Protein: UBP8
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)

Gene: UBP8, USP8
Organism: Homo sapiens
Interactions: 126
UniProt ID: P40818

Gene Ontology (top 5):
GO:0000281 - mitotic cytokinesis
GO:0004197 - cysteine-type endopeptidase activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

475440

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

10

20

Small-scale

0.973

High

777079

RNF41
E3 ubiquitin-protein ligase NRDP1

5

20

Small-scale

0.930

High

683179

1433B
14-3-3 protein beta/alpha

8

20

Small-scale

0.752

High

777029

1433Z
14-3-3 protein zeta/delta

8

20

Small-scale

0.750

High

777027

1433E
14-3-3 protein epsilon

7

3

Small-scale

0.748

High

646698

1433T
14-3-3 protein theta

7

20

Small-scale

0.747

High

338061

EGFR
Epidermal growth factor receptor

6

11

Small-scale

0.729

High

777025

1433G
14-3-3 protein gamma

5

20

High-throughput

0.716

High

275176

GRAP2
GRB2-related adapter protein 2

5

16

Small-scale

0.716

High

777022

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

13

High-throughput

0.698

High

777061

STAM1
Signal transducing adapter molecule 1

4

9

Small-scale

0.694

High

777034

1433F
14-3-3 protein eta

4

20

High-throughput

0.690

High

277018

STAM2
Signal transducing adapter molecule 2

4

10

Small-scale

0.689

High

777050

CHM1B
Charged multivesicular body protein 1b

3

8

Small-scale

0.687

High

777086

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

13

High-throughput

0.665

High

683881

1433S
14-3-3 protein sigma

3

20

Small-scale

0.657

High

777069

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

16

High-throughput

0.647

High

777085

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

14

High-throughput

0.647

High

777091

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

15

High-throughput

0.647

High

777082

BIRC6
Baculoviral IAP repeat-containing protein 6

3

11

Small-scale

0.640

High

181589

CFLAR
CASP8 and FADD-like apoptosis regulator

2

4

Small-scale

0.634

High

777081

CHM1A
Charged multivesicular body protein 1a

2

9

Small-scale

0.629

High

201251

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

6

Small-scale

0.624

High

226736

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

681706

AKT1
RAC-alpha serine/threonine-protein kinase

1

7

Small-scale

0.618

High

777063

CHM4C
Charged multivesicular body protein 4c

2

8

Small-scale

0.613

High

384415

NTRK1
High affinity nerve growth factor receptor

2

11

High-throughput

0.584

High

566952

CXA1
Gap junction alpha-1 protein

2

2

Small-scale

0.584

High

739915

TGFR2
TGF-beta receptor type-2

1

11

Small-scale

0.578

High

777037

SQSTM
Sequestosome-1

1

5

Small-scale

0.578

High

777045

NTRK2
BDNF/NT-3 growth factors receptor

1

11

Small-scale

0.578

High

777012

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

15

Small-scale

0.575

High

777031

CD83
CD83 antigen

2

1

High-throughput

0.574

High

742101

SYUA
Alpha-synuclein

1

3

Small-scale

0.573

High

777083

PD1L1
Programmed cell death 1 ligand 1

2

3

Small-scale

0.570

High

777015

EPS15
Epidermal growth factor receptor substrate 15

1

2

Small-scale

0.561

High

777046

HIF1A
Hypoxia-inducible factor 1-alpha

1

6

Small-scale

0.561

High

777070

EPAS1
Endothelial PAS domain-containing protein 1

1

6

Small-scale

0.561

High

777035

TADBP
TAR DNA-binding protein 43

1

10

Small-scale

0.552

High

777053

RN149
E3 ubiquitin-protein ligase RNF149

1

6

High-throughput

0.536

High

777056

TPC2
Two pore channel protein 2

1

1

High-throughput

0.536

High

777058

ACTT1
Actin-related protein T1

1

3

High-throughput

0.536

High

777093

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.536

High

777039

NBR1
Next to BRCA1 gene 1 protein

1

0

Small-scale

0.529

High

777038

BTG3
Protein BTG3

1

0

High-throughput

0.518

High

280779

KRT36
Keratin, type I cuticular Ha6

1

18

High-throughput

0.515

High

777030

KRT85
Keratin, type II cuticular Hb5

1

7

High-throughput

0.515

High

777043

K1H1
Keratin, type I cuticular Ha1

1

18

High-throughput

0.515

High

777057

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

0

High-throughput

0.513

High

208820

CHM2A
Charged multivesicular body protein 2a

1

6

Small-scale

0.501

High

302263

SC31A
Protein transport protein Sec31A

1

7

Small-scale

0.501

High

522830

SRC
Proto-oncogene tyrosine-protein kinase Src

1

6

Small-scale

0.501

High

777021

BACE1
Beta-secretase 1

1

1

Small-scale

0.501

High

777028

GRB2
Growth factor receptor-bound protein 2

1

9

Small-scale

0.501

High

777047

H2A2C
Histone H2A type 2-C

1

16

Small-scale

0.501

High

777048

H2B2E
Histone H2B type 2-E

1

16

Small-scale

0.501

High

777055

PJA1
E3 ubiquitin-protein ligase Praja-1

1

4

High-throughput

0.501

High

777060

CHMP7
Charged multivesicular body protein 7

1

11

Small-scale

0.501

High

777062

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.501

High

777065

CHMP6
Charged multivesicular body protein 6

1

9

Small-scale

0.501

High

777073

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

10

Small-scale

0.501

High

777074

TRI54
Tripartite motif-containing protein 54

1

20

High-throughput

0.501

High

777075

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.501

High

777078

CHM4B
Charged multivesicular body protein 4b

1

8

Small-scale

0.501

High

777084

CHMP5
Charged multivesicular body protein 5

1

12

Small-scale

0.501

High

777087

CHM2B
Charged multivesicular body protein 2b

1

11

Small-scale

0.501

High

777088

CHMP3
Charged multivesicular body protein 3

1

9

Small-scale

0.501

High

777092

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

9

Small-scale

0.501

High

777020

IST1
IST1 homolog

1

0

High-throughput

0.493

High

183356

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

2

Small-scale

0.479

High

212750

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

369123

ESR1
Estrogen receptor

1

15

Small-scale

0.479

High

377159

GCR
Glucocorticoid receptor

1

13

High-throughput

0.479

High

452367

PGFRB
Platelet-derived growth factor receptor beta

1

4

High-throughput

0.479

High

456519

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

11

Small-scale

0.479

High

507895

FGFR1
Fibroblast growth factor receptor 1

1

11

High-throughput

0.479

High

521778

CADH1
Cadherin-1

1

1

High-throughput

0.479

High

552123

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

557057

PGFRA
Platelet-derived growth factor receptor alpha

1

5

High-throughput

0.479

High

601475

FGFR2
Fibroblast growth factor receptor 2

1

11

High-throughput

0.479

High

632628

TYY1
Transcriptional repressor protein YY1

1

2

Small-scale

0.479

High

650554

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

713764

RYK
Tyrosine-protein kinase RYK

1

16

High-throughput

0.479

High

739581

SCNNA
Amiloride-sensitive sodium channel subunit alpha

1

6

Small-scale

0.479

High

777013

CCNF
Cyclin-F

1

8

High-throughput

0.479

High

777014

ID1
DNA-binding protein inhibitor ID-1

1

2

Small-scale

0.479

High

777016

NOTC1
Neurogenic locus notch homolog protein 1

1

11

Small-scale

0.479

High

777024

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

Small-scale

0.479

High

777026

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

2

Small-scale

0.479

High

777033

KIF23
Kinesin-like protein KIF23

1

5

Small-scale

0.479

High

777040

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

777041

PTPA
Serine/threonine-protein phosphatase 2A activator

1

1

Small-scale

0.479

High

777042

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

10

Small-scale

0.479

High

777044

SIX1
Homeobox protein SIX1

1

1

Small-scale

0.479

High

777049

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

777051

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

777059

RN128
E3 ubiquitin-protein ligase RNF128

1

6

Small-scale

0.479

High

777064

OTUB1
Ubiquitin thioesterase OTUB1

1

3

Small-scale

0.479

High

777068

RAB3I
Rab-3A-interacting protein

1

1

High-throughput

0.479

High

777076

P63
Tumor protein 63

1

6

Small-scale

0.479

High

777077

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

3

Small-scale

0.479

High

777089

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

777090

TRRAP
Transformation/transcription domain-associated protein

1

7

High-throughput

0.479

High

777017

LEPR
Leptin receptor

1

2

Small-scale

0.470

High

777054

MCPH1
Microcephalin

1

0

Small-scale

0.458

High

777072

VAMP8
Vesicle-associated membrane protein 8

1

0

Small-scale

0.458

High

777080

EPG5
Ectopic P granules protein 5 homolog

1

0

Small-scale

0.458

High

537561

PA2GA
Phospholipase A2, membrane associated

1

4

Small-scale

0.457

High

777067

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

169393

BET1
BET1 homolog

1

1

High-throughput

0.437

High

205130

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.437

High

525857

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.437

High

601829

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

8

Small-scale

0.437

High

607903

FGFR4
Fibroblast growth factor receptor 4

1

11

High-throughput

0.437

High

719859

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

777018

SCNNB
Amiloride-sensitive sodium channel subunit beta

1

6

Small-scale

0.437

High

777019

SCNNG
Amiloride-sensitive sodium channel subunit gamma

1

6

Small-scale

0.437

High

777032

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

777036

FZD5
Frizzled-5

1

2

Small-scale

0.437

High

777052

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.437

High

777066

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

1

2

Small-scale

0.437

High

67812

IQCF5
IQ domain-containing protein F5

1

0

High-throughput

0.269

Low

489571

OSTP
Osteopontin

1

0

Small-scale

0.251

Low

777071

TMM79
Transmembrane protein 79

1

0

Small-scale

0.249

Low

777023

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024