Protein: S1PR1
Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363)

Gene: S1PR1
Organism: Homo sapiens
Interactions: 105
UniProt ID: P21453

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001664 - G protein-coupled receptor binding
GO:0001955 - blood vessel maturation
GO:0003245 - cardiac muscle tissue growth involved in heart morphogenesis
GO:0003376 - sphingosine-1-phosphate receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

444664

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

20

Small-scale

0.740

High

598724

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

20

Small-scale

0.740

High

598719

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

20

High-throughput

0.691

High

598736

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

20

High-throughput

0.691

High

530828

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

2

20

High-throughput

0.628

High

598721

AT12A
Potassium-transporting ATPase alpha chain 2

2

20

High-throughput

0.628

High

598731

CD47
Leukocyte surface antigen CD47

2

4

High-throughput

0.628

High

598747

GRIN1
G protein-regulated inducer of neurite outgrowth 1

2

3

High-throughput

0.628

High

598776

TTYH3
Protein tweety homolog 3

2

12

High-throughput

0.628

High

598789

CLC2D
C-type lectin domain family 2 member D

2

12

High-throughput

0.628

High

445744

5HT1A
5-hydroxytryptamine receptor 1A

1

19

Small-scale

0.618

High

598718

5HT1D
5-hydroxytryptamine receptor 1D

1

18

Small-scale

0.618

High

503201

PPAL
Lysosomal acid phosphatase

2

5

High-throughput

0.574

High

60296

POTEF
POTE ankyrin domain family member F

1

7

High-throughput

0.536

High

119611

STXB3
Syntaxin-binding protein 3

1

2

High-throughput

0.536

High

155526

TNPO2
Transportin-2

1

4

High-throughput

0.536

High

163561

BTAF1
TATA-binding protein-associated factor 172

1

2

High-throughput

0.536

High

173432

RER1
Protein RER1

1

3

High-throughput

0.536

High

178109

IPO8
Importin-8

1

9

High-throughput

0.536

High

217135

EXTL3
Exostosin-like 3

1

3

High-throughput

0.536

High

312181

IPO7
Importin-7

1

9

High-throughput

0.536

High

326021

TSN15
Tetraspanin-15

1

20

High-throughput

0.536

High

349122

RASH
GTPase HRas

1

9

High-throughput

0.536

High

486011

RAP2A
Ras-related protein Rap-2a

1

11

High-throughput

0.536

High

522771

SRC
Proto-oncogene tyrosine-protein kinase Src

1

11

High-throughput

0.536

High

528151

CY24A
Cytochrome b-245 light chain

1

2

High-throughput

0.536

High

598725

GBG5

1

3

High-throughput

0.536

High

598726

AT2C1
Calcium-transporting ATPase type 2C member 1

1

20

High-throughput

0.536

High

598727

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

20

High-throughput

0.536

High

598729

CKAP4
Cytoskeleton-associated protein 4

1

5

High-throughput

0.536

High

598732

TMED1
Transmembrane emp24 domain-containing protein 1

1

4

High-throughput

0.536

High

598733

PKD2
Polycystin-2

1

3

High-throughput

0.536

High

598734

CKAP5
Cytoskeleton-associated protein 5

1

3

High-throughput

0.536

High

598735

ZMYM3
Zinc finger MYM-type protein 3

1

1

High-throughput

0.536

High

598738

AT2B3
Plasma membrane calcium-transporting ATPase 3

1

20

High-throughput

0.536

High

598740

COL12
Collectin-12

1

2

High-throughput

0.536

High

598742

CNNM4
Metal transporter CNNM4

1

6

High-throughput

0.536

High

598743

S39A4
Zinc transporter ZIP4

1

20

High-throughput

0.536

High

598746

DYM
Dymeclin

1

3

High-throughput

0.536

High

598751

GP180
Integral membrane protein GPR180

1

3

High-throughput

0.536

High

598755

VP37A
Vacuolar protein sorting-associated protein 37A

1

1

High-throughput

0.536

High

598756

TBC15
TBC1 domain family member 15

1

3

High-throughput

0.536

High

598762

F241B
Protein FAM241B

1

5

High-throughput

0.536

High

598763

SAAL1
Protein SAAL1

1

2

High-throughput

0.536

High

598764

IPO9
Importin-9

1

10

High-throughput

0.536

High

598765

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

8

High-throughput

0.536

High

598766

RMD3
Regulator of microtubule dynamics protein 3

1

1

High-throughput

0.536

High

598767

SORT
Sortilin

1

1

High-throughput

0.536

High

598768

TS101
Tumor susceptibility gene 101 protein

1

2

High-throughput

0.536

High

598770

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

4

High-throughput

0.536

High

598772

TTYH2
Protein tweety homolog 2

1

12

High-throughput

0.536

High

598774

FACD2
Fanconi anemia group D2 protein

1

3

High-throughput

0.536

High

598775

XPO4
Exportin-4

1

6

High-throughput

0.536

High

598777

YIPF3
Protein YIPF3

1

4

High-throughput

0.536

High

598778

T126A
Transmembrane protein 126A

1

3

High-throughput

0.536

High

598783

TM9S3
Transmembrane 9 superfamily member 3

1

12

High-throughput

0.536

High

598784

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

2

High-throughput

0.536

High

598787

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

5

High-throughput

0.536

High

598791

S39AA
Zinc transporter ZIP10

1

20

High-throughput

0.536

High

598796

TNPO3
Transportin-3

1

10

High-throughput

0.536

High

598730

CD69
Early activation antigen CD69

1

12

Small-scale

0.515

High

195881

TTI1
TELO2-interacting protein 1 homolog

1

0

High-throughput

0.513

High

598722

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

598790

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

High-throughput

0.513

High

394112

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

175557

TM9S1
Transmembrane 9 superfamily member 1

1

12

High-throughput

0.489

High

206459

B4GA1
Beta-1,4-glucuronyltransferase 1

1

2

High-throughput

0.489

High

237784

TSN3
Tetraspanin-3

1

20

High-throughput

0.489

High

273363

PPM1B
Protein phosphatase 1B

1

1

High-throughput

0.489

High

598723

SYJ2B
Synaptojanin-2-binding protein

1

18

High-throughput

0.489

High

598739

MBRL
Membralin

1

4

High-throughput

0.489

High

598741

IPIL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

1

2

High-throughput

0.489

High

598744

THADA
tRNA

1

3

High-throughput

0.489

High

598745

CERS6
Ceramide synthase 6

1

13

High-throughput

0.489

High

598748

MON2
Protein MON2 homolog

1

5

High-throughput

0.489

High

598749

FRMD5
FERM domain-containing protein 5

1

5

High-throughput

0.489

High

598750

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

5

High-throughput

0.489

High

598752

MIRO2
Mitochondrial Rho GTPase 2

1

8

High-throughput

0.489

High

598753

K2013
Uncharacterized protein KIAA2013

1

5

High-throughput

0.489

High

598754

ARL10
ADP-ribosylation factor-like protein 10

1

10

High-throughput

0.489

High

598757

THEM6
Protein THEM6

1

2

High-throughput

0.489

High

598758

LMBR1
Limb region 1 protein homolog

1

2

High-throughput

0.489

High

598759

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

3

High-throughput

0.489

High

598760

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

5

High-throughput

0.489

High

598761

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

20

High-throughput

0.489

High

598773

PTSS2
Phosphatidylserine synthase 2

1

5

High-throughput

0.489

High

598780

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

3

High-throughput

0.489

High

598781

S38AA
Solute carrier family 38 member 10

1

2

High-throughput

0.489

High

598782

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

1

3

High-throughput

0.489

High

598785

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

2

High-throughput

0.489

High

598786

TM160
Transmembrane protein 160

1

2

High-throughput

0.489

High

598788

COX16
Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial

1

1

High-throughput

0.489

High

598792

TMCO1
Calcium load-activated calcium channel

1

2

High-throughput

0.489

High

598793

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

1

High-throughput

0.489

High

598794

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

4

High-throughput

0.489

High

598795

TMED5
Transmembrane emp24 domain-containing protein 5

1

4

High-throughput

0.489

High

125153

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

8

Small-scale

0.479

High

434942

SP1
Transcription factor Sp1

1

1

High-throughput

0.479

High

452351

PGFRB
Platelet-derived growth factor receptor beta

1

4

Small-scale

0.479

High

598728

CAV1
Caveolin-1

1

4

Small-scale

0.479

High

598737

TRIP6
Thyroid receptor-interacting protein 6

1

2

Small-scale

0.479

High

598769

CMS1
Protein CMSS1

1

0

High-throughput

0.282

High

598720

HXK3
Hexokinase-3

1

0

High-throughput

0.279

Low

598771

MIC25
MICOS complex subunit MIC25

1

0

High-throughput

0.279

Low

598779

GLP3L
Golgi phosphoprotein 3-like

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024