Protein: AMFR
E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78)

Gene: AMFR
Organism: Homo sapiens
Interactions: 205
UniProt ID: Q9UKV5

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

891448

UB2G2
Ubiquitin-conjugating enzyme E2 G2

17

20

Small-scale

0.988

High

476551

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

12

18

Small-scale

0.980

High

1062934

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

8

2

Small-scale

0.968

High

908273

UB2G1
Ubiquitin-conjugating enzyme E2 G1

7

20

Small-scale

0.958

High

803801

BAG6
Large proline-rich protein BAG6

6

11

Small-scale

0.947

High

1356609

AMFR
E3 ubiquitin-protein ligase AMFR

5

15

Small-scale

0.938

High

919902

UB2D2
Ubiquitin-conjugating enzyme E2 D2

5

20

Small-scale

0.928

High

849484

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

20

Small-scale

0.902

High

1198708

SYVN1
E3 ubiquitin-protein ligase synoviolin

4

19

Small-scale

0.878

High

1314264

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

3

2

Small-scale

0.855

High

895950

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

High-throughput

0.815

High

896564

UBE2N
Ubiquitin-conjugating enzyme E2 N

2

20

High-throughput

0.815

High

1284897

UBE2W
Ubiquitin-conjugating enzyme E2 W

2

20

High-throughput

0.815

High

1356614

UB2D4
Ubiquitin-conjugating enzyme E2 D4

2

20

High-throughput

0.815

High

1262541

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

14

High-throughput

0.811

High

509744

UBL4A
Ubiquitin-like protein 4A

2

20

Small-scale

0.806

High

875419

TERA
Transitional endoplasmic reticulum ATPase

25

7

Small-scale

0.768

High

1287221

FAF2
FAS-associated factor 2

8

11

Small-scale

0.747

High

181127

INSI1
Insulin-induced gene 1 protein

6

5

Small-scale

0.726

High

1326111

DERL2
Derlin-2

5

8

Small-scale

0.711

High

1313101

DERL1
Derlin-1

5

8

Small-scale

0.704

High

1342657

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

20

High-throughput

0.698

High

444007

CP3A4
Cytochrome P450 3A4

4

1

Small-scale

0.698

High

300005

ERLN2
Erlin-2

4

7

Small-scale

0.697

High

1240062

UBAC2
Ubiquitin-associated domain-containing protein 2

4

1

Small-scale

0.686

High

266273

ERLN1
Erlin-1

3

5

Small-scale

0.662

High

373164

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

3

12

Small-scale

0.656

High

529893

CFTR
Cystic fibrosis transmembrane conductance regulator

3

2

Small-scale

0.656

High

1292363

RN185
E3 ubiquitin-protein ligase RNF185

3

13

Small-scale

0.656

High

896395

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

20

Small-scale

0.647

High

502672

BIP
Endoplasmic reticulum chaperone BiP

3

10

Small-scale

0.640

High

134686

NPT3
Sodium-dependent phosphate transport protein 3

2

1

High-throughput

0.628

High

977427

KCNC4
Potassium voltage-gated channel subfamily C member 4

2

3

High-throughput

0.628

High

230180

MGRN1
E3 ubiquitin-protein ligase MGRN1

2

2

Small-scale

0.624

High

1272244

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

2

1

Small-scale

0.624

High

924212

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

12

High-throughput

0.618

High

941570

RNF4
E3 ubiquitin-protein ligase RNF4

1

6

High-throughput

0.618

High

1204863

GOLI
E3 ubiquitin-protein ligase RNF130

1

18

High-throughput

0.618

High

1240830

RN149
E3 ubiquitin-protein ligase RNF149

1

19

High-throughput

0.618

High

61238

5HT3E
5-hydroxytryptamine receptor 3E

2

4

High-throughput

0.611

High

832174

PSB2
Proteasome subunit beta type-2

2

16

High-throughput

0.611

High

879865

TPTE
Putative tyrosine-protein phosphatase TPTE

2

2

High-throughput

0.611

High

1283323

CCD47
PAT complex subunit CCDC47

2

2

Small-scale

0.611

High

1318009

OSBL8
Oxysterol-binding protein-related protein 8

2

2

High-throughput

0.611

High

380423

CD3D
T-cell surface glycoprotein CD3 delta chain

2

1

Small-scale

0.601

High

653107

CD82
CD82 antigen

2

3

Small-scale

0.584

High

1034559

OS9
Protein OS-9

2

2

Small-scale

0.584

High

1251729

NPL4
Nuclear protein localization protein 4 homolog

2

1

Small-scale

0.584

High

1307271

RNF5
E3 ubiquitin-protein ligase RNF5

2

11

Small-scale

0.584

High

1309559

SELS
Selenoprotein S

2

1

Small-scale

0.584

High

1356618

INSI2
Insulin-induced gene 2 protein

2

5

Small-scale

0.584

High

1356620

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

2

2

Small-scale

0.584

High

336616

SODC
Superoxide dismutase [Cu-Zn]

1

1

Small-scale

0.561

High

417775

G6PI
Glucose-6-phosphate isomerase

1

1

Small-scale

0.561

High

607531

CCL1
C-C motif chemokine 1

1

1

Small-scale

0.561

High

792077

HD
Huntingtin

1

4

Small-scale

0.561

High

1060961

IMB1
Importin subunit beta-1

1

7

Small-scale

0.561

High

1234347

TAB3
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

1

4

Small-scale

0.561

High

1260104

IASPP
RelA-associated inhibitor

1

1

Small-scale

0.561

High

1273586

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

6

Small-scale

0.561

High

1184870

GET4
Golgi to ER traffic protein 4 homolog

2

0

Small-scale

0.559

High

1356610

TMCO1
Calcium load-activated calcium channel

1

0

Small-scale

0.537

High

1052797

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

17

Small-scale

0.536

High

63616

ASB14
Ankyrin repeat and SOCS box protein 14

1

1

High-throughput

0.536

High

131102

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

7

High-throughput

0.536

High

156372

PSA7
Proteasome subunit alpha type-7

1

11

High-throughput

0.536

High

172278

GP182
G-protein coupled receptor 182

1

3

High-throughput

0.536

High

198750

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

2

High-throughput

0.536

High

255228

ICOSL
ICOS ligand

1

7

High-throughput

0.536

High

299488

UBXN7
UBX domain-containing protein 7

1

10

High-throughput

0.536

High

513764

CP19A
Aromatase

1

2

High-throughput

0.536

High

558797

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

3

High-throughput

0.536

High

569043

KCNA6
Potassium voltage-gated channel subfamily A member 6

1

3

High-throughput

0.536

High

594657

PSB1
Proteasome subunit beta type-1

1

19

High-throughput

0.536

High

599026

FPR1
fMet-Leu-Phe receptor

1

3

High-throughput

0.536

High

616647

GLRA2
Glycine receptor subunit alpha-2

1

5

High-throughput

0.536

High

626696

ADA1D
Alpha-1D adrenergic receptor

1

2

Small-scale

0.536

High

637599

PSA1
Proteasome subunit alpha type-1

1

10

High-throughput

0.536

High

637752

PSA2
Proteasome subunit alpha type-2

1

12

High-throughput

0.536

High

638038

PSA3
Proteasome subunit alpha type-3

1

9

High-throughput

0.536

High

638214

PSA4
Proteasome subunit alpha type-4

1

9

High-throughput

0.536

High

656334

PSA5
Proteasome subunit alpha type-5

1

11

High-throughput

0.536

High

656541

PSB4
Proteasome subunit beta type-4

1

18

High-throughput

0.536

High

656658

PSB6
Proteasome subunit beta type-6

1

12

High-throughput

0.536

High

656791

PSB5
Proteasome subunit beta type-5

1

12

High-throughput

0.536

High

723432

APJ
Apelin receptor

1

3

High-throughput

0.536

High

725062

MYH9
Myosin-9

1

6

High-throughput

0.536

High

725265

MYH10
Myosin-10

1

6

High-throughput

0.536

High

730381

PRS7
26S proteasome regulatory subunit 7

1

10

High-throughput

0.536

High

739569

DHB3
17-beta-hydroxysteroid dehydrogenase type 3

1

4

High-throughput

0.536

High

832055

PSB3
Proteasome subunit beta type-3

1

12

High-throughput

0.536

High

893769

PSA6
Proteasome subunit alpha type-6

1

12

High-throughput

0.536

High

946453

EREP3
Protein ENTREP3

1

1

High-throughput

0.536

High

979373

UBXN1
UBX domain-containing protein 1

1

10

High-throughput

0.536

High

991951

SCN1B
Sodium channel subunit beta-1

1

1

High-throughput

0.536

High

1062507

SPCS2
Signal peptidase complex subunit 2

1

1

High-throughput

0.536

High

1062893

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

2

High-throughput

0.536

High

1188442

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.536

High

1217383

CNGA4
Cyclic nucleotide-gated channel alpha-4

1

2

High-throughput

0.536

High

1235214

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

1

High-throughput

0.536

High

1253095

TLC3A
TLC domain-containing protein 3A

1

1

High-throughput

0.536

High

1292729

ZDH12
Palmitoyltransferase ZDHHC12

1

4

High-throughput

0.536

High

1303493

PSB7
Proteasome subunit beta type-7

1

9

High-throughput

0.536

High

1356612

FAF1
FAS-associated factor 1

1

12

High-throughput

0.536

High

1356613

GPR55
G-protein coupled receptor 55

1

5

High-throughput

0.536

High

1356615

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

1

High-throughput

0.536

High

1356619

GPR45
Probable G-protein coupled receptor 45

1

5

High-throughput

0.536

High

1299210

DGAT2
Diacylglycerol O-acyltransferase 2

1

1

Small-scale

0.515

High

1026966

S13A2
Solute carrier family 13 member 2

1

0

High-throughput

0.513

High

1053840

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1061398

PSME4
Proteasome activator complex subunit 4

1

0

High-throughput

0.513

High

1109957

SHSL1
Protein shisa-like-1

1

0

High-throughput

0.513

High

1191388

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

0

High-throughput

0.513

High

1233067

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

1245406

OR4N2
Olfactory receptor 4N2

1

0

High-throughput

0.513

High

1274120

STMN2
Stathmin-2

1

0

High-throughput

0.513

High

1356616

O10H1
Olfactory receptor 10H1

1

0

High-throughput

0.513

High

659325

DUS1
Dual specificity protein phosphatase 1

1

1

Small-scale

0.512

High

272828

TM1L1
TOM1-like protein 1

1

3

High-throughput

0.508

High

1050908

DPYL1
Dihydropyrimidinase-related protein 1

1

5

High-throughput

0.508

High

1057023

MDC1
Mediator of DNA damage checkpoint protein 1

1

4

High-throughput

0.504

High

1264294

BRI3B
BRI3-binding protein

1

1

High-throughput

0.489

High

335326

DYR
Dihydrofolate reductase

1

0

Small-scale

0.480

High

398447

CP2E1
Cytochrome P450 2E1

1

0

Small-scale

0.480

High

118489

HAX1
HCLS1-associated protein X-1

1

1

Small-scale

0.479

High

123759

PGRC1
Membrane-associated progesterone receptor component 1

1

2

High-throughput

0.479

High

129853

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

4

High-throughput

0.479

High

136234

SCD
Stearoyl-CoA desaturase

1

1

High-throughput

0.479

High

168073

NPC1
NPC intracellular cholesterol transporter 1

1

12

High-throughput

0.479

High

208404

SPY1
Protein sprouty homolog 1

1

6

Small-scale

0.479

High

212232

ERD23
ER lumen protein-retaining receptor 3

1

1

Small-scale

0.479

High

277460

SOAT2
Sterol O-acyltransferase 2

1

1

Small-scale

0.479

High

325453

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

Small-scale

0.479

High

326898

FADS2
Acyl-CoA 6-desaturase

1

3

High-throughput

0.479

High

385698

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.479

High

429154

ADRB2
Beta-2 adrenergic receptor

1

2

High-throughput

0.479

High

495636

THIO
Thioredoxin

1

2

Small-scale

0.479

High

500203

CH60
60 kDa heat shock protein, mitochondrial

1

1

Small-scale

0.479

High

538441

ENPL
Endoplasmin

1

6

Small-scale

0.479

High

561710

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

2

Small-scale

0.479

High

566503

KPCA
Protein kinase C alpha type

1

5

Small-scale

0.479

High

573523

TCPA
T-complex protein 1 subunit alpha

1

3

Small-scale

0.479

High

577076

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

13

High-throughput

0.479

High

654891

CALX
Calnexin

1

4

Small-scale

0.479

High

660879

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

12

High-throughput

0.479

High

714092

HS71L
Heat shock 70 kDa protein 1-like

1

6

Small-scale

0.479

High

714458

HSP74
Heat shock 70 kDa protein 4

1

11

Small-scale

0.479

High

717420

CTNB1
Catenin beta-1

1

4

High-throughput

0.479

High

854268

DGKE
Diacylglycerol kinase epsilon

1

4

High-throughput

0.479

High

868361

ATX3
Ataxin-3

1

2

Small-scale

0.479

High

874610

XPO2
Exportin-2

1

7

Small-scale

0.479

High

932913

EF1A1
Elongation factor 1-alpha 1

1

1

Small-scale

0.479

High

964860

PMP22
Peripheral myelin protein 22

1

1

Small-scale

0.479

High

976819

TAP2
Antigen peptide transporter 2

1

2

Small-scale

0.479

High

1024128

PDIA2
Protein disulfide-isomerase A2

1

3

Small-scale

0.479

High

1030006

TIF1B
Transcription intermediary factor 1-beta

1

10

Small-scale

0.479

High

1055250

ERG1
Squalene monooxygenase

1

1

High-throughput

0.479

High

1063200

SEPT2
Septin-2

1

1

High-throughput

0.479

High

1114389

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

1

Small-scale

0.479

High

1129439

WIPI1
WD repeat domain phosphoinositide-interacting protein 1

1

7

Small-scale

0.479

High

1138869

OTU1
Ubiquitin thioesterase OTU1

1

2

Small-scale

0.479

High

1157288

ZNT6
Zinc transporter 6

1

4

High-throughput

0.479

High

1166057

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1173891

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

5

Small-scale

0.479

High

1190125

MAVS
Mitochondrial antiviral-signaling protein

1

6

Small-scale

0.479

High

1201351

SERC5
Serine incorporator 5

1

1

Small-scale

0.479

High

1220735

MIRO1
Mitochondrial Rho GTPase 1

1

4

Small-scale

0.479

High

1244056

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

1

High-throughput

0.479

High

1245506

SVIP
Small VCP/p97-interacting protein

1

1

Small-scale

0.479

High

1263641

ATLA1
Atlastin-1

1

4

Small-scale

0.479

High

1267628

UBXN4
UBX domain-containing protein 4

1

9

Small-scale

0.479

High

1268032

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

3

High-throughput

0.479

High

1272275

GSLG1
Golgi apparatus protein 1

1

2

High-throughput

0.479

High

1286070

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

Small-scale

0.479

High

1300192

DERL3
Derlin-3

1

8

Small-scale

0.479

High

1313834

PTSS2
Phosphatidylserine synthase 2

1

1

High-throughput

0.479

High

1315540

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

3

High-throughput

0.479

High

1335656

TM165
Putative divalent cation/proton antiporter TMEM165

1

1

High-throughput

0.479

High

1336531

SEC12
Guanine nucleotide-exchange factor SEC12

1

10

High-throughput

0.479

High

1347533

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

2

High-throughput

0.479

High

1354367

SE1L1
Protein sel-1 homolog 1

1

4

Small-scale

0.479

High

1356611

S45A2
Membrane-associated transporter protein

1

1

High-throughput

0.479

High

1356617

SRPRB
Signal recognition particle receptor subunit beta

1

4

Small-scale

0.479

High

149773

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

806216

RL5
Large ribosomal subunit protein uL18

1

0

Small-scale

0.458

High

890504

SC61B
Protein transport protein Sec61 subunit beta

1

0

Small-scale

0.458

High

1056335

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

0

Small-scale

0.458

High

1072985

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.458

High

1124466

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.458

High

1185648

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.458

High

1218538

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1284499

CIDEC
Lipid transferase CIDEC

1

0

Small-scale

0.458

High

1295781

RN170
E3 ubiquitin-protein ligase RNF170

1

0

High-throughput

0.458

High

1319289

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

Small-scale

0.458

High

1336776

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.458

High

1348904

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

90146

D6RGY6
Solute carrier family 45 member 2

1

1

High-throughput

0.445

High

101274

APRIO
Alternative prion protein

1

1

Small-scale

0.437

High

1172214

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.437

High

1192652

VTCN1
V-set domain-containing T-cell activation inhibitor 1

1

4

Small-scale

0.437

High

1222121

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

1253164

WDR20
WD repeat-containing protein 20

1

9

Small-scale

0.437

High

1260713

THEM6
Protein THEM6

1

1

High-throughput

0.437

High

99697

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High


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Last updated: 15 Jul 2024