Protein: GAB2
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)

Gene: GAB2
Organism: Homo sapiens
Interactions: 124
UniProt ID: Q9UQC2

Gene Ontology (top 5):
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005547 - phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

924959

GRB2
Growth factor receptor-bound protein 2

21

20

Small-scale

0.991

High

275242

GRAP2
GRB2-related adapter protein 2

6

20

Small-scale

0.948

High

802920

CRKL
Crk-like protein

3

20

Small-scale

0.854

High

682077

AKT1
RAC-alpha serine/threonine-protein kinase

2

6

Small-scale

0.838

High

339151

EGFR
Epidermal growth factor receptor

3

20

Small-scale

0.805

High

647712

MK03
Mitogen-activated protein kinase 3

2

4

Small-scale

0.797

High

659093

MK01
Mitogen-activated protein kinase 1

2

4

Small-scale

0.778

High

986059

PTN11
Tyrosine-protein phosphatase non-receptor type 11

16

15

Small-scale

0.760

High

1357876

GAB2
GRB2-associated-binding protein 2

2

13

Small-scale

0.757

High

655510

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

10

20

Small-scale

0.752

High

927669

1433Z
14-3-3 protein zeta/delta

7

20

Small-scale

0.739

High

919310

RAN
GTP-binding nuclear protein Ran

2

14

High-throughput

0.737

High

1069668

STK38
Serine/threonine-protein kinase 38

2

11

High-throughput

0.737

High

982632

1433F
14-3-3 protein eta

6

20

Small-scale

0.727

High

647389

1433T
14-3-3 protein theta

6

20

Small-scale

0.720

High

905271

1433G
14-3-3 protein gamma

5

20

Small-scale

0.716

High

64752

RHG32
Rho GTPase-activating protein 32

1

16

Small-scale

0.713

High

910172

1433E
14-3-3 protein epsilon

5

10

Small-scale

0.712

High

683824

1433B
14-3-3 protein beta/alpha

4

20

Small-scale

0.694

High

666193

SHC1
SHC-transforming protein 1

4

20

Small-scale

0.692

High

684404

1433S
14-3-3 protein sigma

4

20

Small-scale

0.666

High

557834

NCK1
SH2/SH3 adapter protein NCK1

1

20

Small-scale

0.647

High

581081

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

8

Small-scale

0.647

High

1040322

GRAP
GRB2-related adapter protein

1

20

Small-scale

0.647

High

825301

TGM4
Protein-glutamine gamma-glutamyltransferase 4

2

2

High-throughput

0.628

High

1035417

GAB1
GRB2-associated-binding protein 1

1

13

Small-scale

0.621

High

166634

DCLK1
Serine/threonine-protein kinase DCLK1

1

10

High-throughput

0.618

High

230934

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

8

High-throughput

0.618

High

253434

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

14

High-throughput

0.618

High

349013

RASN
GTPase NRas

1

20

High-throughput

0.618

High

349739

RASH
GTPase HRas

1

20

High-throughput

0.618

High

350696

RASK
GTPase KRas

1

20

High-throughput

0.618

High

384030

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.618

High

385735

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

434086

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.618

High

441588

MET
Hepatocyte growth factor receptor

1

20

Small-scale

0.618

High

506681

BCR
Breakpoint cluster region protein

1

14

Small-scale

0.618

High

523213

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.618

High

562669

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

5

Small-scale

0.618

High

796489

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

Small-scale

0.618

High

802781

CRK
Adapter molecule crk

1

20

High-throughput

0.618

High

960428

CDK16
Cyclin-dependent kinase 16

1

4

High-throughput

0.618

High

1105501

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

2

High-throughput

0.618

High

1136564

SPD2A
SH3 and PX domain-containing protein 2A

1

13

High-throughput

0.618

High

1183151

MARK2
Serine/threonine-protein kinase MARK2

1

1

Small-scale

0.618

High

1218003

KSR1
Kinase suppressor of Ras 1

1

20

High-throughput

0.618

High

1259724

FRS2
Fibroblast growth factor receptor substrate 2

1

1

Small-scale

0.618

High

1301726

TESK2
Dual specificity testis-specific protein kinase 2

1

3

High-throughput

0.618

High

1311612

RTKN
Rhotekin

1

3

High-throughput

0.618

High

1343637

KI13B
Kinesin-like protein KIF13B

1

8

High-throughput

0.618

High

1346688

ARL8B
ADP-ribosylation factor-like protein 8B

1

5

High-throughput

0.618

High

1357703

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

9

High-throughput

0.618

High

414116

GELS
Gelsolin

2

4

High-throughput

0.571

High

500219

CH60
60 kDa heat shock protein, mitochondrial

2

3

High-throughput

0.571

High

502690

BIP
Endoplasmic reticulum chaperone BiP

2

8

High-throughput

0.571

High

515972

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

4

High-throughput

0.571

High

542480

PLAK
Junction plakoglobin

2

13

High-throughput

0.571

High

564211

HSP76
Heat shock 70 kDa protein 6

2

4

High-throughput

0.571

High

923811

PPIA
Peptidyl-prolyl cis-trans isomerase A

2

1

High-throughput

0.571

High

929379

IF5A1
Eukaryotic translation initiation factor 5A-1

2

2

High-throughput

0.571

High

970858

DSG1
Desmoglein-1

2

9

High-throughput

0.571

High

1326727

IF5A2
Eukaryotic translation initiation factor 5A-2

2

2

High-throughput

0.571

High

388806

HSPB1
Heat shock protein beta-1

2

0

High-throughput

0.547

High

907595

RS8
Small ribosomal subunit protein eS8

2

0

High-throughput

0.547

High

913839

RL7A
Large ribosomal subunit protein eL8

2

0

High-throughput

0.547

High

1304267

PARK7
Parkinson disease protein 7

2

0

High-throughput

0.547

High

129351

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.536

High

167047

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

4

High-throughput

0.536

High

963925

SET
Protein SET

1

3

High-throughput

0.536

High

1173895

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

6

High-throughput

0.536

High

1197962

TPC6B
Trafficking protein particle complex subunit 6B

1

1

High-throughput

0.536

High

1216770

TPPC5
Trafficking protein particle complex subunit 5

1

1

High-throughput

0.536

High

1239521

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

4

High-throughput

0.536

High

1350443

TBC14
TBC1 domain family member 14

1

2

High-throughput

0.536

High

1356736

TPC2L
Trafficking protein particle complex subunit 2-like protein

1

1

High-throughput

0.536

High

1357877

TPPC4
Trafficking protein particle complex subunit 4

1

1

High-throughput

0.536

High

1357881

TPPC1
Trafficking protein particle complex subunit 1

1

1

High-throughput

0.536

High

1153638

IF5AL
Eukaryotic translation initiation factor 5A-1-like

2

2

High-throughput

0.521

High

792101

HD
Huntingtin

1

4

High-throughput

0.515

High

1264896

RFFL
E3 ubiquitin-protein ligase rififylin

1

6

High-throughput

0.515

High

1295659

MY15B
Unconventional myosin-XVB

1

7

High-throughput

0.515

High

61226

TPC13
Trafficking protein particle complex subunit 13

1

0

High-throughput

0.513

High

208754

TPPC3
Trafficking protein particle complex subunit 3

1

0

High-throughput

0.513

High

1188136

TPC11
Trafficking protein particle complex subunit 11

1

0

High-throughput

0.513

High

1261778

TPC12
Trafficking protein particle complex subunit 12

1

0

High-throughput

0.513

High

1357878

TPPC8
Trafficking protein particle complex subunit 8

1

0

High-throughput

0.513

High

445585

RSSA
Small ribosomal subunit protein uS2

1

0

High-throughput

0.493

High

163480

XPO1
Exportin-1

1

11

High-throughput

0.479

High

196532

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

4

High-throughput

0.479

High

207499

LAT
Linker for activation of T-cells family member 1

1

1

Small-scale

0.479

High

237348

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

3

High-throughput

0.479

High

264444

GGYF1
GRB10-interacting GYF protein 1

1

7

High-throughput

0.479

High

316291

NADK
NAD kinase

1

2

High-throughput

0.479

High

483356

TPC2B
Trafficking protein particle complex subunit 2B

1

1

High-throughput

0.479

High

598547

NF1
Neurofibromin

1

9

High-throughput

0.479

High

665968

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

16

Small-scale

0.479

High

673538

MPIP2
M-phase inducer phosphatase 2

1

6

High-throughput

0.479

High

787406

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

7

Small-scale

0.479

High

880859

HDAC4
Histone deacetylase 4

1

6

High-throughput

0.479

High

1060652

ZN638
Zinc finger protein 638

1

6

High-throughput

0.479

High

1139654

DEN4C
DENN domain-containing protein 4C

1

7

High-throughput

0.479

High

1173165

SYDE1
Rho GTPase-activating protein SYDE1

1

17

High-throughput

0.479

High

1253348

F110B
Protein FAM110B

1

4

High-throughput

0.479

High

1256270

DEN1A
DENN domain-containing protein 1A

1

6

High-throughput

0.479

High

1263480

SRS12
Serine/arginine-rich splicing factor 12

1

10

High-throughput

0.479

High

1300452

RAB3I
Rab-3A-interacting protein

1

2

High-throughput

0.479

High

1300696

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

19

High-throughput

0.479

High

1308736

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

2

High-throughput

0.479

High

1309186

F110A
Protein FAM110A

1

4

High-throughput

0.479

High

1350027

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

3

High-throughput

0.479

High

1350454

CING
Cingulin

1

5

High-throughput

0.479

High

1355281

LIMA1
LIM domain and actin-binding protein 1

1

9

High-throughput

0.479

High

1356319

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

2

High-throughput

0.479

High

1356894

ZBT21
Zinc finger and BTB domain-containing protein 21

1

14

High-throughput

0.479

High

1356975

PPM1H
Protein phosphatase 1H

1

3

High-throughput

0.479

High

1357879

CBY1
Protein chibby homolog 1

1

3

High-throughput

0.479

High

1357880

KCTD3
BTB/POZ domain-containing protein KCTD3

1

5

High-throughput

0.479

High

596600

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

Small-scale

0.458

High

781674

ETV6
Transcription factor ETV6

1

0

Small-scale

0.458

High

1109703

TBC25
TBC1 domain family member 25

1

1

High-throughput

0.437

High

1149014

AN34A
Ankyrin repeat domain-containing protein 34A

1

9

High-throughput

0.437

High

1348460

FA53C
Protein FAM53C

1

2

High-throughput

0.437

High

503253

PPAL
Lysosomal acid phosphatase

1

0

High-throughput

0.268

Low


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Last updated: 15 Jul 2024