Protein: PKN2
Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)

Gene: PKN2
Organism: Homo sapiens
Interactions: 167
UniProt ID: Q16513

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004697 - diacylglycerol-dependent serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

900514

RHOA
Transforming protein RhoA

6

20

Small-scale

0.944

High

739983

TGFR2
TGF-beta receptor type-2

3

6

High-throughput

0.861

High

66660

ZN785
Zinc finger protein 785

2

1

High-throughput

0.811

High

1016725

CETN1
Centrin-1

2

4

High-throughput

0.811

High

1082013

CAMKV
CaM kinase-like vesicle-associated protein

2

7

High-throughput

0.811

High

182166

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

19

Small-scale

0.800

High

1081991

PKN2
Serine/threonine-protein kinase N2

2

19

Small-scale

0.778

High

781550

CETN2
Centrin-2

2

4

High-throughput

0.776

High

227575

PRKN
E3 ubiquitin-protein ligase parkin

2

20

High-throughput

0.754

High

431895

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.754

High

915706

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

1081999

DEFI8
Differentially expressed in FDCP 8 homolog

2

19

High-throughput

0.726

High

1082015

HAVR2
Hepatitis A virus cellular receptor 2

2

1

High-throughput

0.726

High

681871

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

Small-scale

0.713

High

278821

DNJC8
DnaJ homolog subfamily C member 8

1

2

High-throughput

0.691

High

538556

CCNB1
G2/mitotic-specific cyclin-B1

1

4

High-throughput

0.691

High

565120

ZNF8
Zinc finger protein 8

1

1

High-throughput

0.691

High

1081921

PKN1
Serine/threonine-protein kinase N1

1

18

High-throughput

0.691

High

1082012

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

1

High-throughput

0.691

High

1082020

ZN524
Zinc finger protein 524

1

2

High-throughput

0.691

High

1081996

FRPD2
FERM and PDZ domain-containing protein 2

3

16

High-throughput

0.667

High

275882

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

8

High-throughput

0.656

High

581013

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

3

Small-scale

0.647

High

1057937

RRP5
Protein RRP5 homolog

1

0

High-throughput

0.631

High

1082038

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

2

20

High-throughput

0.628

High

814959

LEG7
Galectin-7

3

0

High-throughput

0.622

High

1082028

ZN747
Zinc finger protein 747

1

2

High-throughput

0.618

High

120458

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

348687

RASN
GTPase NRas

1

12

High-throughput

0.618

High

350201

RASK
GTPase KRas

1

12

High-throughput

0.618

High

436326

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

438207

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

508025

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

545401

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

779491

CCNF
Cyclin-F

1

11

High-throughput

0.618

High

793331

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.618

High

852497

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

894056

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

925308

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

951021

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1034869

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

12

High-throughput

0.618

High

1066173

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.618

High

1076592

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1077378

ELAV1
ELAV-like protein 1

1

6

Small-scale

0.618

High

1082001

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.618

High

1082010

SKAP1
Src kinase-associated phosphoprotein 1

1

20

High-throughput

0.618

High

1082022

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

1082029

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

1

High-throughput

0.618

High

1082033

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.618

High

1082034

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1082035

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1082036

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1082041

ANFY1
Rabankyrin-5

1

1

High-throughput

0.618

High

283107

DFFB
DNA fragmentation factor subunit beta

2

0

High-throughput

0.602

High

850066

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

4

High-throughput

0.601

High

209064

NCK2
Cytoplasmic protein NCK2

2

20

Small-scale

0.595

High

557706

NCK1
SH2/SH3 adapter protein NCK1

2

20

Small-scale

0.595

High

1067966

PDK1
[Pyruvate dehydrogenase

2

7

Small-scale

0.595

High

1020167

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

12

Small-scale

0.592

High

874979

TERA
Transitional endoplasmic reticulum ATPase

2

5

High-throughput

0.584

High

1082046

HDAC5
Histone deacetylase 5

1

9

Small-scale

0.578

High

1073424

KS6A1
Ribosomal protein S6 kinase alpha-1

1

18

Small-scale

0.575

High

1081994

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.575

High

1082045

PNMA2
Paraneoplastic antigen Ma2

2

4

High-throughput

0.574

High

483823

PAL4G
Peptidyl-prolyl cis-trans isomerase A-like 4G

2

4

High-throughput

0.552

High

201598

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

9

High-throughput

0.536

High

301144

KDM4B
Lysine-specific demethylase 4B

1

1

High-throughput

0.536

High

310654

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.536

High

376248

ANXA1
Annexin A1

1

4

High-throughput

0.536

High

388469

HSPB1
Heat shock protein beta-1

1

13

High-throughput

0.536

High

541369

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

2

High-throughput

0.536

High

561589

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

5

High-throughput

0.536

High

566761

JUNB
Transcription factor JunB

1

8

High-throughput

0.536

High

574360

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.536

High

643868

SYVC
Valine--tRNA ligase

1

9

High-throughput

0.536

High

644050

EF1G
Elongation factor 1-gamma

1

8

High-throughput

0.536

High

667971

SPB3
Serpin B3

1

7

High-throughput

0.536

High

684062

1433S
14-3-3 protein sigma

1

20

High-throughput

0.536

High

783044

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

6

High-throughput

0.536

High

820313

SPB4
Serpin B4

1

8

High-throughput

0.536

High

880119

SYMC
Methionine--tRNA ligase, cytoplasmic

1

7

High-throughput

0.536

High

990463

CKAP4
Cytoskeleton-associated protein 4

1

10

High-throughput

0.536

High

1039597

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.536

High

1065520

SYK
Lysine--tRNA ligase

1

2

High-throughput

0.536

High

1081998

WDR74
WD repeat-containing protein 74

1

9

High-throughput

0.536

High

1082004

MOB1B
MOB kinase activator 1B

1

2

High-throughput

0.536

High

1082007

MILR1
Allergin-1

1

3

High-throughput

0.536

High

1082008

KTN1
Kinectin

1

6

High-throughput

0.536

High

1082026

RUFY1
RUN and FYVE domain-containing protein 1

1

12

High-throughput

0.536

High

1082039

SYLC
Leucine--tRNA ligase, cytoplasmic

1

6

High-throughput

0.536

High

1082043

CTNA3
Catenin alpha-3

1

2

High-throughput

0.536

High

1082047

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.536

High

614335

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

3

High-throughput

0.515

High

1082014

WDR20
WD repeat-containing protein 20

1

12

High-throughput

0.515

High

266168

ERLN1
Erlin-1

1

0

High-throughput

0.513

High

430965

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

0

High-throughput

0.513

High

590949

BTF3
Transcription factor BTF3

1

0

High-throughput

0.513

High

602844

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.513

High

623274

AT5F1
ATP synthase F(0) complex subunit B1, mitochondrial

1

0

High-throughput

0.513

High

801514

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

1

0

High-throughput

0.513

High

867710

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.513

High

1075506

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.513

High

1082003

FBX50
F-box only protein 50

1

0

High-throughput

0.513

High

1082005

TRM1L
TRMT1-like protein

1

0

High-throughput

0.513

High

1082011

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1082018

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

1082027

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1082030

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

932722

EF1A1
Elongation factor 1-alpha 1

1

1

High-throughput

0.508

High

1035111

MYO9B
Unconventional myosin-IXb

1

8

High-throughput

0.508

High

808138

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

16

High-throughput

0.501

High

902608

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

135737

EST2
Cocaine esterase

1

1

High-throughput

0.489

High

314995

SGPL1
Sphingosine-1-phosphate lyase 1

1

4

High-throughput

0.489

High

725794

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.489

High

1081992

INSY1
Inhibitory synaptic factor 1

1

2

High-throughput

0.489

High

1081993

RABL3
Rab-like protein 3

1

9

High-throughput

0.489

High

1082000

TBCD9
TBC1 domain family member 9

1

1

High-throughput

0.489

High

1082025

F193B
Protein FAM193B

1

0

High-throughput

0.486

High

314334

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

2

Small-scale

0.479

High

322692

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

346893

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.479

High

455488

PARP1
Poly [ADP-ribose] polymerase 1

1

7

High-throughput

0.479

High

470397

H2A1
Histone H2A type 1

1

15

High-throughput

0.479

High

489066

H14
Histone H1.4

1

19

High-throughput

0.479

High

507036

LAMP1
Lysosome-associated membrane glycoprotein 1

1

5

High-throughput

0.479

High

521962

CADH1
Cadherin-1

1

4

High-throughput

0.479

High

547077

EZRI
Ezrin

1

8

High-throughput

0.479

High

552832

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

651317

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

656242

PSA5
Proteasome subunit alpha type-5

1

1

Small-scale

0.479

High

669380

EF1D
Elongation factor 1-delta

1

2

High-throughput

0.479

High

684763

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.479

High

720569

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.479

High

813499

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.479

High

831371

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

Small-scale

0.479

High

832845

TSP3
Thrombospondin-3

1

4

High-throughput

0.479

High

890684

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.479

High

904614

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

998767

EP300
Histone acetyltransferase p300

1

11

High-throughput

0.479

High

1064340

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1081995

CE162
Centrosomal protein of 162 kDa

1

11

High-throughput

0.479

High

1081997

RICTR
Rapamycin-insensitive companion of mTOR

1

6

High-throughput

0.479

High

1082002

CE128
Centrosomal protein of 128 kDa

1

10

High-throughput

0.479

High

1082006

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

1082009

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1082016

PARD3
Partitioning defective 3 homolog

1

20

High-throughput

0.479

High

1082019

VP33A
Vacuolar protein sorting-associated protein 33A

1

5

High-throughput

0.479

High

1082032

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1082037

CENPJ
Centromere protein J

1

9

High-throughput

0.479

High

1082040

HECW2
E3 ubiquitin-protein ligase HECW2

1

16

High-throughput

0.479

High

1082042

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1082044

ANC2
Anaphase-promoting complex subunit 2

1

4

High-throughput

0.479

High

393788

SCG1
Secretogranin-1

1

1

High-throughput

0.464

High

1082021

CC136
Coiled-coil domain-containing protein 136

1

12

High-throughput

0.464

High

262465

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

930532

TYB10
Thymosin beta-10

1

0

High-throughput

0.458

High

1068721

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.458

High

1082023

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1082031

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.458

High

87371

C9JE12
Transmembrane and ubiquitin like domain containing 1

1

1

High-throughput

0.445

High

388887

CP1A1
Cytochrome P450 1A1

1

1

High-throughput

0.437

High

1075554

TRAM1
Translocating chain-associated membrane protein 1

1

3

High-throughput

0.437

High

103338

G3XAN4
Translocating chain-associated membrane protein 1

1

3

High-throughput

0.407

High

1082017

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.279

Low

1082024

MBOA7
Lysophospholipid acyltransferase 7

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024