Protein: SAHH
Adenosylhomocysteinase (AdoHcyase) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase)

Gene: SAHH, AHCY
Organism: Homo sapiens
Interactions: 172
UniProt ID: P23526

Gene Ontology (top 5):
GO:0004013 - adenosylhomocysteinase activity
GO:0005634 - nucleus
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0006730 - one-carbon metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

216444

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

3

10

High-throughput

0.861

High

617803

SAHH
Adenosylhomocysteinase

1

10

High-throughput

0.698

High

617892

CA050
Uncharacterized protein C1orf50

10

2

High-throughput

0.692

High

617884

SAHH3
Adenosylhomocysteinase 3

1

10

High-throughput

0.691

High

617860

ANR40
Ankyrin repeat domain-containing protein 40

7

1

High-throughput

0.688

High

226544

PRKN
E3 ubiquitin-protein ligase parkin

3

5

High-throughput

0.656

High

528562

CFTR
Cystic fibrosis transmembrane conductance regulator

3

1

High-throughput

0.650

High

373691

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

1

High-throughput

0.584

High

617859

A16L1
Autophagy-related protein 16-1

2

2

High-throughput

0.584

High

617870

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

0

Small-scale

0.580

High

329365

AGR2
Anterior gradient protein 2 homolog

2

0

Small-scale

0.576

High

617899

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

2

4

Small-scale

0.571

High

617881

APBP2
Amyloid protein-binding protein 2

1

0

High-throughput

0.549

High

617818

HSP13
Heat shock 70 kDa protein 13

1

3

High-throughput

0.541

High

161623

GAK
Cyclin-G-associated kinase

1

4

High-throughput

0.536

High

345330

FOS
Protein c-Fos

1

10

High-throughput

0.536

High

386109

P53
Cellular tumor antigen p53

1

3

High-throughput

0.536

High

496320

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.536

High

547704

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

7

High-throughput

0.536

High

617813

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

4

High-throughput

0.536

High

617831

FOXK1
Forkhead box protein K1

1

9

High-throughput

0.536

High

617836

KPCZ
Protein kinase C zeta type

1

1

High-throughput

0.536

High

617846

CUL1
Cullin-1

1

2

High-throughput

0.536

High

617847

CUL3
Cullin-3

1

2

High-throughput

0.536

High

617848

CUL4B
Cullin-4B

1

2

High-throughput

0.536

High

617855

NEDD8
NEDD8

1

1

High-throughput

0.536

High

617876

RIN3
Ras and Rab interactor 3

1

2

High-throughput

0.536

High

617882

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.536

High

617904

E41L5
Band 4.1-like protein 5

1

2

High-throughput

0.536

High

617819

PAXI
Paxillin

1

0

High-throughput

0.518

High

617824

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.518

High

128444

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

176384

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.513

High

201219

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

299844

ERLN2
Erlin-2

1

0

High-throughput

0.513

High

447654

ENOG
Gamma-enolase

1

0

High-throughput

0.513

High

617868

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

617873

LMBL4
Lethal(3)malignant brain tumor-like protein 4

1

0

High-throughput

0.513

High

617896

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.513

High

617901

KDM4C
Lysine-specific demethylase 4C

1

0

High-throughput

0.513

High

475346

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.501

High

617805

1433T
14-3-3 protein theta

1

1

High-throughput

0.501

High

119174

LEG9
Galectin-9

1

1

High-throughput

0.479

High

175824

P73
Tumor protein p73

1

3

High-throughput

0.479

High

294376

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

302911

HEXI1
Protein HEXIM1

1

4

High-throughput

0.479

High

345944

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

379024

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

411299

INSR
Insulin receptor

1

9

High-throughput

0.479

High

503451

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

542188

PLAK
Junction plakoglobin

1

1

High-throughput

0.479

High

551965

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

568545

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

2

Small-scale

0.479

High

569197

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

572284

LEG3
Galectin-3

1

1

Small-scale

0.479

High

617806

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

617807

PML
Protein PML

1

2

High-throughput

0.479

High

617810

CTNB1
Catenin beta-1

1

2

High-throughput

0.479

High

617812

FUS
RNA-binding protein FUS

1

1

High-throughput

0.479

High

617816

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

617817

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

617823

ATX3
Ataxin-3

1

4

High-throughput

0.479

High

617825

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

High-throughput

0.479

High

617826

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

617827

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

4

Small-scale

0.479

High

617829

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

617830

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.479

High

617835

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

617837

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

617840

FOXC1
Forkhead box protein C1

1

9

High-throughput

0.479

High

617841

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

High-throughput

0.479

High

617843

PAK2
Serine/threonine-protein kinase PAK 2

1

3

High-throughput

0.479

High

617844

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

617849

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.479

High

617854

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

617861

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.479

High

617865

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

617871

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.479

High

617875

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

617879

SMAP2
Stromal membrane-associated protein 2

1

2

High-throughput

0.479

High

617880

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

617887

RUFY1
RUN and FYVE domain-containing protein 1

1

1

High-throughput

0.479

High

617888

NECD
Necdin

1

1

High-throughput

0.479

High

617889

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

617893

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

5

High-throughput

0.479

High

617894

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

617914

HDAC6
Histone deacetylase 6

1

1

High-throughput

0.479

High

617916

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

617918

HDAC5
Histone deacetylase 5

1

1

High-throughput

0.479

High

617923

TRAF6
TNF receptor-associated factor 6

1

3

High-throughput

0.479

High

298160

UFL1
E3 UFM1-protein ligase 1

1

0

Small-scale

0.460

High

617822

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.460

High

166670

CE290
Centrosomal protein of 290 kDa

1

0

High-throughput

0.458

High

211500

ACTN4
Alpha-actinin-4

1

0

High-throughput

0.458

High

214091

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.458

High

241971

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

260357

ZN217
Zinc finger protein 217

1

0

High-throughput

0.458

High

322195

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

354293

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

450721

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

617426

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

617804

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

617808

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

617809

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

617814

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

617815

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

617821

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

617828

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

617832

DAB2
Disabled homolog 2

1

0

Small-scale

0.458

High

617833

VIGLN
Vigilin

1

0

High-throughput

0.458

High

617834

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

617838

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

617839

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.458

High

617842

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

617845

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

617851

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

617852

CUL7
Cullin-7

1

0

High-throughput

0.458

High

617853

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

617856

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

617863

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

617866

LBN
Limbin

1

0

High-throughput

0.458

High

617867

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

617874

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

617877

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.458

High

617885

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

617886

ASB16
Ankyrin repeat and SOCS box protein 16

1

0

High-throughput

0.458

High

617890

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.458

High

617891

DERL1
Derlin-1

1

0

Small-scale

0.458

High

617895

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

617905

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

617906

ANLN
Anillin

1

0

High-throughput

0.458

High

617907

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

617911

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

617912

RCC2
Protein RCC2

1

0

High-throughput

0.458

High

617917

MYO6
Unconventional myosin-VI

1

0

High-throughput

0.458

High

617920

FND3A
Fibronectin type-III domain-containing protein 3A

1

0

High-throughput

0.458

High

617922

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

173839

MK13
Mitogen-activated protein kinase 13

1

1

Small-scale

0.445

High

305968

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

4

High-throughput

0.445

High

401431

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

617858

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

617900

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

4

High-throughput

0.445

High

617902

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

4

High-throughput

0.445

High

617919

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

100489

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

239494

EIF1B
Eukaryotic translation initiation factor 1b

1

1

High-throughput

0.437

High

275538

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

1

High-throughput

0.437

High

384280

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.437

High

617811

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

617850

RBM39
RNA-binding protein 39

1

3

High-throughput

0.437

High

617862

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

617864

ASXL2
Putative Polycomb group protein ASXL2

1

2

High-throughput

0.437

High

617869

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.437

High

617872

NIN
Ninein

1

2

High-throughput

0.437

High

617898

ASXL3
Putative Polycomb group protein ASXL3

1

1

High-throughput

0.437

High

617903

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

617913

HECW2
E3 ubiquitin-protein ligase HECW2

1

2

High-throughput

0.437

High

377933

PRIO
Major prion protein

1

0

High-throughput

0.426

High

617820

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.408

High

111636

K7ERW4
Ankyrin repeat domain 40

1

1

High-throughput

0.407

High

617897

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

617909

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.282

High

617878

MIPT3
TRAF3-interacting protein 1

1

0

Small-scale

0.279

Low

617883

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.269

Low

62877

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.249

Low

230953

CE104
Centrosomal protein of 104 kDa

1

0

High-throughput

0.249

Low

617857

E2F4
Transcription factor E2F4

1

0

High-throughput

0.249

Low

617908

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

617910

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

617915

SAE2
SUMO-activating enzyme subunit 2

1

0

High-throughput

0.249

Low

617921

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024