Protein: MYLK
Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]

Gene: MYLK
Organism: Homo sapiens
Interactions: 103
UniProt ID: Q15746

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0003779 - actin binding
GO:0004687 - myosin light chain kinase activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1077864

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

3

20

High-throughput

0.871

High

1077863

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

2

16

High-throughput

0.737

High

1026170

PAK1
Serine/threonine-protein kinase PAK 1

1

4

Small-scale

0.735

High

894044

CDC42
Cell division control protein 42 homolog

1

8

High-throughput

0.691

High

895493

RAB10
Ras-related protein Rab-10

1

3

High-throughput

0.691

High

972513

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

6

High-throughput

0.691

High

1077866

ANLN
Anillin

1

2

High-throughput

0.691

High

1077857

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

10

High-throughput

0.665

High

1077860

OSBL8
Oxysterol-binding protein-related protein 8

1

0

High-throughput

0.656

High

580651

ML12A
Myosin regulatory light chain 12A

1

18

Small-scale

0.647

High

1026915

PAK2
Serine/threonine-protein kinase PAK 2

1

3

Small-scale

0.647

High

1028462

KGP2
cGMP-dependent protein kinase 2

1

3

Small-scale

0.647

High

159577

ML12B
Myosin regulatory light chain 12B

1

17

High-throughput

0.618

High

161376

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

12

High-throughput

0.618

High

227554

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.618

High

523003

SRC
Proto-oncogene tyrosine-protein kinase Src

1

9

Small-scale

0.618

High

557704

NCK1
SH2/SH3 adapter protein NCK1

1

11

High-throughput

0.618

High

624354

MYL9
Myosin regulatory light polypeptide 9

1

17

High-throughput

0.618

High

655385

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

4

High-throughput

0.618

High

924597

GRB2
Growth factor receptor-bound protein 2

1

14

High-throughput

0.618

High

1077849

MPRIP
Myosin phosphatase Rho-interacting protein

1

12

High-throughput

0.618

High

1077861

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

11

High-throughput

0.618

High

1077869

ALK
ALK tyrosine kinase receptor

1

8

Small-scale

0.618

High

1077852

APBP2
Amyloid protein-binding protein 2

2

4

High-throughput

0.606

High

1039068

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

17

High-throughput

0.575

High

1077856

ZBT18
Zinc finger and BTB domain-containing protein 18

1

3

High-throughput

0.575

High

903250

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.553

High

388465

HSPB1
Heat shock protein beta-1

1

9

High-throughput

0.541

High

340460

PGK1
Phosphoglycerate kinase 1

1

2

High-throughput

0.536

High

423239

PDIA1
Protein disulfide-isomerase

1

6

High-throughput

0.536

High

444898

ANXA5
Annexin A5

1

1

High-throughput

0.536

High

499399

ESTD
S-formylglutathione hydrolase

1

1

High-throughput

0.536

High

547071

EZRI
Ezrin

1

15

High-throughput

0.536

High

556623

CBR1
Carbonyl reductase [NADPH] 1

1

1

High-throughput

0.536

High

606426

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.536

High

607075

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

4

High-throughput

0.536

High

643755

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

3

High-throughput

0.536

High

666914

TKT
Transketolase

1

1

High-throughput

0.536

High

670712

PRDX6
Peroxiredoxin-6

1

2

High-throughput

0.536

High

676674

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

1

High-throughput

0.536

High

713523

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

2

High-throughput

0.536

High

724846

MYH9
Myosin-9

1

4

High-throughput

0.536

High

777571

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

813495

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.536

High

825830

NASP
Nuclear autoantigenic sperm protein

1

7

High-throughput

0.536

High

852729

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

1

High-throughput

0.536

High

854793

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

High-throughput

0.536

High

862398

ACLY
ATP-citrate synthase

1

1

High-throughput

0.536

High

906473

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

6

High-throughput

0.536

High

929301

IF5A1
Eukaryotic translation initiation factor 5A-1

1

2

High-throughput

0.536

High

944261

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

High-throughput

0.536

High

1022501

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

1

High-throughput

0.536

High

1067713

PDIA6
Protein disulfide-isomerase A6

1

7

High-throughput

0.536

High

1069352

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

1077846

AAAT
Neutral amino acid transporter B(0)

1

1

High-throughput

0.536

High

1077855

MYO19
Unconventional myosin-XIX

1

13

High-throughput

0.536

High

1077859

TX101
Testis-expressed protein 101

1

1

High-throughput

0.536

High

1077867

XPP1
Xaa-Pro aminopeptidase 1

1

1

High-throughput

0.536

High

1077870

CHIP
E3 ubiquitin-protein ligase CHIP

1

7

High-throughput

0.536

High

1077872

MYO5A
Unconventional myosin-Va

1

12

High-throughput

0.536

High

117410

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.513

High

123608

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.513

High

337237

AATM
Aspartate aminotransferase, mitochondrial

1

0

High-throughput

0.513

High

378533

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.513

High

602104

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.513

High

615538

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.513

High

682504

PUR9
Bifunctional purine biosynthesis protein ATIC

1

0

High-throughput

0.513

High

782907

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.513

High

838646

GDIB
Rab GDP dissociation inhibitor beta

1

0

High-throughput

0.513

High

878526

PSA
Puromycin-sensitive aminopeptidase

1

0

High-throughput

0.513

High

1074037

SC23B
Protein transport protein Sec23B

1

0

High-throughput

0.513

High

1077848

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.513

High

1077865

INO1
Inositol-3-phosphate synthase 1

1

0

High-throughput

0.513

High

1077871

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.513

High

1077873

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.513

High

1052209

SRC8
Src substrate cortactin

1

8

Small-scale

0.501

High

396472

ALDH2
Aldehyde dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

536368

GLU2B
Glucosidase 2 subunit beta

1

2

High-throughput

0.489

High

623937

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

1

High-throughput

0.489

High

654362

CALX
Calnexin

1

4

High-throughput

0.489

High

1077850

TXND5
Thioredoxin domain-containing protein 5

1

7

High-throughput

0.489

High

1077853

KCD12
BTB/POZ domain-containing protein KCTD12

1

2

High-throughput

0.489

High

1077854

TRM61
tRNA

1

1

High-throughput

0.489

High

1065780

MLC1
Membrane protein MLC1

1

0

Small-scale

0.480

High

386803

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

651303

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

891531

MYL6
Myosin light polypeptide 6

1

12

High-throughput

0.479

High

908607

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

9

High-throughput

0.479

High

1077868

SEPT9
Septin-9

1

1

Small-scale

0.479

High

893040

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

1077847

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

378064

PRIO
Major prion protein

1

1

High-throughput

0.445

High

717859

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.445

High

1032428

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.445

High

100794

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

552821

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

720557

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1077851

RHBL4
Rhomboid-related protein 4

1

2

High-throughput

0.437

High

402066

JUN
Transcription factor Jun

1

7

High-throughput

0.407

High

1077862

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.279

Low

63857

D42E2
Putative short-chain dehydrogenase/reductase family 42E member 2

1

0

High-throughput

0.249

Low

1047554

CNCG
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

1

0

High-throughput

0.249

Low

1077858

RT63
Large ribosomal subunit protein mL63

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024