Protein: IF4E
Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)

Gene: IF4E, EIF4E
Organism: Homo sapiens
Interactions: 154
UniProt ID: P06730

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000339 - RNA cap binding
GO:0000340 - RNA 7-methylguanosine cap binding
GO:0000932 - P-body
GO:0001662 - behavioral fear response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

416982

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

56

15

Small-scale

0.997

High

416983

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

17

15

Small-scale

0.988

High

417031

4ET
Eukaryotic translation initiation factor 4E transporter

13

2

Small-scale

0.986

High

236380

4EBP3
Eukaryotic translation initiation factor 4E-binding protein 3

8

15

Small-scale

0.977

High

416970

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

33

18

Small-scale

0.770

High

203332

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

8

18

Small-scale

0.753

High

416958

IF4A1
Eukaryotic initiation factor 4A-I

8

5

Small-scale

0.752

High

417006

ANKH1
Ankyrin repeat and KH domain-containing protein 1

6

1

Small-scale

0.726

High

416955

EIF3B
Eukaryotic translation initiation factor 3 subunit B

5

4

Small-scale

0.718

High

416935

PML
Protein PML

7

0

Small-scale

0.712

High

416994

KANK2
KN motif and ankyrin repeat domain-containing protein 2

4

2

High-throughput

0.705

High

64106

I4E1B
Eukaryotic translation initiation factor 4E type 1B

1

3

High-throughput

0.691

High

416927

TRI27
Zinc finger protein RFP

3

2

High-throughput

0.676

High

417045

ANGE1
Protein angel homolog 1

4

0

High-throughput

0.670

High

416987

IF4A2
Eukaryotic initiation factor 4A-II

3

5

High-throughput

0.667

High

416969

HHEX
Hematopoietically-expressed homeobox protein HHEX

3

3

Small-scale

0.664

High

133842

DDX3X
ATP-dependent RNA helicase DDX3X

3

2

Small-scale

0.657

High

124728

EIF3F
Eukaryotic translation initiation factor 3 subunit F

3

3

Small-scale

0.656

High

416992

UBX11
UBX domain-containing protein 11

2

1

High-throughput

0.646

High

275781

EIF3G
Eukaryotic translation initiation factor 3 subunit G

2

5

High-throughput

0.628

High

416925

PABP1
Polyadenylate-binding protein 1

2

2

Small-scale

0.621

High

416950

T23O
Tryptophan 2,3-dioxygenase

2

0

High-throughput

0.618

High

176919

EIF3H
Eukaryotic translation initiation factor 3 subunit H

2

3

High-throughput

0.611

High

416946

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

2

0

Small-scale

0.602

High

416990

ELAV1
ELAV-like protein 1

2

3

Small-scale

0.601

High

178092

IPO8
Importin-8

2

0

Small-scale

0.598

High

162339

XPO1
Exportin-1

2

2

Small-scale

0.595

High

416986

EIF3A
Eukaryotic translation initiation factor 3 subunit A

2

0

Small-scale

0.585

High

416933

DDX6
Probable ATP-dependent RNA helicase DDX6

2

6

High-throughput

0.584

High

416947

DCC
Netrin receptor DCC

2

2

Small-scale

0.584

High

416962

RS6
Small ribosomal subunit protein eS6

2

1

Small-scale

0.584

High

416966

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

2

18

Small-scale

0.584

High

416968

CD83
CD83 antigen

1

0

High-throughput

0.584

High

416981

BIRC2
Baculoviral IAP repeat-containing protein 2

1

3

Small-scale

0.578

High

368822

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

416936

HXA9
Homeobox protein Hox-A9

1

1

Small-scale

0.561

High

417044

CHIP
E3 ubiquitin-protein ligase CHIP

2

0

Small-scale

0.559

High

417014

GEMI5
Gem-associated protein 5

1

2

Small-scale

0.536

High

416923

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

3

Small-scale

0.536

High

416928

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

2

High-throughput

0.536

High

416932

KS6B1
Ribosomal protein S6 kinase beta-1

1

1

Small-scale

0.536

High

416943

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

2

High-throughput

0.536

High

416944

MTOR
Serine/threonine-protein kinase mTOR

1

2

Small-scale

0.536

High

416948

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.536

High

416964

RACK1
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.536

High

416979

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

2

High-throughput

0.536

High

416984

DX39B
Spliceosome RNA helicase DDX39B

1

3

Small-scale

0.536

High

416999

RS27L
Ribosomal protein eS27-like

1

1

High-throughput

0.536

High

417012

LS14A
Protein LSM14 homolog A

1

2

High-throughput

0.536

High

417015

PSPC1
Paraspeckle component 1

1

6

High-throughput

0.536

High

417021

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.536

High

417022

RBM42
RNA-binding protein 42

1

2

High-throughput

0.536

High

417046

WDR3
WD repeat-containing protein 3

1

3

High-throughput

0.536

High

416971

EMX2
Homeobox protein EMX2

1

2

Small-scale

0.534

High

417023

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

4

Small-scale

0.534

High

417019

RENT1
Regulator of nonsense transcripts 1

1

0

Small-scale

0.530

High

416924

TAU
Microtubule-associated protein tau

2

0

High-throughput

0.528

High

417041

PRDM4
PR domain zinc finger protein 4

1

0

High-throughput

0.518

High

416965

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

1

Small-scale

0.515

High

60277

POTEF
POTE ankyrin domain family member F

1

0

High-throughput

0.513

High

176704

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.513

High

255022

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

283359

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

416949

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

416952

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

416954

IF5
Eukaryotic translation initiation factor 5

1

0

High-throughput

0.513

High

416956

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.513

High

416960

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

416988

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

417001

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

0

High-throughput

0.513

High

417034

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.513

High

417036

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.513

High

417039

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

417047

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.513

High

417048

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.513

High

417050

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

264263

GGYF1
GRB10-interacting GYF protein 1

1

8

Small-scale

0.501

High

393927

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

416931

HME2
Homeobox protein engrailed-2

1

3

Small-scale

0.501

High

416937

TLX1
T-cell leukemia homeobox protein 1

1

4

Small-scale

0.501

High

416938

OTX2
Homeobox protein OTX2

1

1

Small-scale

0.501

High

416997

GGYF2
GRB10-interacting GYF protein 2

1

8

Small-scale

0.501

High

417002

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

1

Small-scale

0.501

High

417028

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

3

Small-scale

0.501

High

416973

NCBP1
Nuclear cap-binding protein subunit 1

1

1

Small-scale

0.500

High

417024

RBM4
RNA-binding protein 4

1

4

Small-scale

0.500

High

416945

CASP3
Caspase-3

1

0

High-throughput

0.493

High

416957

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

High-throughput

0.480

High

127988

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

1

High-throughput

0.479

High

148030

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

4

High-throughput

0.479

High

226267

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

294267

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

322077

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

416934

TTP
mRNA decay activator protein ZFP36

1

1

High-throughput

0.479

High

416939

CTNB1
Catenin beta-1

1

1

High-throughput

0.479

High

416953

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.479

High

416959

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.479

High

416961

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

416963

SUMO1
Small ubiquitin-related modifier 1

1

1

Small-scale

0.479

High

416967

SRSF3
Serine/arginine-rich splicing factor 3

1

5

Small-scale

0.479

High

416972

FMR1
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.479

High

416976

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

High-throughput

0.479

High

416977

PAK2
Serine/threonine-protein kinase PAK 2

1

1

High-throughput

0.479

High

416978

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.479

High

416980

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

416985

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

4

Small-scale

0.479

High

416989

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

416993

RN123
E3 ubiquitin-protein ligase RNF123

1

3

High-throughput

0.479

High

416998

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

417003

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

417004

PATL1
Protein PAT1 homolog 1

1

2

High-throughput

0.479

High

417008

TRI22
E3 ubiquitin-protein ligase TRIM22

1

2

Small-scale

0.479

High

417009

RPTOR
Regulatory-associated protein of mTOR

1

3

Small-scale

0.479

High

417017

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

417018

CELF1
CUGBP Elav-like family member 1

1

3

High-throughput

0.479

High

417027

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

417033

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

417038

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

417049

TRAF6
TNF receptor-associated factor 6

1

4

High-throughput

0.479

High

417051

YTHD2
YTH domain-containing family protein 2

1

1

High-throughput

0.479

High

417052

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.479

High

182506

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

416926

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

416974

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

0

Small-scale

0.458

High

416975

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

416991

HSPB2
Heat shock protein beta-2

1

0

Small-scale

0.458

High

416995

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.458

High

417005

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

0

Small-scale

0.458

High

417010

OTU6B
Deubiquitinase OTUD6B

1

0

Small-scale

0.458

High

417016

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

417020

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

417029

DCP1A
mRNA-decapping enzyme 1A

1

0

High-throughput

0.458

High

417030

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

417032

SMYD2
N-lysine methyltransferase SMYD2

1

0

High-throughput

0.458

High

417035

AATF
Protein AATF

1

0

High-throughput

0.458

High

417040

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

1

0

Small-scale

0.458

High

373525

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.445

High

416940

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.445

High

416941

IRS1
Insulin receptor substrate 1

1

1

Small-scale

0.445

High

417025

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

1

High-throughput

0.445

High

417042

AGO2
Protein argonaute-2

1

5

Small-scale

0.445

High

416929

VINC
Vinculin

1

0

High-throughput

0.438

High

417000

ASXL2
Putative Polycomb group protein ASXL2

1

3

High-throughput

0.437

High

417007

ASXL1
Polycomb group protein ASXL1

1

3

High-throughput

0.437

High

417026

ASXL3
Putative Polycomb group protein ASXL3

1

4

High-throughput

0.437

High

416930

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

417037

NXF1
Nuclear RNA export factor 1

1

0

Small-scale

0.426

High

417043

INT6
Integrator complex subunit 6

1

0

Small-scale

0.426

High

416996

CLC4G
C-type lectin domain family 4 member G

1

1

Small-scale

0.407

High

416951

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

416942

ACVL1
Serine/threonine-protein kinase receptor R3

1

0

Small-scale

0.292

High

417013

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.279

Low

384097

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

417011

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024