Protein: SP100
Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa)

Gene: SP100
Organism: Homo sapiens
Interactions: 198
UniProt ID: P23497

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000723 - telomere maintenance
GO:0000781 - chromosome, telomeric region
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

617244

SP100
Nuclear autoantigen Sp-100

6

16

Small-scale

0.953

High

449542

HMGB1
High mobility group protein B1

4

14

High-throughput

0.895

High

617247

HMGB2
High mobility group protein B2

2

18

High-throughput

0.789

High

617254

CBX5
Chromobox protein homolog 5

9

20

Small-scale

0.755

High

617279

UBC9
SUMO-conjugating enzyme UBC9

7

8

Small-scale

0.748

High

617277

SUMO1
Small ubiquitin-related modifier 1

6

12

Small-scale

0.739

High

617293

CBX3
Chromobox protein homolog 3

5

20

Small-scale

0.721

High

617272

SUMO2
Small ubiquitin-related modifier 2

4

12

Small-scale

0.692

High

617250

ACTN2
Alpha-actinin-2

3

5

High-throughput

0.683

High

617341

GIPC2
PDZ domain-containing protein GIPC2

4

0

High-throughput

0.668

High

617284

CBX1
Chromobox protein homolog 1

3

20

Small-scale

0.661

High

617393

T3JAM
TRAF3-interacting JNK-activating modulator

4

10

High-throughput

0.637

High

386107

P53
Cellular tumor antigen p53

1

8

High-throughput

0.618

High

617363

PKP2
Plakophilin-2

1

17

High-throughput

0.618

High

617270

SUMO3
Small ubiquitin-related modifier 3

2

12

Small-scale

0.611

High

617338

SNIP1
Smad nuclear-interacting protein 1

2

3

High-throughput

0.606

High

617366

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

1

High-throughput

0.606

High

617261

RBP2
E3 SUMO-protein ligase RanBP2

2

10

Small-scale

0.602

High

617248

PML
Protein PML

2

14

Small-scale

0.586

High

617368

HEMGN
Hemogen

2

2

Small-scale

0.576

High

617362

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

Small-scale

0.573

High

617301

RBM39
RNA-binding protein 39

1

12

High-throughput

0.573

High

617347

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

16

High-throughput

0.573

High

617355

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

7

High-throughput

0.573

High

617402

DNM3A
DNA

1

1

High-throughput

0.573

High

486743

MYB
Transcriptional activator Myb

1

4

High-throughput

0.541

High

617268

TERF1
Telomeric repeat-binding factor 1

1

5

High-throughput

0.541

High

617289

CREM
cAMP-responsive element modulator

1

8

High-throughput

0.541

High

617299

TRI29
Tripartite motif-containing protein 29

1

5

High-throughput

0.541

High

617307

TERF2
Telomeric repeat-binding factor 2

1

5

High-throughput

0.541

High

617382

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.541

High

199668

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

7

High-throughput

0.536

High

214850

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

2

High-throughput

0.536

High

508341

TOP1
DNA topoisomerase 1

1

10

High-throughput

0.536

High

613335

SFPQ
Splicing factor, proline- and glutamine-rich

1

7

High-throughput

0.536

High

617245

TYY1
Transcriptional repressor protein YY1

1

8

High-throughput

0.536

High

617246

DDX6
Probable ATP-dependent RNA helicase DDX6

1

15

High-throughput

0.536

High

617252

RS19
Small ribosomal subunit protein eS19

1

5

High-throughput

0.536

High

617255

CRKL
Crk-like protein

1

4

High-throughput

0.536

High

617256

RL29
Large ribosomal subunit protein eL29

1

1

High-throughput

0.536

High

617257

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

5

High-throughput

0.536

High

617258

KC1D
Casein kinase I isoform delta

1

5

High-throughput

0.536

High

617260

RBM25
RNA-binding protein 25

1

16

High-throughput

0.536

High

617265

MECP2
Methyl-CpG-binding protein 2

1

15

High-throughput

0.536

High

617269

MFAP1
Microfibrillar-associated protein 1

1

2

High-throughput

0.536

High

617274

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

10

High-throughput

0.536

High

617275

RL23A
Large ribosomal subunit protein uL23

1

3

High-throughput

0.536

High

617276

RL8
Large ribosomal subunit protein uL2

1

4

High-throughput

0.536

High

617278

IF5A1
Eukaryotic translation initiation factor 5A-1

1

3

High-throughput

0.536

High

617296

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

20

High-throughput

0.536

High

617304

NONO
Non-POU domain-containing octamer-binding protein

1

9

High-throughput

0.536

High

617311

LSM12
Protein LSM12

1

1

High-throughput

0.536

High

617323

MEPCE
7SK snRNA methylphosphate capping enzyme

1

3

High-throughput

0.536

High

617324

NUFP2
FMR1-interacting protein NUFIP2

1

3

High-throughput

0.536

High

617326

DDX42
ATP-dependent RNA helicase DDX42

1

10

High-throughput

0.536

High

617331

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

5

High-throughput

0.536

High

617332

PR38A
Pre-mRNA-splicing factor 38A

1

1

High-throughput

0.536

High

617342

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

8

High-throughput

0.536

High

617344

PSPC1
Paraspeckle component 1

1

9

High-throughput

0.536

High

617357

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

9

High-throughput

0.536

High

617358

FIZ1
Flt3-interacting zinc finger protein 1

1

2

High-throughput

0.536

High

617361

POP1
Ribonucleases P/MRP protein subunit POP1

1

2

High-throughput

0.536

High

617369

NUF2
Kinetochore protein Nuf2

1

12

High-throughput

0.536

High

617370

GTPB4
GTP-binding protein 4

1

8

High-throughput

0.536

High

617372

NSRP1
Nuclear speckle splicing regulatory protein 1

1

7

High-throughput

0.536

High

617381

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

4

High-throughput

0.536

High

617396

NOP16
Nucleolar protein 16

1

1

High-throughput

0.536

High

617400

MAFB
Transcription factor MafB

1

11

High-throughput

0.536

High

541982

ETS1
Protein C-ets-1

1

17

Small-scale

0.529

High

617354

ZC21A
Zinc finger C2HC domain-containing protein 1A

1

1

High-throughput

0.523

High

617394

AMOL2
Angiomotin-like protein 2

1

9

High-throughput

0.523

High

617346

H1X
Histone H1.10

1

2

High-throughput

0.515

High

617251

SYUA
Alpha-synuclein

1

2

High-throughput

0.515

High

617314

Q59GP6
Polyhomeotic-like protein 1 variant

1

20

High-throughput

0.515

High

617403

V9HWG0
Epididymis luminal protein 25

1

20

High-throughput

0.515

High

617329

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.513

High

617352

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.513

High

617389

C8AP2
CASP8-associated protein 2

1

0

Small-scale

0.506

High

617316

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.501

High

617319

NIPBL
Nipped-B-like protein

1

14

Small-scale

0.501

High

617383

SENP1
Sentrin-specific protease 1

1

6

Small-scale

0.501

High

617330

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

3

High-throughput

0.494

High

617401

ZN706
Zinc finger protein 706

1

0

High-throughput

0.493

High

617249

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

1

High-throughput

0.489

High

617291

CKAP4
Cytoskeleton-associated protein 4

1

11

High-throughput

0.489

High

617315

FA76B
Protein FAM76B

1

2

High-throughput

0.489

High

617343

ATX2L
Ataxin-2-like protein

1

14

High-throughput

0.489

High

617364

CG050
Uncharacterized protein C7orf50

1

2

High-throughput

0.489

High

617365

MMTA2
Multiple myeloma tumor-associated protein 2

1

1

High-throughput

0.489

High

594232

MX1
Interferon-induced GTP-binding protein Mx1

1

6

Small-scale

0.481

High

617282

PHC1
Polyhomeotic-like protein 1

1

20

High-throughput

0.481

High

617349

CBP
CREB-binding protein

1

20

Small-scale

0.481

High

92161

E9PAV9
G patch domain-containing protein 4

1

1

High-throughput

0.479

High

153085

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

7

High-throughput

0.479

High

164182

ZN609
Zinc finger protein 609

1

12

High-throughput

0.479

High

167134

ZN536
Zinc finger protein 536

1

7

High-throughput

0.479

High

168107

TBX3
T-box transcription factor TBX3

1

10

High-throughput

0.479

High

201655

MSI1H
RNA-binding protein Musashi homolog 1

1

17

High-throughput

0.479

High

215585

AKAP8
A-kinase anchor protein 8

1

7

High-throughput

0.479

High

231279

GANP
Germinal-center associated nuclear protein

1

11

High-throughput

0.479

High

257915

DNJB6
DnaJ homolog subfamily B member 6

1

8

High-throughput

0.479

High

260757

H2AY
Core histone macro-H2A.1

1

20

High-throughput

0.479

High

270909

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

4

High-throughput

0.479

High

271733

PRDM1
PR domain zinc finger protein 1

1

9

Small-scale

0.479

High

485106

GLI3
Transcriptional activator GLI3

1

12

High-throughput

0.479

High

488907

H14
Histone H1.4

1

9

High-throughput

0.479

High

505936

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

6

High-throughput

0.479

High

559557

H12
Histone H1.2

1

9

High-throughput

0.479

High

602389

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

1

1

High-throughput

0.479

High

603359

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

3

High-throughput

0.479

High

613916

TBG1
Tubulin gamma-1 chain

1

7

High-throughput

0.479

High

617253

GATA4
Transcription factor GATA-4

1

13

High-throughput

0.479

High

617259

CTCF
Transcriptional repressor CTCF

1

7

High-throughput

0.479

High

617262

TAF6
Transcription initiation factor TFIID subunit 6

1

1

High-throughput

0.479

High

617263

RT29
Small ribosomal subunit protein mS29

1

4

High-throughput

0.479

High

617266

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

High-throughput

0.479

High

617271

FOXL2
Forkhead box protein L2

1

20

Small-scale

0.479

High

617273

DCAF7
DDB1- and CUL4-associated factor 7

1

20

High-throughput

0.479

High

617281

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

617283

RAE1L
mRNA export factor RAE1

1

20

High-throughput

0.479

High

617285

RL19
Large ribosomal subunit protein eL19

1

3

High-throughput

0.479

High

617287

FLI1
Friend leukemia integration 1 transcription factor

1

17

Small-scale

0.479

High

617288

IRF8
Interferon regulatory factor 8

1

5

Small-scale

0.479

High

617292

FOXC1
Forkhead box protein C1

1

20

High-throughput

0.479

High

617294

TBX2
T-box transcription factor TBX2

1

10

High-throughput

0.479

High

617295

BIRC2
Baculoviral IAP repeat-containing protein 2

1

4

High-throughput

0.479

High

617297

PEX6
Peroxisomal ATPase PEX6

1

2

High-throughput

0.479

High

617298

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

20

High-throughput

0.479

High

617300

RCN2
Reticulocalbin-2

1

5

High-throughput

0.479

High

617306

TAF5
Transcription initiation factor TFIID subunit 5

1

20

High-throughput

0.479

High

617308

IF16
Gamma-interferon-inducible protein 16

1

5

High-throughput

0.479

High

617309

ZN827
Zinc finger protein 827

1

8

High-throughput

0.479

High

617310

RGPA2
Ral GTPase-activating protein subunit alpha-2

1

4

High-throughput

0.479

High

617312

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

2

High-throughput

0.479

High

617321

BCOR
BCL-6 corepressor

1

20

High-throughput

0.479

High

617322

H32
Histone H3.2

1

20

High-throughput

0.479

High

617325

ZFHX4
Zinc finger homeobox protein 4

1

13

High-throughput

0.479

High

617327

FOXP4
Forkhead box protein P4

1

20

High-throughput

0.479

High

617333

MLKL
Mixed lineage kinase domain-like protein

1

3

High-throughput

0.479

High

617334

AFG2A
ATPase family gene 2 protein homolog A

1

2

High-throughput

0.479

High

617335

ZN740
Zinc finger protein 740

1

16

High-throughput

0.479

High

617336

COP1
E3 ubiquitin-protein ligase COP1

1

20

High-throughput

0.479

High

617339

G45IP
Large ribosomal subunit protein mL64

1

3

High-throughput

0.479

High

617348

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

617351

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

4

High-throughput

0.479

High

617353

PTCD3
Small ribosomal subunit protein mS39

1

4

High-throughput

0.479

High

617359

RSF1
Remodeling and spacing factor 1

1

20

High-throughput

0.479

High

617360

HTF4
Transcription factor 12

1

6

High-throughput

0.479

High

617367

GNL3
Guanine nucleotide-binding protein-like 3

1

9

High-throughput

0.479

High

617371

BC11B
B-cell lymphoma/leukemia 11B

1

5

High-throughput

0.479

High

617373

BC11A
B-cell lymphoma/leukemia 11A

1

3

High-throughput

0.479

High

617374

HIPK2
Homeodomain-interacting protein kinase 2

1

19

Small-scale

0.479

High

617375

FOXP1
Forkhead box protein P1

1

20

High-throughput

0.479

High

617376

ZN768
Zinc finger protein 768

1

3

High-throughput

0.479

High

617378

ANLN
Anillin

1

6

High-throughput

0.479

High

617379

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

1

High-throughput

0.479

High

617380

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

1

7

High-throughput

0.479

High

617385

RCOR3
REST corepressor 3

1

20

High-throughput

0.479

High

617386

MYEF2
Myelin expression factor 2

1

9

High-throughput

0.479

High

617387

TRPS1
Zinc finger transcription factor Trps1

1

17

High-throughput

0.479

High

617388

RCOR1
REST corepressor 1

1

20

High-throughput

0.479

High

617390

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.479

High

617391

AKP8L
A-kinase anchor protein 8-like

1

7

High-throughput

0.479

High

617392

TRI33
E3 ubiquitin-protein ligase TRIM33

1

18

High-throughput

0.479

High

617395

ZN281
Zinc finger protein 281

1

11

High-throughput

0.479

High

617397

CHTOP
Chromatin target of PRMT1 protein

1

3

High-throughput

0.479

High

617398

SALL2
Sal-like protein 2

1

12

High-throughput

0.479

High

617399

DCAF1
DDB1- and CUL4-associated factor 1

1

20

High-throughput

0.479

High

343947

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.458

High

617264

GALK1
Galactokinase

1

0

High-throughput

0.458

High

617286

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.458

High

617290

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

617345

S39A7
Zinc transporter SLC39A7

1

0

High-throughput

0.458

High

102150

SUMO5
Small ubiquitin-related modifier 5

1

12

High-throughput

0.457

High

617317

GPTC4
G patch domain-containing protein 4

1

1

High-throughput

0.445

High

398225

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

2

High-throughput

0.437

High

520687

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

3

High-throughput

0.437

High

617280

3BP2
SH3 domain-binding protein 2

1

5

High-throughput

0.437

High

617302

GSE1
Genetic suppressor element 1

1

3

High-throughput

0.437

High

617305

RCN1
Reticulocalbin-1

1

2

High-throughput

0.437

High

617313

SWAHC
Ankyrin repeat domain-containing protein SOWAHC

1

10

High-throughput

0.437

High

617320

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.437

High

617328

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.437

High

617340

NUBPL
Iron-sulfur cluster transfer protein NUBPL

1

1

High-throughput

0.437

High

617350

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.437

High

617356

SFXN2
Sideroflexin-2

1

1

High-throughput

0.437

High

617377

FBSL
Fibrosin-1-like protein

1

4

High-throughput

0.437

High

617384

PHRF1
PHD and RING finger domain-containing protein 1

1

20

High-throughput

0.437

High

617303

RTP5
Receptor-transporting protein 5

3

0

High-throughput

0.352

High

296870

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.279

Low

617318

USPL1
SUMO-specific isopeptidase USPL1

1

0

Small-scale

0.261

Low

64179

CP096
Uncharacterized protein C16orf96

1

0

High-throughput

0.249

Low

153215

ACOT8
Acyl-coenzyme A thioesterase 8

1

0

High-throughput

0.249

Low

166208

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.249

Low

215429

SCO2
Protein SCO2 homolog, mitochondrial

1

0

High-throughput

0.249

Low

617267

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

617337

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024