Protein: TPM4
Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)

Gene: TPM4
Organism: Homo sapiens
Interactions: 187
UniProt ID: P67936

Gene Ontology (top 5):
GO:0001649 - osteoblast differentiation
GO:0001725 - stress fiber
GO:0002102 - podosome
GO:0005509 - calcium ion binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

451235

TPM1
Tropomyosin alpha-1 chain

5

15

High-throughput

0.923

High

418935

TPM3
Tropomyosin alpha-3 chain

5

15

High-throughput

0.920

High

434370

TPM2
Tropomyosin beta chain

3

16

High-throughput

0.847

High

724765

MYH9
Myosin-9

1

6

High-throughput

0.691

High

932031

MY18A
Unconventional myosin-XVIIIa

1

13

High-throughput

0.691

High

932038

MYO19
Unconventional myosin-XIX

1

9

High-throughput

0.691

High

528953

CFTR
Cystic fibrosis transmembrane conductance regulator

3

3

High-throughput

0.650

High

932057

ANLN
Anillin

3

4

High-throughput

0.640

High

897032

ACTZ
Alpha-centractin

1

13

High-throughput

0.618

High

625341

CDK2
Cyclin-dependent kinase 2

2

7

High-throughput

0.611

High

310927

SNAPN
SNARE-associated protein Snapin

2

3

High-throughput

0.606

High

397899

ISG15
Ubiquitin-like protein ISG15

2

6

Small-scale

0.595

High

932056

SMUF1
E3 ubiquitin-protein ligase SMURF1

2

2

Small-scale

0.595

High

932059

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

522892

SRC
Proto-oncogene tyrosine-protein kinase Src

2

2

High-throughput

0.571

High

845431

RAB9A
Ras-related protein Rab-9A

2

0

High-throughput

0.547

High

346478

MYC
Myc proto-oncogene protein

2

6

High-throughput

0.543

High

135428

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

2

High-throughput

0.536

High

170325

TIF1A
Transcription intermediary factor 1-alpha

1

6

High-throughput

0.536

High

213894

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

16

High-throughput

0.536

High

547777

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

11

High-throughput

0.536

High

570520

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

2

High-throughput

0.536

High

579190

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

15

High-throughput

0.536

High

598054

FLNA
Filamin-A

1

6

High-throughput

0.536

High

681779

AKT1
RAC-alpha serine/threonine-protein kinase

1

7

Small-scale

0.536

High

725943

ADDA
Alpha-adducin

1

4

High-throughput

0.536

High

737733

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

8

High-throughput

0.536

High

739065

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

809261

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

5

High-throughput

0.536

High

906405

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

8

High-throughput

0.536

High

932011

DUS7
Dual specificity protein phosphatase 7

1

2

High-throughput

0.536

High

932021

PIM3
Serine/threonine-protein kinase pim-3

1

11

High-throughput

0.536

High

932036

VMP1
Vacuole membrane protein 1

1

8

High-throughput

0.536

High

932058

PDLI7
PDZ and LIM domain protein 7

1

11

High-throughput

0.536

High

932060

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.536

High

932069

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

3

High-throughput

0.536

High

100667

APRIO
Alternative prion protein

2

1

High-throughput

0.533

High

932044

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

1

0

High-throughput

0.518

High

431203

CATB
Cathepsin B

1

3

High-throughput

0.515

High

648716

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.515

High

932073

DUS12
Dual specificity protein phosphatase 12

1

3

High-throughput

0.515

High

126793

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.513

High

175378

PPM1D
Protein phosphatase 1D

1

0

High-throughput

0.513

High

532843

HEM2
Delta-aminolevulinic acid dehydratase

1

0

High-throughput

0.513

High

673565

MPIP3
M-phase inducer phosphatase 3

1

0

High-throughput

0.513

High

827160

ARRB1
Beta-arrestin-1

1

0

High-throughput

0.513

High

932009

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

932023

RM50
Large ribosomal subunit protein mL50

1

0

High-throughput

0.513

High

932049

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

0

High-throughput

0.513

High

932062

LANC2
LanC-like protein 2

1

0

High-throughput

0.513

High

932072

ASC
Apoptosis-associated speck-like protein containing a CARD

1

0

Small-scale

0.513

High

932074

PPR3C
Protein phosphatase 1 regulatory subunit 3C

1

0

High-throughput

0.513

High

932034

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

High-throughput

0.501

High

849882

STA5B
Signal transducer and activator of transcription 5B

1

3

High-throughput

0.500

High

858087

NKX25
Homeobox protein Nkx-2.5

1

5

High-throughput

0.500

High

931993

IRF8
Interferon regulatory factor 8

1

1

High-throughput

0.500

High

932043

KLF6
Krueppel-like factor 6

1

11

High-throughput

0.500

High

932076

KLF12
Krueppel-like factor 12

1

11

High-throughput

0.500

High

932061

PHP14
14 kDa phosphohistidine phosphatase

1

0

High-throughput

0.493

High

932004

FL2D
Pre-mRNA-splicing regulator WTAP

1

2

High-throughput

0.489

High

932028

DUS19
Dual specificity protein phosphatase 19

1

3

High-throughput

0.489

High

932032

ESR2
Estrogen receptor beta

1

9

Small-scale

0.489

High

932045

HDAC8
Histone deacetylase 8

1

6

High-throughput

0.489

High

932051

DUS21
Dual specificity protein phosphatase 21

1

2

High-throughput

0.489

High

932055

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

2

High-throughput

0.489

High

932066

CFA97
Cilia- and flagella-associated protein 97

1

2

High-throughput

0.489

High

260544

TP4A3
Protein tyrosine phosphatase type IVA 3

1

1

High-throughput

0.488

High

932007

TRIP6
Thyroid receptor-interacting protein 6

1

11

Small-scale

0.481

High

932054

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

2

Small-scale

0.481

High

120382

RHOD
Rho-related GTP-binding protein RhoD

1

10

High-throughput

0.479

High

148661

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.479

High

167895

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

177862

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.479

High

225604

PCDH7
Protocadherin-7

1

1

High-throughput

0.479

High

227127

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

231086

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

4

High-throughput

0.479

High

256241

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

10

High-throughput

0.479

High

297602

RHBT1
Rho-related BTB domain-containing protein 1

1

13

High-throughput

0.479

High

301749

TRI37
E3 ubiquitin-protein ligase TRIM37

1

11

High-throughput

0.479

High

304817

MFN2
Mitofusin-2

1

1

High-throughput

0.479

High

338262

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

345393

FOS
Protein c-Fos

1

12

High-throughput

0.479

High

374031

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

384630

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

386496

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

429869

CATL1
Procathepsin L

1

3

High-throughput

0.479

High

435035

SP1
Transcription factor Sp1

1

7

Small-scale

0.479

High

456540

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

4

Small-scale

0.479

High

456846

FURIN
Furin

1

3

High-throughput

0.479

High

487321

ANDR
Androgen receptor

1

9

High-throughput

0.479

High

525475

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

2

High-throughput

0.479

High

525898

IFM1
Interferon-induced transmembrane protein 1

1

2

High-throughput

0.479

High

562548

IL7RA
Interleukin-7 receptor subunit alpha

1

1

High-throughput

0.479

High

569567

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

590825

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

657482

TMOD1
Tropomodulin-1

1

6

High-throughput

0.479

High

779215

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

785845

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

3

High-throughput

0.479

High

812986

CAZA2
F-actin-capping protein subunit alpha-2

1

5

High-throughput

0.479

High

813369

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.479

High

841153

CDK7
Cyclin-dependent kinase 7

1

7

High-throughput

0.479

High

841640

CDK9
Cyclin-dependent kinase 9

1

9

High-throughput

0.479

High

849989

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

High-throughput

0.479

High

901119

RND3
Rho-related GTP-binding protein RhoE

1

12

High-throughput

0.479

High

908341

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

925177

RAC1
Ras-related C3 botulinum toxin substrate 1

1

7

High-throughput

0.479

High

931994

RON
Macrophage-stimulating protein receptor

1

2

High-throughput

0.479

High

931995

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.479

High

931996

FOXO1
Forkhead box protein O1

1

4

High-throughput

0.479

High

931997

TRI26
Tripartite motif-containing protein 26

1

4

Small-scale

0.479

High

932000

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

14

High-throughput

0.479

High

932001

SCRB2
Lysosome membrane protein 2

1

3

High-throughput

0.479

High

932003

CUL7
Cullin-7

1

1

High-throughput

0.479

High

932005

TNIP1
TNFAIP3-interacting protein 1

1

12

High-throughput

0.479

High

932006

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

932008

RHOH
Rho-related GTP-binding protein RhoH

1

9

High-throughput

0.479

High

932012

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

3

High-throughput

0.479

High

932013

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

932014

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

932015

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

5

High-throughput

0.479

High

932016

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

932017

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

4

High-throughput

0.479

High

932019

RHOU
Rho-related GTP-binding protein RhoU

1

12

High-throughput

0.479

High

932020

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

932026

RIN3
Ras and Rab interactor 3

1

2

High-throughput

0.479

High

932030

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

932035

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

932037

AURKB
Aurora kinase B

1

9

High-throughput

0.479

High

932039

RHOV
Rho-related GTP-binding protein RhoV

1

12

High-throughput

0.479

High

932046

RHBT2
Rho-related BTB domain-containing protein 2

1

14

High-throughput

0.479

High

932048

DDX24
ATP-dependent RNA helicase DDX24

1

3

High-throughput

0.479

High

932052

ECT2
Protein ECT2

1

3

High-throughput

0.479

High

932053

RHOF
Rho-related GTP-binding protein RhoF

1

10

High-throughput

0.479

High

932067

HDAC6
Histone deacetylase 6

1

6

High-throughput

0.479

High

932068

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

932070

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.479

High

932071

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.479

High

932075

AKT3
RAC-gamma serine/threonine-protein kinase

1

7

High-throughput

0.479

High

637235

CATS
Cathepsin S

1

3

High-throughput

0.470

High

503865

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

547526

FOLR1
Folate receptor alpha

1

0

High-throughput

0.458

High

583315

HXK1
Hexokinase-1

1

0

High-throughput

0.458

High

828979

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

870744

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

932018

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.458

High

932022

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.458

High

932033

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

234704

ZIC3
Zinc finger protein ZIC 3

1

5

High-throughput

0.457

High

679086

TLX1
T-cell leukemia homeobox protein 1

1

2

High-throughput

0.457

High

785350

ELK3
ETS domain-containing protein Elk-3

1

2

High-throughput

0.457

High

798844

GATA4
Transcription factor GATA-4

1

2

High-throughput

0.457

High

884127

KLF3
Krueppel-like factor 3

1

11

High-throughput

0.457

High

931998

KLF10
Krueppel-like factor 10

1

10

High-throughput

0.457

High

496812

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

717674

BMI1
Polycomb complex protein BMI-1

1

9

High-throughput

0.445

High

931991

RHOG
Rho-related GTP-binding protein RhoG

1

7

Small-scale

0.445

High

932041

CEP63
Centrosomal protein of 63 kDa

1

17

High-throughput

0.445

High

932027

LNX1
E3 ubiquitin-protein ligase LNX

1

4

High-throughput

0.439

High

154777

TCRG1
Transcription elongation regulator 1

1

3

Small-scale

0.437

High

205257

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.437

High

308603

KI20A
Kinesin-like protein KIF20A

1

7

High-throughput

0.437

High

328801

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.437

High

352573

TNFA
Tumor necrosis factor

1

9

High-throughput

0.437

High

832349

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.437

High

855896

ZN131
Zinc finger protein 131

1

2

High-throughput

0.437

High

931992

IFM3
Interferon-induced transmembrane protein 3

1

2

High-throughput

0.437

High

932010

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

932024

FHI1B
FHF complex subunit HOOK-interacting protein 1B

1

2

High-throughput

0.437

High

932029

CLC4D
C-type lectin domain family 4 member D

1

3

High-throughput

0.437

High

932047

UNK
RING finger protein unkempt homolog

1

2

High-throughput

0.437

High

932050

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

932063

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

932065

RN181
E3 ubiquitin-protein ligase RNF181

1

2

High-throughput

0.437

High

378024

PRIO
Major prion protein

1

0

High-throughput

0.426

High

239922

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.407

High

931999

CTBP1
C-terminal-binding protein 1

1

3

High-throughput

0.407

High

932042

ZBT18
Zinc finger and BTB domain-containing protein 18

1

5

High-throughput

0.407

High

69679

HACD1
Very-long-chain

1

0

High-throughput

0.279

Low

932002

PTCA
Protein tyrosine phosphatase receptor type C-associated protein

1

0

High-throughput

0.279

Low

932025

PPTC7
Protein phosphatase PTC7 homolog

1

0

High-throughput

0.279

Low

932040

PPM1M
Protein phosphatase 1M

1

0

High-throughput

0.279

Low

269554

JERKY
Jerky protein homolog

1

0

High-throughput

0.268

Low

658478

TEAD1
Transcriptional enhancer factor TEF-1

1

0

High-throughput

0.261

Low

727721

SOX5
Transcription factor SOX-5

1

0

High-throughput

0.261

Low

932064

VSX1
Visual system homeobox 1

1

0

High-throughput

0.261

Low

842106

R144A
E3 ubiquitin-protein ligase RNF144A

1

0

Small-scale

0.249

Low

931990

CBX1
Chromobox protein homolog 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024