Protein: PTPRF
Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR)

Gene: PTPRF
Organism: Homo sapiens
Interactions: 199
UniProt ID: P10586

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005001 - transmembrane receptor protein tyrosine phosphatase activity
GO:0005886 - plasma membrane
GO:0007155 - cell adhesion
GO:0007185 - cell surface receptor protein tyrosine phosphatase signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

246335

SCN2B
Sodium channel subunit beta-2

3

6

High-throughput

0.861

High

337831

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.843

High

411959

FYN
Tyrosine-protein kinase Fyn

2

20

Small-scale

0.815

High

489962

I13R2
Interleukin-13 receptor subunit alpha-2

2

18

High-throughput

0.811

High

489956

LIPA1
Liprin-alpha-1

4

11

Small-scale

0.803

High

489936

RHOA
Transforming protein RhoA

2

20

Small-scale

0.800

High

489910

RYK
Tyrosine-protein kinase RYK

2

20

Small-scale

0.789

High

489917

TGFR2
TGF-beta receptor type-2

2

3

High-throughput

0.789

High

68222

HECA2
HEPACAM family member 2

3

14

High-throughput

0.770

High

489970

CEA21
Carcinoembryonic antigen-related cell adhesion molecule 21

3

15

High-throughput

0.770

High

279833

TRIO
Triple functional domain protein

2

2

Small-scale

0.754

High

490011

LRIQ1
Leucine-rich repeat and IQ domain-containing protein 1

2

4

High-throughput

0.726

High

411565

LCK
Tyrosine-protein kinase Lck

1

20

Small-scale

0.724

High

167065

ARHGB
Rho guanine nucleotide exchange factor 11

1

7

Small-scale

0.713

High

254437

ROCK2
Rho-associated protein kinase 2

1

2

Small-scale

0.713

High

259635

LIPA2
Liprin-alpha-2

1

13

Small-scale

0.713

High

489931

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.713

High

490033

ARHGC
Rho guanine nucleotide exchange factor 12

1

6

Small-scale

0.713

High

489947

KC1G2
Casein kinase I isoform gamma-2

1

3

High-throughput

0.691

High

489953

CD83
CD83 antigen

1

1

High-throughput

0.691

High

489958

AVR2B
Activin receptor type-2B

1

3

High-throughput

0.691

High

489973

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

1

1

High-throughput

0.691

High

489980

BT2A1
Butyrophilin subfamily 2 member A1

1

3

High-throughput

0.691

High

490002

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

18

High-throughput

0.691

High

490025

LRTM1
Leucine-rich repeat and transmembrane domain-containing protein 1

1

8

High-throughput

0.691

High

490037

CLC4A
C-type lectin domain family 4 member A

1

6

High-throughput

0.691

High

490003

ARHG2
Rho guanine nucleotide exchange factor 2

1

6

Small-scale

0.662

High

489988

SH2D3
SH2 domain-containing protein 3C

2

20

High-throughput

0.659

High

489927

TPTE
Putative tyrosine-protein phosphatase TPTE

1

0

High-throughput

0.656

High

489948

NGAL
Neutrophil gelatinase-associated lipocalin

1

0

High-throughput

0.656

High

489914

CTNB1
Catenin beta-1

3

19

Small-scale

0.656

High

149944

NCAN
Neurocan core protein

1

3

Small-scale

0.647

High

434120

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

Small-scale

0.647

High

489893

CSPG2
Versican core protein

1

3

Small-scale

0.647

High

489894

NID1
Nidogen-1

1

2

Small-scale

0.647

High

489902

PTPRZ
Receptor-type tyrosine-protein phosphatase zeta

1

16

Small-scale

0.647

High

489903

OMGP
Oligodendrocyte-myelin glycoprotein

1

7

Small-scale

0.647

High

489887

CLUS
Clusterin

2

2

High-throughput

0.628

High

489971

CC50B
Cell cycle control protein 50B

2

2

High-throughput

0.628

High

489986

PIANP
PILR alpha-associated neural protein

2

1

High-throughput

0.628

High

490009

MRAP2
Melanocortin-2 receptor accessory protein 2

2

2

High-throughput

0.628

High

490028

PCDBG
Protocadherin beta-16

2

16

High-throughput

0.628

High

490044

PCDGD
Protocadherin gamma-B1

2

16

High-throughput

0.628

High

489926

FCGRN
IgG receptor FcRn large subunit p51

1

5

High-throughput

0.618

High

490035

OPT
Opticin

1

9

High-throughput

0.618

High

120286

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

349083

RASH
GTPase HRas

1

11

High-throughput

0.618

High

349822

RASK
GTPase KRas

1

17

High-throughput

0.618

High

384155

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

436131

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

489896

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

489899

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

489921

MUC18
Cell surface glycoprotein MUC18

1

14

High-throughput

0.618

High

489922

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.618

High

489923

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

489932

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

489933

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

489934

RAB2A
Ras-related protein Rab-2A

1

3

High-throughput

0.618

High

489937

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

489940

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

489942

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

489951

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

489957

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

17

High-throughput

0.618

High

489965

RAB35
Ras-related protein Rab-35

1

5

High-throughput

0.618

High

489966

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

489969

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

16

High-throughput

0.618

High

489981

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

489999

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

490021

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

490024

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

490040

GIT1
ARF GTPase-activating protein GIT1

1

2

Small-scale

0.618

High

489945

TBB4B
Tubulin beta-4B chain

2

1

Small-scale

0.614

High

490034

MARH2
E3 ubiquitin-protein ligase MARCHF2

2

7

High-throughput

0.611

High

489961

WFDC2
WAP four-disulfide core domain protein 2

2

0

High-throughput

0.602

High

489955

CAV1
Caveolin-1

2

1

Small-scale

0.601

High

489895

PLAK
Junction plakoglobin

2

20

Small-scale

0.595

High

490023

MANS1
MANSC domain-containing protein 1

2

1

High-throughput

0.574

High

489989

RN149
E3 ubiquitin-protein ligase RNF149

2

8

High-throughput

0.558

High

255234

LIPA3
Liprin-alpha-3

1

11

Small-scale

0.555

High

489974

SWAHC
Ankyrin repeat domain-containing protein SOWAHC

1

3

Small-scale

0.555

High

489979

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.553

High

490000

ESR2
Estrogen receptor beta

1

1

High-throughput

0.553

High

489886

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

16

Small-scale

0.545

High

132250

DLL1
Delta-like protein 1

1

3

High-throughput

0.536

High

156779

FFAR1
Free fatty acid receptor 1

1

5

High-throughput

0.536

High

259198

CAD16
Cadherin-16

1

20

High-throughput

0.536

High

489912

CNR2
Cannabinoid receptor 2

1

2

Small-scale

0.536

High

489916

TNR3
Tumor necrosis factor receptor superfamily member 3

1

8

High-throughput

0.536

High

489920

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

5

High-throughput

0.536

High

489960

KCNC3
Potassium voltage-gated channel subfamily C member 3

1

4

High-throughput

0.536

High

489976

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.536

High

489978

I20RB
Interleukin-20 receptor subunit beta

1

4

High-throughput

0.536

High

489983

T150A
Transmembrane protein 150A

1

1

High-throughput

0.536

High

489987

IZUM1
Izumo sperm-egg fusion protein 1

1

1

High-throughput

0.536

High

489990

ARRD4
Arrestin domain-containing protein 4

1

4

High-throughput

0.536

High

489991

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

7

High-throughput

0.536

High

489992

PKR1
Prokineticin receptor 1

1

5

High-throughput

0.536

High

490005

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

3

High-throughput

0.536

High

490007

ARRD3
Arrestin domain-containing protein 3

1

4

High-throughput

0.536

High

490008

TSN17
Tetraspanin-17

1

6

High-throughput

0.536

High

490013

OPALI
Opalin

1

1

High-throughput

0.536

High

490015

SYT11
Synaptotagmin-11

1

1

High-throughput

0.536

High

490019

PCDC1
Protocadherin alpha-C1

1

18

High-throughput

0.536

High

490026

PCD12
Protocadherin-12

1

17

High-throughput

0.536

High

490032

GPC5B
G-protein coupled receptor family C group 5 member B

1

1

High-throughput

0.536

High

490038

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

6

High-throughput

0.536

High

490042

RNF11
RING finger protein 11

1

7

High-throughput

0.536

High

490045

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

2

High-throughput

0.536

High

237553

DIAP1
Protein diaphanous homolog 1

1

0

Small-scale

0.529

High

489924

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

1

0

Small-scale

0.529

High

489994

DEP1B
DEP domain-containing protein 1B

1

2

Small-scale

0.527

High

489900

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

3

High-throughput

0.514

High

489952

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

489998

BSND
Barttin

1

0

High-throughput

0.513

High

490027

NPDC1
Neural proliferation differentiation and control protein 1

1

0

High-throughput

0.513

High

263490

PR40A
Pre-mRNA-processing factor 40 homolog A

1

1

High-throughput

0.508

High

266524

GPC4
Glypican-4

1

8

Small-scale

0.501

High

489941

H4
Histone H4

1

0

High-throughput

0.493

High

489949

DLK1
Protein delta homolog 1

1

5

High-throughput

0.489

High

489968

SGCA
Alpha-sarcoglycan

1

2

High-throughput

0.489

High

489996

RN133
E3 ubiquitin-protein ligase RNF133

1

8

High-throughput

0.489

High

489997

KCNE4
Potassium voltage-gated channel subfamily E member 4

1

1

High-throughput

0.489

High

490004

I22R2
Interleukin-22 receptor subunit alpha-2

1

4

High-throughput

0.489

High

490022

TM231
Transmembrane protein 231

1

1

High-throughput

0.489

High

490031

CLDN1
Claudin domain-containing protein 1

1

1

High-throughput

0.489

High

489890

SKIL
Ski-like protein

1

0

High-throughput

0.486

High

334114

LDHA
L-lactate dehydrogenase A chain

1

1

Small-scale

0.481

High

380978

SEMG1
Semenogelin-1

1

1

Small-scale

0.481

High

421951

LDHB
L-lactate dehydrogenase B chain

1

1

Small-scale

0.481

High

489888

BIP
Endoplasmic reticulum chaperone BiP

1

2

Small-scale

0.481

High

489889

HSP7C
Heat shock cognate 71 kDa protein

1

1

Small-scale

0.481

High

489904

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

1

Small-scale

0.481

High

489906

EF1G
Elongation factor 1-gamma

1

1

Small-scale

0.481

High

489911

HS71L
Heat shock 70 kDa protein 1-like

1

1

Small-scale

0.481

High

489918

GRP75
Stress-70 protein, mitochondrial

1

3

Small-scale

0.481

High

489954

SEMG2
Semenogelin-2

1

1

Small-scale

0.481

High

204965

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

489891

CADH1
Cadherin-1

1

20

Small-scale

0.479

High

489892

IFM1
Interferon-induced transmembrane protein 1

1

2

High-throughput

0.479

High

489907

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.479

High

489913

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

8

High-throughput

0.479

High

489915

IRS1
Insulin receptor substrate 1

1

6

Small-scale

0.479

High

489928

H2B1D
Histone H2B type 1-D

1

2

High-throughput

0.479

High

489939

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

489977

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

489982

TM11B
Transmembrane protease serine 11B

1

7

High-throughput

0.479

High

490006

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.479

High

490016

ACE2
Angiotensin-converting enzyme 2

1

2

Small-scale

0.479

High

490020

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

489985

NUDC3
NudC domain-containing protein 3

1

1

High-throughput

0.470

High

381760

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

Small-scale

0.460

High

431461

HS90A
Heat shock protein HSP 90-alpha

1

0

Small-scale

0.460

High

489898

CBR1
Carbonyl reductase [NADPH] 1

1

0

Small-scale

0.460

High

489905

ATPA
ATP synthase subunit alpha, mitochondrial

1

0

Small-scale

0.460

High

489943

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.460

High

197200

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.458

High

489938

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

0

High-throughput

0.458

High

490018

NAA50
N-alpha-acetyltransferase 50

1

0

High-throughput

0.458

High

152238

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

5

High-throughput

0.445

High

239737

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.445

High

489901

CD9
CD9 antigen

1

5

High-throughput

0.445

High

489929

CD81
CD81 antigen

1

6

High-throughput

0.445

High

489959

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

7

High-throughput

0.445

High

490039

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

489944

TBA1B
Tubulin alpha-1B chain

1

1

Small-scale

0.439

High

385973

P53
Cellular tumor antigen p53

1

1

High-throughput

0.437

High

489908

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

489909

PML
Protein PML

1

1

High-throughput

0.437

High

489930

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.437

High

489946

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

489964

CUL7
Cullin-7

1

1

High-throughput

0.437

High

489975

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

7

High-throughput

0.437

High

489984

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

7

High-throughput

0.437

High

489993

RN128
E3 ubiquitin-protein ligase RNF128

1

8

High-throughput

0.437

High

490041

SGT1
Protein SGT1 homolog

1

1

High-throughput

0.437

High

490043

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.437

High

120811

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.426

High

489967

NF2L2
Nuclear factor erythroid 2-related factor 2

1

0

High-throughput

0.426

High

490017

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

175598

VA0E1
V-type proton ATPase subunit e 1

2

0

High-throughput

0.328

High

490036

SEPT9
Septin-9

1

0

Small-scale

0.288

High

489972

SHSL1
Protein shisa-like-1

1

0

High-throughput

0.279

Low

489995

TM171
Transmembrane protein 171

1

0

High-throughput

0.279

Low

490010

CYYR1
Cysteine and tyrosine-rich protein 1

1

0

High-throughput

0.279

Low

490030

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.279

Low

490012

Z512B
Zinc finger protein 512B

1

0

High-throughput

0.265

Low

489950

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

Small-scale

0.251

Low

490001

CBP
CREB-binding protein

1

0

Small-scale

0.251

Low

68128

F1712
Protein FAM171A2

1

0

High-throughput

0.249

Low

177575

BCAT2
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

High-throughput

0.249

Low

195877

TTI1
TELO2-interacting protein 1 homolog

1

0

High-throughput

0.249

Low

489897

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

489919

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

489925

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

489935

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.249

Low

489963

NC2A
Dr1-associated corepressor

1

0

High-throughput

0.249

Low

490014

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.249

Low

490029

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024