Protein: OTUB2
Ubiquitin thioesterase OTUB2 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB2) (OTU domain-containing ubiquitin aldehyde-binding protein 2) (Otubain-2) (Ubiquitin-specific-processing protease OTUB2)

Gene: OTUB2
Organism: Homo sapiens
Interactions: 97
UniProt ID: Q96DC9

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0006508 - proteolysis
GO:0016579 - protein deubiquitination
GO:0035871 - protein K11-linked deubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

476180

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

5

5

Small-scale

0.920

High

1288113

TRAF6
TNF receptor-associated factor 6

4

8

Small-scale

0.685

High

1288092

TRIM8
E3 ubiquitin-protein ligase TRIM8

3

15

High-throughput

0.654

High

896513

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

11

Small-scale

0.647

High

1079572

NEDD8
NEDD8

1

2

Small-scale

0.647

High

981683

REL
Proto-oncogene c-Rel

3

0

High-throughput

0.646

High

1043727

ASPP2
Apoptosis-stimulating of p53 protein 2

2

1

High-throughput

0.633

High

537987

KPYM
Pyruvate kinase PKM

2

1

Small-scale

0.624

High

1288090

TRI54
Tripartite motif-containing protein 54

3

14

High-throughput

0.611

High

868290

ATX3
Ataxin-3

2

0

High-throughput

0.585

High

1288097

NMRL1
NmrA-like family domain-containing protein 1

2

1

Small-scale

0.584

High

1065157

DAZP2
DAZ-associated protein 2

2

0

High-throughput

0.580

High

1288096

CDIP1
Cell death-inducing p53-target protein 1

2

0

High-throughput

0.580

High

1216683

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

High-throughput

0.573

High

641888

U2AF2
Splicing factor U2AF 65 kDa subunit

1

1

Small-scale

0.561

High

1084564

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.549

High

1245288

PJA1
E3 ubiquitin-protein ligase Praja-1

2

4

Small-scale

0.543

High

796328

MAGAB
Melanoma-associated antigen 11

1

2

High-throughput

0.541

High

485082

GLI2
Zinc finger protein GLI2

1

0

Small-scale

0.537

High

175705

TRI18
E3 ubiquitin-protein ligase Midline-1

1

14

High-throughput

0.523

High

1288086

LZTS2
Leucine zipper putative tumor suppressor 2

1

1

High-throughput

0.523

High

1288105

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

14

High-throughput

0.523

High

751759

GRP75
Stress-70 protein, mitochondrial

1

4

High-throughput

0.515

High

985573

Q05BL1
TP53BP2 protein

1

1

High-throughput

0.515

High

1203328

GPBP1
Vasculin

1

0

High-throughput

0.513

High

1261770

TPC12
Trafficking protein particle complex subunit 12

1

0

High-throughput

0.513

High

132982

SDCB1
Syntenin-1

1

1

Small-scale

0.501

High

1281998

TRI63
E3 ubiquitin-protein ligase TRIM63

1

15

High-throughput

0.501

High

1288085

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

3

High-throughput

0.501

High

1288091

TRI55
Tripartite motif-containing protein 55

1

15

High-throughput

0.501

High

1288106

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

3

High-throughput

0.501

High

435156

SP1
Transcription factor Sp1

1

1

High-throughput

0.500

High

942230

GTF2I
General transcription factor II-I

1

0

High-throughput

0.493

High

1241189

KCTD6
BTB/POZ domain-containing protein KCTD6

1

1

High-throughput

0.489

High

1288107

NEB1
Neurabin-1

1

1

High-throughput

0.489

High

536975

TRI27
Zinc finger protein RFP

1

4

High-throughput

0.481

High

1019352

TRI26
Tripartite motif-containing protein 26

1

4

High-throughput

0.481

High

1288087

RN126
E3 ubiquitin-protein ligase RNF126

1

4

High-throughput

0.481

High

1288089

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

2

High-throughput

0.481

High

1288099

TRI39
E3 ubiquitin-protein ligase TRIM39

1

4

High-throughput

0.481

High

326743

SNAI1
Zinc finger protein SNAI1

1

1

Small-scale

0.479

High

347548

MYC
Myc proto-oncogene protein

1

1

Small-scale

0.479

High

382101

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

Small-scale

0.479

High

418534

NPM
Nucleophosmin

1

1

Small-scale

0.479

High

585031

RO52
E3 ubiquitin-protein ligase TRIM21

1

4

Small-scale

0.479

High

611487

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

2

Small-scale

0.479

High

717274

CTNB1
Catenin beta-1

1

1

Small-scale

0.479

High

757709

IF4A3
Eukaryotic initiation factor 4A-III

1

3

Small-scale

0.479

High

808834

YAP1
Transcriptional coactivator YAP1

1

2

Small-scale

0.479

High

1288095

WWTR1
WW domain-containing transcription regulator protein 1

1

2

Small-scale

0.479

High

1288108

PRP19
Pre-mRNA-processing factor 19

1

1

Small-scale

0.479

High

1076498

TRIP6
Thyroid receptor-interacting protein 6

1

0

High-throughput

0.460

High

643566

PTBP1
Polypyrimidine tract-binding protein 1

1

0

Small-scale

0.458

High

760224

RL3
Large ribosomal subunit protein uL3

1

0

Small-scale

0.458

High

855167

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

0

Small-scale

0.458

High

881824

SOX10
Transcription factor SOX-10

1

0

Small-scale

0.458

High

932819

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.458

High

1033077

ZN211
Zinc finger protein 211

1

0

Small-scale

0.458

High

1240918

SERB1
SERPINE1 mRNA-binding protein 1

1

0

Small-scale

0.458

High

1288088

PDIP3
Polymerase delta-interacting protein 3

1

0

Small-scale

0.458

High

1288101

SENP1
Sentrin-specific protease 1

1

0

Small-scale

0.458

High

1288111

RTCB
RNA-splicing ligase RtcB homolog

1

0

Small-scale

0.458

High

1288112

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

395443

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.457

High

1264874

RFFL
E3 ubiquitin-protein ligase rififylin

1

3

High-throughput

0.457

High

1052730

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

8

High-throughput

0.439

High

1071324

K1H1
Keratin, type I cuticular Ha1

1

1

High-throughput

0.439

High

1149278

K1C40
Keratin, type I cytoskeletal 40

1

1

High-throughput

0.439

High

1288093

TRIM5
Tripartite motif-containing protein 5

1

4

High-throughput

0.439

High

1288094

TRIM2
Tripartite motif-containing protein 2

1

11

High-throughput

0.439

High

443714

VIME
Vimentin

1

1

Small-scale

0.437

High

1024731

TRAF3
TNF receptor-associated factor 3

1

7

Small-scale

0.437

High

1190053

MAVS
Mitochondrial antiviral-signaling protein

1

1

Small-scale

0.437

High

1288100

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

Small-scale

0.437

High

1288102

RCC2
Protein RCC2

1

2

Small-scale

0.437

High

1130428

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.407

High

1267373

F168A
Protein FAM168A

5

0

High-throughput

0.374

High

1285040

ARRD3
Arrestin domain-containing protein 3

3

0

High-throughput

0.352

High

1120839

PHLA2
Pleckstrin homology-like domain family A member 2

2

0

High-throughput

0.316

High

1229715

SPART
Spartin

2

0

High-throughput

0.316

High

1282577

PMEPA
Protein TMEPAI

2

0

High-throughput

0.316

High

1287259

PKHB2
Pleckstrin homology domain-containing family B member 2

2

0

High-throughput

0.316

High

1288104

MKRN1
E3 ubiquitin-protein ligase makorin-1

2

0

High-throughput

0.316

High

61218

TPC13
Trafficking protein particle complex subunit 13

1

0

High-throughput

0.279

Low

686721

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.279

Low

1013401

NEXN
Nexilin

1

0

High-throughput

0.279

Low

1167359

NPSR1
Neuropeptide S receptor

1

0

High-throughput

0.279

Low

1167397

MPRIP
Myosin phosphatase Rho-interacting protein

1

0

High-throughput

0.279

Low

1188122

TPC11
Trafficking protein particle complex subunit 11

1

0

High-throughput

0.279

Low

1197955

TPC6B
Trafficking protein particle complex subunit 6B

1

0

High-throughput

0.279

Low

1261369

CPLX3
Complexin-3

1

0

High-throughput

0.279

Low

1288103

PEMT
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.279

Low

1288109

TPPC4
Trafficking protein particle complex subunit 4

1

0

High-throughput

0.279

Low

1288110

TPPC8
Trafficking protein particle complex subunit 8

1

0

High-throughput

0.279

Low

1140688

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.249

Low

1288098

NCOA5
Nuclear receptor coactivator 5

1

0

Small-scale

0.249

Low

1288114

PIAS3
E3 SUMO-protein ligase PIAS3

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024