Protein: EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

Gene: EDEM2
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q9BV94

Gene Ontology (top 5):
GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 - calcium ion binding
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
GO:0005975 - carbohydrate metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1121774

FBLN7
Fibulin-7

3

1

High-throughput

0.667

High

1313601

CHST8
Carbohydrate sulfotransferase 8

3

3

High-throughput

0.667

High

1313607

CC50A
Cell cycle control protein 50A

3

2

High-throughput

0.667

High

1306424

NOE1
Noelin

3

0

High-throughput

0.638

High

907144

PRS8
26S proteasome regulatory subunit 8

2

1

High-throughput

0.628

High

992194

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

2

1

High-throughput

0.628

High

1313599

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

4

Small-scale

0.618

High

968912

NAAA
N-acylethanolamine-hydrolyzing acid amidase

2

2

High-throughput

0.611

High

68245

HECA2
HEPACAM family member 2

3

3

High-throughput

0.609

High

1162563

TXD11
Thioredoxin domain-containing protein 11

3

11

Small-scale

0.609

High

69685

HACD1
Very-long-chain

2

0

High-throughput

0.602

High

723652

TSP2
Thrombospondin-2

2

0

High-throughput

0.602

High

768510

TYRP2
L-dopachrome tautomerase

2

0

High-throughput

0.602

High

1074643

SURF1
Surfeit locus protein 1

2

0

High-throughput

0.602

High

1133364

TMTC4
Protein O-mannosyl-transferase TMTC4

2

0

High-throughput

0.602

High

1158718

CC033
Protein C3orf33

2

0

High-throughput

0.602

High

1224336

AGRG5
Adhesion G-protein coupled receptor G5

2

0

High-throughput

0.602

High

1252080

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

2

0

High-throughput

0.602

High

1290328

TV23C
Golgi apparatus membrane protein TVP23 homolog C

2

0

High-throughput

0.602

High

1313605

S38AA
Solute carrier family 38 member 10

2

0

High-throughput

0.602

High

215852

ANGL7
Angiopoietin-related protein 7

2

4

High-throughput

0.574

High

500868

CLUS
Clusterin

2

2

High-throughput

0.574

High

557344

GDC
Solute carrier family 25 member 16

2

1

High-throughput

0.574

High

1165540

LYZL1
Lysozyme-like protein 1

2

3

High-throughput

0.574

High

1176152

BRNP3
BMP/retinoic acid-inducible neural-specific protein 3

2

1

High-throughput

0.574

High

1198158

TM11B
Transmembrane protease serine 11B

2

7

High-throughput

0.574

High

1251666

UHMK1
Serine/threonine-protein kinase Kist

2

1

High-throughput

0.574

High

1289292

OMA1
Metalloendopeptidase OMA1, mitochondrial

2

1

High-throughput

0.574

High

1313600

BRNP2
BMP/retinoic acid-inducible neural-specific protein 2

2

1

High-throughput

0.574

High

1313609

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

2

1

High-throughput

0.574

High

61711

CDHR4
Cadherin-related family member 4

1

3

High-throughput

0.536

High

362028

FIBG
Fibrinogen gamma chain

1

4

High-throughput

0.536

High

964691

IL5RA
Interleukin-5 receptor subunit alpha

1

3

High-throughput

0.536

High

1034525

OS9
Protein OS-9

1

4

High-throughput

0.536

High

1109947

SHSL1
Protein shisa-like-1

1

1

High-throughput

0.536

High

1116851

GXLT1
Glucoside xylosyltransferase 1

1

1

High-throughput

0.536

High

1183824

CHST9
Carbohydrate sulfotransferase 9

1

3

High-throughput

0.536

High

1284432

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

2

High-throughput

0.536

High

1313606

SDF2L
Stromal cell-derived factor 2-like protein 1

1

1

High-throughput

0.536

High

1313610

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

4

High-throughput

0.536

High

1313611

DNJB9
DnaJ homolog subfamily B member 9

1

7

High-throughput

0.536

High

1313614

FBX2
F-box only protein 2

1

2

High-throughput

0.536

High

898464

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.518

High

267253

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

0

High-throughput

0.513

High

396650

ITB2
Integrin beta-2

1

0

High-throughput

0.513

High

591401

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

0

High-throughput

0.513

High

824967

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.513

High

1040240

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.513

High

1219521

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.513

High

1313598

ABCA2
ATP-binding cassette sub-family A member 2

1

0

High-throughput

0.513

High

158975

NCTR3
Natural cytotoxicity triggering receptor 3

1

1

High-throughput

0.489

High

265793

CRLF1
Cytokine receptor-like factor 1

1

2

High-throughput

0.489

High

389491

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

2

High-throughput

0.489

High

426538

KLK3
Prostate-specific antigen

1

9

High-throughput

0.489

High

474773

CFC1
Cryptic protein

1

1

High-throughput

0.489

High

533060

PRG2
Bone marrow proteoglycan

1

3

High-throughput

0.489

High

685285

CEAM8
Carcinoembryonic antigen-related cell adhesion molecule 8

1

3

High-throughput

0.489

High

1032203

ITAD
Integrin alpha-D

1

1

High-throughput

0.489

High

1150660

IL31
Interleukin-31

1

1

High-throughput

0.489

High

1217169

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

1

High-throughput

0.489

High

1240101

TM87A
Transmembrane protein 87A

1

1

High-throughput

0.489

High

1265940

CLC2B
C-type lectin domain family 2 member B

1

4

High-throughput

0.489

High

1271351

GGH
Gamma-glutamyl hydrolase

1

1

High-throughput

0.489

High

1285502

ESPB1
Epididymal sperm-binding protein 1

1

4

High-throughput

0.489

High

1313602

KLK15
Kallikrein-15

1

6

High-throughput

0.489

High

1313604

TMPS5
Transmembrane protease serine 5

1

7

High-throughput

0.489

High

1313613

BTNL2
Butyrophilin-like protein 2

1

2

High-throughput

0.489

High

1313615

ANGP4
Angiopoietin-4

1

4

High-throughput

0.489

High

205917

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

423344

PDIA1
Protein disulfide-isomerase

1

11

Small-scale

0.479

High

654717

CALX
Calnexin

1

4

Small-scale

0.479

High

1074303

SHH
Sonic hedgehog protein

1

2

Small-scale

0.479

High

1313612

SE1L1
Protein sel-1 homolog 1

1

4

Small-scale

0.479

High

1220978

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

1060427

KI2S5
Killer cell immunoglobulin-like receptor 2DS5

1

3

High-throughput

0.445

High

240485

CYTIP
Cytohesin-interacting protein

3

0

High-throughput

0.347

High

1084761

TAZ
Tafazzin

3

0

High-throughput

0.347

High

427780

CO8G
Complement component C8 gamma chain

2

0

High-throughput

0.328

High

1165343

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.328

High

1242986

MCU
Calcium uniporter protein, mitochondrial

2

0

High-throughput

0.328

High

1257288

MOT10
Monocarboxylate transporter 10

2

0

High-throughput

0.328

High

1311088

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

2

0

High-throughput

0.328

High

1313595

MAD3
Max dimerization protein 3

2

0

High-throughput

0.328

High

233990

NMD3B
Glutamate receptor ionotropic, NMDA 3B

1

0

High-throughput

0.279

Low

309913

UCP5
Brain mitochondrial carrier protein 1

1

0

High-throughput

0.279

Low

398570

PPB1
Alkaline phosphatase, placental type

1

0

High-throughput

0.279

Low

535679

EDN3
Endothelin-3

1

0

High-throughput

0.279

Low

846521

BLK
Tyrosine-protein kinase Blk

1

0

High-throughput

0.279

Low

1198316

K1328
Protein hinderin

1

0

High-throughput

0.279

Low

1204328

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.279

Low

1229563

SYCE1
Synaptonemal complex central element protein 1

1

0

High-throughput

0.279

Low

1262856

HPSE2
Inactive heparanase-2

1

0

High-throughput

0.279

Low

1313596

SFXN3
Sideroflexin-3

1

0

High-throughput

0.279

Low

1313597

PRR14
Proline-rich protein 14

1

0

High-throughput

0.279

Low

1313608

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.279

Low

1313616

LIPG
Endothelial lipase

1

0

High-throughput

0.279

Low

533168

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

0

High-throughput

0.249

Low

1313603

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

0

Small-scale

0.249

Low

353992

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024