Protein: KMT2B
Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)

Gene: KMT2B
Organism: Homo sapiens
Interactions: 128
UniProt ID: Q9UMN6

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0008270 - zinc ion binding
GO:0032259 - methylation
GO:0035097 - histone methyltransferase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

903604

WDR5
WD repeat-containing protein 5

15

19

Small-scale

0.985

High

1354085

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

10

20

Small-scale

0.976

High

1070808

RBBP5
Retinoblastoma-binding protein 5

9

20

Small-scale

0.967

High

935368

H31
Histone H3.1

3

20

Small-scale

0.834

High

975346

KMT2A
Histone-lysine N-methyltransferase 2A

2

19

Small-scale

0.768

High

1166735

WDR82
WD repeat-containing protein 82

2

20

Small-scale

0.754

High

123091

MEN1
Menin

5

5

Small-scale

0.713

High

1057802

NCOA6
Nuclear receptor coactivator 6

4

20

Small-scale

0.694

High

1087483

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

1357298

HCFC2
Host cell factor 2

3

20

High-throughput

0.667

High

1174689

H32
Histone H3.2

1

20

Small-scale

0.647

High

855256

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

8

Small-scale

0.646

High

1309314

MEP50
Methylosome protein WDR77

1

16

Small-scale

0.646

High

152700

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.618

High

165737

SET1A
Histone-lysine N-methyltransferase SETD1A

1

19

High-throughput

0.618

High

183176

KDM6A
Lysine-specific demethylase 6A

1

20

High-throughput

0.618

High

211281

BUB3
Mitotic checkpoint protein BUB3

1

20

High-throughput

0.618

High

828421

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

918135

H4
Histone H4

1

8

High-throughput

0.618

High

918772

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

952698

H33
Histone H3.3

1

20

High-throughput

0.618

High

1027329

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.618

High

1243852

KMT2C
Histone-lysine N-methyltransferase 2C

1

17

High-throughput

0.618

High

1244566

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

1285394

PF21A
PHD finger protein 21A

1

19

High-throughput

0.618

High

1288387

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

16

High-throughput

0.618

High

1349847

CXXC1
CXXC-type zinc finger protein 1

1

19

High-throughput

0.618

High

1350537

RERE
Arginine-glutamic acid dipeptide repeats protein

1

20

High-throughput

0.618

High

1357294

SET1B
Histone-lysine N-methyltransferase SETD1B

1

20

High-throughput

0.618

High

1173276

PAXI1
PAX-interacting protein 1

2

20

Small-scale

0.611

High

1318622

DPY30
Protein dpy-30 homolog

2

7

Small-scale

0.611

High

266073

PSIP1
PC4 and SFRS1-interacting protein

2

10

Small-scale

0.594

High

848317

HCFC1
Host cell factor 1

2

20

Small-scale

0.594

High

348225

MYC
Myc proto-oncogene protein

2

13

High-throughput

0.584

High

370701

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1140853

RN123
E3 ubiquitin-protein ligase RNF123

1

15

High-throughput

0.553

High

1282073

TRI63
E3 ubiquitin-protein ligase TRIM63

1

11

High-throughput

0.541

High

1317542

TRI55
Tripartite motif-containing protein 55

1

15

High-throughput

0.541

High

781483

BCL6
B-cell lymphoma 6 protein

1

3

Small-scale

0.536

High

931937

CSK2B
Casein kinase II subunit beta

1

3

High-throughput

0.536

High

934556

CSK21
Casein kinase II subunit alpha

1

9

High-throughput

0.536

High

1246387

THOC2
THO complex subunit 2

1

18

High-throughput

0.536

High

1267455

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

12

High-throughput

0.526

High

376336

ANXA1
Annexin A1

1

7

High-throughput

0.508

High

378789

KITH
Thymidine kinase, cytosolic

1

1

High-throughput

0.508

High

578493

RCC1
Regulator of chromosome condensation

1

3

High-throughput

0.508

High

589254

ANXA7
Annexin A7

1

7

High-throughput

0.508

High

950325

SMAD3
Mothers against decapentaplegic homolog 3

1

14

High-throughput

0.508

High

1038086

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

High-throughput

0.508

High

1077360

T22D1
TSC22 domain family protein 1

1

19

High-throughput

0.508

High

1084936

SMN
Survival motor neuron protein

1

1

High-throughput

0.508

High

1296268

Z512B
Zinc finger protein 512B

1

8

High-throughput

0.508

High

1017260

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

4

Small-scale

0.501

High

1273097

FUBP2
Far upstream element-binding protein 2

1

8

Small-scale

0.500

High

661480

S10A2
Protein S100-A2

1

6

High-throughput

0.489

High

303815

RPP14
Ribonuclease P protein subunit p14

1

0

High-throughput

0.486

High

758364

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.486

High

868802

ATX1
Ataxin-1

1

0

High-throughput

0.486

High

68328

P20L1
PHD finger protein 20-like protein 1

1

11

High-throughput

0.479

High

179884

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

5

High-throughput

0.479

High

232588

KDM1A
Lysine-specific histone demethylase 1A

1

8

High-throughput

0.479

High

267717

TADA3
Transcriptional adapter 3

1

1

High-throughput

0.479

High

317029

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

337592

ABL1
Tyrosine-protein kinase ABL1

1

10

High-throughput

0.479

High

412407

FYN
Tyrosine-protein kinase Fyn

1

10

High-throughput

0.479

High

486845

MYB
Transcriptional activator Myb

1

7

High-throughput

0.479

High

554048

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

557827

NCK1
SH2/SH3 adapter protein NCK1

1

11

High-throughput

0.479

High

575624

EGR1
Early growth response protein 1

1

7

High-throughput

0.479

High

632951

TYY1
Transcriptional repressor protein YY1

1

9

High-throughput

0.479

High

653029

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

High-throughput

0.479

High

669075

PML
Protein PML

1

15

High-throughput

0.479

High

692200

ELF1
ETS-related transcription factor Elf-1

1

20

High-throughput

0.479

High

721771

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

782694

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

785424

ELK3
ETS domain-containing protein Elk-3

1

20

High-throughput

0.479

High

802775

CRK
Adapter molecule crk

1

8

High-throughput

0.479

High

809021

YAP1
Transcriptional coactivator YAP1

1

16

High-throughput

0.479

High

831794

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.479

High

855962

ZN131
Zinc finger protein 131

1

11

High-throughput

0.479

High

869556

ATN1
Atrophin-1

1

20

High-throughput

0.479

High

884265

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

900315

RL37A
Large ribosomal subunit protein eL43

1

2

High-throughput

0.479

High

924950

GRB2
Growth factor receptor-bound protein 2

1

15

High-throughput

0.479

High

987019

SUH
Recombining binding protein suppressor of hairless

1

2

High-throughput

0.479

High

1038822

HDAC1
Histone deacetylase 1

1

18

High-throughput

0.479

High

1060388

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1077618

ELF2
ETS-related transcription factor Elf-2

1

20

High-throughput

0.479

High

1188209

KANL1
KAT8 regulatory NSL complex subunit 1

1

3

High-throughput

0.479

High

1223211

ZZZ3
ZZ-type zinc finger-containing protein 3

1

3

High-throughput

0.479

High

1242696

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

20

Small-scale

0.479

High

1244252

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

14

High-throughput

0.479

High

1254959

SP7
Transcription factor Sp7

1

18

High-throughput

0.479

High

1269924

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1290784

MCRS1
Microspherule protein 1

1

4

High-throughput

0.479

High

1304723

FEV
Protein FEV

1

20

High-throughput

0.479

High

1304910

ELF4
ETS-related transcription factor Elf-4

1

20

High-throughput

0.479

High

1312207

PAGR1
PAXIP1-associated glutamate-rich protein 1

1

2

Small-scale

0.479

High

1313851

PHF20
PHD finger protein 20

1

17

High-throughput

0.479

High

1315397

KLF16
Krueppel-like factor 16

1

18

High-throughput

0.479

High

1333260

KAT8
Histone acetyltransferase KAT8

1

5

High-throughput

0.479

High

1333504

CSR2B
Cysteine-rich protein 2-binding protein

1

20

High-throughput

0.479

High

1334373

KANL2
KAT8 regulatory NSL complex subunit 2

1

3

High-throughput

0.479

High

1345377

MBIP1
MAP3K12-binding inhibitory protein 1

1

3

High-throughput

0.479

High

1348390

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

1350473

KANL3
KAT8 regulatory NSL complex subunit 3

1

4

High-throughput

0.479

High

1354851

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1356489

RCOR1
REST corepressor 1

1

12

High-throughput

0.479

High

1356854

ZN608
Zinc finger protein 608

1

10

High-throughput

0.479

High

1356945

YETS2
YEATS domain-containing protein 2

1

19

High-throughput

0.479

High

1357295

ASF1A
Histone chaperone ASF1A

1

3

High-throughput

0.479

High

1357296

ZN330
Zinc finger protein 330

1

2

High-throughput

0.479

High

1357297

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.479

High

393491

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

1

High-throughput

0.464

High

897970

RAP1B
Ras-related protein Rap-1b

1

8

High-throughput

0.464

High

1054109

GRB7
Growth factor receptor-bound protein 7

1

11

High-throughput

0.464

High

1267810

SEPT8
Septin-8

1

5

High-throughput

0.464

High

1167247

DPPA3
Developmental pluripotency-associated protein 3

1

0

High-throughput

0.458

High

1266895

TOPB1
DNA topoisomerase 2-binding protein 1

1

12

Small-scale

0.457

High

807879

MAP1B
Microtubule-associated protein 1B

1

9

Small-scale

0.457

High

1327868

QRIC2
Glutamine-rich protein 2

1

18

Small-scale

0.457

High

964282

FOXK2
Forkhead box protein K2

1

8

High-throughput

0.445

High

207847

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

2

High-throughput

0.437

High

932454

ACTC
Actin, alpha cardiac muscle 1

1

3

High-throughput

0.437

High

1344827

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.417

High

1190533

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

2

0

High-throughput

0.328

High

1028293

SBP1
Methanethiol oxidase

1

0

High-throughput

0.279

Low

1083812

NREP
Neuronal regeneration-related protein

1

0

High-throughput

0.265

Low


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Last updated: 15 Jul 2024