Protein: BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1)

Gene: BUB1B
Organism: Homo sapiens
Interactions: 160
UniProt ID: O60566

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000940 - outer kinetochore
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

236918

CDC20
Cell division cycle protein 20 homolog

67

20

Small-scale

0.998

High

211084

BUB3
Mitotic checkpoint protein BUB3

32

16

Small-scale

0.994

High

236990

APC4
Anaphase-promoting complex subunit 4

19

2

Small-scale

0.986

High

210960

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

8

20

Small-scale

0.968

High

236991

ANC2
Anaphase-promoting complex subunit 2

5

16

High-throughput

0.932

High

236912

RAE1L
mRNA export factor RAE1

3

14

High-throughput

0.861

High

236994

FZR1
Fizzy-related protein homolog

3

20

Small-scale

0.840

High

236858

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

2

19

Small-scale

0.776

High

236886

CDC27
Cell division cycle protein 27 homolog

25

17

Small-scale

0.767

High

236921

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

22

10

Small-scale

0.767

High

236919

CDC16
Cell division cycle protein 16 homolog

7

18

Small-scale

0.744

High

236988

APC7
Anaphase-promoting complex subunit 7

7

17

Small-scale

0.741

High

236987

CDC23
Cell division cycle protein 23 homolog

6

18

Small-scale

0.735

High

236900

PLK1
Serine/threonine-protein kinase PLK1

6

19

Small-scale

0.733

High

236955

KNL1
Kinetochore scaffold 1

5

1

Small-scale

0.733

High

236861

UBR5
E3 ubiquitin-protein ligase UBR5

5

17

Small-scale

0.709

High

236978

APC1
Anaphase-promoting complex subunit 1

4

2

Small-scale

0.691

High

236933

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

3

6

Small-scale

0.679

High

236976

MIS12
Protein MIS12 homolog

3

1

Small-scale

0.662

High

236914

CENPE
Centromere-associated protein E

3

2

Small-scale

0.660

High

236923

HDAC1
Histone deacetylase 1

3

11

Small-scale

0.656

High

236963

KAT2B
Histone acetyltransferase KAT2B

2

7

Small-scale

0.641

High

236896

MXI1
Max-interacting protein 1

3

15

Small-scale

0.640

High

236965

APC16
Anaphase-promoting complex subunit 16

3

0

High-throughput

0.634

High

236863

BAG2
BAG family molecular chaperone regulator 2

2

3

High-throughput

0.628

High

236898

BRCA2
Breast cancer type 2 susceptibility protein

3

0

Small-scale

0.625

High

236947

WDR74
WD repeat-containing protein 74

1

12

High-throughput

0.618

High

236998

FBW1A
F-box/WD repeat-containing protein 1A

1

11

High-throughput

0.618

High

236931

MD2BP
MAD2L1-binding protein

3

0

Small-scale

0.613

High

236944

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

2

0

High-throughput

0.602

High

236989

APC5
Anaphase-promoting complex subunit 5

2

1

High-throughput

0.601

High

236936

PCH2
Pachytene checkpoint protein 2 homolog

2

13

Small-scale

0.595

High

177145

HDAC3
Histone deacetylase 3

2

11

Small-scale

0.584

High

236872

PARP1
Poly [ADP-ribose] polymerase 1

2

7

Small-scale

0.584

High

236910

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

20

Small-scale

0.584

High

236961

HDAC2
Histone deacetylase 2

2

13

Small-scale

0.584

High

236967

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

1

Small-scale

0.578

High

236956

CDC26
Anaphase-promoting complex subunit CDC26

2

0

High-throughput

0.576

High

236859

SYUG
Gamma-synuclein

1

4

Small-scale

0.573

High

175798

P73
Tumor protein p73

1

5

Small-scale

0.561

High

236864

PTTG1
Securin

1

2

Small-scale

0.561

High

236980

PLK3
Serine/threonine-protein kinase PLK3

1

19

Small-scale

0.561

High

236922

2A5G
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

1

6

Small-scale

0.552

High

154897

NDC80
Kinetochore protein NDC80 homolog

1

15

High-throughput

0.536

High

236866

VTDB
Vitamin D-binding protein

1

1

High-throughput

0.536

High

236869

HSPB1
Heat shock protein beta-1

1

10

High-throughput

0.536

High

236877

EF2
Elongation factor 2

1

4

High-throughput

0.536

High

236881

PSA3
Proteasome subunit alpha type-3

1

5

High-throughput

0.536

High

236882

PSA4
Proteasome subunit alpha type-4

1

6

High-throughput

0.536

High

236884

PSB5
Proteasome subunit beta type-5

1

8

High-throughput

0.536

High

236885

SPB3
Serpin B3

1

4

High-throughput

0.536

High

236887

KPYR
Pyruvate kinase PKLR

1

1

High-throughput

0.536

High

236889

S10AB
Protein S100-A11

1

8

High-throughput

0.536

High

236892

MTREX
Exosome RNA helicase MTR4

1

3

High-throughput

0.536

High

236894

KI67
Proliferation marker protein Ki-67

1

4

High-throughput

0.536

High

236901

MK12
Mitogen-activated protein kinase 12

1

16

High-throughput

0.536

High

236902

HSP72
Heat shock-related 70 kDa protein 2

1

8

High-throughput

0.536

High

236905

PSA6
Proteasome subunit alpha type-6

1

8

High-throughput

0.536

High

236911

TCPB
T-complex protein 1 subunit beta

1

10

High-throughput

0.536

High

236920

RM28
Large ribosomal subunit protein bL28m

1

1

High-throughput

0.536

High

236924

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.536

High

236930

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

2

High-throughput

0.536

High

236946

PMF1
Polyamine-modulated factor 1

1

1

High-throughput

0.536

High

236953

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

6

Small-scale

0.536

High

236959

HS105
Heat shock protein 105 kDa

1

13

High-throughput

0.536

High

236960

GCN1
Stalled ribosome sensor GCN1

1

9

High-throughput

0.536

High

236966

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

6

High-throughput

0.536

High

236971

CDC5L
Cell division cycle 5-like protein

1

9

High-throughput

0.536

High

236974

NUF2
Kinetochore protein Nuf2

1

9

High-throughput

0.536

High

236979

DSN1
Kinetochore-associated protein DSN1 homolog

1

1

High-throughput

0.536

High

236908

AP2B1
AP-2 complex subunit beta

1

11

Small-scale

0.527

High

236977

COMD4
COMM domain-containing protein 4

1

0

High-throughput

0.518

High

146572

SOCS2
Suppressor of cytokine signaling 2

1

20

High-throughput

0.515

High

154711

TCRG1
Transcription elongation regulator 1

1

5

High-throughput

0.515

High

236862

ZWINT
ZW10 interactor

1

2

High-throughput

0.515

High

236915

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.515

High

200309

AP5Z1
AP-5 complex subunit zeta-1

1

0

High-throughput

0.513

High

230290

ZC3H1
Zinc finger C3H1 domain-containing protein

1

0

High-throughput

0.513

High

236871

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.513

High

236893

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.513

High

236904

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

236943

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.513

High

236958

CERK1
Ceramide kinase

1

0

High-throughput

0.513

High

236948

DNMBP
Dynamin-binding protein

1

17

High-throughput

0.508

High

236879

CCNA2
Cyclin-A2

1

6

Small-scale

0.501

High

236880

APC
Adenomatous polyposis coli protein

1

10

Small-scale

0.501

High

236999

FBX7
F-box only protein 7

1

3

High-throughput

0.501

High

237000

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

2

Small-scale

0.501

High

236865

FETUA
Alpha-2-HS-glycoprotein

1

1

High-throughput

0.489

High

236873

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

1

High-throughput

0.489

High

236891

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

3

High-throughput

0.489

High

236935

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.489

High

236975

SEM4C
Semaphorin-4C

1

1

High-throughput

0.489

High

236927

DHX8
ATP-dependent RNA helicase DHX8

1

2

Small-scale

0.481

High

236929

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

6

Small-scale

0.481

High

236934

2A5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

1

6

Small-scale

0.481

High

236938

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

6

Small-scale

0.481

High

162246

XPO1
Exportin-1

1

10

High-throughput

0.479

High

231895

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.479

High

232739

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

16

High-throughput

0.479

High

236860

TRI37
E3 ubiquitin-protein ligase TRIM37

1

17

High-throughput

0.479

High

236868

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

236870

K2C8
Keratin, type II cytoskeletal 8

1

5

High-throughput

0.479

High

236874

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

12

Small-scale

0.479

High

236875

HSP7C
Heat shock cognate 71 kDa protein

1

8

High-throughput

0.479

High

236876

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.479

High

236878

VINC
Vinculin

1

6

High-throughput

0.479

High

236883

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

236888

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

236895

YAP1
Transcriptional coactivator YAP1

1

18

High-throughput

0.479

High

236897

VASP
Vasodilator-stimulated phosphoprotein

1

7

High-throughput

0.479

High

236899

NEK2
Serine/threonine-protein kinase Nek2

1

19

Small-scale

0.479

High

236903

HDAC4
Histone deacetylase 4

1

18

Small-scale

0.479

High

236906

1433E
14-3-3 protein epsilon

1

11

High-throughput

0.479

High

236907

RL39
Large ribosomal subunit protein eL39

1

3

High-throughput

0.479

High

236909

SUMO1
Small ubiquitin-related modifier 1

1

6

Small-scale

0.479

High

236913

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.479

High

236916

EP300
Histone acetyltransferase p300

1

10

Small-scale

0.479

High

236925

CUL3
Cullin-3

1

12

High-throughput

0.479

High

236926

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.479

High

236937

ZYX
Zyxin

1

8

High-throughput

0.479

High

236942

DAB2P
Disabled homolog 2-interacting protein

1

20

Small-scale

0.479

High

236949

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.479

High

236950

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

236951

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

236954

NKAP
NF-kappa-B-activating protein

1

2

Small-scale

0.479

High

236962

KAT2A
Histone acetyltransferase KAT2A

1

12

Small-scale

0.479

High

236968

AURKB
Aurora kinase B

1

16

Small-scale

0.479

High

236969

AJUBA
LIM domain-containing protein ajuba

1

8

Small-scale

0.479

High

236972

DNJC7
DnaJ homolog subfamily C member 7

1

18

High-throughput

0.479

High

236981

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

236982

EGLN3
Prolyl hydroxylase EGLN3

1

5

High-throughput

0.479

High

236984

FBX6
F-box only protein 6

1

1

Small-scale

0.479

High

236992

RCOR1
REST corepressor 1

1

7

High-throughput

0.479

High

236993

TPX2
Targeting protein for Xklp2

1

1

High-throughput

0.479

High

236995

APC10
Anaphase-promoting complex subunit 10

1

5

Small-scale

0.479

High

236996

TRI33
E3 ubiquitin-protein ligase TRIM33

1

8

Small-scale

0.479

High

236997

HDAC5
Histone deacetylase 5

1

18

Small-scale

0.479

High

237002

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

3

High-throughput

0.479

High

236973

HOP
Homeodomain-only protein

1

0

Small-scale

0.460

High

236941

SGO1
Shugoshin 1

1

0

Small-scale

0.458

High

236970

HS12B
Heat shock 70 kDa protein 12B

1

0

High-throughput

0.458

High

236983

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

236985

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.458

High

236917

AP1B1
AP-1 complex subunit beta-1

1

11

Small-scale

0.457

High

237001

AP4B1
AP-4 complex subunit beta-1

1

12

Small-scale

0.457

High

236890

RFA3
Replication protein A 14 kDa subunit

1

9

High-throughput

0.437

High

236928

ITPR2
Inositol 1,4,5-trisphosphate receptor type 2

1

15

High-throughput

0.437

High

236964

PF21A
PHD finger protein 21A

1

6

High-throughput

0.437

High

119894

AP3B1
AP-3 complex subunit beta-1

1

11

Small-scale

0.417

High

236940

R39L5
Putative ribosomal protein eL39-like 5

1

3

High-throughput

0.407

High

236945

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

1

Small-scale

0.407

High

236867

STAT
Statherin

1

0

High-throughput

0.279

Low

236932

P2RY6
P2Y purinoceptor 6

1

0

High-throughput

0.279

Low

236939

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.279

Low

236952

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

236957

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.279

Low

236986

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.269

Low

64169

CO061
Uncharacterized protein C15orf61

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024