Protein: MK01
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)

Gene: MK01, Mapk1
Organism: Rattus norvegicus
Interactions: 168
UniProt ID: P63086

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001784 - phosphotyrosine residue binding
GO:0003690 - double-stranded DNA binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

926490

DCC
Netrin receptor DCC

1

2

Small-scale

0.800

High

600373

MK03
Mitogen-activated protein kinase 3

2

19

Small-scale

0.737

High

926496

DUS6
Dual specificity protein phosphatase 6

1

20

Small-scale

0.647

High

139211

DGKZ
Diacylglycerol kinase zeta

1

5

High-throughput

0.618

High

448414

KPCE
Protein kinase C epsilon type

1

9

High-throughput

0.618

High

450585

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed]

1

5

High-throughput

0.618

High

519444

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

4

High-throughput

0.618

High

519447

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

4

High-throughput

0.618

High

526552

KCC4
Calcium/calmodulin-dependent protein kinase type IV

1

14

High-throughput

0.618

High

576047

GSK3B
Glycogen synthase kinase-3 beta

1

20

High-throughput

0.618

High

829627

DGKG
Diacylglycerol kinase gamma

1

11

High-throughput

0.618

High

829628

DGKB
Diacylglycerol kinase beta

1

10

High-throughput

0.618

High

926286

DNJA1
DnaJ homolog subfamily A member 1

1

7

High-throughput

0.618

High

926445

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

6

High-throughput

0.618

High

926446

KPCB
Protein kinase C beta type

1

9

High-throughput

0.618

High

926447

FAK2
Protein-tyrosine kinase 2-beta

1

5

High-throughput

0.618

High

926451

KALRN
Kalirin

1

5

High-throughput

0.618

High

926456

SRSF5
Serine/arginine-rich splicing factor 5

1

8

High-throughput

0.618

High

926460

Q3SWU5
Protein kinase, cAMP dependent regulatory, type I, beta

1

5

High-throughput

0.618

High

926475

DCLK2
Serine/threonine-protein kinase DCLK2

1

17

High-throughput

0.618

High

926480

RHEB
GTP-binding protein Rheb

1

1

High-throughput

0.618

High

926481

CAPS1
Calcium-dependent secretion activator 1

1

1

High-throughput

0.618

High

926483

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

5

High-throughput

0.618

High

926486

ROCK2
Rho-associated protein kinase 2

1

8

High-throughput

0.618

High

926489

CAMKV
CaM kinase-like vesicle-associated protein

1

15

High-throughput

0.618

High

926493

CDC37
Hsp90 co-chaperone Cdc37

1

8

High-throughput

0.618

High

926494

RAB3D
GTP-binding protein Rab-3D

1

1

High-throughput

0.618

High

926503

PHIPL
Phytanoyl-CoA hydroxylase-interacting protein-like

1

1

High-throughput

0.618

High

926516

PPM1E
Protein phosphatase 1E

1

14

High-throughput

0.618

High

926517

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

7

High-throughput

0.618

High

926518

CSKI1
Caskin-1

1

6

High-throughput

0.618

High

926528

GIT1
ARF GTPase-activating protein GIT1

1

7

High-throughput

0.618

High

926512

RAC1
Ras-related C3 botulinum toxin substrate 1

1

0

Small-scale

0.586

High

926465

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

8

High-throughput

0.553

High

926505

TANC1
Protein TANC1

1

5

High-throughput

0.553

High

94088

F1LSE6
PTPRF interacting protein alpha 3

1

0

High-throughput

0.517

High

741629

CNN3
Calponin-3

1

4

Small-scale

0.512

High

362114

MBP
Myelin basic protein

1

6

Small-scale

0.501

High

739627

SCNNB
Amiloride-sensitive sodium channel subunit beta

1

1

Small-scale

0.501

High

739629

SCNNG
Amiloride-sensitive sodium channel subunit gamma

1

1

Small-scale

0.501

High

926454

CNN1
Calponin-1

1

7

Small-scale

0.501

High

88532

H15
Histone H1.5

1

2

High-throughput

0.479

High

88683

TRIM2
Tripartite motif-containing protein 2

1

4

High-throughput

0.479

High

94062

F1LPP6
A-kinase anchoring protein 5

1

4

High-throughput

0.479

High

94196

F1LST4
Microtubule-associated protein

1

9

High-throughput

0.479

High

94323

RPGF2
Rap guanine nucleotide exchange factor 2

1

3

High-throughput

0.479

High

192863

RABE1
Rab GTPase-binding effector protein 1

1

1

High-throughput

0.479

High

193637

SH3G1
Endophilin-A2

1

2

High-throughput

0.479

High

250673

TRIM3
Tripartite motif-containing protein 3

1

4

High-throughput

0.479

High

472790

MAP1S
Microtubule-associated protein 1S

1

4

High-throughput

0.479

High

527225

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

3

High-throughput

0.479

High

594790

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

8

High-throughput

0.479

High

621628

RS27L
Small ribosomal subunit protein eS27-like

1

1

High-throughput

0.479

High

676645

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

11

High-throughput

0.479

High

677771

DLG4
Disks large homolog 4

1

9

High-throughput

0.479

High

722990

PGH2
Prostaglandin G/H synthase 2

1

2

Small-scale

0.479

High

783513

TOP2A
DNA topoisomerase 2-alpha

1

3

High-throughput

0.479

High

812781

RP3A
Rabphilin-3A

1

1

High-throughput

0.479

High

825310

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.479

High

854016

AP1B1
AP-1 complex subunit beta-1

1

3

High-throughput

0.479

High

856977

PYC
Pyruvate carboxylase, mitochondrial

1

5

High-throughput

0.479

High

888135

RUVB1
RuvB-like 1

1

7

High-throughput

0.479

High

906971

PRS4
26S proteasome regulatory subunit 4

1

1

High-throughput

0.479

High

907219

PRS8
26S proteasome regulatory subunit 8

1

3

High-throughput

0.479

High

916474

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

923850

AP2B1
AP-2 complex subunit beta

1

3

High-throughput

0.479

High

926449

AP2M1
AP-2 complex subunit mu

1

2

High-throughput

0.479

High

926450

EFTU
Elongation factor Tu, mitochondrial

1

10

High-throughput

0.479

High

926452

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

926453

H2B1
Histone H2B type 1

1

9

High-throughput

0.479

High

926455

PGTA
Geranylgeranyl transferase type-2 subunit alpha

1

4

High-throughput

0.479

High

926457

CRTC1
CREB-regulated transcription coactivator 1

1

3

High-throughput

0.479

High

926458

KINH
Kinesin-1 heavy chain

1

1

High-throughput

0.479

High

926459

IF4A3
Eukaryotic initiation factor 4A-III

1

5

High-throughput

0.479

High

926462

COPG1
Coatomer subunit gamma-1

1

4

High-throughput

0.479

High

926463

STML2
Stomatin-like protein 2, mitochondrial

1

1

High-throughput

0.479

High

926464

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

High-throughput

0.479

High

926467

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

1

High-throughput

0.479

High

926468

PHYIP
Phytanoyl-CoA hydroxylase-interacting protein

1

1

High-throughput

0.479

High

926469

Q56R20
Importin subunit alpha

1

1

High-throughput

0.479

High

926470

ARHG2
Rho guanine nucleotide exchange factor 2

1

5

High-throughput

0.479

High

926471

Q5FVT5
Protein-serine/threonine kinase

1

1

High-throughput

0.479

High

926474

MAP4
Microtubule-associated protein 4

1

13

High-throughput

0.479

High

926476

AKA12
A-kinase anchor protein 12

1

2

High-throughput

0.479

High

926479

MARE3
Microtubule-associated protein RP/EB family member 3

1

2

High-throughput

0.479

High

926484

RABE2
Rab GTPase-binding effector protein 2

1

1

High-throughput

0.479

High

926487

SYNJ1
Synaptojanin-1

1

2

High-throughput

0.479

High

926488

DLG3
Disks large homolog 3

1

7

High-throughput

0.479

High

926491

PRS7
26S proteasome regulatory subunit 7

1

3

High-throughput

0.479

High

926492

MAP6
Microtubule-associated protein 6

1

4

High-throughput

0.479

High

926498

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

3

High-throughput

0.479

High

926499

PDK2
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

926504

RTCB
RNA-splicing ligase RtcB homolog

1

1

High-throughput

0.479

High

926506

Q6GMM8
long-chain-fatty-acid--CoA ligase

1

1

High-throughput

0.479

High

926513

RS27
Small ribosomal subunit protein eS27

1

1

High-throughput

0.479

High

926514

SRR
Serine racemase

1

2

High-throughput

0.479

High

926515

FMR1
Fragile X messenger ribonucleoprotein 1

1

3

High-throughput

0.479

High

926521

ACBG1
Long-chain-fatty-acid--CoA ligase ACSBG1

1

2

High-throughput

0.479

High

926522

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.479

High

926523

CLAP2
CLIP-associating protein 2

1

2

High-throughput

0.479

High

926524

WDR7
WD repeat-containing protein 7

1

6

High-throughput

0.479

High

926525

DBNL
Drebrin-like protein

1

4

High-throughput

0.479

High

926526

DCTN4
Dynactin subunit 4

1

1

High-throughput

0.479

High

926527

PDE10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

1

1

High-throughput

0.479

High

102546

G3V8L9
Caveolae associated protein 1

1

0

High-throughput

0.458

High

102562

G3V8V3
Alpha-1,4 glucan phosphorylase

1

0

High-throughput

0.458

High

140038

MADD
MAP kinase-activating death domain protein

1

0

High-throughput

0.458

High

250753

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.458

High

291948

PACS1
Phosphofurin acidic cluster sorting protein 1

1

0

High-throughput

0.458

High

357590

RLA2
Large ribosomal subunit protein P2

1

0

High-throughput

0.458

High

456145

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

517018

RL18
Large ribosomal subunit protein eL18

1

0

High-throughput

0.458

High

525689

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

577089

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.458

High

588364

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.458

High

592831

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

0

Small-scale

0.458

High

599226

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

615506

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.458

High

621625

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.458

High

655926

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.458

High

665139

RS9
Small ribosomal subunit protein uS4

1

0

High-throughput

0.458

High

741133

KLC1
Kinesin light chain 1

1

0

High-throughput

0.458

High

760421

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.458

High

780908

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.458

High

794678

H10
Histone H1.0

1

0

High-throughput

0.458

High

842152

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.458

High

899427

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.458

High

905803

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.458

High

911310

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

913866

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.458

High

915151

RS4X
Small ribosomal subunit protein eS4

1

0

High-throughput

0.458

High

915353

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.458

High

917022

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

920134

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

922046

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

922768

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.458

High

926448

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.458

High

926461

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

0

High-throughput

0.458

High

926466

ROGDI
Protein rogdi homolog

1

0

High-throughput

0.458

High

926472

IMPCT
Protein IMPACT

1

0

High-throughput

0.458

High

926473

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

1

0

High-throughput

0.458

High

926477

Q5RK10
Large ribosomal subunit protein uL13

1

0

High-throughput

0.458

High

926478

PITM1
Membrane-associated phosphatidylinositol transfer protein 1

1

0

High-throughput

0.458

High

926482

EXOC4
Exocyst complex component 4

1

0

High-throughput

0.458

High

926485

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.458

High

926497

LXN
Latexin

1

0

High-throughput

0.458

High

926501

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.458

High

926507

NDRG1
Protein NDRG1

1

0

High-throughput

0.458

High

926508

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.458

High

926509

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

926510

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

926511

ATLA1
Atlastin-1

1

0

High-throughput

0.458

High

926519

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

926520

ASGL1
Isoaspartyl peptidase/L-asparaginase

1

0

High-throughput

0.458

High

581973

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.445

High

582856

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

4

High-throughput

0.445

High

102479

G3V6I9
Large ribosomal subunit protein uL24

1

1

High-throughput

0.437

High

893231

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

911588

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.437

High

926500

Q66HM2
AP-2 complex subunit alpha

1

4

High-throughput

0.437

High

926502

RPAP3
RNA polymerase II-associated protein 3

1

2

High-throughput

0.437

High

69530

B0K031
Large ribosomal subunit protein uL30

1

0

High-throughput

0.249

Low

102540

G3V8J5
Pleckstrin and Sec7 domain containing

1

0

High-throughput

0.249

Low

907627

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.249

Low

908250

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.249

Low

910795

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.249

Low

920425

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.249

Low

926495

Q642E2
Large ribosomal subunit protein eL28

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024