Protein: DEF5
Defensin alpha 5 (Defensin-5) (HD5(20-94)) [Cleaved into: HD5(23-94); HD5(29-94); HD5(56-94); HD5(63-94)]

Gene: DEF5, DEFA5
Organism: Homo sapiens
Interactions: 71
UniProt ID: Q01523

Gene Ontology (top 5):
GO:0002227 - innate immune response in mucosa
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005796 - Golgi lumen
GO:0019731 - antibacterial humoral response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

234427

NRP2
Neuropilin-2

2

2

High-throughput

0.628

High

302387

CSTN1
Calsyntenin-1

2

1

High-throughput

0.628

High

965231

TGBR3
Transforming growth factor beta receptor type 3

2

1

High-throughput

0.628

High

965233

LTBP1
Latent-transforming growth factor beta-binding protein 1

2

2

High-throughput

0.628

High

965236

T132A
Transmembrane protein 132A

2

1

High-throughput

0.628

High

965237

MICA
MHC class I polypeptide-related sequence A

2

1

High-throughput

0.628

High

965239

METRL
Meteorin-like protein

2

1

High-throughput

0.628

High

965251

C1QL4
Complement C1q-like protein 4

2

2

High-throughput

0.628

High

965252

CILP2
Cartilage intermediate layer protein 2

2

1

High-throughput

0.628

High

965253

SULF2
Extracellular sulfatase Sulf-2

2

4

High-throughput

0.628

High

965257

HTRA1
Serine protease HTRA1

2

1

High-throughput

0.628

High

965260

EMIL2
EMILIN-2

2

1

High-throughput

0.628

High

965272

LOXL2
Lysyl oxidase homolog 2

2

1

High-throughput

0.628

High

965230

DEF5
Defensin alpha 5

1

3

Small-scale

0.618

High

965261

ACE2
Angiotensin-converting enzyme 2

2

1

Small-scale

0.602

High

126527

QSOX1
Sulfhydryl oxidase 1

2

0

High-throughput

0.602

High

300665

GLCE
D-glucuronyl C5-epimerase

2

0

High-throughput

0.602

High

965234

RHG19
Rho GTPase-activating protein 19

2

0

High-throughput

0.602

High

965235

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

2

0

High-throughput

0.602

High

965245

WAPL
Wings apart-like protein homolog

2

0

High-throughput

0.602

High

965266

KTU
Protein kintoun

2

0

High-throughput

0.602

High

165191

PLXB2
Plexin-B2

2

5

High-throughput

0.574

High

225297

H6ST1
Heparan-sulfate 6-O-sulfotransferase 1

2

1

High-throughput

0.574

High

253461

PLXA2
Plexin-A2

2

5

High-throughput

0.574

High

280150

C1QRF
C1q-related factor

2

2

High-throughput

0.574

High

835672

GSK3B
Glycogen synthase kinase-3 beta

2

2

High-throughput

0.574

High

965238

FREM2
FRAS1-related extracellular matrix protein 2

2

2

High-throughput

0.574

High

965247

KAISO
Transcriptional regulator Kaiso

2

1

High-throughput

0.574

High

965249

FRAS1
Extracellular matrix organizing protein FRAS1

2

3

High-throughput

0.574

High

965256

IP6K1
Inositol hexakisphosphate kinase 1

2

1

High-throughput

0.574

High

965259

MCMBP
Mini-chromosome maintenance complex-binding protein

2

1

High-throughput

0.574

High

965267

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

2

1

High-throughput

0.574

High

965269

PLXA1
Plexin-A1

2

5

High-throughput

0.574

High

965274

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

2

1

High-throughput

0.574

High

537516

NID1
Nidogen-1

1

2

High-throughput

0.536

High

726512

TIMP3
Metalloproteinase inhibitor 3

1

1

High-throughput

0.536

High

949084

HTRA3
Serine protease HTRA3

1

1

High-throughput

0.536

High

965243

CD109
CD109 antigen

1

1

High-throughput

0.536

High

965258

PADC1
Protease-associated domain-containing protein 1

1

1

High-throughput

0.536

High

965270

METRN
Meteorin

1

1

High-throughput

0.536

High

352380

GAST
Gastrin [Cleaved into: Gastrin-71

1

0

High-throughput

0.513

High

835330

GSK3A
Glycogen synthase kinase-3 alpha

1

2

High-throughput

0.489

High

965241

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

837936

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

717713

BMI1
Polycomb complex protein BMI-1

3

0

Small-scale

0.355

High

68556

NUD19
Acyl-coenzyme A diphosphatase NUDT19

2

0

High-throughput

0.328

High

229767

SUSD5
Sushi domain-containing protein 5

2

0

High-throughput

0.328

High

275565

BCAR3
Breast cancer anti-estrogen resistance protein 3

2

0

High-throughput

0.328

High

513568

PYC
Pyruvate carboxylase, mitochondrial

2

0

High-throughput

0.328

High

616260

RS3
Small ribosomal subunit protein uS3

2

0

High-throughput

0.328

High

655318

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

0

High-throughput

0.328

High

787209

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

2

0

High-throughput

0.328

High

827345

EFTU
Elongation factor Tu, mitochondrial

2

0

High-throughput

0.328

High

949445

RL24
Large ribosomal subunit protein eL24

2

0

High-throughput

0.328

High

965232

HSP7E
Heat shock 70 kDa protein 14

2

0

High-throughput

0.328

High

965240

VIR
Protein virilizer homolog

2

0

High-throughput

0.328

High

965242

KLD10
Kelch domain-containing protein 10

2

0

High-throughput

0.328

High

965244

TMTC3
Protein O-mannosyl-transferase TMTC3

2

0

High-throughput

0.328

High

965248

SHLD2
Shieldin complex subunit 2

2

0

High-throughput

0.328

High

965254

RDH13
Retinol dehydrogenase 13

2

0

High-throughput

0.328

High

965255

XAGE3
X antigen family member 3

2

0

High-throughput

0.328

High

965263

DEFM
Peptide deformylase, mitochondrial

2

0

High-throughput

0.328

High

965264

PCDBG
Protocadherin beta-16

2

0

High-throughput

0.328

High

965265

ZN277
Zinc finger protein 277

2

0

High-throughput

0.328

High

965268

EPHA6
Ephrin type-A receptor 6

2

0

High-throughput

0.328

High

965271

C170B
Centrosomal protein of 170 kDa protein B

2

0

High-throughput

0.328

High

965250

DTX1
E3 ubiquitin-protein ligase DTX1

1

0

High-throughput

0.282

High

965246

GALT7
N-acetylgalactosaminyltransferase 7

1

0

High-throughput

0.279

Low

965262

REN3B
Regulator of nonsense transcripts 3B

1

0

High-throughput

0.279

Low

965273

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024