Protein: RFFL
E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin)

Gene: RFFL
Organism: Homo sapiens
Interactions: 95
UniProt ID: Q8WZ73

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0002039 - p53 binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

895862

UB2D3
Ubiquitin-conjugating enzyme E2 D3

4

20

Small-scale

0.888

High

1264872

RNF34
E3 ubiquitin-protein ligase RNF34

3

14

Small-scale

0.847

High

1264867

RFFL
E3 ubiquitin-protein ligase rififylin

3

15

Small-scale

0.845

High

919804

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

Small-scale

0.778

High

228212

PRKN
E3 ubiquitin-protein ligase parkin

1

19

Small-scale

0.724

High

891421

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

20

High-throughput

0.698

High

666142

SHC1
SHC-transforming protein 1

3

1

High-throughput

0.667

High

1264883

KPCD2
Serine/threonine-protein kinase D2

3

6

High-throughput

0.667

High

849387

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

Small-scale

0.647

High

896506

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.647

High

1079005

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

Small-scale

0.647

High

957744

XIAP
E3 ubiquitin-protein ligase XIAP

1

13

Small-scale

0.618

High

962889

MDM2
E3 ubiquitin-protein ligase Mdm2

1

2

Small-scale

0.618

High

66589

EFCB7
EF-hand calcium-binding domain-containing protein 7

3

2

High-throughput

0.609

High

1153103

IQCE
IQ domain-containing protein E

3

2

High-throughput

0.609

High

387202

P53
Cellular tumor antigen p53

2

5

Small-scale

0.584

High

1167460

RFIP1
Rab11 family-interacting protein 1

1

4

Small-scale

0.578

High

1264887

EHD1
EH domain-containing protein 1

1

8

Small-scale

0.578

High

1264893

CHIP
E3 ubiquitin-protein ligase CHIP

1

5

Small-scale

0.578

High

1038292

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

20

Small-scale

0.561

High

1232323

MILK1
MICAL-like protein 1

1

8

Small-scale

0.561

High

564139

HSP76
Heat shock 70 kDa protein 6

1

8

High-throughput

0.536

High

647640

MK03
Mitogen-activated protein kinase 3

1

3

High-throughput

0.536

High

659015

MK01
Mitogen-activated protein kinase 1

1

3

High-throughput

0.536

High

871704

HSP72
Heat shock-related 70 kDa protein 2

1

8

High-throughput

0.536

High

1264881

TBB2B
Tubulin beta-2B chain

1

4

High-throughput

0.536

High

158214

GIPC1
PDZ domain-containing protein GIPC1

1

1

High-throughput

0.515

High

336936

F13A
Coagulation factor XIII A chain

1

3

High-throughput

0.515

High

358843

CRYAA
Alpha-crystallin A chain

1

4

High-throughput

0.515

High

613165

PGH1
Prostaglandin G/H synthase 1

1

1

High-throughput

0.515

High

682639

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

12

High-throughput

0.515

High

1026195

PAK1
Serine/threonine-protein kinase PAK 1

1

5

High-throughput

0.515

High

1217764

Q8IVP1
SH3-domain GRB2-like 3, isoform CRA_a

1

2

High-throughput

0.515

High

1264896

GAB2
GRB2-associated-binding protein 2

1

6

High-throughput

0.515

High

1264900

BACE2
Beta-secretase 2

1

2

High-throughput

0.515

High

800606

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

12

High-throughput

0.501

High

868275

ATX3
Ataxin-3

1

4

High-throughput

0.501

High

1264869

STAM1
Signal transducing adapter molecule 1

1

5

High-throughput

0.501

High

1264871

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

7

High-throughput

0.501

High

1264873

OPTN
Optineurin

1

12

Small-scale

0.501

High

1264875

OTUB1
Ubiquitin thioesterase OTUB1

1

3

High-throughput

0.501

High

1264879

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

14

High-throughput

0.501

High

1264886

ATX3L
Ataxin-3-like protein

1

4

High-throughput

0.501

High

1264899

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

2

High-throughput

0.501

High

1264898

CSEN
Calsenilin

1

0

High-throughput

0.493

High

1056800

ESPL1
Separin

1

0

High-throughput

0.480

High

168429

SCAM1
Secretory carrier-associated membrane protein 1

1

2

Small-scale

0.479

High

178701

STX7
Syntaxin-7

1

2

Small-scale

0.479

High

214631

MYO1B
Unconventional myosin-Ib

1

5

Small-scale

0.479

High

403927

ITB1
Integrin beta-1

1

1

Small-scale

0.479

High

517812

NFH
Neurofilament heavy polypeptide

1

8

High-throughput

0.479

High

682376

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

8

Small-scale

0.479

High

702951

KINH
Kinesin-1 heavy chain

1

3

Small-scale

0.479

High

845116

RAB7A
Ras-related protein Rab-7a

1

7

Small-scale

0.479

High

845874

RAB13
Ras-related protein Rab-13

1

5

Small-scale

0.479

High

875158

TERA
Transitional endoplasmic reticulum ATPase

1

3

Small-scale

0.479

High

894783

RAB8A
Ras-related protein Rab-8A

1

6

Small-scale

0.479

High

895529

RAB10
Ras-related protein Rab-10

1

6

Small-scale

0.479

High

896659

RAB14
Ras-related protein Rab-14

1

5

Small-scale

0.479

High

913023

ARF6
ADP-ribosylation factor 6

1

3

Small-scale

0.479

High

992373

KLC1
Kinesin light chain 1

1

2

Small-scale

0.479

High

1017023

KCNH2
Potassium voltage-gated channel subfamily H member 2

1

3

Small-scale

0.479

High

1021684

MYO1E
Unconventional myosin-Ie

1

5

Small-scale

0.479

High

1042168

CUL3
Cullin-3

1

6

High-throughput

0.479

High

1052719

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

12

Small-scale

0.479

High

1059332

CASP8
Caspase-8

1

20

Small-scale

0.479

High

1079947

RB11B
Ras-related protein Rab-11B

1

4

Small-scale

0.479

High

1131916

ARH
Low density lipoprotein receptor adapter protein 1

1

1

Small-scale

0.479

High

1174178

UBP43
Ubiquitin carboxyl-terminal hydrolase 43

1

16

Small-scale

0.479

High

1185255

RFIP2
Rab11 family-interacting protein 2

1

3

Small-scale

0.479

High

1191851

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

5

Small-scale

0.479

High

1222037

MILK2
MICAL-like protein 2

1

9

Small-scale

0.479

High

1264870

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

11

Small-scale

0.479

High

1264878

KI16B
Kinesin-like protein KIF16B

1

4

Small-scale

0.479

High

1264880

VAMP8
Vesicle-associated membrane protein 8

1

1

Small-scale

0.479

High

1264882

RFIP5
Rab11 family-interacting protein 5

1

6

Small-scale

0.479

High

1264884

EHD4
EH domain-containing protein 4

1

8

Small-scale

0.479

High

1264889

KI13B
Kinesin-like protein KIF13B

1

6

Small-scale

0.479

High

1264890

EHD2
EH domain-containing protein 2

1

8

Small-scale

0.479

High

1264892

MYO6
Unconventional myosin-VI

1

1

Small-scale

0.479

High

1264894

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

3

Small-scale

0.479

High

1264901

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

1

Small-scale

0.479

High

1216511

ZDH17
Palmitoyltransferase ZDHHC17

1

18

High-throughput

0.470

High

1174351

UN13D
Protein unc-13 homolog D

1

0

Small-scale

0.458

High

1264868

NDRG1
Protein NDRG1

1

0

Small-scale

0.458

High

1264876

VPS50
Syndetin

1

0

Small-scale

0.458

High

1264877

VCIP1
Deubiquitinating protein VCPIP1

1

0

Small-scale

0.458

High

1264885

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

Small-scale

0.458

High

1264888

SPE39
Spermatogenesis-defective protein 39 homolog

1

0

Small-scale

0.458

High

1264891

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

0

Small-scale

0.458

High

1264895

STX8
Syntaxin-8

1

0

Small-scale

0.458

High

1264874

OTUB2
Ubiquitin thioesterase OTUB2

1

3

High-throughput

0.457

High

1264897

SAC2
Phosphatidylinositide phosphatase SAC2

1

2

Small-scale

0.437

High

277264

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024