Protein: GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)

Gene: GNAI1
Organism: Homo sapiens
Interactions: 138
UniProt ID: P63096

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001664 - G protein-coupled receptor binding
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

207517

RGS14
Regulator of G-protein signaling 14

7

20

Small-scale

0.966

High

926727

GPSM3
G-protein-signaling modulator 3

5

3

Small-scale

0.939

High

926717

RIC8A
Synembryn-A

5

13

Small-scale

0.927

High

158608

RGS12
Regulator of G-protein signaling 12

4

20

Small-scale

0.902

High

926692

GPSM1
G-protein-signaling modulator 1

4

15

Small-scale

0.899

High

926713

GBB4
Guanine nucleotide-binding protein subunit beta-4

4

20

Small-scale

0.899

High

444707

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

4

11

High-throughput

0.895

High

67800

GNAT3
Guanine nucleotide-binding protein G(t) subunit alpha-3

3

12

High-throughput

0.861

High

451001

GNAO

3

12

High-throughput

0.861

High

920929

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

3

20

Small-scale

0.857

High

815857

MTR1A
Melatonin receptor type 1A

2

20

Small-scale

0.819

High

825681

MTR1B
Melatonin receptor type 1B

2

19

Small-scale

0.819

High

834937

RGS4
Regulator of G-protein signaling 4

2

20

Small-scale

0.778

High

834879

RGS19
Regulator of G-protein signaling 19

2

20

Small-scale

0.754

High

283183

RGS20
Regulator of G-protein signaling 20

1

20

Small-scale

0.740

High

598724

S1PR1
Sphingosine 1-phosphate receptor 1

1

20

Small-scale

0.740

High

926723

RGS17
Regulator of G-protein signaling 17

1

20

High-throughput

0.740

High

926693

PCP2
Purkinje cell protein 2 homolog

2

11

High-throughput

0.700

High

229239

GBG7

3

20

High-throughput

0.667

High

837675

GBG4

3

20

High-throughput

0.667

High

926668

GBG5

3

20

High-throughput

0.667

High

926680

MTR1L
Melatonin-related receptor

1

20

Small-scale

0.665

High

180657

RGS16
Regulator of G-protein signaling 16

1

20

Small-scale

0.647

High

210414

RGS10
Regulator of G-protein signaling 10

1

20

Small-scale

0.647

High

429011

ADRB2
Beta-2 adrenergic receptor

1

10

Small-scale

0.647

High

602195

DRD4
D(4) dopamine receptor

1

11

Small-scale

0.647

High

921512

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

20

Small-scale

0.647

High

926720

RGS18
Regulator of G-protein signaling 18

1

20

Small-scale

0.647

High

926669

GPSM2
G-protein-signaling modulator 2

1

14

Small-scale

0.646

High

926667

GBG3

2

20

High-throughput

0.628

High

887099

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

2

20

Small-scale

0.619

High

182448

RGS5
Regulator of G-protein signaling 5

1

20

Small-scale

0.618

High

225262

AGRB2
Adhesion G protein-coupled receptor B2

1

3

Small-scale

0.618

High

391376

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

11

High-throughput

0.618

High

599336

CNR1
Cannabinoid receptor 1

1

20

Small-scale

0.618

High

714730

CRFR1
Corticotropin-releasing factor receptor 1

1

9

Small-scale

0.618

High

926674

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

1

9

Small-scale

0.618

High

926683

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

11

High-throughput

0.618

High

926712

ECT2
Protein ECT2

1

12

High-throughput

0.618

High

837689

GBG10

2

20

High-throughput

0.611

High

792232

MTHR
Methylenetetrahydrofolate reductase

3

1

High-throughput

0.609

High

887790

CD81
CD81 antigen

2

7

Small-scale

0.601

High

779202

CCNF
Cyclin-F

2

4

High-throughput

0.584

High

926718

ANLN
Anillin

2

8

High-throughput

0.584

High

317553

ADCY5
Adenylate cyclase type 5

1

1

Small-scale

0.575

High

926706

SMO
Protein smoothened

1

2

Small-scale

0.575

High

926687

KPCD1
Serine/threonine-protein kinase D1

2

5

High-throughput

0.571

High

850613

GP143
G-protein coupled receptor 143

1

0

Small-scale

0.537

High

496793

TAU
Microtubule-associated protein tau

1

16

High-throughput

0.536

High

598050

FLNA
Filamin-A

1

1

High-throughput

0.536

High

724760

MYH9
Myosin-9

1

3

High-throughput

0.536

High

926677

STK3
Serine/threonine-protein kinase 3

1

4

High-throughput

0.536

High

926684

NUMA1
Nuclear mitotic apparatus protein 1

1

4

Small-scale

0.536

High

926691

COX15
Heme A synthase COX15

1

1

High-throughput

0.536

High

926697

HASP
Serine/threonine-protein kinase haspin

1

4

High-throughput

0.536

High

926700

MYO19
Unconventional myosin-XIX

1

4

High-throughput

0.536

High

926721

PAK5
Serine/threonine-protein kinase PAK 5

1

10

High-throughput

0.536

High

926724

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

20

High-throughput

0.536

High

305074

SPN1
Snurportin-1

1

0

High-throughput

0.513

High

926685

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

890587

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.501

High

926725

RASD1
Dexamethasone-induced Ras-related protein 1

1

3

Small-scale

0.501

High

157313

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

3

High-throughput

0.489

High

801673

RAGP1
Ran GTPase-activating protein 1

1

1

High-throughput

0.481

High

926673

NUCB1
Nucleobindin-1

1

7

High-throughput

0.481

High

581158

EPOR
Erythropoietin receptor

1

0

Small-scale

0.480

High

155328

NRP1
Neuropilin-1

1

5

High-throughput

0.479

High

209874

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.479

High

308599

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

318601

EYA4
Eyes absent homolog 4

1

5

High-throughput

0.479

High

338256

EGFR
Epidermal growth factor receptor

1

9

Small-scale

0.479

High

374020

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

High-throughput

0.479

High

414479

PRGR
Progesterone receptor

1

10

Small-scale

0.479

High

435603

IGF1R
Insulin-like growth factor 1 receptor

1

12

Small-scale

0.479

High

436698

GLI1
Zinc finger protein GLI1

1

1

Small-scale

0.479

High

456845

FURIN
Furin

1

2

High-throughput

0.479

High

487312

ANDR
Androgen receptor

1

10

High-throughput

0.479

High

507941

FGFR1
Fibroblast growth factor receptor 1

1

10

Small-scale

0.479

High

537620

NCF1
Neutrophil cytosol factor 1

1

1

Small-scale

0.479

High

552460

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

557090

PGFRA
Platelet-derived growth factor receptor alpha

1

6

Small-scale

0.479

High

587802

NCF2
Neutrophil cytosol factor 2

1

2

Small-scale

0.479

High

590815

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

594734

ATP4A
Potassium-transporting ATPase alpha chain 1

1

6

Small-scale

0.479

High

610340

CBL
E3 ubiquitin-protein ligase CBL

1

3

High-throughput

0.479

High

648715

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.479

High

649083

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

3

High-throughput

0.479

High

650913

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

720196

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

724427

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

1

Small-scale

0.479

High

726142

BASI
Basigin

1

3

High-throughput

0.479

High

808488

YAP1
Transcriptional coactivator YAP1

1

10

High-throughput

0.479

High

854091

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

1

2

High-throughput

0.479

High

858609

PPP5
Serine/threonine-protein phosphatase 5

1

2

Small-scale

0.479

High

926670

IFM3
Interferon-induced transmembrane protein 3

1

5

High-throughput

0.479

High

926672

KIF23
Kinesin-like protein KIF23

1

14

High-throughput

0.479

High

926675

B2CL1
Bcl-2-like protein 1

1

1

High-throughput

0.479

High

926676

TFCP2
Alpha-globin transcription factor CP2

1

8

High-throughput

0.479

High

926686

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

926689

DUS6
Dual specificity protein phosphatase 6

1

16

High-throughput

0.479

High

926694

EMC5
ER membrane protein complex subunit 5

1

3

High-throughput

0.479

High

926696

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

926699

CLC4D
C-type lectin domain family 4 member D

1

4

High-throughput

0.479

High

926705

ABCA3
Phospholipid-transporting ATPase ABCA3

1

5

High-throughput

0.479

High

926709

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.479

High

926711

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

926714

NMRL1
NmrA-like family domain-containing protein 1

1

3

High-throughput

0.479

High

926715

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

8

High-throughput

0.479

High

926719

DUS22
Dual specificity protein phosphatase 22

1

15

High-throughput

0.479

High

926722

HDAC6
Histone deacetylase 6

1

7

High-throughput

0.479

High

926726

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

1

High-throughput

0.479

High

926708

THAP7
THAP domain-containing protein 7

1

0

High-throughput

0.460

High

313799

SVIL
Supervillin

1

0

Small-scale

0.458

High

315186

CNEP1
CTD nuclear envelope phosphatase 1

1

0

High-throughput

0.458

High

388000

MT1A
Metallothionein-1A

1

0

Small-scale

0.458

High

541237

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.458

High

569556

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

795489

RAD52
DNA repair protein RAD52 homolog

1

0

Small-scale

0.458

High

926678

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

0

High-throughput

0.458

High

926688

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

926701

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

926716

NGB
Neuroglobin

1

1

Small-scale

0.457

High

239916

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

8

High-throughput

0.445

High

401805

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

926671

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.445

High

926679

TBB3
Tubulin beta-3 chain

1

3

High-throughput

0.445

High

926681

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.445

High

926682

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

11

High-throughput

0.445

High

926690

TBA1A
Tubulin alpha-1A chain

1

2

High-throughput

0.445

High

926702

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

14

High-throughput

0.445

High

926703

SCN2A
Sodium channel protein type 2 subunit alpha

1

11

High-throughput

0.445

High

926704

ZBT18
Zinc finger and BTB domain-containing protein 18

1

5

High-throughput

0.445

High

926710

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

328798

TOP3B
DNA topoisomerase 3-beta-1

1

3

High-throughput

0.437

High

926695

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.437

High

926698

RN138
E3 ubiquitin-protein ligase RNF138

1

4

High-throughput

0.437

High

120884

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.426

High

926707

OVOL2
Transcription factor Ovo-like 2

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024