Protein: TSHR
Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R)

Gene: TSHR
Organism: Homo sapiens
Interactions: 83
UniProt ID: P16473

Gene Ontology (top 5):
GO:0004996 - thyroid-stimulating hormone receptor activity
GO:0005886 - plasma membrane
GO:0007166 - cell surface receptor signaling pathway
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007187 - G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

560502

PTK7
Inactive tyrosine-protein kinase 7

2

12

High-throughput

0.789

High

560512

LAMA3
Laminin subunit alpha-3

3

8

High-throughput

0.770

High

560507

SCRIB
Protein scribble homolog

1

20

Small-scale

0.756

High

560490

AA1R
Adenosine receptor A1

1

20

High-throughput

0.752

High

428907

ADRB2
Beta-2 adrenergic receptor

1

15

Small-scale

0.713

High

560511

MOG
Myelin-oligodendrocyte glycoprotein

1

3

High-throughput

0.698

High

507834

FGFR1
Fibroblast growth factor receptor 1

1

8

High-throughput

0.691

High

545067

PVR
Poliovirus receptor

1

5

High-throughput

0.691

High

433119

LAMB1
Laminin subunit beta-1

1

7

High-throughput

0.618

High

502811

LAMC1
Laminin subunit gamma-1

1

6

High-throughput

0.618

High

560493

LAMB2
Laminin subunit beta-2

1

7

High-throughput

0.618

High

501647

BIP
Endoplasmic reticulum chaperone BiP

2

6

Small-scale

0.611

High

560525

TBA1A
Tubulin alpha-1A chain

2

12

High-throughput

0.611

High

60292

POTEF
POTE ankyrin domain family member F

3

12

High-throughput

0.609

High

560494

MLF1
Myeloid leukemia factor 1

2

1

High-throughput

0.574

High

513527

PYC
Pyruvate carboxylase, mitochondrial

2

2

High-throughput

0.558

High

560483

SYT1
Synaptotagmin-1

1

0

High-throughput

0.558

High

560504

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

2

High-throughput

0.553

High

560495

CD81
CD81 antigen

1

11

High-throughput

0.541

High

560496

ACTB
Actin, cytoplasmic 1

1

8

High-throughput

0.541

High

428004

TBB5
Tubulin beta chain

1

10

High-throughput

0.536

High

560488

PCSK6
Proprotein convertase subtilisin/kexin type 6

1

9

High-throughput

0.536

High

560522

CSPG4
Chondroitin sulfate proteoglycan 4

1

2

High-throughput

0.536

High

560543

JAG2
Protein jagged-2

1

4

High-throughput

0.536

High

560547

AGRG1
Adhesion G-protein coupled receptor G1

1

4

High-throughput

0.536

High

560516

TM119
Transmembrane protein 119

1

0

High-throughput

0.518

High

560529

JPH3
Junctophilin-3

1

0

High-throughput

0.518

High

560487

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

7

Small-scale

0.515

High

165156

PLXB2
Plexin-B2

1

0

High-throughput

0.513

High

344788

TIMP1
Metalloproteinase inhibitor 1

1

0

High-throughput

0.513

High

560489

ACHA5
Neuronal acetylcholine receptor subunit alpha-5

1

0

High-throughput

0.513

High

560499

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.513

High

560506

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

0

High-throughput

0.513

High

560513

T132A
Transmembrane protein 132A

1

0

High-throughput

0.513

High

560533

NEUR1
Sialidase-1

1

0

High-throughput

0.513

High

560536

COMD4
COMM domain-containing protein 4

1

0

High-throughput

0.513

High

362785

FINC
Fibronectin

1

9

Small-scale

0.501

High

453127

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.494

High

560492

PTSS1
Phosphatidylserine synthase 1

1

4

High-throughput

0.494

High

560523

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

1

1

High-throughput

0.494

High

381113

TBB4A
Tubulin beta-4A chain

1

10

High-throughput

0.489

High

560497

TBA4A
Tubulin alpha-4A chain

1

12

High-throughput

0.489

High

560508

DPOD3
DNA polymerase delta subunit 3

1

2

High-throughput

0.489

High

560509

NOMO1
BOS complex subunit NOMO1

1

1

High-throughput

0.489

High

560514

TBB8
Tubulin beta-8 chain

1

10

High-throughput

0.489

High

560520

SPSB3
SPRY domain-containing SOCS box protein 3

1

5

High-throughput

0.489

High

560524

CREL2
Protein disulfide isomerase CRELD2

1

4

High-throughput

0.489

High

560527

MIRO2
Mitochondrial Rho GTPase 2

1

10

High-throughput

0.489

High

560539

SG196
Protein O-mannose kinase

1

20

High-throughput

0.489

High

560540

ESRP2
Epithelial splicing regulatory protein 2

1

4

High-throughput

0.489

High

238349

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.479

High

560484

JAK1
Tyrosine-protein kinase JAK1

1

19

Small-scale

0.479

High

560485

CALR
Calreticulin

1

10

Small-scale

0.479

High

560491

STAT3
Signal transducer and activator of transcription 3

1

2

Small-scale

0.479

High

560505

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

3

High-throughput

0.479

High

560538

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.479

High

560486

CALX
Calnexin

1

10

Small-scale

0.437

High

560500

GOGA2
Golgin subfamily A member 2

1

3

High-throughput

0.437

High

560521

SAMD1
Sterile alpha motif domain-containing protein 1

1

3

High-throughput

0.437

High

560546

SALL2
Sal-like protein 2

1

1

High-throughput

0.437

High

261194

FLNB
Filamin-B

1

11

Small-scale

0.408

High

560519

BORA
Protein aurora borealis

3

0

High-throughput

0.347

High

560530

MOCOS
Molybdenum cofactor sulfurase

3

0

High-throughput

0.347

High

560535

ITPA
Inosine triphosphate pyrophosphatase

3

0

High-throughput

0.347

High

560528

TRM44
Probable tRNA

2

0

High-throughput

0.318

High

560534

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

2

0

High-throughput

0.318

High

560545

FBX7
F-box only protein 7

2

0

High-throughput

0.318

High

560541

M1IP1
Mid1-interacting protein 1

1

0

High-throughput

0.304

High

560498

CRADD
Death domain-containing protein CRADD

1

0

High-throughput

0.282

High

560501

SEC20
Vesicle transport protein SEC20

1

0

High-throughput

0.282

High

560517

RUN3A
RUN domain-containing protein 3A

1

0

High-throughput

0.282

High

560518

ASPH1
Aspartate beta-hydroxylase domain-containing protein 1

1

0

High-throughput

0.282

High

215426

SCO2
Protein SCO2 homolog, mitochondrial

1

0

High-throughput

0.279

Low

271520

ERAL1
GTPase Era, mitochondrial

1

0

High-throughput

0.279

Low

560503

OS9
Protein OS-9

1

0

High-throughput

0.279

Low

560515

ERFE
Erythroferrone

1

0

High-throughput

0.279

Low

560526

OAF
Out at first protein homolog

1

0

High-throughput

0.279

Low

560531

NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

1

0

High-throughput

0.279

Low

560532

NAR5
Ecto-ADP-ribosyltransferase 5

1

0

High-throughput

0.279

Low

560537

LMA2L
VIP36-like protein

1

0

High-throughput

0.279

Low

560542

T11L1
T-complex protein 11-like protein 1

1

0

High-throughput

0.279

Low

560544

MA2B2
Epididymis-specific alpha-mannosidase

1

0

High-throughput

0.279

Low

560510

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024