Protein: GPN1
GPN-loop GTPase 1 (EC 3.6.5.-) (MBD2-interacting protein) (MBDin) (RNAPII-associated protein 4) (XPA-binding protein 1)

Gene: GPN1
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q9HCN4

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1336406

GPN3
GPN-loop GTPase 3

7

10

Small-scale

0.960

High

1334507

GPN2
GPN-loop GTPase 2

6

10

Small-scale

0.947

High

1221368

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

6

3

High-throughput

0.736

High

913960

RPB7
DNA-directed RNA polymerase II subunit RPB7

5

4

High-throughput

0.718

High

677015

RPB2
DNA-directed RNA polymerase II subunit RPB2

5

13

Small-scale

0.715

High

583591

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

8

High-throughput

0.694

High

854476

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

4

7

High-throughput

0.694

High

583805

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

3

High-throughput

0.675

High

1336395

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

3

6

High-throughput

0.667

High

1336397

RPC5
DNA-directed RNA polymerase III subunit RPC5

3

1

High-throughput

0.667

High

1336398

RPC2
DNA-directed RNA polymerase III subunit RPC2

3

13

High-throughput

0.667

High

125725

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

3

Small-scale

0.656

High

625054

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

9

High-throughput

0.656

High

1336399

PIHD1
PIH1 domain-containing protein 1

4

1

High-throughput

0.633

High

169961

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

8

High-throughput

0.628

High

317164

RPA1
DNA-directed RNA polymerase I subunit RPA1

2

9

High-throughput

0.628

High

638405

RBTN2
Rhombotin-2

2

1

High-throughput

0.628

High

897633

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

3

High-throughput

0.628

High

1150699

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

4

2

High-throughput

0.617

High

156069

RPC1
DNA-directed RNA polymerase III subunit RPC1

2

9

High-throughput

0.611

High

181461

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

1

High-throughput

0.611

High

1042589

CUL3
Cullin-3

2

3

High-throughput

0.611

High

1298997

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

2

6

High-throughput

0.611

High

1314731

RPAP1
RNA polymerase II-associated protein 1

3

3

Small-scale

0.600

High

934495

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.569

High

1336401

MBD2
Methyl-CpG-binding domain protein 2

1

0

Small-scale

0.549

High

179834

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.536

High

402752

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

1

High-throughput

0.536

High

416515

S10A9
Protein S100-A9

1

1

High-throughput

0.536

High

864992

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

5

High-throughput

0.536

High

921170

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

4

High-throughput

0.536

High

1085512

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.536

High

1274056

CUL5
Cullin-5

1

3

High-throughput

0.536

High

1326421

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.536

High

1327914

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

3

High-throughput

0.536

High

1334509

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

13

High-throughput

0.536

High

1336402

UXT
Protein UXT

1

1

High-throughput

0.536

High

1336405

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.536

High

1336409

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

5

High-throughput

0.536

High

1336410

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

4

High-throughput

0.536

High

330594

ZBED1
E3 SUMO-protein ligase ZBED1

1

0

High-throughput

0.518

High

1251241

WDR48
WD repeat-containing protein 48

1

2

High-throughput

0.515

High

207114

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

270222

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.513

High

818485

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

820391

SPB4
Serpin B4

1

0

High-throughput

0.513

High

473925

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

2

2

High-throughput

0.504

High

1267390

F168A
Protein FAM168A

1

1

High-throughput

0.489

High

612503

XPA
DNA repair protein complementing XP-A cells

1

0

Small-scale

0.486

High

163316

XPO1
Exportin-1

1

12

High-throughput

0.479

High

295278

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

295676

RMP
Unconventional prefoldin RPB5 interactor 1

1

1

High-throughput

0.479

High

438546

HS90B
Heat shock protein HSP 90-beta

1

3

High-throughput

0.479

High

476419

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

553776

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

573491

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.479

High

682996

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

2

High-throughput

0.479

High

738889

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

5

High-throughput

0.479

High

749870

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

751842

GRP75
Stress-70 protein, mitochondrial

1

2

High-throughput

0.479

High

771058

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.479

High

808949

YAP1
Transcriptional coactivator YAP1

1

5

Small-scale

0.479

High

821422

TCPE
T-complex protein 1 subunit epsilon

1

2

High-throughput

0.479

High

843062

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.479

High

843399

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.479

High

854372

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

3

High-throughput

0.479

High

878745

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

2

High-throughput

0.479

High

1026546

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

1048239

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

1

High-throughput

0.479

High

1064740

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1101305

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1137956

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

5

High-throughput

0.479

High

1332495

RPAP3
RNA polymerase II-associated protein 3

1

1

High-throughput

0.479

High

1332637

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1336396

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

High-throughput

0.479

High

1336403

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1336407

PUF60
Poly(U)-binding-splicing factor PUF60

1

1

High-throughput

0.479

High

1336408

RUVB1
RuvB-like 1

1

4

High-throughput

0.479

High

304661

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.458

High

504795

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

652314

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

668994

PML
Protein PML

1

0

High-throughput

0.458

High

721506

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

780139

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

853481

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.458

High

909152

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

962385

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.458

High

1034132

TCOF
Treacle protein

1

0

High-throughput

0.458

High

1076202

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

High-throughput

0.458

High

1082404

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.458

High

1163870

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1243950

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1254270

BICD2
Protein bicaudal D homolog 2

1

0

High-throughput

0.458

High

1336404

ARMX3
Armadillo repeat-containing X-linked protein 3

1

0

High-throughput

0.458

High

1336411

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

0

High-throughput

0.458

High

484417

RPC22
Protein POLR1D, isoform 2

1

1

High-throughput

0.445

High

72350

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

1

High-throughput

0.437

High

1333176

SFR19
Splicing factor, arginine/serine-rich 19

1

1

High-throughput

0.437

High

1336400

PHRF1
PHD and RING finger domain-containing protein 1

1

1

High-throughput

0.437

High

1169437

NBEL2
Neurobeachin-like protein 2

1

0

High-throughput

0.426

High

66445

A2ML1
Alpha-2-macroglobulin-like protein 1

1

1

High-throughput

0.407

High

473883

MYZAP
Myocardial zonula adherens protein

1

2

High-throughput

0.407

High

484483

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

7

High-throughput

0.407

High

1221402

T183A
Transmembrane protein 183A

1

0

High-throughput

0.279

Low

1253370

LRC20
Leucine-rich repeat-containing protein 20

1

0

High-throughput

0.279

Low

1171807

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1331345

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

353821

IGHG2
Immunoglobulin heavy constant gamma 2

1

0

High-throughput

0.232

Low

1185459

ZN627
Zinc finger protein 627

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024