Protein: TF3C1
General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha)

Gene: TF3C1, GTF3C1
Organism: Homo sapiens
Interactions: 214
UniProt ID: Q12789

Gene Ontology (top 5):
GO:0000127 - transcription factor TFIIIC complex
GO:0000995 - RNA polymerase III general transcription initiation factor activity
GO:0003677 - DNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

346639

MYC
Myc proto-oncogene protein

4

2

High-throughput

0.686

High

603472

FBRL
rRNA 2'-O-methyltransferase fibrillarin

5

0

High-throughput

0.682

High

1016393

TF3C2
General transcription factor 3C polypeptide 2

5

0

Small-scale

0.676

High

1016451

TF3C4
General transcription factor 3C polypeptide 4

3

0

Small-scale

0.642

High

934700

H31
Histone H3.1

3

2

High-throughput

0.640

High

212811

STX6
Syntaxin-6

3

0

High-throughput

0.638

High

1016464

TF3C3
General transcription factor 3C polypeptide 3

3

0

Small-scale

0.634

High

1016408

ZN764
Zinc finger protein 764

3

1

High-throughput

0.604

High

1016366

TEBP
Prostaglandin E synthase 3

2

0

High-throughput

0.602

High

1016368

EZH2
Histone-lysine N-methyltransferase EZH2

2

0

High-throughput

0.588

High

550737

RS2
Small ribosomal subunit protein uS5

2

0

High-throughput

0.585

High

642313

RL13
Large ribosomal subunit protein eL13

2

0

High-throughput

0.585

High

607814

USF1
Upstream stimulatory factor 1

2

2

Small-scale

0.584

High

1016438

WDR76
WD repeat-containing protein 76

2

1

High-throughput

0.584

High

66655

ZN785
Zinc finger protein 785

2

1

High-throughput

0.574

High

713083

SDC2
Syndecan-2

2

1

High-throughput

0.574

High

718799

PHB1
Prohibitin 1

2

0

Small-scale

0.559

High

917175

H4
Histone H4

2

0

High-throughput

0.559

High

1016406

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.549

High

1016418

KLF6
Krueppel-like factor 6

1

2

High-throughput

0.541

High

316023

CBX6
Chromobox protein homolog 6

1

2

High-throughput

0.536

High

380284

HG2A
HLA class II histocompatibility antigen gamma chain

1

1

High-throughput

0.536

High

801105

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.536

High

949763

CBX1
Chromobox protein homolog 1

1

2

High-throughput

0.536

High

1016353

FOXL1
Forkhead box protein L1

1

2

High-throughput

0.536

High

1016445

FOXJ2
Forkhead box protein J2

1

2

High-throughput

0.536

High

1016453

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.536

High

227293

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.533

High

1016396

ESR2
Estrogen receptor beta

2

0

High-throughput

0.528

High

864860

MK10
Mitogen-activated protein kinase 10

1

0

High-throughput

0.518

High

878302

NH2L1
NHP2-like protein 1

1

0

High-throughput

0.518

High

1016388

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.518

High

1016430

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

High-throughput

0.518

High

203920

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.513

High

418213

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

562555

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.513

High

586711

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

736421

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

782336

KDM5C
Lysine-specific demethylase 5C

1

0

High-throughput

0.513

High

805648

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.513

High

806499

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.513

High

861721

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.513

High

897509

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

1016367

RNPS1
RNA-binding protein with serine-rich domain 1

1

0

High-throughput

0.513

High

1016404

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1016407

AURKB
Aurora kinase B

1

0

High-throughput

0.513

High

1016421

RBM4B
RNA-binding protein 4B

1

0

High-throughput

0.513

High

1016425

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1016433

SENP3
Sentrin-specific protease 3

1

0

High-throughput

0.513

High

551045

CHIN
N-chimaerin

1

1

High-throughput

0.494

High

572509

IBP3
Insulin-like growth factor-binding protein 3

1

1

High-throughput

0.494

High

609266

FGFR3
Fibroblast growth factor receptor 3

1

1

High-throughput

0.494

High

243003

EDF1
Endothelial differentiation-related factor 1

1

0

High-throughput

0.493

High

1016449

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

515270

KPSH1
Serine/threonine-protein kinase H1

1

1

High-throughput

0.489

High

680357

SDC4
Syndecan-4

1

1

High-throughput

0.489

High

971832

HEN2
Helix-loop-helix protein 2

1

1

High-throughput

0.489

High

1016413

PNMA5
Paraneoplastic antigen-like protein 5

1

2

High-throughput

0.489

High

1016414

PSKH2
Serine/threonine-protein kinase H2

1

1

High-throughput

0.489

High

1016420

FOXB1
Forkhead box protein B1

1

4

High-throughput

0.489

High

1016426

FOXQ1
Forkhead box protein Q1

1

4

High-throughput

0.489

High

830337

KC1E
Casein kinase I isoform epsilon

1

0

High-throughput

0.486

High

1016381

RBM23
Probable RNA-binding protein 23

1

1

High-throughput

0.481

High

475674

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

902551

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

179618

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

244351

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

260857

H2AY
Core histone macro-H2A.1

1

2

High-throughput

0.479

High

268050

EED
Polycomb protein EED

1

2

High-throughput

0.479

High

379336

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

391672

H2A1B
Histone H2A type 1-B/E

1

1

High-throughput

0.479

High

455367

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

506578

BCR
Breakpoint cluster region protein

1

1

High-throughput

0.479

High

555431

H2AX
Histone H2AX

1

2

High-throughput

0.479

High

632709

TYY1
Transcriptional repressor protein YY1

1

1

High-throughput

0.479

High

641389

PAX6
Paired box protein Pax-6

1

1

High-throughput

0.479

High

717758

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.479

High

781170

ETV3
ETS translocation variant 3

1

1

High-throughput

0.479

High

808551

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

817980

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

826261

CDK8
Cyclin-dependent kinase 8

1

1

High-throughput

0.479

High

828211

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.479

High

952298

H33
Histone H3.3

1

2

High-throughput

0.479

High

961374

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

1

High-throughput

0.479

High

998615

EP300
Histone acetyltransferase p300

1

3

Small-scale

0.479

High

1016352

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1016354

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.479

High

1016361

MDC1
Mediator of DNA damage checkpoint protein 1

1

2

High-throughput

0.479

High

1016382

SKAP1
Src kinase-associated phosphoprotein 1

1

1

High-throughput

0.479

High

1016384

RPTOR
Regulatory-associated protein of mTOR

1

1

Small-scale

0.479

High

1016386

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.479

High

1016397

KAT6A
Histone acetyltransferase KAT6A

1

1

High-throughput

0.479

High

1016415

CIC
Protein capicua homolog

1

2

High-throughput

0.479

High

1016416

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

1016428

WWTR1
WW domain-containing transcription regulator protein 1

1

2

High-throughput

0.479

High

1016429

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

1016442

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

1016456

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

1016457

CC14A
Dual specificity protein phosphatase CDC14A

1

1

High-throughput

0.479

High

1016461

KLF12
Krueppel-like factor 12

1

2

High-throughput

0.479

High

1016369

Q1RN33
Melanoma antigen A 4

1

1

High-throughput

0.470

High

122706

MEN1
Menin

1

0

High-throughput

0.458

High

125415

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

182721

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

205334

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

294764

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

298466

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

312060

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

0

Small-scale

0.458

High

442105

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

508481

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.458

High

552588

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

578312

PGAM1
Phosphoglycerate mutase 1

1

0

High-throughput

0.458

High

582254

NUCL
Nucleolin

1

0

High-throughput

0.458

High

622442

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.458

High

651060

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

652830

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

720328

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

750240

COIL
Coilin

1

0

High-throughput

0.458

High

787466

MTOR
Serine/threonine-protein kinase mTOR

1

0

Small-scale

0.458

High

793924

MATR3
Matrin-3

1

0

High-throughput

0.458

High

798874

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

827923

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

831268

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.458

High

841181

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

867190

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

Small-scale

0.458

High

874870

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

918321

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

1016355

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1016356

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1016359

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1016364

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1016380

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

1016385

STAG2
Cohesin subunit SA-2

1

0

High-throughput

0.458

High

1016387

ZBT38
Zinc finger and BTB domain-containing protein 38

1

0

Small-scale

0.458

High

1016392

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1016395

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1016399

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

1016400

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1016403

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

1016409

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1016412

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1016419

BARD1
BRCA1-associated RING domain protein 1

1

0

High-throughput

0.458

High

1016423

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

Small-scale

0.458

High

1016427

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1016434

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

0

High-throughput

0.458

High

1016436

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1016441

ANLN
Anillin

1

0

High-throughput

0.458

High

1016443

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1016444

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1016446

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1016448

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1016450

MCM8
DNA helicase MCM8

1

0

High-throughput

0.458

High

1016458

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.458

High

1016460

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

983110

UBE3A
Ubiquitin-protein ligase E3A

1

1

Small-scale

0.457

High

795813

MAGA4
Melanoma-associated antigen 4

1

1

High-throughput

0.439

High

1016422

HGH1
Protein HGH1 homolog

1

1

High-throughput

0.439

High

123924

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.438

High

213327

TLX2
T-cell leukemia homeobox protein 2

1

1

High-throughput

0.437

High

384734

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

1016363

NFIX
Nuclear factor 1 X-type

1

1

High-throughput

0.437

High

1016365

BRD3
Bromodomain-containing protein 3

1

3

High-throughput

0.437

High

1016371

BRDT
Bromodomain testis-specific protein

1

3

High-throughput

0.437

High

1016417

FEV
Protein FEV

1

1

High-throughput

0.437

High

1016424

KLF16
Krueppel-like factor 16

1

2

High-throughput

0.437

High

1016455

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

401906

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

990027

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.426

High

1016357

SQSTM
Sequestosome-1

1

0

High-throughput

0.426

High

1016358

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.426

High

1016362

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1016398

TF3C6
General transcription factor 3C polypeptide 6

1

0

Small-scale

0.426

High

1016439

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

1016452

AGO1
Protein argonaute-1

1

0

High-throughput

0.426

High

1016463

TF3C5
General transcription factor 3C polypeptide 5

1

0

Small-scale

0.426

High

1016374

Q6IA98
RNPC4 protein

1

1

High-throughput

0.417

High

1016405

Q96BK8
Protein HGH1 homolog

1

1

High-throughput

0.417

High

555133

CD44
CD44 antigen

2

0

High-throughput

0.328

High

1016390

GP156
Probable G-protein coupled receptor 156

2

0

High-throughput

0.328

High

159709

CASQ2
Calsequestrin-2

2

0

High-throughput

0.318

High

1016376

ATRAP
Type-1 angiotensin II receptor-associated protein

1

0

High-throughput

0.299

High

562467

CBPE
Carboxypeptidase E

1

0

High-throughput

0.282

High

1016437

AKTIP
AKT-interacting protein

1

0

High-throughput

0.282

High

1016440

TBC17
TBC1 domain family member 17

1

0

High-throughput

0.282

High

796555

KSYK
Tyrosine-protein kinase SYK

1

0

High-throughput

0.279

Low

863886

CRBA4
Beta-crystallin A4

1

0

High-throughput

0.279

Low

1016360

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1016372

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

1

0

High-throughput

0.279

Low

1016383

CUL9
Cullin-9

1

0

High-throughput

0.279

Low

1016391

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1016394

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

0

High-throughput

0.279

Low

1016401

CPNE4
Copine-4

1

0

High-throughput

0.279

Low

1016402

TRI52
E3 ubiquitin-protein ligase TRIM52

1

0

High-throughput

0.279

Low

1016410

ZN668
Zinc finger protein 668

1

0

High-throughput

0.279

Low

1016411

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.279

Low

1016432

TXNIP
Thioredoxin-interacting protein

1

0

High-throughput

0.279

Low

1016454

INTU
Protein inturned

1

0

High-throughput

0.279

Low

1016459

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

0

High-throughput

0.279

Low

1016462

NGN3
Neurogenin-3

1

0

High-throughput

0.279

Low

1016465

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.279

Low

255727

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

297611

RHBT1
Rho-related BTB domain-containing protein 1

1

0

High-throughput

0.249

Low

441730

CFAH
Complement factor H

1

0

Small-scale

0.249

Low

779312

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

1016370

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

0

Small-scale

0.249

Low

1016373

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.249

Low

1016375

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.249

Low

1016377

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1016378

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.249

Low

1016379

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1016389

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

1016431

DUS15
Dual specificity protein phosphatase 15

1

0

High-throughput

0.249

Low

1016435

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1016447

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024