Protein: UBE2A
Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)

Gene: UBE2A
Organism: Homo sapiens
Interactions: 223
UniProt ID: P49459

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000209 - protein polyubiquitination
GO:0000785 - chromatin
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

829067

RAD18
E3 ubiquitin-protein ligase RAD18

20

6

Small-scale

0.991

High

829017

BRE1A
E3 ubiquitin-protein ligase BRE1A

6

16

Small-scale

0.950

High

256227

BRE1B
E3 ubiquitin-protein ligase BRE1B

6

16

Small-scale

0.944

High

607023

UBA1
Ubiquitin-like modifier-activating enzyme 1

6

19

Small-scale

0.942

High

828960

UBE2A
Ubiquitin-conjugating enzyme E2 A

4

15

Small-scale

0.896

High

828975

UBE2B
Ubiquitin-conjugating enzyme E2 B

3

15

Small-scale

0.861

High

475485

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

20

Small-scale

0.834

High

829020

L2GL2
LLGL scribble cell polarity complex component 2

2

1

High-throughput

0.811

High

828987

MDM2
E3 ubiquitin-protein ligase Mdm2

2

13

Small-scale

0.781

High

386309

P53
Cellular tumor antigen p53

4

3

Small-scale

0.700

High

828984

XIAP
E3 ubiquitin-protein ligase XIAP

1

20

High-throughput

0.691

High

132776

SDCB1
Syntenin-1

3

1

High-throughput

0.675

High

829086

UBQL1
Ubiquilin-1

1

4

High-throughput

0.665

High

829023

UBR3
E3 ubiquitin-protein ligase UBR3

3

14

Small-scale

0.658

High

226844

PRKN
E3 ubiquitin-protein ligase parkin

1

20

Small-scale

0.647

High

304067

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

Small-scale

0.647

High

517129

PCNA
Proliferating cell nuclear antigen

1

4

Small-scale

0.647

High

828982

RNF4
E3 ubiquitin-protein ligase RNF4

1

20

Small-scale

0.647

High

829001

HLTF
Helicase-like transcription factor

1

10

Small-scale

0.647

High

829013

HECD3
E3 ubiquitin-protein ligase HECTD3

1

20

Small-scale

0.647

High

829015

RC3H1
Roquin-1

1

6

Small-scale

0.647

High

829063

RN167
E3 ubiquitin-protein ligase RNF167

1

20

Small-scale

0.647

High

707552

H2B1B
Histone H2B type 1-B

2

8

Small-scale

0.634

High

211136

BUB3
Mitotic checkpoint protein BUB3

1

5

High-throughput

0.618

High

474958

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

High-throughput

0.618

High

828991

RBBP4
Histone-binding protein RBBP4

1

5

High-throughput

0.618

High

828994

CUL4B
Cullin-4B

1

14

High-throughput

0.618

High

829005

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

8

Small-scale

0.618

High

829018

RN123
E3 ubiquitin-protein ligase RNF123

1

7

High-throughput

0.618

High

829066

AAAS
Aladin

1

4

High-throughput

0.618

High

829082

HERC5
E3 ISG15--protein ligase HERC5

1

20

Small-scale

0.618

High

829027

UBR1
E3 ubiquitin-protein ligase UBR1

2

14

Small-scale

0.600

High

829009

H2B2E
Histone H2B type 2-E

2

8

Small-scale

0.595

High

829073

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

20

Small-scale

0.586

High

829054

SLF1
SMC5-SMC6 complex localization factor protein 1

2

8

Small-scale

0.584

High

829014

UBR4
E3 ubiquitin-protein ligase UBR4

2

9

Small-scale

0.576

High

829060

SKI8
Superkiller complex protein 8

1

1

Small-scale

0.575

High

800318

CBX5
Chromobox protein homolog 5

1

3

Small-scale

0.561

High

828963

CDK9
Cyclin-dependent kinase 9

1

3

Small-scale

0.561

High

829028

UBR2
E3 ubiquitin-protein ligase UBR2

1

14

Small-scale

0.561

High

829077

ZMYM2
Zinc finger MYM-type protein 2

1

1

Small-scale

0.552

High

536757

TRI27
Zinc finger protein RFP

1

20

High-throughput

0.541

High

829025

TAXB1
Tax1-binding protein 1

1

3

High-throughput

0.536

High

829032

FBXL6
F-box/LRR-repeat protein 6

1

3

High-throughput

0.536

High

829050

Z512B
Zinc finger protein 512B

1

1

High-throughput

0.536

High

829062

Q9H4D1
Protein kinase

1

1

High-throughput

0.536

High

314743

PSMG1
Proteasome assembly chaperone 1

1

0

High-throughput

0.518

High

263559

PR40A
Pre-mRNA-processing factor 40 homolog A

1

18

High-throughput

0.515

High

265503

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

2

High-throughput

0.515

High

609211

FGFR3
Fibroblast growth factor receptor 3

1

2

High-throughput

0.515

High

780626

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

2

High-throughput

0.515

High

828965

HSP72
Heat shock-related 70 kDa protein 2

1

1

High-throughput

0.515

High

828972

RAN
GTP-binding nuclear protein Ran

1

1

High-throughput

0.515

High

829047

OPTN
Optineurin

1

3

High-throughput

0.515

High

829075

ATX10
Ataxin-10

1

0

High-throughput

0.513

High

828998

DPYL1
Dihydropyrimidinase-related protein 1

1

1

High-throughput

0.508

High

625230

CDK2
Cyclin-dependent kinase 2

1

2

Small-scale

0.501

High

669305

EF1D
Elongation factor 1-delta

1

1

Small-scale

0.501

High

157878

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

413861

GELS
Gelsolin

1

0

High-throughput

0.493

High

657911

CLAT
Choline O-acetyltransferase

1

0

High-throughput

0.493

High

828966

CASP6
Caspase-6

1

0

High-throughput

0.493

High

829040

RPGF4
Rap guanine nucleotide exchange factor 4

1

0

High-throughput

0.493

High

161994

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

3

High-throughput

0.479

High

163586

BTAF1
TATA-binding protein-associated factor 172

1

1

High-throughput

0.479

High

164584

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

2

High-throughput

0.479

High

195373

DHX15
ATP-dependent RNA helicase DHX15

1

1

High-throughput

0.479

High

198574

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.479

High

202094

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

1

High-throughput

0.479

High

235757

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

High-throughput

0.479

High

236719

CCNT1
Cyclin-T1

1

1

Small-scale

0.479

High

242682

IF2P
Eukaryotic translation initiation factor 5B

1

1

High-throughput

0.479

High

244107

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

246190

NBN
Nibrin

1

2

Small-scale

0.479

High

359316

K1C14
Keratin, type I cytoskeletal 14

1

3

High-throughput

0.479

High

360625

SPTA1
Spectrin alpha chain, erythrocytic 1

1

2

High-throughput

0.479

High

380451

K2C6B
Keratin, type II cytoskeletal 6B

1

1

High-throughput

0.479

High

427490

ANXA2
Annexin A2

1

3

High-throughput

0.479

High

432600

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

1

High-throughput

0.479

High

444338

K1C19
Keratin, type I cytoskeletal 19

1

3

High-throughput

0.479

High

531541

K2C5
Keratin, type II cytoskeletal 5

1

1

High-throughput

0.479

High

532428

TCTP
Translationally-controlled tumor protein

1

3

High-throughput

0.479

High

582135

NUCL
Nucleolin

1

2

High-throughput

0.479

High

609755

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

High-throughput

0.479

High

613374

SFPQ
Splicing factor, proline- and glutamine-rich

1

1

High-throughput

0.479

High

640372

DDX6
Probable ATP-dependent RNA helicase DDX6

1

2

High-throughput

0.479

High

640710

CTNA2
Catenin alpha-2

1

1

High-throughput

0.479

High

641664

U2AF2
Splicing factor U2AF 65 kDa subunit

1

2

High-throughput

0.479

High

716625

CTNA1
Catenin alpha-1

1

1

High-throughput

0.479

High

757509

IF4A3
Eukaryotic initiation factor 4A-III

1

2

High-throughput

0.479

High

770742

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.479

High

779014

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

790708

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

1

Small-scale

0.479

High

828967

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

1

High-throughput

0.479

High

828968

H2B1D
Histone H2B type 1-D

1

8

High-throughput

0.479

High

828969

RS15A
Small ribosomal subunit protein uS8

1

1

High-throughput

0.479

High

828971

H2B1C
Histone H2B type 1-C/E/F/G/I

1

8

High-throughput

0.479

High

828980

CSK21
Casein kinase II subunit alpha

1

4

High-throughput

0.479

High

828981

H31
Histone H3.1

1

3

High-throughput

0.479

High

828983

SRSF3
Serine/arginine-rich splicing factor 3

1

1

High-throughput

0.479

High

828986

CDK5
Cyclin-dependent kinase 5

1

2

High-throughput

0.479

High

828988

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

828993

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

8

High-throughput

0.479

High

828995

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

3

High-throughput

0.479

High

828997

KEAP1
Kelch-like ECH-associated protein 1

1

5

High-throughput

0.479

High

829002

PLSI
Plastin-1

1

2

High-throughput

0.479

High

829006

NONO
Non-POU domain-containing octamer-binding protein

1

2

High-throughput

0.479

High

829010

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

2

High-throughput

0.479

High

829012

TB10B
TBC1 domain family member 10B

1

1

High-throughput

0.479

High

829016

OBSCN
Obscurin

1

5

High-throughput

0.479

High

829021

PKN3
Serine/threonine-protein kinase N3

1

1

High-throughput

0.479

High

829024

H32
Histone H3.2

1

3

High-throughput

0.479

High

829029

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

1

High-throughput

0.479

High

829030

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

1

High-throughput

0.479

High

829037

PDC6I
Programmed cell death 6-interacting protein

1

1

High-throughput

0.479

High

829039

TITIN
Titin

1

1

High-throughput

0.479

High

829041

TCPW
T-complex protein 1 subunit zeta-2

1

1

High-throughput

0.479

High

829044

GCN1
Stalled ribosome sensor GCN1

1

1

High-throughput

0.479

High

829045

ARHG2
Rho guanine nucleotide exchange factor 2

1

1

High-throughput

0.479

High

829056

WAC
WW domain-containing adapter protein with coiled-coil

1

1

Small-scale

0.479

High

829057

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

3

High-throughput

0.479

High

829064

BRD9
Bromodomain-containing protein 9

1

5

High-throughput

0.479

High

829065

SYSM
Serine--tRNA ligase, mitochondrial

1

1

Small-scale

0.479

High

829070

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

1

Small-scale

0.479

High

829072

ATD3A
ATPase family AAA domain-containing protein 3A

1

2

High-throughput

0.479

High

829079

NPS3A
Protein NipSnap homolog 3A

1

3

Small-scale

0.479

High

829080

TES
Testin

1

1

High-throughput

0.479

High

829083

TNIK
TRAF2 and NCK-interacting protein kinase

1

2

High-throughput

0.479

High

829087

NISCH
Nischarin

1

1

High-throughput

0.479

High

829088

TR150
Thyroid hormone receptor-associated protein 3

1

1

High-throughput

0.479

High

62902

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.458

High

124799

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

High-throughput

0.458

High

176742

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.458

High

271278

NPM3
Nucleoplasmin-3

1

0

High-throughput

0.458

High

330643

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

0

High-throughput

0.458

High

430094

PROF1
Profilin-1

1

0

High-throughput

0.458

High

444690

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

0

High-throughput

0.458

High

448303

GSTP1
Glutathione S-transferase P

1

0

High-throughput

0.458

High

486385

RO60
RNA-binding protein RO60

1

0

High-throughput

0.458

High

518837

TPR
Nucleoprotein TPR

1

0

High-throughput

0.458

High

538650

MYL6B
Myosin light chain 6B

1

0

High-throughput

0.458

High

538862

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.458

High

566972

CXA1
Gap junction alpha-1 protein

1

0

High-throughput

0.458

High

610823

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

High-throughput

0.458

High

657310

ABCD3
ATP-binding cassette sub-family D member 3

1

0

High-throughput

0.458

High

671167

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.458

High

681368

DNJA1
DnaJ homolog subfamily A member 1

1

0

High-throughput

0.458

High

719415

MERL
Merlin

1

0

High-throughput

0.458

High

739660

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.458

High

790302

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.458

High

796830

NAMPT
Nicotinamide phosphoribosyltransferase

1

0

High-throughput

0.458

High

806759

RS9
Small ribosomal subunit protein uS4

1

0

High-throughput

0.458

High

828961

MRE11
Double-strand break repair protein MRE11

1

0

High-throughput

0.458

High

828962

EMD
Emerin

1

0

High-throughput

0.458

High

828964

CLCN7
H(+)/Cl(-) exchange transporter 7

1

0

High-throughput

0.458

High

828970

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.458

High

828973

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.458

High

828974

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.458

High

828976

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

High-throughput

0.458

High

828977

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.458

High

828978

YBOX1
Y-box-binding protein 1

1

0

High-throughput

0.458

High

828979

TPM4
Tropomyosin alpha-4 chain

1

0

High-throughput

0.458

High

828985

METK1
S-adenosylmethionine synthase isoform type-1

1

0

High-throughput

0.458

High

828999

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.458

High

829007

ELAV1
ELAV-like protein 1

1

0

High-throughput

0.458

High

829031

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

0

High-throughput

0.458

High

829033

ARF
Tumor suppressor ARF

1

0

Small-scale

0.458

High

829036

NU133
Nuclear pore complex protein Nup133

1

0

High-throughput

0.458

High

829042

PSMF1
Proteasome inhibitor PI31 subunit

1

0

High-throughput

0.458

High

829052

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.458

High

829055

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

829059

AP1M1
AP-1 complex subunit mu-1

1

0

High-throughput

0.458

High

829068

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.458

High

829069

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.458

High

829074

SYLC
Leucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

829076

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.458

High

829078

ZO2
Tight junction protein ZO-2

1

0

High-throughput

0.458

High

829081

PUF60
Poly(U)-binding-splicing factor PUF60

1

0

High-throughput

0.458

High

829084

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

1

0

High-throughput

0.458

High

657901

PEX2
Peroxisome biogenesis factor 2

1

2

Small-scale

0.445

High

829019

CDC73
Parafibromin

1

2

Small-scale

0.445

High

829022

CTR9
RNA polymerase-associated protein CTR9 homolog

1

3

Small-scale

0.445

High

829038

LEO1
RNA polymerase-associated protein LEO1

1

3

Small-scale

0.445

High

829043

RTF1
RNA polymerase-associated protein RTF1 homolog

1

2

Small-scale

0.445

High

158758

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.438

High

829071

EKI2
Ethanolamine kinase 2

1

0

High-throughput

0.438

High

436075

ANXA6
Annexin A6

1

3

High-throughput

0.437

High

577603

SON
Protein SON

1

1

High-throughput

0.437

High

828989

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

Small-scale

0.437

High

828990

LG3BP
Galectin-3-binding protein

1

6

High-throughput

0.437

High

829008

H2A2C
Histone H2A type 2-C

1

4

High-throughput

0.437

High

829011

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

3

High-throughput

0.437

High

829046

LRC59
Leucine-rich repeat-containing protein 59

1

3

High-throughput

0.437

High

829048

CPNE2
Copine-2

1

6

High-throughput

0.437

High

829053

NIPS1
Protein NipSnap homolog 1

1

3

Small-scale

0.437

High

829085

F184B
Protein FAM184B

1

1

High-throughput

0.437

High

829089

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

1

Small-scale

0.437

High

726083

BASI
Basigin

1

1

High-throughput

0.417

High

829049

JPH4
Junctophilin-4

2

0

High-throughput

0.328

High

534177

CD59
CD59 glycoprotein

2

0

High-throughput

0.318

High

275554

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

0

High-throughput

0.279

Low

829026

RETR3
Reticulophagy regulator 3

1

0

High-throughput

0.279

Low

151291

IDLC
Axonemal dynein light intermediate polypeptide 1

1

0

High-throughput

0.268

Low

527349

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.268

Low

674115

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.268

Low

828992

Q0VDC6
peptidylprolyl isomerase

1

0

High-throughput

0.268

Low

829004

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

0

High-throughput

0.268

Low

829058

NUP58
Nucleoporin p58/p45

1

0

High-throughput

0.268

Low

829091

Q9Y649
GW128

1

0

High-throughput

0.268

Low

315321

NSA2
Ribosome biogenesis protein NSA2 homolog

1

0

High-throughput

0.249

Low

451865

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.249

Low

474303

ONCO
Oncomodulin-1

1

0

High-throughput

0.249

Low

623905

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

0

High-throughput

0.249

Low

714744

TRY3
Trypsin-3

1

0

High-throughput

0.249

Low

828996

DSG2
Desmoglein-2

1

0

High-throughput

0.249

Low

829000

FLOT2
Flotillin-2

1

0

High-throughput

0.249

Low

829003

LBR
Delta(14)-sterol reductase LBR

1

0

High-throughput

0.249

Low

829034

FA98A
Protein FAM98A

1

0

High-throughput

0.249

Low

829051

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.249

Low

829061

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.249

Low

829090

CD2AP
CD2-associated protein

1

0

High-throughput

0.249

Low

829035

CKLF2
CKLF-like MARVEL transmembrane domain-containing protein 2

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024