Protein: SH2D3
SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1)

Gene: SH2D3, SH2D3C
Organism: Homo sapiens
Interactions: 170
UniProt ID: Q8N5H7

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0007254 - JNK cascade
GO:0007264 - small GTPase-mediated signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

338698

EGFR
Epidermal growth factor receptor

4

20

High-throughput

0.887

High

882427

BCAR1
Breast cancer anti-estrogen resistance protein 1

3

20

Small-scale

0.886

High

199516

EFS
Embryonal Fyn-associated substrate

2

20

High-throughput

0.702

High

489988

PTPRF
Receptor-type tyrosine-protein phosphatase F

2

20

High-throughput

0.659

High

383882

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

1070984

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

441537

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.619

High

499275

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.619

High

433893

LYN
Tyrosine-protein kinase Lyn

1

19

Small-scale

0.618

High

1054782

CASL
Enhancer of filamentation 1

1

20

Small-scale

0.618

High

1234529

SH2D3
SH2 domain-containing protein 3C

1

20

High-throughput

0.618

High

601949

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.579

High

117426

BACH
Cytosolic acyl coenzyme A thioester hydrolase

2

1

High-throughput

0.571

High

128237

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

2

17

High-throughput

0.571

High

373405

CATA
Catalase

2

1

High-throughput

0.571

High

388587

HSPB1
Heat shock protein beta-1

2

8

High-throughput

0.571

High

398033

ISG15
Ubiquitin-like protein ISG15

2

14

High-throughput

0.571

High

413993

GELS
Gelsolin

2

14

High-throughput

0.571

High

427617

ANXA2
Annexin A2

2

11

High-throughput

0.571

High

448365

GSTP1
Glutathione S-transferase P

2

3

High-throughput

0.571

High

509258

G6PD
Glucose-6-phosphate 1-dehydrogenase

2

1

High-throughput

0.571

High

515903

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

15

High-throughput

0.571

High

519689

ANXA3
Annexin A3

2

11

High-throughput

0.571

High

547138

EZRI
Ezrin

2

20

High-throughput

0.571

High

549013

NQO1
NAD(P)H dehydrogenase [quinone] 1

2

1

High-throughput

0.571

High

607113

UBA1
Ubiquitin-like modifier-activating enzyme 1

2

1

High-throughput

0.571

High

636373

DNJB1
DnaJ homolog subfamily B member 1

2

8

High-throughput

0.571

High

657629

ITPI2
Protein ITPRID2

2

2

High-throughput

0.571

High

685727

PRDX2
Peroxiredoxin-2

2

4

High-throughput

0.571

High

757684

IF4A3
Eukaryotic initiation factor 4A-III

2

13

High-throughput

0.571

High

854808

GDIR1
Rho GDP-dissociation inhibitor 1

2

1

High-throughput

0.571

High

863011

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

2

2

High-throughput

0.571

High

893411

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

15

High-throughput

0.571

High

904855

1433G
14-3-3 protein gamma

2

20

High-throughput

0.571

High

923737

PPIA
Peptidyl-prolyl cis-trans isomerase A

2

10

High-throughput

0.571

High

927304

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.571

High

933524

TBA4A
Tubulin alpha-4A chain

2

20

High-throughput

0.571

High

934603

PA1B2
Platelet-activating factor acetylhydrolase IB subunit alpha2

2

2

High-throughput

0.571

High

943955

GSTO1
Glutathione S-transferase omega-1

2

4

High-throughput

0.571

High

964027

SRSF2
Serine/arginine-rich splicing factor 2

2

12

High-throughput

0.571

High

973778

AKA12
A-kinase anchor protein 12

2

18

High-throughput

0.571

High

996410

PPID
Peptidyl-prolyl cis-trans isomerase D

2

6

High-throughput

0.571

High

1017407

CDC20
Cell division cycle protein 20 homolog

2

5

High-throughput

0.571

High

1020800

TRAF2
TNF receptor-associated factor 2

2

20

High-throughput

0.571

High

1039117

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

2

12

High-throughput

0.571

High

1044790

RIN1
Ras and Rab interactor 1

2

20

High-throughput

0.571

High

1045056

CD166
CD166 antigen

2

18

High-throughput

0.571

High

1047969

COTL1
Coactosin-like protein

2

4

High-throughput

0.571

High

1067874

PA1B3
Platelet-activating factor acetylhydrolase IB subunit alpha1

2

2

High-throughput

0.571

High

1069424

TEBP
Prostaglandin E synthase 3

2

2

High-throughput

0.571

High

1076468

TRIP6
Thyroid receptor-interacting protein 6

2

20

High-throughput

0.571

High

1079543

NEDD8
NEDD8

2

5

High-throughput

0.571

High

1115545

GLYR1
Cytokine-like nuclear factor N-PAC

2

4

High-throughput

0.571

High

1139697

CARL1
F-actin-uncapping protein LRRC16A

2

6

High-throughput

0.571

High

1173850

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

2

14

High-throughput

0.571

High

1184530

SYPM
Probable proline--tRNA ligase, mitochondrial

2

3

High-throughput

0.571

High

1204669

DDX42
ATP-dependent RNA helicase DDX42

2

7

High-throughput

0.571

High

1234297

SRBD1
S1 RNA-binding domain-containing protein 1

2

1

High-throughput

0.571

High

1234531

DHB11
Estradiol 17-beta-dehydrogenase 11

2

1

High-throughput

0.571

High

1234536

GEMI5
Gem-associated protein 5

2

3

High-throughput

0.571

High

1234540

NDRG1
Protein NDRG1

2

1

High-throughput

0.571

High

1234542

LPP
Lipoma-preferred partner

2

20

High-throughput

0.571

High

1234543

EXOC4
Exocyst complex component 4

2

1

High-throughput

0.571

High

1234546

OTUB1
Ubiquitin thioesterase OTUB1

2

1

High-throughput

0.571

High

1234547

PDLI5
PDZ and LIM domain protein 5

2

20

High-throughput

0.571

High

1234557

OSBL8
Oxysterol-binding protein-related protein 8

2

2

High-throughput

0.571

High

1234570

EHD2
EH domain-containing protein 2

2

8

High-throughput

0.571

High

1234572

RCC2
Protein RCC2

2

6

High-throughput

0.571

High

1234573

VPS29
Vacuolar protein sorting-associated protein 29

2

2

High-throughput

0.571

High

1234574

GRHPR
Glyoxylate reductase/hydroxypyruvate reductase

2

1

High-throughput

0.571

High

1234576

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

2

7

High-throughput

0.571

High

1234582

MYO6
Unconventional myosin-VI

2

16

High-throughput

0.571

High

1234583

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

2

14

High-throughput

0.571

High

1234586

NOC2L
Nucleolar complex protein 2 homolog

2

1

High-throughput

0.571

High

1234587

TLN1
Talin-1

2

20

High-throughput

0.571

High

276664

IDHC
Isocitrate dehydrogenase [NADP] cytoplasmic

2

0

High-throughput

0.547

High

313085

AGM1
Phosphoacetylglucosamine mutase

2

0

High-throughput

0.547

High

340490

PGK1
Phosphoglycerate kinase 1

2

0

High-throughput

0.547

High

519230

KCRB
Creatine kinase B-type

2

0

High-throughput

0.547

High

602551

COMT
Catechol O-methyltransferase

2

0

High-throughput

0.547

High

604176

PUR2
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

2

0

High-throughput

0.547

High

814381

AL1A3
Retinaldehyde dehydrogenase 3

2

0

High-throughput

0.547

High

877212

ADK
Adenosine kinase

2

0

High-throughput

0.547

High

1050368

TTL12
Tubulin--tyrosine ligase-like protein 12

2

0

High-throughput

0.547

High

1144485

RN213
E3 ubiquitin-protein ligase RNF213

2

0

High-throughput

0.547

High

1157067

ARMC6
Armadillo repeat-containing protein 6

2

0

High-throughput

0.547

High

1216315

RIOX2
Ribosomal oxygenase 2

2

0

High-throughput

0.547

High

1234549

ABHEB
Putative protein-lysine deacylase ABHD14B

2

0

High-throughput

0.547

High

1234565

SYFB
Phenylalanine--tRNA ligase beta subunit

2

0

High-throughput

0.547

High

1234578

NB5R1
NADH-cytochrome b5 reductase 1

2

0

High-throughput

0.547

High

1234584

HPS5
BLOC-2 complex member HPS5

2

0

High-throughput

0.547

High

1234585

RRP44
Exosome complex exonuclease RRP44

2

0

High-throughput

0.547

High

1234589

SERC
Phosphoserine aminotransferase

2

0

High-throughput

0.547

High

487591

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

851594

NEK4
Serine/threonine-protein kinase Nek4

1

20

High-throughput

0.536

High

124628

CLIC1
Chloride intracellular channel protein 1

2

4

High-throughput

0.521

High

211614

ACTN4
Alpha-actinin-4

2

12

High-throughput

0.521

High

225890

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

15

High-throughput

0.521

High

262885

CISY
Citrate synthase, mitochondrial

2

3

High-throughput

0.521

High

274579

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

2

12

High-throughput

0.521

High

327195

TXD12
Thioredoxin domain-containing protein 12

2

4

High-throughput

0.521

High

351087

LDLR
Low-density lipoprotein receptor

2

4

High-throughput

0.521

High

1137532

RIF1
Telomere-associated protein RIF1

2

16

High-throughput

0.521

High

488294

HLAC
HLA class I histocompatibility antigen, C alpha chain

2

5

High-throughput

0.521

High

623962

THIL
Acetyl-CoA acetyltransferase, mitochondrial

2

1

High-throughput

0.521

High

624958

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

4

High-throughput

0.521

High

687245

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

2

2

High-throughput

0.521

High

823270

MRP
MARCKS-related protein

2

1

High-throughput

0.521

High

838417

CRIP1
Cysteine-rich protein 1

2

20

High-throughput

0.521

High

850946

HDGF
Hepatoma-derived growth factor

2

6

High-throughput

0.521

High

873454

P5CS
Delta-1-pyrroline-5-carboxylate synthase

2

1

High-throughput

0.521

High

992290

DPOE1
DNA polymerase epsilon catalytic subunit A

2

3

High-throughput

0.521

High

1022733

MALL
MAL-like protein

2

6

High-throughput

0.521

High

1048941

UBE4A
Ubiquitin conjugation factor E4 A

2

5

High-throughput

0.521

High

1055342

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

2

15

High-throughput

0.521

High

1069125

PON2
Serum paraoxonase/arylesterase 2

2

1

High-throughput

0.521

High

1146066

TBC9B
TBC1 domain family member 9B

2

5

High-throughput

0.521

High

1168480

TRI72
Tripartite motif-containing protein 72

2

20

High-throughput

0.521

High

1230482

CCAR2
Cell cycle and apoptosis regulator protein 2

2

3

High-throughput

0.521

High

1234533

COQ8A
Atypical kinase COQ8A, mitochondrial

2

3

High-throughput

0.521

High

1234534

S2540
Mitochondrial glutathione transporter SLC25A40

2

13

High-throughput

0.521

High

1234537

IPO4
Importin-4

2

7

High-throughput

0.521

High

1234539

AP3S1
AP-3 complex subunit sigma-1

2

12

High-throughput

0.521

High

1234544

P5CR2
Pyrroline-5-carboxylate reductase 2

2

2

High-throughput

0.521

High

1234550

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

2

2

High-throughput

0.521

High

1234551

UHRF1
E3 ubiquitin-protein ligase UHRF1

2

12

High-throughput

0.521

High

1234552

S29A1
Equilibrative nucleoside transporter 1

2

2

High-throughput

0.521

High

1234556

EIF2A
Eukaryotic translation initiation factor 2A

2

1

High-throughput

0.521

High

1234559

WDR13
WD repeat-containing protein 13

2

5

High-throughput

0.521

High

1234560

AMPB
Aminopeptidase B

2

3

High-throughput

0.521

High

1234561

GRPE1
GrpE protein homolog 1, mitochondrial

2

2

High-throughput

0.521

High

1234564

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

2

1

High-throughput

0.521

High

1234566

TM14B
Transmembrane protein 14B

2

1

High-throughput

0.521

High

1234568

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

2

3

High-throughput

0.521

High

1234571

STIM2
Stromal interaction molecule 2

2

1

High-throughput

0.521

High

1234575

WNT16
Protein Wnt-16

2

1

High-throughput

0.521

High

1234577

DPP2
Dipeptidyl peptidase 2

2

1

High-throughput

0.521

High

1234579

ATIF1
ATPase inhibitor, mitochondrial

2

1

High-throughput

0.521

High

1234580

TF3C4
General transcription factor 3C polypeptide 4

2

1

High-throughput

0.521

High

1234581

ACSL5
Long-chain-fatty-acid--CoA ligase 5

2

2

High-throughput

0.521

High

1234588

HYOU1
Hypoxia up-regulated protein 1

2

20

High-throughput

0.521

High

1234591

S4A7
Sodium bicarbonate cotransporter 3

2

2

High-throughput

0.521

High

974924

CAV1
Caveolin-1

1

9

Small-scale

0.501

High

1234590

SNCAP
Synphilin-1

1

18

High-throughput

0.481

High

1234535

CE192
Centrosomal protein of 192 kDa

1

1

High-throughput

0.445

High

1234562

Q9HCK3
KIAA1569 protein

1

1

High-throughput

0.437

High

64119

AXA2L
Putative annexin A2-like protein

1

11

High-throughput

0.407

High

66879

D11L8
Putative ATP-dependent RNA helicase DDX11-like protein 8

1

1

High-throughput

0.407

High

68473

TM14D
Transmembrane protein 14DP

1

1

High-throughput

0.407

High

354506

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

5

High-throughput

0.407

High

1234541

DDX12
Putative ATP-dependent RNA helicase DDX12

1

1

High-throughput

0.407

High

199595

B4GT5
Beta-1,4-galactosyltransferase 5

2

0

High-throughput

0.298

High

275649

POP7
Ribonuclease P protein subunit p20

2

0

High-throughput

0.298

High

487035

LYAG
Lysosomal alpha-glucosidase

2

0

High-throughput

0.298

High

727398

DEK
Protein DEK

2

0

High-throughput

0.298

High

1205263

DAAF5
Dynein axonemal assembly factor 5

2

0

High-throughput

0.298

High

1223539

K2013
Uncharacterized protein KIAA2013

2

0

High-throughput

0.298

High

1234530

S43A3
Equilibrative nucleobase transporter 1

2

0

High-throughput

0.298

High

1234532

LEMD2
LEM domain-containing protein 2

2

0

High-throughput

0.298

High

1234538

PTCD2
Pentatricopeptide repeat-containing protein 2, mitochondrial

2

0

High-throughput

0.298

High

1234545

TLCD1
TLC domain-containing protein 1

2

0

High-throughput

0.298

High

1234548

GMPPA
Mannose-1-phosphate guanyltransferase alpha

2

0

High-throughput

0.298

High

1234553

CAB45
45 kDa calcium-binding protein

2

0

High-throughput

0.298

High

1234554

TBCD
Tubulin-specific chaperone D

2

0

High-throughput

0.298

High

1234555

HINT2
Adenosine 5'-monophosphoramidase HINT2

2

0

High-throughput

0.298

High

1234558

T126A
Transmembrane protein 126A

2

0

High-throughput

0.298

High

1234563

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

2

0

High-throughput

0.298

High

1234567

CLN6
Ceroid-lipofuscinosis neuronal protein 6

2

0

High-throughput

0.298

High

1234569

CISD1
CDGSH iron-sulfur domain-containing protein 1

2

0

High-throughput

0.298

High


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Last updated: 15 Jul 2024