Protein: TLE1
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)

Gene: TLE1
Organism: Homo sapiens
Interactions: 202
UniProt ID: Q04724

Gene Ontology (top 5):
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005667 - transcription regulator complex
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

980584

TLE2
Transducin-like enhancer protein 2

4

17

Small-scale

0.902

High

980586

TLE4
Transducin-like enhancer protein 4

4

18

Small-scale

0.886

High

980583

TLE1
Transducin-like enhancer protein 1

3

17

Small-scale

0.875

High

980590

TLE5
TLE family member 5

3

16

Small-scale

0.855

High

980585

TLE3
Transducin-like enhancer protein 3

3

17

High-throughput

0.847

High

980587

HME1
Homeobox protein engrailed-1

5

20

Small-scale

0.716

High

980604

HES1
Transcription factor HES-1

5

20

Small-scale

0.711

High

600012

SAT1
Diamine acetyltransferase 1

1

1

High-throughput

0.698

High

980609

PA1B3
Platelet-activating factor acetylhydrolase IB subunit alpha1

1

3

High-throughput

0.698

High

980614

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

Small-scale

0.691

High

150098

UTY
Histone demethylase UTY

1

18

Small-scale

0.680

High

877602

FOXG1
Forkhead box protein G1

4

20

Small-scale

0.680

High

308074

VENTX
Homeobox protein VENTX

3

20

High-throughput

0.669

High

980638

HES6
Transcription cofactor HES-6

3

20

Small-scale

0.669

High

211837

TLX3
T-cell leukemia homeobox protein 3

3

20

Small-scale

0.661

High

622942

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

1

High-throughput

0.656

High

980603

GRB7
Growth factor receptor-bound protein 7

1

10

High-throughput

0.656

High

980667

TBX20
T-box transcription factor TBX20

3

20

High-throughput

0.656

High

980598

HDAC1
Histone deacetylase 1

2

20

Small-scale

0.639

High

980608

DAZP2
DAZ-associated protein 2

3

1

High-throughput

0.639

High

770197

IL6RB
Interleukin-6 receptor subunit beta

1

5

Small-scale

0.637

High

980665

LEF1
Lymphoid enhancer-binding factor 1

2

20

Small-scale

0.635

High

315169

SIX6
Homeobox protein SIX6

2

20

Small-scale

0.626

High

679096

TLX1
T-cell leukemia homeobox protein 1

2

20

Small-scale

0.624

High

183106

KDM6A
Lysine-specific demethylase 6A

1

14

Small-scale

0.621

High

378673

KITH
Thymidine kinase, cytosolic

2

1

High-throughput

0.620

High

309473

MTMR5
Myotubularin-related protein 5

1

3

High-throughput

0.618

High

980628

RHG24
Rho GTPase-activating protein 24

1

5

High-throughput

0.618

High

213321

TLX2
T-cell leukemia homeobox protein 2

2

20

High-throughput

0.614

High

878395

PAX9
Paired box protein Pax-9

2

20

High-throughput

0.614

High

980593

RIPP1
Protein ripply1

2

19

High-throughput

0.611

High

980605

HLX
H2.0-like homeobox protein

2

20

High-throughput

0.611

High

980621

RIPP2
Protein ripply2

2

19

High-throughput

0.611

High

980671

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

2

20

Small-scale

0.611

High

551506

TFE2
Transcription factor E2-alpha

2

8

Small-scale

0.602

High

227232

PRKN
E3 ubiquitin-protein ligase parkin

2

20

High-throughput

0.601

High

980669

FOXA2
Hepatocyte nuclear factor 3-beta

2

20

Small-scale

0.601

High

271753

PRDM1
PR domain zinc finger protein 1

2

6

Small-scale

0.595

High

817954

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.584

High

964303

RUNX1
Runt-related transcription factor 1

1

9

Small-scale

0.582

High

980600

RUNX3
Runt-related transcription factor 3

1

9

Small-scale

0.582

High

268039

EED
Polycomb protein EED

1

16

Small-scale

0.575

High

980607

SUZ12
Polycomb protein SUZ12

1

2

Small-scale

0.575

High

974243

HHEX
Hematopoietically-expressed homeobox protein HHEX

1

20

Small-scale

0.573

High

980636

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

2

Small-scale

0.573

High

980650

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

4

Small-scale

0.573

High

980663

HESX1
Homeobox expressed in ES cells 1

1

20

Small-scale

0.561

High

547789

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

10

Small-scale

0.554

High

980623

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

980648

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

121737

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

2

High-throughput

0.541

High

430146

PROF1
Profilin-1

1

1

High-throughput

0.541

High

552545

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.541

High

588881

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

2

High-throughput

0.541

High

724224

MSX2
Homeobox protein MSX-2

1

20

High-throughput

0.541

High

734507

ARL3
ADP-ribosylation factor-like protein 3

1

7

High-throughput

0.541

High

790968

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

6

High-throughput

0.541

High

839519

SPB9
Serpin B9

1

3

High-throughput

0.541

High

858093

NKX25
Homeobox protein Nkx-2.5

1

20

High-throughput

0.541

High

877703

FOXA1
Hepatocyte nuclear factor 3-alpha

1

20

High-throughput

0.541

High

877990

FOXA3
Hepatocyte nuclear factor 3-gamma

1

20

High-throughput

0.541

High

878488

CCL18
C-C motif chemokine 18

1

3

High-throughput

0.541

High

912031

RUXG
Small nuclear ribonucleoprotein G

1

19

High-throughput

0.541

High

950770

ERH
Enhancer of rudimentary homolog

1

1

High-throughput

0.541

High

980620

CELF3
CUGBP Elav-like family member 3

1

3

High-throughput

0.541

High

980629

RNF10
E3 ubiquitin-protein ligase RNF10

1

5

High-throughput

0.541

High

980634

FUBP1
Far upstream element-binding protein 1

1

12

High-throughput

0.541

High

980643

BTBD2
BTB/POZ domain-containing protein 2

1

4

High-throughput

0.541

High

980644

BARH1
BarH-like 1 homeobox protein

1

20

High-throughput

0.541

High

551124

ITF2
Transcription factor 4

1

8

Small-scale

0.536

High

203427

TBX1
T-box transcription factor TBX1

1

20

High-throughput

0.536

High

567682

UBF1
Nucleolar transcription factor 1

1

20

Small-scale

0.536

High

585946

HME2
Homeobox protein engrailed-2

1

20

High-throughput

0.536

High

883095

DSCR6
Protein ripply3

1

19

High-throughput

0.536

High

884298

PCBP3
Poly(rC)-binding protein 3

1

11

High-throughput

0.536

High

980599

CUL4B
Cullin-4B

1

20

Small-scale

0.536

High

980602

RUNX2
Runt-related transcription factor 2

1

9

Small-scale

0.536

High

980625

MAEA
E3 ubiquitin-protein transferase MAEA

1

2

High-throughput

0.536

High

980626

ARMC8
Armadillo repeat-containing protein 8

1

8

High-throughput

0.536

High

980627

FXL14
F-box/LRR-repeat protein 14

1

5

High-throughput

0.536

High

980641

FOXB1
Forkhead box protein B1

1

20

High-throughput

0.536

High

980651

HES4
Transcription factor HES-4

1

20

High-throughput

0.536

High

980647

HIPK2
Homeodomain-interacting protein kinase 2

1

19

Small-scale

0.527

High

311439

SIX3
Homeobox protein SIX3

1

20

Small-scale

0.527

High

417818

DPOLB
DNA polymerase beta

1

0

High-throughput

0.518

High

657904

PEX2
Peroxisome biogenesis factor 2

1

0

High-throughput

0.518

High

880340

DPOE2
DNA polymerase epsilon subunit 2

1

0

High-throughput

0.518

High

974234

GSTM4
Glutathione S-transferase Mu 4

1

0

High-throughput

0.518

High

980639

MPH6
M-phase phosphoprotein 6

1

0

High-throughput

0.518

High

660469

GRN
Progranulin

1

4

High-throughput

0.515

High

980661

ATX10
Ataxin-10

1

2

High-throughput

0.515

High

980670

RNF11
RING finger protein 11

1

4

High-throughput

0.515

High

739698

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

966962

SATB1
DNA-binding protein SATB1

1

0

High-throughput

0.513

High

578422

RCC1
Regulator of chromosome condensation

1

5

High-throughput

0.508

High

589180

ANXA7
Annexin A7

1

4

High-throughput

0.508

High

758196

CDN1A
Cyclin-dependent kinase inhibitor 1

1

2

High-throughput

0.508

High

835684

GSK3B
Glycogen synthase kinase-3 beta

1

8

High-throughput

0.508

High

897881

RAP1B
Ras-related protein Rap-1b

1

5

High-throughput

0.508

High

931598

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.508

High

980613

T22D1
TSC22 domain family protein 1

1

17

High-throughput

0.508

High

414877

CDK1
Cyclin-dependent kinase 1

1

4

Small-scale

0.501

High

449690

HMGB1
High mobility group protein B1

1

20

Small-scale

0.501

High

717016

CTNB1
Catenin beta-1

1

12

Small-scale

0.501

High

914640

ERR3
Estrogen-related receptor gamma

1

20

Small-scale

0.501

High

917150

H4
Histone H4

1

9

Small-scale

0.501

High

354829

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

2

High-throughput

0.494

High

830736

ARL4D
ADP-ribosylation factor-like protein 4D

1

5

High-throughput

0.494

High

901343

CH10
10 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.494

High

875824

MFAP4
Microfibril-associated glycoprotein 4

1

7

High-throughput

0.489

High

214909

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.486

High

879510

BID
BH3-interacting domain death agonist

1

0

High-throughput

0.486

High

980589

B2CL1
Bcl-2-like protein 1

1

0

High-throughput

0.486

High

980616

SMN
Survival motor neuron protein

1

0

High-throughput

0.486

High

60101

A4PIW0
Fusion protein SYT-SSX2

1

4

Small-scale

0.484

High

869457

ATN1
Atrophin-1

1

12

High-throughput

0.481

High

135106

NFIB
Nuclear factor 1 B-type

1

18

High-throughput

0.479

High

171017

TBXT
T-box transcription factor T

1

20

High-throughput

0.479

High

197699

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

204165

KLF4
Krueppel-like factor 4

1

20

High-throughput

0.479

High

225730

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.479

High

244322

BRD4
Bromodomain-containing protein 4

1

16

High-throughput

0.479

High

260299

PROP1
Homeobox protein prophet of Pit-1

1

20

Small-scale

0.479

High

345406

FOS
Protein c-Fos

1

12

High-throughput

0.479

High

369456

ESR1
Estrogen receptor

1

20

High-throughput

0.479

High

443170

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

487355

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

505209

EGR2
E3 SUMO-protein ligase EGR2

1

7

High-throughput

0.479

High

507403

ERG
Transcriptional regulator ERG

1

20

High-throughput

0.479

High

545960

MYOD1
Myoblast determination protein 1

1

7

High-throughput

0.479

High

554431

GATA1
Erythroid transcription factor

1

20

High-throughput

0.479

High

620142

PAX7
Paired box protein Pax-7

1

20

High-throughput

0.479

High

620329

GATA2
Endothelial transcription factor GATA-2

1

20

High-throughput

0.479

High

620481

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

20

High-throughput

0.479

High

641377

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.479

High

658485

TEAD1
Transcriptional enhancer factor TEF-1

1

3

High-throughput

0.479

High

727504

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

727732

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.479

High

727850

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

771927

VHL
von Hippel-Lindau disease tumor suppressor

1

1

High-throughput

0.479

High

782522

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

785356

ELK3
ETS domain-containing protein Elk-3

1

20

High-throughput

0.479

High

794534

ETV4
ETS translocation variant 4

1

20

High-throughput

0.479

High

818792

SOX9
Transcription factor SOX-9

1

20

High-throughput

0.479

High

822627

LHX1
LIM/homeobox protein Lhx1

1

11

High-throughput

0.479

High

822798

TNNI2
Troponin I, fast skeletal muscle

1

3

High-throughput

0.479

High

829830

HXA1
Homeobox protein Hox-A1

1

18

High-throughput

0.479

High

839732

LHX2
LIM/homeobox protein Lhx2

1

12

High-throughput

0.479

High

881797

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.479

High

882121

GSC
Homeobox protein goosecoid

1

20

High-throughput

0.479

High

884133

KLF3
Krueppel-like factor 3

1

19

High-throughput

0.479

High

971721

IRF8
Interferon regulatory factor 8

1

3

High-throughput

0.479

High

973842

PAX2
Paired box protein Pax-2

1

20

High-throughput

0.479

High

978719

TF65
Transcription factor p65

1

5

Small-scale

0.479

High

980588

PAX8
Paired box protein Pax-8

1

20

High-throughput

0.479

High

980594

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

980595

FOXI1
Forkhead box protein I1

1

20

High-throughput

0.479

High

980596

FOXL1
Forkhead box protein L1

1

20

High-throughput

0.479

High

980597

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

3

Small-scale

0.479

High

980601

KLF5
Krueppel-like factor 5

1

18

High-throughput

0.479

High

980606

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

980610

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

1

3

High-throughput

0.479

High

980611

IRF4
Interferon regulatory factor 4

1

3

High-throughput

0.479

High

980612

SSXT
Protein SSXT

1

8

Small-scale

0.479

High

980615

SSX2
Protein SSX2

1

2

Small-scale

0.479

High

980617

TBR1
T-box brain protein 1

1

20

High-throughput

0.479

High

980618

ISX
Intestine-specific homeobox

1

20

High-throughput

0.479

High

980622

LHX8
LIM/homeobox protein Lhx8

1

11

High-throughput

0.479

High

980630

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

980631

SP7
Transcription factor Sp7

1

16

High-throughput

0.479

High

980632

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

4

High-throughput

0.479

High

980633

LHX4
LIM/homeobox protein Lhx4

1

12

High-throughput

0.479

High

980640

FEV
Protein FEV

1

18

High-throughput

0.479

High

980642

SOX7
Transcription factor SOX-7

1

20

High-throughput

0.479

High

980645

FOXQ1
Forkhead box protein Q1

1

20

High-throughput

0.479

High

980649

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

980652

GCM1
Chorion-specific transcription factor GCMa

1

2

High-throughput

0.479

High

980654

SIX2
Homeobox protein SIX2

1

20

High-throughput

0.479

High

980659

VSX1
Visual system homeobox 1

1

20

High-throughput

0.479

High

980662

LHX3
LIM/homeobox protein Lhx3

1

12

High-throughput

0.479

High

980666

ELF5
ETS-related transcription factor Elf-5

1

20

High-throughput

0.479

High

980660

RERE
Arginine-glutamic acid dipeptide repeats protein

1

14

High-throughput

0.457

High

60095

A4PIV8
Fusion protein SYT-SSX1

1

4

Small-scale

0.445

High

177268

HDAC3
Histone deacetylase 3

1

20

Small-scale

0.445

High

980635

APH1A
Gamma-secretase subunit APH-1A

1

2

High-throughput

0.439

High

912810

TYB4
Thymosin beta-4

1

0

High-throughput

0.438

High

980657

ZF64B
Zinc finger protein 64

1

0

High-throughput

0.438

High

980591

GOGA2
Golgin subfamily A member 2

1

20

High-throughput

0.437

High

980592

FGL1
Fibrinogen-like protein 1

1

7

High-throughput

0.437

High

980619

PRC2B
Protein PRRC2B

1

20

High-throughput

0.437

High

980653

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

9

High-throughput

0.437

High

980655

STAR7
StAR-related lipid transfer protein 7, mitochondrial

1

2

High-throughput

0.437

High

980656

PLS4
Phospholipid scramblase 4

1

1

High-throughput

0.437

High

980658

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

4

High-throughput

0.437

High

980646

FXYD6
FXYD domain-containing ion transport regulator 6

1

0

High-throughput

0.282

High

980664

CRCT1
Cysteine-rich C-terminal protein 1

1

0

High-throughput

0.282

High

980668

PCDA4
Protocadherin alpha-4

1

0

High-throughput

0.282

High

980637

IFT43
Intraflagellar transport protein 43 homolog

1

0

High-throughput

0.279

Low

429521

HEXB
Beta-hexosaminidase subunit beta

1

0

High-throughput

0.268

Low

980624

K0408
Uncharacterized protein KIAA0408

1

0

High-throughput

0.265

Low

199227

LEU1
Leukemia-associated protein 1

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024