Protein: SETX
Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin)

Gene: SETX
Organism: Homo sapiens
Interactions: 159
UniProt ID: Q7Z333

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0000228 - nuclear chromosome
GO:0000781 - chromosome, telomeric region
GO:0001147 - transcription termination site sequence-specific DNA binding
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1188022

SETX
Probable helicase senataxin

1

6

Small-scale

0.740

High

749620

BRCA1
Breast cancer type 1 susceptibility protein

4

6

Small-scale

0.701

High

993029

RHG01
Rho GTPase-activating protein 1

2

1

High-throughput

0.628

High

1026183

PAK1
Serine/threonine-protein kinase PAK 1

2

3

High-throughput

0.628

High

1188076

FZD10
Frizzled-10

2

1

High-throughput

0.628

High

930277

UBC9
SUMO-conjugating enzyme UBC9

2

1

Small-scale

0.620

High

146363

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

1

High-throughput

0.609

High

120959

APBB1
Amyloid beta precursor protein binding family B member 1

2

0

High-throughput

0.602

High

132020

VMA5A
von Willebrand factor A domain-containing protein 5A

2

0

High-throughput

0.602

High

1121357

SETMR
Histone-lysine N-methyltransferase SETMAR

2

0

High-throughput

0.602

High

1188074

VPS28
Vacuolar protein sorting-associated protein 28 homolog

2

0

High-throughput

0.602

High

1188077

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

0

High-throughput

0.602

High

1188079

NGN3
Neurogenin-3

2

0

High-throughput

0.602

High

1188080

CD2AP
CD2-associated protein

2

0

High-throughput

0.602

High

928125

SUMO1
Small ubiquitin-related modifier 1

2

2

Small-scale

0.595

High

1188031

PNKD
Probable hydrolase PNKD

2

0

High-throughput

0.585

High

668785

PML
Protein PML

2

9

High-throughput

0.584

High

783667

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

1

High-throughput

0.574

High

347164

MYC
Myc proto-oncogene protein

2

7

High-throughput

0.571

High

369900

ESR1
Estrogen receptor

2

11

High-throughput

0.571

High

1188060

CAD19
Cadherin-19

2

1

High-throughput

0.558

High

624947

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

5

Small-scale

0.554

High

71160

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

15

High-throughput

0.536

High

123997

SPT5H
Transcription elongation factor SPT5

1

3

High-throughput

0.536

High

276251

CIB2
Calcium and integrin-binding family member 2

1

2

High-throughput

0.536

High

296457

ACL6B
Actin-like protein 6B

1

2

High-throughput

0.536

High

309858

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

1

High-throughput

0.536

High

428274

TBB5
Tubulin beta chain

1

2

High-throughput

0.536

High

622956

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

1

High-throughput

0.536

High

885378

LOXL3
Lysyl oxidase homolog 3

1

1

High-throughput

0.536

High

897552

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

1

High-throughput

0.536

High

913915

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

3

High-throughput

0.536

High

933867

TBB4B
Tubulin beta-4B chain

1

2

High-throughput

0.536

High

996733

SSRP1
FACT complex subunit SSRP1

1

9

High-throughput

0.536

High

1026926

PAK2
Serine/threonine-protein kinase PAK 2

1

3

High-throughput

0.536

High

1069394

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.536

High

1136816

FAXC
Failed axon connections homolog

1

1

High-throughput

0.536

High

1188029

CNTRB
Centrobin

1

1

High-throughput

0.536

High

1188030

PIAS4
E3 SUMO-protein ligase PIAS4

1

2

High-throughput

0.536

High

1188040

TRI52
E3 ubiquitin-protein ligase TRIM52

1

3

High-throughput

0.536

High

1188041

EFMT3
EEF1A lysine methyltransferase 3

1

5

High-throughput

0.536

High

1188050

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

1188052

TS101
Tumor susceptibility gene 101 protein

1

1

High-throughput

0.536

High

1188054

TBL1Y
F-box-like/WD repeat-containing protein TBL1Y

1

6

High-throughput

0.536

High

1188063

SENP3
Sentrin-specific protease 3

1

3

High-throughput

0.536

High

1188075

PNMA2
Paraneoplastic antigen Ma2

1

1

High-throughput

0.536

High

233764

NDK8
Putative nucleoside diphosphate kinase

2

0

High-throughput

0.528

High

614367

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

High-throughput

0.515

High

271124

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

2

High-throughput

0.515

High

1188059

SKI8
Superkiller complex protein 8

1

6

High-throughput

0.515

High

149878

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.513

High

296808

NOL4
Nucleolar protein 4

1

0

High-throughput

0.513

High

362232

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

363829

ALBU
Albumin

1

0

High-throughput

0.513

High

454721

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

471616

TFPT
TCF3 fusion partner

1

0

High-throughput

0.513

High

500828

CLUS
Clusterin

1

0

High-throughput

0.513

High

557173

PGFRA
Platelet-derived growth factor receptor alpha

1

0

High-throughput

0.513

High

957873

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

968787

MEF2A
Myocyte-specific enhancer factor 2A

1

0

High-throughput

0.513

High

1029266

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1084821

SMN
Survival motor neuron protein

1

0

Small-scale

0.513

High

1088099

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.513

High

1156809

SWAP1
ATPase SWSAP1

1

0

High-throughput

0.513

High

1188045

FAH2A
Fumarylacetoacetate hydrolase domain-containing protein 2A

1

0

High-throughput

0.513

High

1188047

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.513

High

1188048

PPM1M
Protein phosphatase 1M

1

0

High-throughput

0.513

High

1188053

CITE1
Cbp/p300-interacting transactivator 1

1

0

High-throughput

0.513

High

1188055

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.513

High

1188057

IFT27
Intraflagellar transport protein 27 homolog

1

0

High-throughput

0.513

High

1188058

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1188065

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

0

High-throughput

0.513

High

1188068

ANR10
Ankyrin repeat domain-containing protein 10

1

0

High-throughput

0.513

High

1188081

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

1188082

NPTN
Neuroplastin

1

0

High-throughput

0.513

High

278119

PIAS1
E3 SUMO-protein ligase PIAS1

1

2

Small-scale

0.508

High

475974

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

Small-scale

0.508

High

986689

EXOS9
Exosome complex component RRP45

1

1

Small-scale

0.508

High

1018551

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

Small-scale

0.508

High

1188062

HIPK2
Homeodomain-interacting protein kinase 2

1

6

Small-scale

0.508

High

1188067

TOPRS
E3 ubiquitin-protein ligase Topors

1

1

Small-scale

0.508

High

890717

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.501

High

153711

ANM5
Protein arginine N-methyltransferase 5

1

3

Small-scale

0.500

High

198109

MTLR
Motilin receptor

1

1

High-throughput

0.489

High

224974

ZNRD2
Protein ZNRD2

1

1

High-throughput

0.489

High

814269

GLR
Glucagon receptor

1

2

High-throughput

0.489

High

1030987

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.489

High

1188026

P2RY8
P2Y purinoceptor 8

1

1

High-throughput

0.489

High

1188049

CIB3
Calcium and integrin-binding family member 3

1

2

High-throughput

0.489

High

1039485

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.486

High

1188071

SAE2
SUMO-activating enzyme subunit 2

1

0

Small-scale

0.486

High

902649

SUMO2
Small ubiquitin-related modifier 2

1

2

Small-scale

0.481

High

125548

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

High-throughput

0.479

High

130965

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

4

High-throughput

0.479

High

148988

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

227889

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

308830

KI20A
Kinesin-like protein KIF20A

1

12

High-throughput

0.479

High

338625

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

374442

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

386995

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

831456

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.479

High

850100

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

Small-scale

0.479

High

917502

H4
Histone H4

1

4

High-throughput

0.479

High

934920

H31
Histone H3.1

1

2

High-throughput

0.479

High

961176

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

982204

1433F
14-3-3 protein eta

1

4

High-throughput

0.479

High

1036692

SQSTM
Sequestosome-1

1

3

High-throughput

0.479

High

1063466

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.479

High

1066318

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

1080072

EZH2
Histone-lysine N-methyltransferase EZH2

1

7

High-throughput

0.479

High

1140564

RN123
E3 ubiquitin-protein ligase RNF123

1

6

High-throughput

0.479

High

1154042

NIPBL
Nipped-B-like protein

1

2

High-throughput

0.479

High

1166686

WDR82
WD repeat-containing protein 82

1

8

High-throughput

0.479

High

1188023

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

1188024

SLN11
Schlafen family member 11

1

3

High-throughput

0.479

High

1188027

SKAP1
Src kinase-associated phosphoprotein 1

1

8

High-throughput

0.479

High

1188028

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1188035

NUP43
Nucleoporin Nup43

1

7

High-throughput

0.479

High

1188037

COP1
E3 ubiquitin-protein ligase COP1

1

5

High-throughput

0.479

High

1188039

ESR2
Estrogen receptor beta

1

11

High-throughput

0.479

High

1188042

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

7

High-throughput

0.479

High

1188043

F120B
Constitutive coactivator of peroxisome proliferator-activated receptor gamma

1

5

Small-scale

0.479

High

1188044

AURKB
Aurora kinase B

1

3

High-throughput

0.479

High

1188056

LST8
Target of rapamycin complex subunit LST8

1

4

High-throughput

0.479

High

1188073

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1019003

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1188064

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1188069

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1188072

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.458

High

1188078

CARD8
Caspase recruitment domain-containing protein 8

1

0

High-throughput

0.458

High

1188083

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

321114

PTBP3
Polypyrimidine tract-binding protein 3

1

9

High-throughput

0.445

High

682866

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

12

Small-scale

0.445

High

1039646

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.445

High

1108471

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

1

High-throughput

0.445

High

1188066

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.437

High

364568

TRFE
Serotransferrin

1

1

High-throughput

0.407

High

1188046

Q96KY9
CDH19 protein

1

1

High-throughput

0.407

High

1188070

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

3

High-throughput

0.407

High

1188025

CMTD1
Catechol O-methyltransferase domain-containing protein 1

3

0

High-throughput

0.347

High

1188034

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.328

High

68069

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

238881

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low

295737

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.279

Low

361359

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.279

Low

600784

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

0

High-throughput

0.279

Low

614215

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.279

Low

1100075

INF2
Inverted formin-2

1

0

High-throughput

0.279

Low

1139954

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.279

Low

1166497

BTNL9
Butyrophilin-like protein 9

1

0

High-throughput

0.279

Low

1188036

CC4L
C-C motif chemokine 4-like

1

0

High-throughput

0.279

Low

1188038

ITLN1
Intelectin-1

1

0

High-throughput

0.279

Low

1188051

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

0

High-throughput

0.279

Low

1188061

ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

1

0

High-throughput

0.279

Low

1188032

SAMD3
Sterile alpha motif domain-containing protein 3

1

0

High-throughput

0.268

Low

897376

ARF3
ADP-ribosylation factor 3

1

0

High-throughput

0.249

Low

1165630

LCN15
Lipocalin-15

1

0

High-throughput

0.249

Low

1188033

CN178
Uncharacterized protein C14orf178

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024