Protein: HERC4
Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4)

Gene: HERC4
Organism: Homo sapiens
Interactions: 54
UniProt ID: Q5GLZ8

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0007283 - spermatogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

475871

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

20

Small-scale

0.778

High

919741

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

Small-scale

0.778

High

932524

UB2L3
Ubiquitin-conjugating enzyme E2 L3

2

20

Small-scale

0.778

High

1125812

HERC4
Probable E3 ubiquitin-protein ligase HERC4

2

17

Small-scale

0.778

High

324438

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.691

High

1125821

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

20

Small-scale

0.647

High

1125824

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

Small-scale

0.647

High

313135

MOCS3
Adenylyltransferase and sulfurtransferase MOCS3

2

11

High-throughput

0.628

High

1125818

NLRX1
NLR family member X1

2

5

High-throughput

0.628

High

1125829

LOXE3
Hydroperoxide isomerase ALOXE3

2

1

High-throughput

0.628

High

1125833

WRP73
WD repeat-containing protein WRAP73

2

5

High-throughput

0.628

High

1125828

FDXA1
Ferredoxin-fold anticodon-binding domain-containing protein 1

2

1

High-throughput

0.621

High

398000

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.618

High

1125820

HERC6
Probable E3 ubiquitin-protein ligase HERC6

1

17

Small-scale

0.618

High

1125814

KLH10
Kelch-like protein 10

2

0

High-throughput

0.602

High

921597

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.536

High

1023175

FLII
Protein flightless-1 homolog

1

5

High-throughput

0.536

High

1109797

WDR72
WD repeat-containing protein 72

1

14

High-throughput

0.536

High

1125826

DNJC7
DnaJ homolog subfamily C member 7

1

12

High-throughput

0.536

High

1125830

NUF2
Kinetochore protein Nuf2

1

9

High-throughput

0.536

High

1125813

Q6ICH2
Apolipoprotein B mRNA editing enzyme catalytic subunit 3D

2

5

High-throughput

0.533

High

267164

GEMI
Geminin

1

0

High-throughput

0.513

High

414309

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.513

High

1075507

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.513

High

1125823

MAFA
Transcription factor MafA

1

9

Small-scale

0.512

High

946398

EREP3
Protein ENTREP3

1

17

High-throughput

0.489

High

1100048

INF2
Inverted formin-2

1

7

High-throughput

0.489

High

1121777

ANR39
Ankyrin repeat domain-containing protein 39

1

8

High-throughput

0.489

High

1125753

ARSH
Arylsulfatase H

1

2

High-throughput

0.489

High

1125816

ABH15
Protein ABHD15

1

1

High-throughput

0.489

High

1125834

ZN215
Zinc finger protein 215

1

2

High-throughput

0.489

High

265139

MAF
Transcription factor Maf

1

1

Small-scale

0.479

High

414514

PRGR
Progesterone receptor

1

18

Small-scale

0.479

High

431935

HS90A
Heat shock protein HSP 90-alpha

1

14

High-throughput

0.479

High

438245

HS90B
Heat shock protein HSP 90-beta

1

14

High-throughput

0.479

High

779537

CCNF
Cyclin-F

1

10

High-throughput

0.479

High

940996

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1035462

SMAD4
Mothers against decapentaplegic homolog 4

1

20

High-throughput

0.479

High

1125817

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.479

High

1125819

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1125831

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

10

High-throughput

0.479

High

1125832

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

3

Small-scale

0.479

High

217898

PRKY
Putative serine/threonine-protein kinase PRKY

1

20

High-throughput

0.445

High

1125825

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

5

High-throughput

0.445

High

384958

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.437

High

720630

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

1125822

PLD5
Inactive phospholipase D5

1

1

High-throughput

0.437

High

1125827

SMO
Protein smoothened

1

3

Small-scale

0.437

High

70157

B2CML4
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3DE

1

5

High-throughput

0.407

High

1125815

CA094
Uncharacterized protein C1orf94

2

0

High-throughput

0.328

High

159372

PLD2
Phospholipase D2

2

0

High-throughput

0.318

High

1125550

CAR16
Caspase recruitment domain-containing protein 16

1

0

High-throughput

0.279

Low

819589

INAR2
Interferon alpha/beta receptor 2

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024