Protein: LAT
Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38)

Gene: LAT
Organism: Homo sapiens
Interactions: 114
UniProt ID: O43561

Gene Ontology (top 5):
GO:0001772 - immunological synapse
GO:0002250 - adaptive immune response
GO:0002260 - lymphocyte homeostasis
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

207423

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

8

2

Small-scale

0.756

High

207440

GRB2
Growth factor receptor-bound protein 2

9

9

Small-scale

0.752

High

207427

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

3

2

Small-scale

0.681

High

207397

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

3

1

High-throughput

0.675

High

207405

EGFR
Epidermal growth factor receptor

3

2

High-throughput

0.672

High

207410

LCK
Tyrosine-protein kinase Lck

2

4

Small-scale

0.655

High

207431

ZAP70
Tyrosine-protein kinase ZAP-70

3

6

Small-scale

0.651

High

207420

VAV
Proto-oncogene vav

2

6

Small-scale

0.629

High

207421

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

2

2

Small-scale

0.629

High

207401

GRAP2
GRB2-related adapter protein 2

2

10

Small-scale

0.624

High

207422

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

2

Small-scale

0.619

High

131296

CLD5
Claudin-5

2

2

High-throughput

0.606

High

156969

FFAR3
Free fatty acid receptor 3

2

3

High-throughput

0.606

High

183202

FFAR2
Free fatty acid receptor 2

2

3

High-throughput

0.606

High

207404

CLD7
Claudin-7

2

2

High-throughput

0.606

High

207433

KI2L3
Killer cell immunoglobulin-like receptor 2DL3

2

1

High-throughput

0.606

High

207434

CXA8
Gap junction alpha-8 protein

2

2

High-throughput

0.606

High

207439

CLD2
Claudin-2

2

2

High-throughput

0.606

High

207453

MF14B
Hippocampus abundant transcript-like protein 1

2

2

High-throughput

0.606

High

207458

LHPL1
LHFPL tetraspan subfamily member 1 protein

2

1

High-throughput

0.606

High

207466

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

1

High-throughput

0.606

High

207467

GP152
Probable G-protein coupled receptor 152

2

1

High-throughput

0.606

High

207468

GP151
G-protein coupled receptor 151

2

1

High-throughput

0.606

High

207475

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

2

1

High-throughput

0.606

High

207479

GP101
Probable G-protein coupled receptor 101

2

1

High-throughput

0.606

High

207497

ZDHC7
Palmitoyltransferase ZDHHC7

2

2

High-throughput

0.606

High

207442

ITK
Tyrosine-protein kinase ITK/TSK

2

4

Small-scale

0.595

High

207446

GRAP
GRB2-related adapter protein

2

9

Small-scale

0.595

High

207426

CBL
E3 ubiquitin-protein ligase CBL

2

2

Small-scale

0.584

High

207448

SHB
SH2 domain-containing adapter protein B

2

6

Small-scale

0.584

High

207409

SLPI
Antileukoproteinase

2

0

High-throughput

0.580

High

207412

ASGR2
Asialoglycoprotein receptor 2

2

0

High-throughput

0.580

High

207417

CD3G
T-cell surface glycoprotein CD3 gamma chain

2

0

High-throughput

0.580

High

207424

CD53
Leukocyte surface antigen CD53

2

0

High-throughput

0.580

High

207429

OPRM
Mu-type opioid receptor

2

0

High-throughput

0.580

High

207436

CAMLG
Guided entry of tail-anchored proteins factor CAMLG

2

0

High-throughput

0.580

High

207449

UT2
Urea transporter 2

2

0

High-throughput

0.580

High

207451

CX066
Uncharacterized protein CXorf66

2

0

High-throughput

0.580

High

207456

MFSD5
Molybdate-anion transporter

2

0

High-throughput

0.580

High

207457

OSTB
Organic solute transporter subunit beta

2

0

High-throughput

0.580

High

207464

SYT2
Synaptotagmin-2

2

0

High-throughput

0.580

High

207465

GOLM1
Golgi membrane protein 1

2

0

High-throughput

0.580

High

207469

SSMM1
Serine-rich single-pass membrane protein 1

2

0

High-throughput

0.580

High

207472

TM45B
Transmembrane protein 45B

2

0

High-throughput

0.580

High

207473

APH1A
Gamma-secretase subunit APH-1A

2

0

High-throughput

0.580

High

207474

T4S18
Transmembrane 4 L6 family member 18

2

0

High-throughput

0.580

High

207477

TMM80
Transmembrane protein 80

2

0

High-throughput

0.580

High

207480

TM237
Transmembrane protein 237

2

0

High-throughput

0.580

High

207485

B2L13
Bcl-2-like protein 13

2

0

High-throughput

0.580

High

207486

S26A6
Solute carrier family 26 member 6

2

0

High-throughput

0.580

High

207488

S19A3
Thiamine transporter 2

2

0

High-throughput

0.580

High

207489

MS4A7
Membrane-spanning 4-domains subfamily A member 7

2

0

High-throughput

0.580

High

207492

IF3M
Translation initiation factor IF-3, mitochondrial

2

0

High-throughput

0.580

High

207495

S35C2
Solute carrier family 35 member C2

2

0

High-throughput

0.580

High

207496

SAR1A
Small COPII coat GTPase SAR1A

2

0

High-throughput

0.580

High

207498

TR10D
Tumor necrosis factor receptor superfamily member 10D

2

0

High-throughput

0.580

High

207444

LCP2
Lymphocyte cytosolic protein 2

2

1

Small-scale

0.571

High

207461

THMS1
Protein THEMIS

2

1

Small-scale

0.570

High

207411

FYN
Tyrosine-protein kinase Fyn

1

4

Small-scale

0.569

High

207443

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

1

Small-scale

0.569

High

207398

CREB3
Cyclic AMP-responsive element-binding protein 3

2

0

High-throughput

0.565

High

207428

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

2

Small-scale

0.561

High

207500

TRAF6
TNF receptor-associated factor 6

2

0

Small-scale

0.559

High

207400

CXB3
Gap junction beta-3 protein

2

2

High-throughput

0.553

High

207415

CXB1
Gap junction beta-1 protein

2

2

High-throughput

0.553

High

207441

3BP2
SH3 domain-binding protein 2

2

1

Small-scale

0.543

High

207454

ZDH20
Palmitoyltransferase ZDHHC20

1

1

High-throughput

0.536

High

207494

ZDHC6
Palmitoyltransferase ZDHHC6

1

2

High-throughput

0.536

High

181962

GPR42
G-protein coupled receptor 42

1

3

High-throughput

0.515

High

207408

ALBU
Albumin

1

0

High-throughput

0.513

High

207491

MAGT1
Magnesium transporter protein 1

1

0

High-throughput

0.513

High

207432

KSYK
Tyrosine-protein kinase SYK

1

7

Small-scale

0.501

High

207414

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.479

High

207418

FCGR1
High affinity immunoglobulin gamma Fc receptor I

1

1

Small-scale

0.479

High

207419

FCG2A
Low affinity immunoglobulin gamma Fc region receptor II-a

1

1

Small-scale

0.479

High

207445

SLAP1
Src-like-adapter

1

5

Small-scale

0.479

High

207471

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

1

Small-scale

0.479

High

207499

GAB2
GRB2-associated-binding protein 2

1

1

Small-scale

0.479

High

111307

J3KQ12
Seipin

1

1

High-throughput

0.470

High

207455

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

207430

MOT8
Monocarboxylate transporter 8

1

0

High-throughput

0.460

High

207482

SERC2
Serine incorporator 2

1

0

High-throughput

0.460

High

207396

SPY1
Protein sprouty homolog 1

1

0

Small-scale

0.458

High

207399

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

0

Small-scale

0.458

High

207402

FLOT1
Flotillin-1

1

0

Small-scale

0.458

High

207413

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

0

Small-scale

0.458

High

207416

4F2
Amino acid transporter heavy chain SLC3A2

1

0

Small-scale

0.458

High

207425

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

Small-scale

0.458

High

207435

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

0

Small-scale

0.458

High

207447

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

0

Small-scale

0.458

High

207483

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

207437

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

207476

BSCL2
Seipin

1

1

High-throughput

0.439

High

68657

LEUTX
Paired-like homeodomain transcription factor LEUTX

2

0

High-throughput

0.316

High

207438

VMAT1
Chromaffin granule amine transporter

2

0

High-throughput

0.316

High

207450

PROL4
Proline-rich protein 4

2

0

High-throughput

0.316

High

207460

NDUF2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

2

0

High-throughput

0.316

High

207462

KCD17
BTB/POZ domain-containing protein KCTD17

2

0

High-throughput

0.316

High

207470

THAP4
Peroxynitrite isomerase THAP4

2

0

High-throughput

0.316

High

207478

JSPR1
Junctional sarcoplasmic reticulum protein 1

2

0

High-throughput

0.316

High

207484

CYBC1
Cytochrome b-245 chaperone 1

2

0

High-throughput

0.316

High

207487

MLP3C
Microtubule-associated proteins 1A/1B light chain 3C

2

0

High-throughput

0.316

High

207490

MFF
Mitochondrial fission factor

2

0

High-throughput

0.316

High

207493

CDIP1
Cell death-inducing p53-target protein 1

2

0

High-throughput

0.316

High

207501

RT18B
Small ribosomal subunit protein mS40

2

0

High-throughput

0.316

High

207502

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

2

0

High-throughput

0.316

High

207463

KASH5
Protein KASH5

1

0

High-throughput

0.292

High

207503

ZHX2
Zinc fingers and homeoboxes protein 2

1

0

High-throughput

0.282

High

207481

LMF1
Lipase maturation factor 1

1

0

High-throughput

0.279

Low

207406

CO1A1
Collagen alpha-1(I) chain

1

0

High-throughput

0.269

Low

207407

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.251

Low

207452

F209A
Protein FAM209A

1

0

High-throughput

0.251

Low

207403

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

0

High-throughput

0.249

Low

207459

CLYBL
Citramalyl-CoA lyase, mitochondrial

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024