Protein: FOXC1
Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3)

Gene: FOXC1
Organism: Homo sapiens
Interactions: 232
UniProt ID: Q12948

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000792 - heterochromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

208911

FOXS1
Forkhead box protein S1

1

19

High-throughput

0.691

High

1021098

FOXD4
Forkhead box protein D4

1

18

High-throughput

0.691

High

1021154

FOXC2
Forkhead box protein C2

1

17

High-throughput

0.691

High

1021173

FOXJ2
Forkhead box protein J2

1

17

High-throughput

0.691

High

1021123

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

3

15

High-throughput

0.675

High

817993

SOX2
Transcription factor SOX-2

3

20

Small-scale

0.656

High

1021135

METL6
tRNA N(3)-methylcytidine methyltransferase METTL6

3

0

High-throughput

0.638

High

503990

HSP7C
Heat shock cognate 71 kDa protein

2

5

High-throughput

0.628

High

672098

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

14

High-throughput

0.628

High

927803

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

2

15

High-throughput

0.628

High

773066

PBX1
Pre-B-cell leukemia transcription factor 1

2

15

Small-scale

0.628

High

178963

FOXP2
Forkhead box protein P2

1

19

Small-scale

0.618

High

1021099

FOXI1
Forkhead box protein I1

1

18

High-throughput

0.618

High

1021100

FOXL1
Forkhead box protein L1

1

18

High-throughput

0.618

High

1021131

FOXP4
Forkhead box protein P4

1

18

Small-scale

0.618

High

1021162

FOXP1
Forkhead box protein P1

1

18

Small-scale

0.618

High

229380

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

2

20

High-throughput

0.611

High

443179

NFIC
Nuclear factor 1 C-type

2

20

High-throughput

0.611

High

801866

RECQ1
ATP-dependent DNA helicase Q1

2

9

High-throughput

0.611

High

915174

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

2

8

High-throughput

0.611

High

1016754

TFCP2
Alpha-globin transcription factor CP2

2

9

Small-scale

0.611

High

1021139

P66B
Transcriptional repressor p66-beta

2

2

High-throughput

0.611

High

652835

APEX1
DNA repair nuclease/redox regulator APEX1

2

1

High-throughput

0.584

High

918328

H2B1C
Histone H2B type 1-C/E/F/G/I

2

4

High-throughput

0.584

High

1021110

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.584

High

1021097

FOXC1
Forkhead box protein C1

1

17

High-throughput

0.575

High

117128

DX39A
ATP-dependent RNA helicase DDX39A

1

12

High-throughput

0.536

High

129974

MEIS1
Homeobox protein Meis1

1

11

High-throughput

0.536

High

153913

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

6

High-throughput

0.536

High

157033

AIM2
Interferon-inducible protein AIM2

1

1

High-throughput

0.536

High

323721

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.536

High

386631

P53
Cellular tumor antigen p53

1

13

High-throughput

0.536

High

556855

CREB1
Cyclic AMP-responsive element-binding protein 1

1

5

High-throughput

0.536

High

567839

HXB9
Homeobox protein Hox-B9

1

20

High-throughput

0.536

High

643852

SYVC
Valine--tRNA ligase

1

18

High-throughput

0.536

High

658661

SMCA1
Probable global transcription activator SNF2L1

1

20

High-throughput

0.536

High

679033

HXC13
Homeobox protein Hox-C13

1

20

High-throughput

0.536

High

723692

HXD13
Homeobox protein Hox-D13

1

20

High-throughput

0.536

High

773109

PBX2
Pre-B-cell leukemia transcription factor 2

1

15

High-throughput

0.536

High

848022

MECP2
Methyl-CpG-binding protein 2

1

4

High-throughput

0.536

High

871547

HSP72
Heat shock-related 70 kDa protein 2

1

5

High-throughput

0.536

High

879764

DLX5
Homeobox protein DLX-5

1

20

High-throughput

0.536

High

966969

SATB1
DNA-binding protein SATB1

1

20

High-throughput

0.536

High

1021113

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

6

High-throughput

0.536

High

1021124

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.536

High

1021126

BCOR
BCL-6 corepressor

1

10

Small-scale

0.536

High

1021129

LDB1
LIM domain-binding protein 1

1

4

High-throughput

0.536

High

1021153

BAG1
BAG family molecular chaperone regulator 1

1

3

High-throughput

0.536

High

1021165

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.536

High

1021169

SALL1
Sal-like protein 1

1

9

High-throughput

0.536

High

1021171

UBIP1
Upstream-binding protein 1

1

9

High-throughput

0.536

High

1021180

SATB2
DNA-binding protein SATB2

1

20

High-throughput

0.536

High

598089

FLNA
Filamin-A

1

5

Small-scale

0.534

High

990033

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

3

Small-scale

0.534

High

1021150

PITX2
Pituitary homeobox 2

1

16

Small-scale

0.515

High

1021176

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.513

High

661249

S10A2
Protein S100-A2

1

5

High-throughput

0.489

High

1021128

CE024
UPF0461 protein C5orf24

1

1

High-throughput

0.489

High

1021172

HPBP1
Hsp70-binding protein 1

1

8

High-throughput

0.489

High

118726

AIP
AH receptor-interacting protein

1

4

High-throughput

0.479

High

122714

MEN1
Menin

1

2

High-throughput

0.479

High

135114

NFIB
Nuclear factor 1 B-type

1

19

High-throughput

0.479

High

146208

ARI1A
AT-rich interactive domain-containing protein 1A

1

18

High-throughput

0.479

High

164869

SC16A
Protein transport protein Sec16A

1

7

High-throughput

0.479

High

171026

TBXT
T-box transcription factor T

1

6

High-throughput

0.479

High

666896

TKT
Transketolase

1

2

High-throughput

0.479

High

195413

DHX15
ATP-dependent RNA helicase DHX15

1

7

High-throughput

0.479

High

202143

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

1

High-throughput

0.479

High

211166

BUB3
Mitotic checkpoint protein BUB3

1

7

High-throughput

0.479

High

211848

TLX3
T-cell leukemia homeobox protein 3

1

19

High-throughput

0.479

High

225737

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.479

High

232132

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.479

High

234943

SNX3
Sorting nexin-3

1

3

High-throughput

0.479

High

254078

WDR1
WD repeat-containing protein 1

1

5

High-throughput

0.479

High

256247

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

7

High-throughput

0.479

High

260864

H2AY
Core histone macro-H2A.1

1

8

High-throughput

0.479

High

261489

NCOR1
Nuclear receptor corepressor 1

1

20

High-throughput

0.479

High

272114

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

10

High-throughput

0.479

High

296004

MTA2
Metastasis-associated protein MTA2

1

10

High-throughput

0.479

High

403206

LA
Lupus La protein

1

4

High-throughput

0.479

High

413903

GELS
Gelsolin

1

1

High-throughput

0.479

High

418948

TPM3
Tropomyosin alpha-3 chain

1

6

High-throughput

0.479

High

442113

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.479

High

448328

GSTP1
Glutathione S-transferase P

1

4

High-throughput

0.479

High

449704

HMGB1
High mobility group protein B1

1

20

High-throughput

0.479

High

453318

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

7

High-throughput

0.479

High

455379

PARP1
Poly [ADP-ribose] polymerase 1

1

12

High-throughput

0.479

High

518862

TPR
Nucleoprotein TPR

1

10

High-throughput

0.479

High

540842

PO2F1
POU domain, class 2, transcription factor 1

1

20

High-throughput

0.479

High

540987

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

4

High-throughput

0.479

High

572561

SPI1
Transcription factor PU.1

1

13

High-throughput

0.479

High

595205

LMNB1
Lamin-B1

1

6

High-throughput

0.479

High

603476

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

1

High-throughput

0.479

High

613434

SFPQ
Splicing factor, proline- and glutamine-rich

1

5

High-throughput

0.479

High

617292

SP100
Nuclear autoantigen Sp-100

1

20

High-throughput

0.479

High

617840

SAHH
Adenosylhomocysteinase

1

9

High-throughput

0.479

High

620149

PAX7
Paired box protein Pax-7

1

19

High-throughput

0.479

High

620341

GATA2
Endothelial transcription factor GATA-2

1

15

High-throughput

0.479

High

620493

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

15

High-throughput

0.479

High

627249

MCM3
DNA replication licensing factor MCM3

1

7

High-throughput

0.479

High

641395

PAX6
Paired box protein Pax-6

1

14

High-throughput

0.479

High

643338

HMGB2
High mobility group protein B2

1

20

High-throughput

0.479

High

651074

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

658494

TEAD1
Transcriptional enhancer factor TEF-1

1

2

High-throughput

0.479

High

671650

PEBP1
Phosphatidylethanolamine-binding protein 1

1

3

High-throughput

0.479

High

678793

HXA10
Homeobox protein Hox-A10

1

20

High-throughput

0.479

High

679105

TLX1
T-cell leukemia homeobox protein 1

1

20

High-throughput

0.479

High

682591

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

10

High-throughput

0.479

High

692130

ELF1
ETS-related transcription factor Elf-1

1

17

High-throughput

0.479

High

708622

MCM5
DNA replication licensing factor MCM5

1

5

High-throughput

0.479

High

708883

MCM7
DNA replication licensing factor MCM7

1

5

High-throughput

0.479

High

727369

DEK
Protein DEK

1

1

High-throughput

0.479

High

727515

HNF1B
Hepatocyte nuclear factor 1-beta

1

18

High-throughput

0.479

High

727739

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.479

High

727858

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

745145

RBMX
RNA-binding motif protein, X chromosome

1

9

High-throughput

0.479

High

750244

COIL
Coilin

1

1

High-throughput

0.479

High

768431

CAPG
Macrophage-capping protein

1

1

High-throughput

0.479

High

776666

STAT3
Signal transducer and activator of transcription 3

1

2

High-throughput

0.479

High

781622

ETV6
Transcription factor ETV6

1

14

High-throughput

0.479

High

782535

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

785891

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

793929

MATR3
Matrin-3

1

3

High-throughput

0.479

High

808562

YAP1
Transcriptional coactivator YAP1

1

11

Small-scale

0.479

High

831275

CEBPA
CCAAT/enhancer-binding protein alpha

1

10

High-throughput

0.479

High

832412

MCM2
DNA replication licensing factor MCM2

1

7

High-throughput

0.479

High

836719

DNLI3
DNA ligase 3

1

5

High-throughput

0.479

High

846764

SMCA2
Probable global transcription activator SNF2L2

1

20

High-throughput

0.479

High

846951

SMCA4
Transcription activator BRG1

1

20

High-throughput

0.479

High

850915

HDGF
Hepatoma-derived growth factor

1

7

High-throughput

0.479

High

852719

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

1

High-throughput

0.479

High

852893

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

3

High-throughput

0.479

High

855464

MSH6
DNA mismatch repair protein Msh6

1

1

High-throughput

0.479

High

878403

PAX9
Paired box protein Pax-9

1

9

High-throughput

0.479

High

898112

MAX
Protein max

1

11

High-throughput

0.479

High

909499

1433E
14-3-3 protein epsilon

1

4

High-throughput

0.479

High

917188

H4
Histone H4

1

6

High-throughput

0.479

High

933776

TBB4B
Tubulin beta-4B chain

1

5

High-throughput

0.479

High

934709

H31
Histone H3.1

1

11

High-throughput

0.479

High

942150

GTF2I
General transcription factor II-I

1

1

High-throughput

0.479

High

944212

PRKDC
DNA-dependent protein kinase catalytic subunit

1

5

High-throughput

0.479

High

952303

H33
Histone H3.3

1

11

High-throughput

0.479

High

964314

RUNX1
Runt-related transcription factor 1

1

1

High-throughput

0.479

High

967139

EWS
RNA-binding protein EWS

1

6

High-throughput

0.479

High

973321

TOP2B
DNA topoisomerase 2-beta

1

10

High-throughput

0.479

High

980740

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.479

High

984487

KPCD
Protein kinase C delta type

1

7

High-throughput

0.479

High

985210

HME1
Homeobox protein engrailed-1

1

20

High-throughput

0.479

High

992745

SRSF1
Serine/arginine-rich splicing factor 1

1

6

High-throughput

0.479

High

994136

DHX9
ATP-dependent RNA helicase A

1

4

High-throughput

0.479

High

996639

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.479

High

998626

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

1018216

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1018780

SF3A3
Splicing factor 3A subunit 3

1

1

High-throughput

0.479

High

1019709

ILF3
Interleukin enhancer-binding factor 3

1

15

High-throughput

0.479

High

1021101

TADBP
TAR DNA-binding protein 43

1

5

High-throughput

0.479

High

1021102

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

8

High-throughput

0.479

High

1021103

CTBP1
C-terminal-binding protein 1

1

8

High-throughput

0.479

High

1021104

IKZF1
DNA-binding protein Ikaros

1

3

High-throughput

0.479

High

1021105

PEBB
Core-binding factor subunit beta

1

1

High-throughput

0.479

High

1021106

RBM39
RNA-binding protein 39

1

8

High-throughput

0.479

High

1021107

MCM6
DNA replication licensing factor MCM6

1

7

High-throughput

0.479

High

1021108

SMC1A
Structural maintenance of chromosomes protein 1A

1

18

High-throughput

0.479

High

1021109

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.479

High

1021111

NUMA1
Nuclear mitotic apparatus protein 1

1

6

High-throughput

0.479

High

1021112

NONO
Non-POU domain-containing octamer-binding protein

1

8

High-throughput

0.479

High

1021114

ELAV1
ELAV-like protein 1

1

3

High-throughput

0.479

High

1021115

CEBPE
CCAAT/enhancer-binding protein epsilon

1

8

High-throughput

0.479

High

1021117

MK14
Mitogen-activated protein kinase 14

1

3

Small-scale

0.479

High

1021118

RBBP7
Histone-binding protein RBBP7

1

7

High-throughput

0.479

High

1021119

SRSF7
Serine/arginine-rich splicing factor 7

1

8

High-throughput

0.479

High

1021120

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

12

High-throughput

0.479

High

1021122

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

8

High-throughput

0.479

High

1021125

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

1021127

I2BP2
Interferon regulatory factor 2-binding protein 2

1

2

High-throughput

0.479

High

1021132

SMC5
Structural maintenance of chromosomes protein 5

1

15

High-throughput

0.479

High

1021133

CCAR2
Cell cycle and apoptosis regulator protein 2

1

1

Small-scale

0.479

High

1021134

SMRC2
SWI/SNF complex subunit SMARCC2

1

19

High-throughput

0.479

High

1021136

SP7
Transcription factor Sp7

1

11

High-throughput

0.479

High

1021138

PSPC1
Paraspeckle component 1

1

8

High-throughput

0.479

High

1021140

DDX17
Probable ATP-dependent RNA helicase DDX17

1

3

High-throughput

0.479

High

1021141

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

5

High-throughput

0.479

High

1021142

FUBP2
Far upstream element-binding protein 2

1

16

High-throughput

0.479

High

1021143

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

8

High-throughput

0.479

High

1021144

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

17

High-throughput

0.479

High

1021145

FUBP1
Far upstream element-binding protein 1

1

14

High-throughput

0.479

High

1021146

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

10

High-throughput

0.479

High

1021147

ANM6
Protein arginine N-methyltransferase 6

1

4

High-throughput

0.479

High

1021148

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1021149

FEV
Protein FEV

1

13

High-throughput

0.479

High

1021151

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

1021152

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

1021155

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

4

High-throughput

0.479

High

1021156

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

12

High-throughput

0.479

High

1021157

DDX23
Probable ATP-dependent RNA helicase DDX23

1

2

High-throughput

0.479

High

1021158

KLF16
Krueppel-like factor 16

1

11

High-throughput

0.479

High

1021159

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

12

High-throughput

0.479

High

1021160

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

1021161

ADNP
Activity-dependent neuroprotector homeobox protein

1

4

High-throughput

0.479

High

1021164

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

1021166

RC3H2
Roquin-2

1

12

High-throughput

0.479

High

1021167

HM20A
High mobility group protein 20A

1

20

High-throughput

0.479

High

1021170

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1021174

RCC2
Protein RCC2

1

6

High-throughput

0.479

High

1021175

DACH1
Dachshund homolog 1

1

5

High-throughput

0.479

High

1021177

FBW1B
F-box/WD repeat-containing protein 11

1

9

High-throughput

0.479

High

1021178

RALY
RNA-binding protein Raly

1

11

High-throughput

0.479

High

1021179

PRP19
Pre-mRNA-processing factor 19

1

8

High-throughput

0.479

High

1021181

SMC3
Structural maintenance of chromosomes protein 3

1

17

High-throughput

0.479

High

62924

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.458

High

214916

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.458

High

577754

NELFE
Negative elongation factor E

1

0

High-throughput

0.458

High

667456

CASP1
Caspase-1

1

0

High-throughput

0.458

High

741968

TALDO
Transaldolase

1

0

High-throughput

0.458

High

844900

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.458

High

867192

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.458

High

979589

GLGB
1,4-alpha-glucan-branching enzyme

1

0

High-throughput

0.458

High

1021137

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1021183

RTCB
RNA-splicing ligase RtcB homolog

1

0

High-throughput

0.458

High

1021184

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.458

High

1021168

PODO
Podocin

1

6

Small-scale

0.457

High

87567

C9JWJ8
Nuclear factor 1

1

20

High-throughput

0.445

High

344491

A2MG
Alpha-2-macroglobulin

1

7

High-throughput

0.437

High

436086

ANXA6
Annexin A6

1

1

High-throughput

0.437

High

469860

CO4A
Complement C4-A

1

7

High-throughput

0.437

High

897355

ARF3
ADP-ribosylation factor 3

1

3

High-throughput

0.437

High

1021121

FKB15
FK506-binding protein 15

1

3

High-throughput

0.437

High

1021163

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

1021182

LC7L2
Putative RNA-binding protein Luc7-like 2

1

2

High-throughput

0.437

High

1021130

NDUAB
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

1

0

High-throughput

0.279

Low

1021116

Q16075
Oct-1B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024