Protein: BLM
RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3)

Gene: BLM
Organism: Homo sapiens
Interactions: 200
UniProt ID: P54132

Gene Ontology (top 5):
GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000228 - nuclear chromosome
GO:0000400 - four-way junction DNA binding
GO:0000403 - Y-form DNA binding
GO:0000405 - bubble DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

867585

TOP3A
DNA topoisomerase 3-alpha

13

11

Small-scale

0.983

High

867615

FANCM
Fanconi anemia group M protein

5

19

Small-scale

0.915

High

867611

MIB1
E3 ubiquitin-protein ligase MIB1

2

6

Small-scale

0.812

High

802408

ATRX
Transcriptional regulator ATRX

2

20

Small-scale

0.806

High

867638

FANCJ
Fanconi anemia group J protein

2

0

Small-scale

0.801

High

867593

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

18

Small-scale

0.761

High

386373

P53
Cellular tumor antigen p53

11

5

Small-scale

0.757

High

650766

RFA1
Replication protein A 70 kDa DNA-binding subunit

12

11

Small-scale

0.756

High

867552

BLM
RecQ-like DNA helicase BLM

2

16

Small-scale

0.754

High

867575

RAD51
DNA repair protein RAD51 homolog 1

9

14

Small-scale

0.754

High

867648

RMI1
RecQ-mediated genome instability protein 1

9

4

Small-scale

0.753

High

776276

MLH1
DNA mismatch repair protein Mlh1

7

3

Small-scale

0.751

High

552323

RFA2
Replication protein A 32 kDa subunit

7

11

Small-scale

0.737

High

720056

RFA3
Replication protein A 14 kDa subunit

6

7

Small-scale

0.724

High

867631

RMI2
RecQ-mediated genome instability protein 2

9

0

Small-scale

0.722

High

477684

TRI49
Tripartite motif-containing protein 49

1

3

Small-scale

0.692

High

346319

MYC
Myc proto-oncogene protein

4

12

Small-scale

0.692

High

176577

FANCA
Fanconi anemia group A protein

5

0

Small-scale

0.678

High

867598

TERF2
Telomeric repeat-binding factor 2

3

4

Small-scale

0.678

High

749276

BRCA1
Breast cancer type 1 susceptibility protein

4

14

Small-scale

0.672

High

867670

EXO1
Exonuclease 1

3

2

Small-scale

0.667

High

867601

RIF1
Telomere-associated protein RIF1

3

7

Small-scale

0.667

High

867582

ATM
Serine-protein kinase ATM

3

10

Small-scale

0.660

High

867640

FACD2
Fanconi anemia group D2 protein

3

9

Small-scale

0.650

High

867578

TP53B
TP53-binding protein 1

3

9

Small-scale

0.646

High

867626

FBXW7
F-box/WD repeat-containing protein 7

2

18

Small-scale

0.646

High

764349

FEN1
Flap endonuclease 1

2

2

Small-scale

0.646

High

867568

H31
Histone H3.1

3

14

High-throughput

0.640

High

867624

RAD50
DNA repair protein RAD50

3

9

Small-scale

0.633

High

401692

JUN
Transcription factor Jun

2

13

Small-scale

0.629

High

867622

TOPB1
DNA topoisomerase 2-binding protein 1

2

9

Small-scale

0.629

High

847988

MECP2
Methyl-CpG-binding protein 2

2

8

High-throughput

0.628

High

867633

ZN512
Zinc finger protein 512

2

2

High-throughput

0.628

High

867658

AIPL1
Aryl-hydrocarbon-interacting protein-like 1

2

2

High-throughput

0.628

High

867569

RNF4
E3 ubiquitin-protein ligase RNF4

2

3

Small-scale

0.624

High

836978

MRE11
Double-strand break repair protein MRE11

3

3

Small-scale

0.624

High

867649

RENT2
Regulator of nonsense transcripts 2

1

1

High-throughput

0.621

High

282584

RNF8
E3 ubiquitin-protein ligase RNF8

2

8

Small-scale

0.619

High

246196

NBN
Nibrin

2

4

Small-scale

0.619

High

508886

TOP2A
DNA topoisomerase 2-alpha

1

1

Small-scale

0.618

High

757521

IF4A3
Eukaryotic initiation factor 4A-III

1

19

High-throughput

0.618

High

867555

MGN
Protein mago nashi homolog

1

4

High-throughput

0.618

High

867560

H4
Histone H4

1

7

High-throughput

0.618

High

867570

RED1
Double-stranded RNA-specific editase 1

1

18

High-throughput

0.618

High

867594

DHX8
ATP-dependent RNA helicase DHX8

1

14

High-throughput

0.618

High

867612

DHX40
Probable ATP-dependent RNA helicase DHX40

1

16

High-throughput

0.618

High

867616

CENPS
Centromere protein S

3

0

Small-scale

0.613

High

274725

RA51D
DNA repair protein RAD51 homolog 4

1

14

Small-scale

0.594

High

455257

PARP1
Poly [ADP-ribose] polymerase 1

2

8

Small-scale

0.584

High

555368

H2AX
Histone H2AX

2

7

Small-scale

0.584

High

867614

SLX4
Structure-specific endonuclease subunit SLX4

2

14

High-throughput

0.584

High

788787

RS27
Small ribosomal subunit protein eS27

1

2

Small-scale

0.581

High

207142

XRCC2
DNA repair protein XRCC2

1

14

Small-scale

0.578

High

867608

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

11

Small-scale

0.578

High

867600

ERC6L
DNA excision repair protein ERCC-6-like

1

20

High-throughput

0.575

High

867579

CAF1A
Chromatin assembly factor 1 subunit A

1

5

Small-scale

0.573

High

867592

SPIDR
DNA repair-scaffolding protein

1

0

Small-scale

0.571

High

369243

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

794218

MSH2
DNA mismatch repair protein Msh2

2

7

Small-scale

0.571

High

855440

MSH6
DNA mismatch repair protein Msh6

2

7

Small-scale

0.571

High

867586

ATR
Serine/threonine-protein kinase ATR

1

11

Small-scale

0.561

High

867553

TERF1
Telomeric repeat-binding factor 1

1

4

Small-scale

0.554

High

867664

HECD1
E3 ubiquitin-protein ligase HECTD1

1

15

High-throughput

0.553

High

867567

UBC9
SUMO-conjugating enzyme UBC9

1

3

Small-scale

0.552

High

180253

MAGB2
Melanoma-associated antigen B2

1

9

High-throughput

0.536

High

231289

GANP
Germinal-center associated nuclear protein

1

1

High-throughput

0.536

High

470305

H2A1
Histone H2A type 1

1

6

High-throughput

0.536

High

535820

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.536

High

594485

PSB1
Proteasome subunit beta type-1

1

10

High-throughput

0.536

High

653941

MAP4
Microtubule-associated protein 4

1

13

High-throughput

0.536

High

739668

SRP14
Signal recognition particle 14 kDa protein

1

1

High-throughput

0.536

High

805602

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.536

High

851401

NEK4
Serine/threonine-protein kinase Nek4

1

6

High-throughput

0.536

High

867554

CORO7
Coronin-7

1

11

High-throughput

0.536

High

867557

RS16
Small ribosomal subunit protein uS9

1

5

High-throughput

0.536

High

867558

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.536

High

867571

RL19
Large ribosomal subunit protein eL19

1

3

High-throughput

0.536

High

867573

RBM3
RNA-binding protein 3

1

20

High-throughput

0.536

High

867588

KRR1
KRR1 small subunit processome component homolog

1

3

High-throughput

0.536

High

867590

NOG2
Nucleolar GTP-binding protein 2

1

4

High-throughput

0.536

High

867595

CASP8
Caspase-8

1

5

High-throughput

0.536

High

867599

H2B2E
Histone H2B type 2-E

1

8

High-throughput

0.536

High

867610

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

10

High-throughput

0.536

High

867625

CSN5
COP9 signalosome complex subunit 5

1

17

High-throughput

0.536

High

867644

FOXP1
Forkhead box protein P1

1

6

High-throughput

0.536

High

867653

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

6

High-throughput

0.536

High

867663

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.536

High

867665

ABT1
Activator of basal transcription 1

1

2

High-throughput

0.536

High

861673

PLK1
Serine/threonine-protein kinase PLK1

1

9

Small-scale

0.534

High

828677

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

867605

COX15
Heme A synthase COX15

1

0

High-throughput

0.513

High

867607

ZN467
Zinc finger protein 467

1

0

High-throughput

0.513

High

867618

ZBT44
Zinc finger and BTB domain-containing protein 44

1

0

High-throughput

0.513

High

867643

PIP30
PSME3-interacting protein

1

0

High-throughput

0.513

High

867646

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

867651

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.513

High

867669

HPS5
BLOC-2 complex member HPS5

1

0

High-throughput

0.513

High

788167

CASP3
Caspase-3

1

5

Small-scale

0.501

High

846680

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

7

Small-scale

0.501

High

867621

NEK11
Serine/threonine-protein kinase Nek11

1

7

Small-scale

0.501

High

867634

UIMC1
BRCA1-A complex subunit RAP80

1

0

Small-scale

0.493

High

867672

FAN1
Fanconi-associated nuclease 1

1

0

Small-scale

0.493

High

615389

KALM
Anosmin-1

1

2

High-throughput

0.489

High

198581

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

2

Small-scale

0.481

High

568504

SYN1
Synapsin-1

1

11

Small-scale

0.481

High

594235

MX1
Interferon-induced GTP-binding protein Mx1

1

2

Small-scale

0.481

High

867556

SUMO2
Small ubiquitin-related modifier 2

1

9

Small-scale

0.481

High

867564

SUMO1
Small ubiquitin-related modifier 1

1

9

Small-scale

0.481

High

867637

SOSB1
SOSS complex subunit B1

1

0

Small-scale

0.479

High

120872

APBB1
Amyloid beta precursor protein binding family B member 1

1

2

Small-scale

0.479

High

133395

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

150921

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

3

High-throughput

0.479

High

179590

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

6

High-throughput

0.479

High

226959

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.479

High

244167

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

246557

MCE1
mRNA-capping enzyme

1

5

High-throughput

0.479

High

308530

KI20A
Kinesin-like protein KIF20A

1

13

High-throughput

0.479

High

319772

HERC2
E3 ubiquitin-protein ligase HERC2

1

12

Small-scale

0.479

High

326532

SNAI1
Zinc finger protein SNAI1

1

5

High-throughput

0.479

High

338177

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

391611

H2A1B
Histone H2A type 1-B/E

1

6

High-throughput

0.479

High

431686

HS90A
Heat shock protein HSP 90-alpha

1

6

Small-scale

0.479

High

486762

MYB
Transcriptional activator Myb

1

6

High-throughput

0.479

High

523624

XRCC6
X-ray repair cross-complementing protein 6

1

10

High-throughput

0.479

High

559616

H12
Histone H1.2

1

4

High-throughput

0.479

High

572605

VGFR1
Vascular endothelial growth factor receptor 1

1

4

High-throughput

0.479

High

636286

DNJB1
DnaJ homolog subfamily B member 1

1

4

High-throughput

0.479

High

668538

PML
Protein PML

1

18

High-throughput

0.479

High

750192

COIL
Coilin

1

1

High-throughput

0.479

High

781161

ETV3
ETS translocation variant 3

1

3

High-throughput

0.479

High

782506

HNF4A
Hepatocyte nuclear factor 4-alpha

1

18

High-throughput

0.479

High

822623

LHX1
LIM/homeobox protein Lhx1

1

2

High-throughput

0.479

High

828178

CENPA
Histone H3-like centromeric protein A

1

14

High-throughput

0.479

High

830728

ARL4D
ADP-ribosylation factor-like protein 4D

1

6

High-throughput

0.479

High

839722

LHX2
LIM/homeobox protein Lhx2

1

2

High-throughput

0.479

High

867559

RS6
Small ribosomal subunit protein eS6

1

4

High-throughput

0.479

High

867561

H2B1C
Histone H2B type 1-C/E/F/G/I

1

8

High-throughput

0.479

High

867562

RS24
Small ribosomal subunit protein eS24

1

2

High-throughput

0.479

High

867563

RL31
Large ribosomal subunit protein eL31

1

6

High-throughput

0.479

High

867565

DYL1
Dynein light chain 1, cytoplasmic

1

1

Small-scale

0.479

High

867572

H33
Histone H3.3

1

14

High-throughput

0.479

High

867574

HEN1
Helix-loop-helix protein 1

1

4

High-throughput

0.479

High

867576

ARL16
ADP-ribosylation factor-like protein 16

1

5

High-throughput

0.479

High

867580

RFA4
Replication protein A 30 kDa subunit

1

11

High-throughput

0.479

High

867581

CBX3
Chromobox protein homolog 3

1

9

High-throughput

0.479

High

867584

SF3B2
Splicing factor 3B subunit 2

1

2

Small-scale

0.479

High

867587

SNW1
SNW domain-containing protein 1

1

5

High-throughput

0.479

High

867589

PWP1
Periodic tryptophan protein 1 homolog

1

20

Small-scale

0.479

High

867591

KLF9
Krueppel-like factor 9

1

7

High-throughput

0.479

High

867596

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

867597

RBBP5
Retinoblastoma-binding protein 5

1

20

High-throughput

0.479

High

867604

PAXI1
PAX-interacting protein 1

1

10

Small-scale

0.479

High

867606

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

867613

SMC5
Structural maintenance of chromosomes protein 5

1

8

High-throughput

0.479

High

867617

SIR6
NAD-dependent protein deacylase sirtuin-6

1

6

High-throughput

0.479

High

867619

FBX22
F-box only protein 22

1

3

High-throughput

0.479

High

867620

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

867623

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

867627

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

16

High-throughput

0.479

High

867630

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

18

High-throughput

0.479

High

867635

CTIP
DNA endonuclease RBBP8

1

1

Small-scale

0.479

High

867636

TEP1
Telomerase protein component 1

1

19

Small-scale

0.479

High

867639

KLF16
Krueppel-like factor 16

1

6

High-throughput

0.479

High

867641

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

16

High-throughput

0.479

High

867645

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.479

High

867647

ECT2
Protein ECT2

1

5

Small-scale

0.479

High

867650

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

6

High-throughput

0.479

High

867652

NLE1
Notchless protein homolog 1

1

13

High-throughput

0.479

High

867654

MIOS
GATOR2 complex protein MIOS

1

4

High-throughput

0.479

High

867656

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.479

High

867659

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

9

High-throughput

0.479

High

867661

KLF15
Krueppel-like factor 15

1

8

High-throughput

0.479

High

867662

NUP50
Nuclear pore complex protein Nup50

1

4

High-throughput

0.479

High

867667

LHX6
LIM/homeobox protein Lhx6

1

3

High-throughput

0.479

High

867668

PHF8
Histone lysine demethylase PHF8

1

3

Small-scale

0.479

High

867671

ASF1A
Histone chaperone ASF1A

1

1

High-throughput

0.479

High

867673

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

867674

KLF12
Krueppel-like factor 12

1

9

High-throughput

0.479

High

867632

MCRS1
Microspherule protein 1

1

0

Small-scale

0.460

High

67725

CENPX
Centromere protein X

1

0

Small-scale

0.458

High

154155

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.458

High

174376

FANCG
Fanconi anemia group G protein

1

0

Small-scale

0.458

High

283077

PDE5A
cGMP-specific 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

318946

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

652794

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

867566

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.458

High

867577

FP100
Fanconi anemia core complex-associated protein 100

1

0

Small-scale

0.458

High

867583

XRCC4
DNA repair protein XRCC4

1

0

Small-scale

0.458

High

867603

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

867628

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

867629

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

867642

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

867655

ETAA1
Ewing's tumor-associated antigen 1

1

0

Small-scale

0.458

High

867660

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.458

High

722200

RFC1
Replication factor C subunit 1

1

5

Small-scale

0.445

High

867609

SHLD2
Shieldin complex subunit 2

1

2

Small-scale

0.445

High

867657

GRHL1
Grainyhead-like protein 1 homolog

1

6

High-throughput

0.445

High

867666

RL26L
Ribosomal protein uL24-like

1

4

High-throughput

0.437

High

867602

INT3
Integrator complex subunit 3

1

0

Small-scale

0.426

High


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Last updated: 15 Jul 2024