Thioredoxin-like protein 1

1

16

High-throughput

0.479

High

203175

AN32C
Putative uncharacterized protein ANP32CP

1

3

High-throughput

0.479

High

216440

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

3

High-throughput

0.479

High

226460

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

243894

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

273682

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.479

High

359641

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

8

High-throughput

0.479

High

390059

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.479

High

390705

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.479

High

436150

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

455070

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

503394

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

545197

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

570473

PRS6A
26S proteasome regulatory subunit 6A

1

14

High-throughput

0.479

High

570475

PSB1
Proteasome subunit beta type-1

1

9

High-throughput

0.479

High

570477

PSA1
Proteasome subunit alpha type-1

1

5

High-throughput

0.479

High

570478

PSA2
Proteasome subunit alpha type-2

1

6

High-throughput

0.479

High

570479

PSA3
Proteasome subunit alpha type-3

1

5

High-throughput

0.479

High

570480

PSA4
Proteasome subunit alpha type-4

1

5

High-throughput

0.479

High

570481

PSA5
Proteasome subunit alpha type-5

1

4

High-throughput

0.479

High

570482

PSB4
Proteasome subunit beta type-4

1

9

High-throughput

0.479

High

570483

PSB5
Proteasome subunit beta type-5

1

5

High-throughput

0.479

High

570491

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

570494

RBM34
RNA-binding protein 34

1

1

High-throughput

0.479

High

570495

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.479

High

570496

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.479

High

570499

PSB3
Proteasome subunit beta type-3

1

5

High-throughput

0.479

High

570500

PSB2
Proteasome subunit beta type-2

1

7

High-throughput

0.479

High

570502

NU153
Nuclear pore complex protein Nup153

1

13

High-throughput

0.479

High

570503

EMD
Emerin

1

1

High-throughput

0.479

High

570504

RAB9A
Ras-related protein Rab-9A

1

9

High-throughput

0.479

High

570505

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.479

High

570506

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

2

High-throughput

0.479

High

570510

ITA1
Integrin alpha-1

1

11

Small-scale

0.479

High

570513

PSA6
Proteasome subunit alpha type-6

1

6

High-throughput

0.479

High

570514

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

570518

H2B1C
Histone H2B type 1-C/E/F/G/I

1

5

High-throughput

0.479

High

570521

RPP30
Ribonuclease P protein subunit p30

1

1

High-throughput

0.479

High

570523

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

570524

UBE3A
Ubiquitin-protein ligase E3A

1

7

Small-scale

0.479

High

570526

CKAP4
Cytoskeleton-associated protein 4

1

4

High-throughput

0.479

High

570531

TIF1B
Transcription intermediary factor 1-beta

1

4

High-throughput

0.479

High

570542

CAH9
Carbonic anhydrase 9

1

7

High-throughput

0.479

High

570547

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

570550

DJC10
DnaJ homolog subfamily C member 10

1

20

High-throughput

0.479

High

570551

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

1

High-throughput

0.479

High

570552

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

1

High-throughput

0.479

High

570553

CXD3
Gap junction delta-3 protein

1

6

High-throughput

0.479

High

570554

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

3

High-throughput

0.479

High

570555

DHB11
Estradiol 17-beta-dehydrogenase 11

1

4

High-throughput

0.479

High

570556

TXND5
Thioredoxin domain-containing protein 5

1

16

High-throughput

0.479

High

570558

G45IP
Large ribosomal subunit protein mL64

1

1

High-throughput

0.479

High

570566

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

3

High-throughput

0.479

High

570567

LRC59
Leucine-rich repeat-containing protein 59

1

3

High-throughput

0.479

High

570568

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

4

High-throughput

0.479

High

570569

TECT2
Tectonic-2

1

3

High-throughput

0.479

High

570570

ZCCHL
Zinc finger CCCH-type antiviral protein 1-like

1

1

High-throughput

0.479

High

570571

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

1

High-throughput

0.479

High

570572

DNJC1
DnaJ homolog subfamily C member 1

1

20

High-throughput

0.479

High

570573

NSUN5
28S rRNA

1

4

High-throughput

0.479

High

570574

PANX1
Pannexin-1

1

1

High-throughput

0.479

High

570575

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

3

High-throughput

0.479

High

570576

PSB7
Proteasome subunit beta type-7

1

2

High-throughput

0.479

High

570577

SEC62
Translocation protein SEC62

1

1

High-throughput

0.479

High

570580

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

3

High-throughput

0.479

High

570581

DERL1
Derlin-1

1

3

High-throughput

0.479

High

570586

LNP
Endoplasmic reticulum junction formation protein lunapark

1

2

High-throughput

0.479

High

570589

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

570591

TMT1A
Thiol S-methyltransferase TMT1A

1

2

High-throughput

0.479

High

570592

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

1

1

High-throughput

0.479

High

570595

ANLN
Anillin

1

2

High-throughput

0.479

High

570596

PXMP2
Peroxisomal membrane protein 2

1

1

High-throughput

0.479

High

570599

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.479

High

570602

ELOV5
Very long chain fatty acid elongase 5

1

3

High-throughput

0.479

High

570603

TM216
Transmembrane protein 216

1

2

High-throughput

0.479

High

570606

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

570607

SEC63
Translocation protein SEC63 homolog

1

7

High-throughput

0.479

High

570612

DIM1
Probable dimethyladenosine transferase

1

2

High-throughput

0.479

High

570616

DUS10
Dual specificity protein phosphatase 10

1

6

High-throughput

0.479

High

324218

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

398636

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

0

High-throughput

0.458

High

570527

GRSF1
G-rich sequence factor 1

1

0

High-throughput

0.458

High

570532

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.458

High

570533

BYST
Bystin

1

0

High-throughput

0.458

High

570538

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

0

High-throughput

0.458

High

570584

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

570594

EXOS4
Exosome complex component RRP41

1

0

High-throughput

0.458

High

570598

PNO1
RNA-binding protein PNO1

1

0

High-throughput

0.458

High

570600

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

0

High-throughput

0.458

High

570605

HOP2
Homologous-pairing protein 2 homolog

1

0

High-throughput

0.458

High

570614

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

0

High-throughput

0.458

High

570557

MSPD2
Motile sperm domain-containing protein 2

1

4

High-throughput

0.445

High

570535

T132D
Transmembrane protein 132D

1

2

Small-scale

0.439

High

570537

UBE3C
Ubiquitin-protein ligase E3C

1

7

High-throughput

0.437

High

570549

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

570559

BRX1
Ribosome biogenesis protein BRX1 homolog

1

3

High-throughput

0.437

High

570561

TFB1M
Dimethyladenosine transferase 1, mitochondrial

1

2

High-throughput

0.437

High

570579

PAAF1
Proteasomal ATPase-associated factor 1

1

5

High-throughput

0.437

High

570587

DJC25
DnaJ homolog subfamily C member 25

1

12

High-throughput

0.437

High

570588

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.437

High

570590

CH033
UPF0488 protein C8orf33

1

1

High-throughput

0.437

High

570597

ST7
Suppressor of tumorigenicity 7 protein

1

2

High-throughput

0.437

High

570613

DJC16
DnaJ homolog subfamily C member 16

1

20

High-throughput

0.437

High

59561

GTPBA
GTP-binding protein 10

1

0

High-throughput

0.249

Low

570565

RL3L
Ribosomal protein uL3-like

1

0

High-throughput

0.249

Low

570583

TR61B
tRNA

1

0

High-throughput

0.249

Low

570593

MRM3
rRNA methyltransferase 3, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024