Protein: ECI2
Enoyl-CoA delta isomerase 2 (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1)

Gene: ECI2
Organism: Homo sapiens
Interactions: 130
UniProt ID: O75521

Gene Ontology (top 5):
GO:0000062 - fatty-acyl-CoA binding
GO:0004165 - delta(3)-delta(2)-enoyl-CoA isomerase activity
GO:0005739 - mitochondrion
GO:0005777 - peroxisome
GO:0005782 - peroxisomal matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

267401

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

5

14

High-throughput

0.927

High

267351

ECI2
Enoyl-CoA delta isomerase 2

2

13

High-throughput

0.754

High

267408

MK06
Mitogen-activated protein kinase 6

3

4

High-throughput

0.675

High

267402

TRAF1
TNF receptor-associated factor 1

3

5

Small-scale

0.667

High

267459

DBNL
Drebrin-like protein

3

2

High-throughput

0.667

High

267385

PEX5
Peroxisomal targeting signal 1 receptor

3

6

Small-scale

0.631

High

267403

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

15

High-throughput

0.618

High

267353

HERC2
E3 ubiquitin-protein ligase HERC2

2

7

Small-scale

0.611

High

267364

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

2

5

High-throughput

0.611

High

267397

UBE3A
Ubiquitin-protein ligase E3A

2

6

Small-scale

0.611

High

267465

TNPO3
Transportin-3

2

1

High-throughput

0.606

High

267418

KANL1
KAT8 regulatory NSL complex subunit 1

2

0

High-throughput

0.602

High

267460

FBXL5
F-box/LRR-repeat protein 5

2

0

High-throughput

0.602

High

267369

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.601

High

267455

ACS2L
Acetyl-coenzyme A synthetase 2-like, mitochondrial

1

0

High-throughput

0.586

High

262650

CISY
Citrate synthase, mitochondrial

2

4

High-throughput

0.584

High

267458

ZRAN1
Ubiquitin thioesterase ZRANB1

2

5

High-throughput

0.584

High

267440

MA7D2
MAP7 domain-containing protein 2

2

6

High-throughput

0.574

High

267412

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

2

2

High-throughput

0.558

High

267436

NEUL4
Neuralized-like protein 4

2

1

Small-scale

0.558

High

234163

PEPL
Periplakin

1

4

High-throughput

0.536

High

267387

RM12
Large ribosomal subunit protein bL12m

1

1

High-throughput

0.536

High

267420

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

267363

ATPB
ATP synthase subunit beta, mitochondrial

1

4

High-throughput

0.515

High

267432

S22AI
Solute carrier family 22 member 18

1

1

High-throughput

0.515

High

267462

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

2

High-throughput

0.515

High

267359

TNNC2
Troponin C, skeletal muscle

1

0

High-throughput

0.513

High

267423

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

267362

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

147464

SOCS6
Suppressor of cytokine signaling 6

1

0

High-throughput

0.493

High

267375

XPA
DNA repair protein complementing XP-A cells

1

2

High-throughput

0.489

High

267378

RADI
Radixin

1

1

High-throughput

0.489

High

267396

HSF2
Heat shock factor protein 2

1

1

High-throughput

0.489

High

267451

Z286A
Zinc finger protein 286A

1

1

High-throughput

0.489

High

116535

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

1

High-throughput

0.479

High

148215

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.479

High

258375

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.479

High

264793

MPPB
Mitochondrial-processing peptidase subunit beta

1

5

High-throughput

0.479

High

266588

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

2

High-throughput

0.479

High

267356

SNAI1
Zinc finger protein SNAI1

1

4

High-throughput

0.479

High

267360

CATA
Catalase

1

1

High-throughput

0.479

High

267365

MET
Hepatocyte growth factor receptor

1

2

High-throughput

0.479

High

267366

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

3

High-throughput

0.479

High

267368

CH60
60 kDa heat shock protein, mitochondrial

1

5

High-throughput

0.479

High

267370

ENPL
Endoplasmin

1

2

High-throughput

0.479

High

267371

IDE
Insulin-degrading enzyme

1

5

High-throughput

0.479

High

267380

MDHM
Malate dehydrogenase, mitochondrial

1

6

High-throughput

0.479

High

267381

EFTS
Elongation factor Ts, mitochondrial

1

4

High-throughput

0.479

High

267382

IF2M
Translation initiation factor IF-2, mitochondrial

1

5

High-throughput

0.479

High

267383

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

267392

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

267393

TFAM
Transcription factor A, mitochondrial

1

4

High-throughput

0.479

High

267394

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.479

High

267398

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

3

High-throughput

0.479

High

267399

MPPA
Mitochondrial-processing peptidase subunit alpha

1

5

High-throughput

0.479

High

267400

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

6

High-throughput

0.479

High

267404

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

267405

PDK1
[Pyruvate dehydrogenase

1

7

High-throughput

0.479

High

267409

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

4

High-throughput

0.479

High

267414

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

267415

MRM1
rRNA methyltransferase 1, mitochondrial

1

3

High-throughput

0.479

High

267419

DHB13
17-beta-hydroxysteroid dehydrogenase 13

1

3

High-throughput

0.479

High

267422

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

267425

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

267431

FAKD4
FAST kinase domain-containing protein 4

1

7

High-throughput

0.479

High

267438

EFGM
Elongation factor G, mitochondrial

1

6

High-throughput

0.479

High

267439

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

2

High-throughput

0.479

High

267442

TR61B
tRNA

1

3

High-throughput

0.479

High

267447

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

267449

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

7

High-throughput

0.479

High

267454

ANLN
Anillin

1

2

High-throughput

0.479

High

267457

MRES1
Mitochondrial transcription rescue factor 1

1

2

High-throughput

0.479

High

267461

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.479

High

267464

RM11
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.479

High

267373

H12
Histone H1.2

1

2

High-throughput

0.470

High

267395

H11
Histone H1.1

1

2

High-throughput

0.470

High

231915

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.464

High

267354

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

267355

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

267357

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.458

High

267433

EF2KT
Protein-lysine N-methyltransferase EEF2KMT

1

0

High-throughput

0.458

High

267361

K2C6B
Keratin, type II cytoskeletal 6B

1

2

High-throughput

0.445

High

267374

K2C4
Keratin, type II cytoskeletal 4

1

2

High-throughput

0.445

High

267386

SMCA2
Probable global transcription activator SNF2L2

1

3

High-throughput

0.445

High

267390

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.445

High

267411

ACTBL
Beta-actin-like protein 2

1

2

High-throughput

0.445

High

267416

K2C80
Keratin, type II cytoskeletal 80

1

3

High-throughput

0.445

High

267421

NKAP
NF-kappa-B-activating protein

1

1

High-throughput

0.445

High

267424

ARI1B
AT-rich interactive domain-containing protein 1B

1

3

High-throughput

0.445

High

267427

TFG
Protein TFG

1

2

High-throughput

0.445

High

267430

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

3

High-throughput

0.445

High

267434

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

3

High-throughput

0.445

High

267435

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

5

High-throughput

0.445

High

267443

RM20
Large ribosomal subunit protein bL20m

1

1

High-throughput

0.445

High

267450

AGO3
Protein argonaute-3

1

2

High-throughput

0.445

High

267453

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

1

High-throughput

0.445

High

267466

SNX9
Sorting nexin-9

1

2

High-throughput

0.445

High

267358

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

267367

H14
Histone H1.4

1

2

High-throughput

0.437

High

267372

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

267377

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

267379

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

267391

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

267417

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

267445

Q9H4D1
Protein kinase

1

2

High-throughput

0.437

High

267446

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

267448

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.437

High

164720

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.426

High

267410

TYSD1
Peroxisomal leader peptide-processing protease

1

0

Small-scale

0.426

High

67900

PDZ1P
Putative PDZ domain-containing protein PDZK1P1

1

2

High-throughput

0.407

High

117237

PDLI1
PDZ and LIM domain protein 1

1

2

High-throughput

0.407

High

146124

ARI1A
AT-rich interactive domain-containing protein 1A

1

3

High-throughput

0.407

High

267376

ZA2G
Zinc-alpha-2-glycoprotein

1

3

High-throughput

0.407

High

267389

GALC
Galactocerebrosidase

1

1

High-throughput

0.407

High

267407

MEA1
Male-enhanced antigen 1

1

1

High-throughput

0.407

High

267413

SKT
Sickle tail protein homolog

1

1

High-throughput

0.407

High

267428

DPF3
Zinc finger protein DPF3

1

3

High-throughput

0.407

High

267429

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

3

High-throughput

0.407

High

267441

MMTA2
Multiple myeloma tumor-associated protein 2

1

1

High-throughput

0.407

High

267437

PRIPO
DNA-directed primase/polymerase protein

2

0

High-throughput

0.328

High

267444

PDGFD
Platelet-derived growth factor D

2

0

High-throughput

0.328

High

267406

CART

1

0

High-throughput

0.279

Low

267452

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

0

High-throughput

0.249

Low

267456

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

267352

RMXL2
RNA-binding motif protein, X-linked-like-2

1

0

High-throughput

0.232

Low

267384

YLPM1
YLP motif-containing protein 1

1

0

High-throughput

0.232

Low

267388

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.232

Low

267426

POF1B
Protein POF1B

1

0

High-throughput

0.232

Low

267463

TR150
Thyroid hormone receptor-associated protein 3

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024