Protein: ALK
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)

Gene: ALK
Organism: Homo sapiens
Interactions: 225
UniProt ID: Q9UM73

Gene Ontology (top 5):
GO:0004713 - protein tyrosine kinase activity
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005886 - plasma membrane
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

924949

GRB2
Growth factor receptor-bound protein 2

4

20

Small-scale

0.890

High

666189

SHC1
SHC-transforming protein 1

3

20

Small-scale

0.861

High

581078

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

3

20

Small-scale

0.857

High

655504

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

Small-scale

0.799

High

665364

EPHA2
Ephrin type-A receptor 2

2

20

High-throughput

0.789

High

1357273

ALK
ALK tyrosine kinase receptor

2

18

Small-scale

0.778

High

854214

JAK3
Tyrosine-protein kinase JAK3

2

20

Small-scale

0.754

High

666663

LTK
Leukocyte tyrosine kinase receptor

2

19

Small-scale

0.737

High

617172

PTPRZ
Receptor-type tyrosine-protein phosphatase zeta

1

20

Small-scale

0.724

High

434310

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.691

High

616937

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

20

High-throughput

0.647

High

617150

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

20

High-throughput

0.647

High

1020121

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

20

High-throughput

0.647

High

155476

NRP1
Neuropilin-1

1

4

High-throughput

0.646

High

384028

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.621

High

129350

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.618

High

153186

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

12

Small-scale

0.618

High

161738

GAK
Cyclin-G-associated kinase

1

15

Small-scale

0.618

High

211691

ACTN4
Alpha-actinin-4

1

3

Small-scale

0.618

High

238445

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

523201

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.618

High

557826

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.618

High

573975

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

20

High-throughput

0.618

High

600704

EPHA1
Ephrin type-A receptor 1

1

19

Small-scale

0.618

High

608191

FGFR4
Fibroblast growth factor receptor 4

1

17

High-throughput

0.618

High

659089

MK01
Mitogen-activated protein kinase 1

1

11

Small-scale

0.618

High

665682

EPHB2
Ephrin type-B receptor 2

1

18

Small-scale

0.618

High

724573

IRS1
Insulin receptor substrate 1

1

20

Small-scale

0.618

High

776856

STAT3
Signal transducer and activator of transcription 3

1

20

Small-scale

0.618

High

789099

ABL2
Tyrosine-protein kinase ABL2

1

20

High-throughput

0.618

High

802919

CRKL
Crk-like protein

1

20

High-throughput

0.618

High

882638

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

20

Small-scale

0.618

High

883401

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

20

Small-scale

0.618

High

981066

KPCT
Protein kinase C theta type

1

20

Small-scale

0.618

High

986056

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

High-throughput

0.618

High

992611

ACK1
Activated CDC42 kinase 1

1

20

Small-scale

0.618

High

1028450

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

16

Small-scale

0.618

High

1035415

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.618

High

1047647

CDK13
Cyclin-dependent kinase 13

1

20

Small-scale

0.618

High

1077869

MYLK
Myosin light chain kinase, smooth muscle

1

8

Small-scale

0.618

High

1087823

MEP1B
Meprin A subunit beta

1

11

Small-scale

0.618

High

1266461

SHC3
SHC-transforming protein 3

1

20

Small-scale

0.618

High

1285224

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

High-throughput

0.618

High

1305601

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

20

Small-scale

0.618

High

1306399

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

13

High-throughput

0.618

High

1332902

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

15

High-throughput

0.618

High

1335084

PKHA1
Pleckstrin homology domain-containing family A member 1

1

20

High-throughput

0.618

High

1357277

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

1

20

High-throughput

0.618

High

1357283

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

7

Small-scale

0.618

High

597437

PTN
Pleiotrophin

2

1

Small-scale

0.595

High

1166746

ALKL1
ALK and LTK ligand 1

1

3

Small-scale

0.589

High

929718

RACK1
Small ribosomal subunit protein RACK1

2

10

Small-scale

0.584

High

1356638

VAV3
Guanine nucleotide exchange factor VAV3

1

20

Small-scale

0.575

High

1357281

NEMO
NF-kappa-B essential modulator

1

16

High-throughput

0.561

High

1357276

MAN1
Inner nuclear membrane protein Man1

2

10

High-throughput

0.558

High

181899

SOCS1
Suppressor of cytokine signaling 1

1

20

Small-scale

0.553

High

256861

SOCS5
Suppressor of cytokine signaling 5

1

20

Small-scale

0.553

High

1023257

FLII
Protein flightless-1 homolog

1

19

Small-scale

0.553

High

1053322

MYPC2
Myosin-binding protein C, fast-type

1

15

Small-scale

0.553

High

1243442

PDZD8
PDZ domain-containing protein 8

1

5

High-throughput

0.553

High

1318012

OSBL8
Oxysterol-binding protein-related protein 8

1

17

High-throughput

0.553

High

1357284

S23IP
SEC23-interacting protein

1

20

High-throughput

0.553

High

728673

PPM1A
Protein phosphatase 1A

1

8

High-throughput

0.541

High

654899

CALX
Calnexin

1

19

High-throughput

0.536

High

714884

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

1

High-throughput

0.536

High

936100

HBA
Hemoglobin subunit alpha

1

3

High-throughput

0.536

High

1040095

MTR1L
Melatonin-related receptor

1

2

High-throughput

0.536

High

1083044

CDC37
Hsp90 co-chaperone Cdc37

1

20

High-throughput

0.536

High

1165041

CSPG4
Chondroitin sulfate proteoglycan 4

1

4

High-throughput

0.536

High

1348805

ERAP1
Endoplasmic reticulum aminopeptidase 1

1

3

High-throughput

0.536

High

1357275

NISCH
Nischarin

1

20

High-throughput

0.536

High

1357278

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.536

High

828639

CENPF
Centromere protein F

2

20

Small-scale

0.533

High

438619

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.515

High

1166322

ALKL2
ALK and LTK ligand 2

1

3

Small-scale

0.515

High

1356002

ERRFI
ERBB receptor feedback inhibitor 1

1

14

Small-scale

0.515

High

600998

MK
Midkine

1

1

Small-scale

0.501

High

266583

GPC4
Glypican-4

1

1

High-throughput

0.500

High

382560

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

15

High-throughput

0.500

High

680395

SDC4
Syndecan-4

1

5

High-throughput

0.500

High

966789

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

13

High-throughput

0.500

High

972984

RASF7
Ras association domain-containing protein 7

1

5

High-throughput

0.500

High

1028125

DNJC3
DnaJ homolog subfamily C member 3

1

20

High-throughput

0.500

High

1121036

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

8

High-throughput

0.500

High

1311043

NTPCR
Cancer-related nucleoside-triphosphatase

1

8

High-throughput

0.500

High

1336439

SDF2L
Stromal cell-derived factor 2-like protein 1

1

9

High-throughput

0.500

High

1259421

DUS19
Dual specificity protein phosphatase 19

1

20

High-throughput

0.494

High

173234

VGF
Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1

1

1

High-throughput

0.489

High

532019

PDIA4
Protein disulfide-isomerase A4

1

20

High-throughput

0.489

High

532249

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

4

High-throughput

0.489

High

901546

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

7

High-throughput

0.489

High

1130936

TM201
Transmembrane protein 201

1

1

High-throughput

0.489

High

1354290

DJB11
DnaJ homolog subfamily B member 11

1

20

High-throughput

0.489

High

151929

IRS4
Insulin receptor substrate 4

1

10

Small-scale

0.479

High

160227

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

20

High-throughput

0.479

High

242910

TRI13
E3 ubiquitin-protein ligase TRIM13

1

8

High-throughput

0.479

High

243669

DNJA2
DnaJ homolog subfamily A member 2

1

20

High-throughput

0.479

High

279050

RAD17
Cell cycle checkpoint protein RAD17

1

4

Small-scale

0.479

High

310863

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

20

High-throughput

0.479

High

316756

ACSL3
Fatty acid CoA ligase Acsl3

1

10

High-throughput

0.479

High

320928

HS74L
Heat shock 70 kDa protein 4L

1

20

High-throughput

0.479

High

398780

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

9

High-throughput

0.479

High

408956

K1C18
Keratin, type I cytoskeletal 18

1

6

Small-scale

0.479

High

432361

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

438889

SRPRA
Signal recognition particle receptor subunit alpha

1

11

High-throughput

0.479

High

438998

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

5

High-throughput

0.479

High

443878

VIME
Vimentin

1

7

Small-scale

0.479

High

500209

CH60
60 kDa heat shock protein, mitochondrial

1

4

Small-scale

0.479

High

502677

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.479

High

574774

ARF4
ADP-ribosylation factor 4

1

14

High-throughput

0.479

High

725069

MYH9
Myosin-9

1

6

Small-scale

0.479

High

725268

MYH10
Myosin-10

1

5

Small-scale

0.479

High

787405

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

20

Small-scale

0.479

High

823515

PAXI
Paxillin

1

17

Small-scale

0.479

High

833671

NUMB
Protein numb homolog

1

19

High-throughput

0.479

High

842042

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

16

High-throughput

0.479

High

863371

COPB
Coatomer subunit beta

1

18

High-throughput

0.479

High

863604

COPA
Coatomer subunit alpha

1

17

High-throughput

0.479

High

892109

ACTB
Actin, cytoplasmic 1

1

7

Small-scale

0.479

High

896566

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

9

High-throughput

0.479

High

934024

TBB4B
Tubulin beta-4B chain

1

11

Small-scale

0.479

High

959761

VIGLN
Vigilin

1

8

High-throughput

0.479

High

997627

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

9

High-throughput

0.479

High

1040300

STIM1
Stromal interaction molecule 1

1

17

High-throughput

0.479

High

1065457

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

6

High-throughput

0.479

High

1066872

KIF14
Kinesin-like protein KIF14

1

14

High-throughput

0.479

High

1070455

RAB35
Ras-related protein Rab-35

1

16

Small-scale

0.479

High

1076018

PCH2
Pachytene checkpoint protein 2 homolog

1

12

High-throughput

0.479

High

1088406

VATF
V-type proton ATPase subunit F

1

5

High-throughput

0.479

High

1138544

F1711
Protein FAM171A1

1

16

High-throughput

0.479

High

1186170

K2C74
Keratin, type II cytoskeletal 74

1

3

Small-scale

0.479

High

1221833

SMC5
Structural maintenance of chromosomes protein 5

1

14

High-throughput

0.479

High

1222901

SMAP1
Stromal membrane-associated protein 1

1

20

High-throughput

0.479

High

1224479

UNC5B
Netrin receptor UNC5B

1

20

High-throughput

0.479

High

1244931

NBEA
Neurobeachin

1

16

High-throughput

0.479

High

1254312

BICD2
Protein bicaudal D homolog 2

1

18

Small-scale

0.479

High

1259723

FRS2
Fibroblast growth factor receptor substrate 2

1

20

High-throughput

0.479

High

1261667

SCFD1
Sec1 family domain-containing protein 1

1

18

High-throughput

0.479

High

1267783

HS105
Heat shock protein 105 kDa

1

20

High-throughput

0.479

High

1273300

ARHG2
Rho guanine nucleotide exchange factor 2

1

20

High-throughput

0.479

High

1283533

SYAP1
Synapse-associated protein 1

1

7

High-throughput

0.479

High

1294127

DDRGK
DDRGK domain-containing protein 1

1

6

High-throughput

0.479

High

1295044

CK5P3
CDK5 regulatory subunit-associated protein 3

1

6

High-throughput

0.479

High

1302142

SMC6
Structural maintenance of chromosomes protein 6

1

19

Small-scale

0.479

High

1312449

NDC1
Nucleoporin NDC1

1

4

High-throughput

0.479

High

1313658

KTNB1
Katanin p80 WD40 repeat-containing subunit B1

1

18

High-throughput

0.479

High

1329456

PDCL3
Phosducin-like protein 3

1

5

High-throughput

0.479

High

1335529

VEZA
Vezatin

1

6

High-throughput

0.479

High

1336620

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.479

High

1343376

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

1346236

DD19A
ATP-dependent RNA helicase DDX19A

1

11

High-throughput

0.479

High

1348861

GGA3
ADP-ribosylation factor-binding protein GGA3

1

20

High-throughput

0.479

High

1350041

STIM2
Stromal interaction molecule 2

1

17

High-throughput

0.479

High

1357065

COR1C
Coronin-1C

1

6

Small-scale

0.479

High

1357257

MYO6
Unconventional myosin-VI

1

12

Small-scale

0.479

High

489341

H14
Histone H1.4

1

5

High-throughput

0.470

High

559291

H15
Histone H1.5

1

5

High-throughput

0.470

High

1357280

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.458

High

1054250

HES1
Transcription factor HES-1

1

1

Small-scale

0.457

High

180106

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

4

High-throughput

0.457

High

778331

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

12

High-throughput

0.457

High

876093

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

9

High-throughput

0.457

High

1116867

GXLT1
Glucoside xylosyltransferase 1

1

2

High-throughput

0.457

High

1348102

DJB12
DnaJ homolog subfamily B member 12

1

20

High-throughput

0.457

High

240260

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

11

High-throughput

0.445

High

1047318

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

8

High-throughput

0.445

High

68613

NUD19
Acyl-coenzyme A diphosphatase NUDT19

1

5

High-throughput

0.437

High

149776

COPE
Coatomer subunit epsilon

1

8

High-throughput

0.437

High

164157

ARHGA
Rho guanine nucleotide exchange factor 10

1

20

High-throughput

0.437

High

170979

PGRC2
Membrane-associated progesterone receptor component 2

1

13

High-throughput

0.437

High

171698

PFD6
Prefoldin subunit 6

1

1

High-throughput

0.437

High

240654

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

5

High-throughput

0.437

High

240811

USO1
General vesicular transport factor p115

1

16

High-throughput

0.437

High

246059

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.437

High

264118

TACC1
Transforming acidic coiled-coil-containing protein 1

1

20

High-throughput

0.437

High

274036

NU155
Nuclear pore complex protein Nup155

1

6

High-throughput

0.437

High

302332

SC31A
Protein transport protein Sec31A

1

19

High-throughput

0.437

High

315611

SC24A
Protein transport protein Sec24A

1

20

High-throughput

0.437

High

315781

SC24B
Protein transport protein Sec24B

1

20

High-throughput

0.437

High

618735

IF4B
Eukaryotic translation initiation factor 4B

1

7

Small-scale

0.437

High

725611

COPB2
Coatomer subunit beta'

1

17

High-throughput

0.437

High

803276

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

Small-scale

0.437

High

819048

COPD
Coatomer subunit delta

1

8

High-throughput

0.437

High

839230

EMD
Emerin

1

10

High-throughput

0.437

High

839705

SERPH
Serpin H1

1

9

High-throughput

0.437

High

848999

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

13

High-throughput

0.437

High

857944

PDX1
Pancreas/duodenum homeobox protein 1

1

5

Small-scale

0.437

High

961599

PLCB2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

1

20

Small-scale

0.437

High

1074025

SC23A
Protein transport protein Sec23A

1

20

High-throughput

0.437

High

1074097

SC23B
Protein transport protein Sec23B

1

20

High-throughput

0.437

High

1100176

INF2
Inverted formin-2

1

5

High-throughput

0.437

High

1120863

PDLI3
PDZ and LIM domain protein 3

1

16

Small-scale

0.437

High

1127345

TGO1
Transport and Golgi organization protein 1 homolog

1

13

High-throughput

0.437

High

1204616

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

5

High-throughput

0.437

High

1217457

NUDC3
NudC domain-containing protein 3

1

8

High-throughput

0.437

High

1222795

M21D2
Nucleotidyltransferase MB21D2

1

6

High-throughput

0.437

High

1239768

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.437

High

1244624

NUP37
Nucleoporin Nup37

1

5

High-throughput

0.437

High

1256840

SMCR8
Guanine nucleotide exchange protein SMCR8

1

3

High-throughput

0.437

High

1270164

TFG
Protein TFG

1

20

High-throughput

0.437

High

1273355

IRF7
Interferon regulatory factor 7

1

1

Small-scale

0.437

High

1298844

CC115
Coiled-coil domain-containing protein 115

1

5

High-throughput

0.437

High

1301880

CLCC1
Chloride channel CLIC-like protein 1

1

9

High-throughput

0.437

High

1305194

CDCA3
Cell division cycle-associated protein 3

1

11

High-throughput

0.437

High

1311293

GCP2
Gamma-tubulin complex component 2

1

5

Small-scale

0.437

High

1311450

ESYT1
Extended synaptotagmin-1

1

13

High-throughput

0.437

High

1326662

EGLN1
Egl nine homolog 1

1

3

High-throughput

0.437

High

1327328

LSG1
Large subunit GTPase 1 homolog

1

6

High-throughput

0.437

High

1330280

GCP60
Golgi resident protein GCP60

1

12

High-throughput

0.437

High

1330394

UN45A
Protein unc-45 homolog A

1

15

High-throughput

0.437

High

1334713

WDR41
WD repeat-containing protein 41

1

8

High-throughput

0.437

High

1342301

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

20

High-throughput

0.437

High

1344745

AAAS
Aladin

1

20

High-throughput

0.437

High

1347932

NSMA3
Sphingomyelin phosphodiesterase 4

1

2

High-throughput

0.437

High

1355170

SEC63
Translocation protein SEC63 homolog

1

20

High-throughput

0.437

High

1357274

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

20

Small-scale

0.437

High

1357279

SRPRB
Signal recognition particle receptor subunit beta

1

20

High-throughput

0.437

High

1357282

NUMBL
Numb-like protein

1

18

High-throughput

0.437

High

1203114

ZC3C1
Zinc finger C3HC-type protein 1

1

0

Small-scale

0.301

High

1012641

FP100
Fanconi anemia core complex-associated protein 100

1

0

High-throughput

0.261

Low

901759

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.249

Low

1304041

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.249

Low

1305227

C10
Protein C10

1

0

High-throughput

0.249

Low

1343514

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024