Protein: NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein)

Gene: NSD1
Organism: Homo sapiens
Interactions: 97
UniProt ID: Q96L73

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003682 - chromatin binding
GO:0003712 - transcription coregulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

935129

H31
Histone H3.1

5

20

Small-scale

0.915

High

917762

H4
Histone H4

4

10

Small-scale

0.878

High

1087342

H2B2E
Histone H2B type 2-E

2

20

High-throughput

0.802

High

1030425

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.692

High

470127

H2AZ
Histone H2A.Z

1

17

High-throughput

0.691

High

1116460

LARP7
La-related protein 7

1

14

High-throughput

0.691

High

516645

PABP1
Polyadenylate-binding protein 1

1

7

High-throughput

0.665

High

1274410

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.665

High

1086280

H31T
Histone H3.1t

1

20

Small-scale

0.647

High

370224

ESR1
Estrogen receptor

3

20

Small-scale

0.636

High

485278

TZAP
Telomere zinc finger-associated protein

2

2

High-throughput

0.628

High

848105

MECP2
Methyl-CpG-binding protein 2

2

10

High-throughput

0.628

High

1296819

ZN692
Zinc finger protein 692

2

7

High-throughput

0.628

High

615456

KALM
Anosmin-1

1

2

High-throughput

0.618

High

828350

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

918612

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

952555

H33
Histone H3.3

1

20

High-throughput

0.618

High

1027195

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.618

High

1067099

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.618

High

1244434

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

1296820

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

9

High-throughput

0.618

High

559895

H12
Histone H1.2

2

16

Small-scale

0.611

High

487688

ANDR
Androgen receptor

2

20

Small-scale

0.609

High

435203

ZFY
Zinc finger Y-chromosomal protein

2

0

High-throughput

0.602

High

1296818

MDFI
MyoD family inhibitor

2

0

High-throughput

0.580

High

1296826

G3BP2
Ras GTPase-activating protein-binding protein 2

1

5

High-throughput

0.579

High

1103488

CEA16
Carcinoembryonic antigen-related cell adhesion molecule 16

1

0

High-throughput

0.578

High

1294644

ZN496
Zinc finger protein 496

1

11

Small-scale

0.573

High

625001

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

12

Small-scale

0.561

High

329900

AGR2
Anterior gradient protein 2 homolog

2

1

High-throughput

0.553

High

180413

MAGB2
Melanoma-associated antigen B2

1

8

High-throughput

0.536

High

418554

NPM
Nucleophosmin

1

5

High-throughput

0.536

High

736654

RL4
Large ribosomal subunit protein uL4

1

3

High-throughput

0.536

High

916317

RL23A
Large ribosomal subunit protein uL23

1

5

High-throughput

0.536

High

1019890

ILF3
Interleukin enhancer-binding factor 3

1

9

High-throughput

0.536

High

1193013

ZN467
Zinc finger protein 467

1

1

High-throughput

0.536

High

1286803

ZN653
Zinc finger protein 653

1

7

High-throughput

0.536

High

489205

H14
Histone H1.4

1

16

High-throughput

0.515

High

564998

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

High-throughput

0.515

High

978856

TF65
Transcription factor p65

1

7

Small-scale

0.515

High

1296817

YTDC1
YTH domain-containing protein 1

1

1

High-throughput

0.515

High

1296823

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

0

High-throughput

0.513

High

559217

H15
Histone H1.5

1

18

Small-scale

0.501

High

559470

H13
Histone H1.3

1

16

Small-scale

0.501

High

802480

ATRX
Transcriptional regulator ATRX

1

20

Small-scale

0.501

High

1273798

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

10

High-throughput

0.501

High

281381

RL1D1
Ribosomal L1 domain-containing protein 1

1

2

High-throughput

0.489

High

1296829

RL36
Large ribosomal subunit protein eL36

1

3

High-throughput

0.489

High

267348

TNR21
Tumor necrosis factor receptor superfamily member 21

1

3

Small-scale

0.481

High

130334

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

20

Small-scale

0.481

High

488013

RARA
Retinoic acid receptor alpha

1

20

Small-scale

0.481

High

490071

NR2F6
Nuclear receptor subfamily 2 group F member 6

1

20

Small-scale

0.481

High

490110

COT1
COUP transcription factor 1

1

20

Small-scale

0.481

High

500500

THB
Thyroid hormone receptor beta

1

20

Small-scale

0.481

High

509976

VDR
Vitamin D3 receptor

1

20

Small-scale

0.481

High

510033

ERR1
Steroid hormone receptor ERR1

1

20

Small-scale

0.481

High

587193

RXRA
Retinoic acid receptor RXR-alpha

1

20

Small-scale

0.481

High

622823

COT2
COUP transcription factor 2

1

20

Small-scale

0.481

High

723193

RORA
Nuclear receptor ROR-alpha

1

20

Small-scale

0.481

High

740584

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.481

High

1055258

HNF4G
Hepatocyte nuclear factor 4-gamma

1

20

Small-scale

0.481

High

1073360

NR6A1
Nuclear receptor subfamily 6 group A member 1

1

20

Small-scale

0.481

High

1123356

Q58EY0
RAR related orphan receptor B isoform 1

1

20

Small-scale

0.481

High

1296830

NR2E1
Nuclear receptor subfamily 2 group E member 1

1

20

Small-scale

0.481

High

133620

NOP56
Nucleolar protein 56

1

3

High-throughput

0.479

High

179778

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

10

High-throughput

0.479

High

360295

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

17

High-throughput

0.479

High

402361

JUN
Transcription factor Jun

1

7

High-throughput

0.479

High

455763

PARP1
Poly [ADP-ribose] polymerase 1

1

16

High-throughput

0.479

High

553460

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

651985

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

652959

APEX1
DNA repair nuclease/redox regulator APEX1

1

4

High-throughput

0.479

High

721186

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

750425

COIL
Coilin

1

4

High-throughput

0.479

High

808857

YAP1
Transcriptional coactivator YAP1

1

12

High-throughput

0.479

High

818361

SOX2
Transcription factor SOX-2

1

20

Small-scale

0.479

High

969924

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.479

High

1043519

CUL4B
Cullin-4B

1

11

Small-scale

0.479

High

1056940

MDC1
Mediator of DNA damage checkpoint protein 1

1

16

High-throughput

0.479

High

1188726

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.479

High

1193155

SLN11
Schlafen family member 11

1

2

High-throughput

0.479

High

1221647

SMC5
Structural maintenance of chromosomes protein 5

1

9

High-throughput

0.479

High

1269382

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1296821

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

2

High-throughput

0.479

High

1296822

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

8

High-throughput

0.479

High

1296824

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.479

High

1296825

NUP50
Nuclear pore complex protein Nup50

1

4

High-throughput

0.479

High

1296827

ASF1A
Histone chaperone ASF1A

1

3

High-throughput

0.479

High

1296828

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

1081569

NTRK3
NT-3 growth factor receptor

1

4

Small-scale

0.439

High

850825

AFF1
AF4/FMR2 family member 1

1

11

Small-scale

0.437

High

922314

RL31
Large ribosomal subunit protein eL31

1

6

High-throughput

0.437

High

928799

RL38
Large ribosomal subunit protein eL38

1

2

High-throughput

0.437

High

1220258

DHX40
Probable ATP-dependent RNA helicase DHX40

1

9

High-throughput

0.437

High

67292

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1109242

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

1206239

CC125
Coiled-coil domain-containing protein 125

2

0

High-throughput

0.316

High


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Last updated: 15 Jul 2024