Protein: HACE1
E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1)

Gene: HACE1
Organism: Homo sapiens
Interactions: 26
UniProt ID: Q8IYU2

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

925423

RAC1
Ras-related C3 botulinum toxin substrate 1

7

20

Small-scale

0.975

High

932547

UB2L3
Ubiquitin-conjugating enzyme E2 L3

7

20

Small-scale

0.960

High

1223640

HACE1
E3 ubiquitin-protein ligase HACE1

2

14

Small-scale

0.812

High

1223642

OPTN
Optineurin

1

17

Small-scale

0.784

High

591922

RAB4A
Ras-related protein Rab-4A

3

2

Small-scale

0.759

High

851584

NEK4
Serine/threonine-protein kinase Nek4

1

17

High-throughput

0.691

High

60363

POTEF
POTE ankyrin domain family member F

1

7

High-throughput

0.665

High

919782

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

High-throughput

0.647

High

1026185

PAK1
Serine/threonine-protein kinase PAK 1

1

16

Small-scale

0.647

High

585503

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

18

Small-scale

0.618

High

914199

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.586

High

1199953

NOXA1
NADPH oxidase activator 1

1

0

Small-scale

0.586

High

624465

CCNC
Cyclin-C

1

5

Small-scale

0.578

High

1223645

SNTG2
Gamma-2-syntrophin

1

12

Small-scale

0.536

High

1223641

IRF7
Interferon regulatory factor 7

1

2

High-throughput

0.536

High

1223644

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

3

High-throughput

0.536

High

781259

CASR
Extracellular calcium-sensing receptor

1

1

Small-scale

0.512

High

487995

RARA
Retinoic acid receptor alpha

1

11

Small-scale

0.479

High

500370

RARB
Retinoic acid receptor beta

1

11

Small-scale

0.479

High

530804

RARG
Retinoic acid receptor gamma

1

11

Small-scale

0.479

High

931270

YBOX1
Y-box-binding protein 1

1

6

Small-scale

0.479

High

1081228

NF2L2
Nuclear factor erythroid 2-related factor 2

1

13

Small-scale

0.479

High

1223643

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

8

High-throughput

0.479

High

1223646

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

253484

PLXA2
Plexin-A2

1

1

Small-scale

0.457

High


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Last updated: 15 Jul 2024