Protein: TGM1
Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1)

Gene: TGM1
Organism: Homo sapiens
Interactions: 224
UniProt ID: P22735

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0003810 - protein-glutamine gamma-glutamyltransferase activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0010838 - positive regulation of keratinocyte proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

611204

TGM1
Protein-glutamine gamma-glutamyltransferase K

2

2

High-throughput

0.783

High

611227

CF298
Cilia- and flagella-associated protein 298

3

1

High-throughput

0.667

High

611211

MPI
Mannose-6-phosphate isomerase

3

0

High-throughput

0.638

High

611338

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

3

0

High-throughput

0.638

High

365151

FRIH
Ferritin heavy chain

2

2

High-throughput

0.628

High

611246

NONO
Non-POU domain-containing octamer-binding protein

2

1

High-throughput

0.628

High

611249

ZIC1
Zinc finger protein ZIC 1

2

1

High-throughput

0.628

High

611319

CDK15
Cyclin-dependent kinase 15

2

1

High-throughput

0.628

High

611362

DD19B
ATP-dependent RNA helicase DDX19B

2

2

High-throughput

0.611

High

274681

B3GL1
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

3

2

High-throughput

0.609

High

327043

GPAN1
G patch domain and ankyrin repeat-containing protein 1

3

2

High-throughput

0.609

High

611313

MITOK
Mitochondrial potassium channel

3

2

High-throughput

0.609

High

611315

GMCL1
Germ cell-less protein-like 1

3

1

High-throughput

0.609

High

448292

GSTP1
Glutathione S-transferase P

2

1

High-throughput

0.606

High

556414

ITB4
Integrin beta-4

2

3

High-throughput

0.606

High

611206

KRA59
Keratin-associated protein 5-9

2

2

High-throughput

0.606

High

611241

SREC
Scavenger receptor class F member 1

2

2

High-throughput

0.606

High

611301

DOCK2
Dedicator of cytokinesis protein 2

2

2

High-throughput

0.606

High

611244

TNIP1
TNFAIP3-interacting protein 1

2

2

High-throughput

0.584

High

398490

PPB1
Alkaline phosphatase, placental type

2

0

High-throughput

0.580

High

526641

GILT
Gamma-interferon-inducible lysosomal thiol reductase

2

0

High-throughput

0.580

High

611245

JOS1
Josephin-1

2

0

High-throughput

0.580

High

611254

LCE1E
Late cornified envelope protein 1E

2

0

High-throughput

0.580

High

611255

LCE1B
Late cornified envelope protein 1B

2

0

High-throughput

0.580

High

611256

LCE3A
Late cornified envelope protein 3A

2

0

High-throughput

0.580

High

611257

LCE4A
Late cornified envelope protein 4A

2

0

High-throughput

0.580

High

611259

VASN
Vasorin

2

0

High-throughput

0.580

High

611279

VSTM4
V-set and transmembrane domain-containing protein 4 [Cleaved into: Peptide Lv]

2

0

High-throughput

0.580

High

611289

CNNM3
Metal transporter CNNM3

2

0

High-throughput

0.580

High

611296

TPC14
Trafficking protein particle complex subunit 14

2

0

High-throughput

0.580

High

611302

NECT2
Nectin-2

2

0

High-throughput

0.580

High

611307

IGSF8
Immunoglobulin superfamily member 8

2

0

High-throughput

0.580

High

611323

KR412
Keratin-associated protein 4-12

2

0

High-throughput

0.580

High

611324

ST4A1
Sulfotransferase 4A1

2

0

High-throughput

0.580

High

611330

C1QT1
Complement C1q tumor necrosis factor-related protein 1

2

0

High-throughput

0.580

High

611371

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

2

0

High-throughput

0.580

High

217442

AIRE
Autoimmune regulator

2

2

High-throughput

0.574

High

611280

CC103
Coiled-coil domain-containing protein 103

2

1

High-throughput

0.574

High

611349

TB22B
TBC1 domain family member 22B

2

2

High-throughput

0.574

High

611258

MYOME
Myomegalin

2

1

High-throughput

0.558

High

200808

ZSC12
Zinc finger and SCAN domain-containing protein 12

2

1

High-throughput

0.552

High

611291

RIN3
Ras and Rab interactor 3

2

0

High-throughput

0.551

High

125971

UPK1A
Uroplakin-1a

1

2

High-throughput

0.536

High

128443

DNM1L
Dynamin-1-like protein

1

3

High-throughput

0.536

High

159890

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

High-throughput

0.536

High

174360

FANCG
Fanconi anemia group G protein

1

1

High-throughput

0.536

High

203340

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

2

High-throughput

0.536

High

213886

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

2

High-throughput

0.536

High

237164

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.536

High

274934

RENR
Renin receptor

1

2

High-throughput

0.536

High

300716

GLSK
Glutaminase kidney isoform, mitochondrial

1

1

High-throughput

0.536

High

320494

OXSR1
Serine/threonine-protein kinase OSR1

1

2

High-throughput

0.536

High

333630

ADH1G
Alcohol dehydrogenase 1C

1

1

High-throughput

0.536

High

518253

ADT3
ADP/ATP translocase 3

1

2

High-throughput

0.536

High

565871

AATC
Aspartate aminotransferase, cytoplasmic

1

2

High-throughput

0.536

High

580929

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

High-throughput

0.536

High

599614

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

3

High-throughput

0.536

High

611208

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

2

High-throughput

0.536

High

611209

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

611210

ERD22
ER lumen protein-retaining receptor 2

1

1

High-throughput

0.536

High

611217

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.536

High

611219

PTSS1
Phosphatidylserine synthase 1

1

1

High-throughput

0.536

High

611221

ASCL1
Achaete-scute homolog 1

1

1

High-throughput

0.536

High

611225

STX17
Syntaxin-17

1

2

High-throughput

0.536

High

611231

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

2

High-throughput

0.536

High

611232

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.536

High

611233

FAK1
Focal adhesion kinase 1

1

4

High-throughput

0.536

High

611239

ZN154
Zinc finger protein 154

1

2

High-throughput

0.536

High

611248

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.536

High

611251

QRIC1
Transcriptional regulator QRICH1

1

1

High-throughput

0.536

High

611261

EDC4
Enhancer of mRNA-decapping protein 4

1

1

High-throughput

0.536

High

611267

APTX
Aprataxin

1

1

High-throughput

0.536

High

611269

ZN550
Zinc finger protein 550

1

1

High-throughput

0.536

High

611271

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.536

High

611275

AROS
Active regulator of SIRT1

1

1

High-throughput

0.536

High

611277

PLCZ1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

1

2

High-throughput

0.536

High

611286

PLD5
Inactive phospholipase D5

1

1

High-throughput

0.536

High

611288

FNDC5
Fibronectin type III domain-containing protein 5

1

4

High-throughput

0.536

High

611292

MYBPP
MYCBP-associated protein

1

1

High-throughput

0.536

High

611293

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

1

High-throughput

0.536

High

611298

THAP4
Peroxynitrite isomerase THAP4

1

4

High-throughput

0.536

High

611299

SIA8A
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

1

1

High-throughput

0.536

High

611303

STAM1
Signal transducing adapter molecule 1

1

2

High-throughput

0.536

High

611304

CBP
CREB-binding protein

1

2

High-throughput

0.536

High

611306

PIGT
GPI transamidase component PIG-T

1

1

High-throughput

0.536

High

611308

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

1

High-throughput

0.536

High

611314

MTNB
Methylthioribulose-1-phosphate dehydratase

1

1

High-throughput

0.536

High

611322

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.536

High

611331

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.536

High

611341

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

1

High-throughput

0.536

High

611346

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

611350

KLH11
Kelch-like protein 11

1

1

High-throughput

0.536

High

611356

THA10
THAP domain-containing protein 10

1

1

High-throughput

0.536

High

611360

PHF11
PHD finger protein 11

1

1

High-throughput

0.536

High

611361

DBNL
Drebrin-like protein

1

2

High-throughput

0.536

High

611364

DYN3
Dynamin-3

1

3

High-throughput

0.536

High

611368

TLN1
Talin-1

1

2

High-throughput

0.536

High

611370

RN115
E3 ubiquitin-protein ligase RNF115

1

1

High-throughput

0.536

High

611372

S23IP
SEC23-interacting protein

1

2

High-throughput

0.536

High

263518

PR40A
Pre-mRNA-processing factor 40 homolog A

1

5

High-throughput

0.515

High

527295

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.515

High

611224

CASP6
Caspase-6

1

2

High-throughput

0.515

High

611367

SHLB1
Endophilin-B1

1

2

High-throughput

0.515

High

209312

TSN6
Tetraspanin-6

1

0

High-throughput

0.513

High

215803

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

0

High-throughput

0.513

High

239781

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.513

High

329083

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.513

High

611214

FEN1
Flap endonuclease 1

1

0

High-throughput

0.513

High

611218

PCP4
Calmodulin regulator protein PCP4

1

0

High-throughput

0.513

High

611222

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

1

0

High-throughput

0.513

High

611223

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.513

High

611247

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.513

High

611265

GGYF2
GRB10-interacting GYF protein 2

1

0

High-throughput

0.513

High

611278

CDKL3
Cyclin-dependent kinase-like 3

1

0

High-throughput

0.513

High

611283

D106A
Beta-defensin 106

1

0

High-throughput

0.513

High

611290

NFAM1
NFAT activation molecule 1

1

0

High-throughput

0.513

High

611297

ITLN2
Intelectin-2

1

0

High-throughput

0.513

High

611300

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.513

High

611311

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.513

High

611312

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.513

High

611316

SNX27
Sorting nexin-27

1

0

High-throughput

0.513

High

611318

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.513

High

611327

MSTO1
Protein misato homolog 1

1

0

High-throughput

0.513

High

611328

THUM3
tRNA

1

0

High-throughput

0.513

High

611329

5NT1A
Cytosolic 5'-nucleotidase 1A

1

0

High-throughput

0.513

High

611337

NELFA
Negative elongation factor A

1

0

High-throughput

0.513

High

611339

COE2
Transcription factor COE2

1

0

High-throughput

0.513

High

611342

M1IP1
Mid1-interacting protein 1

1

0

High-throughput

0.513

High

611347

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.513

High

611354

UBIP1
Upstream-binding protein 1

1

0

High-throughput

0.513

High

265600

E2F6
Transcription factor E2F6

1

1

High-throughput

0.489

High

312775

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

1

High-throughput

0.489

High

392920

IFNA4
Interferon alpha-4

1

1

High-throughput

0.489

High

584539

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

2

High-throughput

0.489

High

610143

RFX1
MHC class II regulatory factor RFX1

1

2

High-throughput

0.489

High

611205

CCNC
Cyclin-C

1

1

High-throughput

0.489

High

611235

FGL1
Fibrinogen-like protein 1

1

2

High-throughput

0.489

High

611252

CR021
UPF0711 protein C18orf21

1

1

High-throughput

0.489

High

611262

SCYL2
SCY1-like protein 2

1

1

High-throughput

0.489

High

611264

AMTN
Amelotin

1

1

High-throughput

0.489

High

611268

PBIR2
PABIR family member 2

1

1

High-throughput

0.489

High

611273

MOGT3
2-acylglycerol O-acyltransferase 3

1

1

High-throughput

0.489

High

611274

ZC3C1
Zinc finger C3HC-type protein 1

1

2

High-throughput

0.489

High

611281

RAVR1
Ribonucleoprotein PTB-binding 1

1

1

High-throughput

0.489

High

611294

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.489

High

611310

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

611325

SH23A
SH2 domain-containing protein 3A

1

3

High-throughput

0.489

High

611326

MMTA2
Multiple myeloma tumor-associated protein 2

1

1

High-throughput

0.489

High

611332

SRRT
Serrate RNA effector molecule homolog

1

1

High-throughput

0.489

High

611334

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

2

High-throughput

0.489

High

611345

TSSP
Thymus-specific serine protease

1

2

High-throughput

0.489

High

611348

RBM12
RNA-binding protein 12

1

3

High-throughput

0.489

High

611363

SATB2
DNA-binding protein SATB2

1

1

High-throughput

0.489

High

611366

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.489

High

311788

TACC2
Transforming acidic coiled-coil-containing protein 2

1

1

High-throughput

0.481

High

611213

SYUA
Alpha-synuclein

1

0

Small-scale

0.480

High

133880

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

Small-scale

0.479

High

282528

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

High-throughput

0.479

High

349878

RASK
GTPase KRas

1

1

High-throughput

0.479

High

384269

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

386099

P53
Cellular tumor antigen p53

1

2

Small-scale

0.479

High

503443

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

528555

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.479

High

611212

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.479

High

611215

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

611220

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

611229

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

611237

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

611242

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

1

High-throughput

0.479

High

611253

Q4LE69
1-phosphatidylinositol 4-kinase

1

2

High-throughput

0.479

High

611263

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

611282

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.479

High

611295

TP4AP
Short transient receptor potential channel 4-associated protein

1

1

High-throughput

0.479

High

611305

RBP56
TATA-binding protein-associated factor 2N

1

6

High-throughput

0.479

High

611309

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

2

Small-scale

0.479

High

611333

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.479

High

611344

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

611355

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.479

High

611358

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

611369

LOXL2
Lysyl oxidase homolog 2

1

3

High-throughput

0.479

High

70874

B2RWP4
TACC2 protein

1

1

High-throughput

0.470

High

611336

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.460

High

611216

PI4KA
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.445

High

611228

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.445

High

611335

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

3

High-throughput

0.445

High

345937

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.437

High

379019

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.437

High

611240

DX39B
Spliceosome RNA helicase DDX39B

1

3

High-throughput

0.437

High

611284

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.437

High

611353

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

2

High-throughput

0.437

High

611287

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

2

High-throughput

0.407

High

611266

DPPA4
Developmental pluripotency-associated protein 4

3

0

High-throughput

0.347

High

351520

ANF
Natriuretic peptides A

2

0

High-throughput

0.328

High

611270

SO6A1
Solute carrier organic anion transporter family member 6A1

2

0

High-throughput

0.328

High

611260

TECT3
Tectonic-3

2

0

High-throughput

0.318

High

611207

ACADL
Long-chain specific acyl-CoA dehydrogenase, mitochondrial

2

0

High-throughput

0.316

High

611272

MYPOP
Myb-related transcription factor, partner of profilin

2

0

High-throughput

0.316

High

611359

CRCT1
Cysteine-rich C-terminal protein 1

2

0

High-throughput

0.316

High

128706

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.279

Low

217540

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

1

0

High-throughput

0.279

Low

303648

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

309363

MBD4
Methyl-CpG-binding domain protein 4

1

0

High-throughput

0.279

Low

525224

UNG
Uracil-DNA glycosylase

1

0

High-throughput

0.279

Low

540783

PO2F1
POU domain, class 2, transcription factor 1

1

0

High-throughput

0.279

Low

611226

DSCR6
Protein ripply3

1

0

High-throughput

0.279

Low

611230

TBPL1
TATA box-binding protein-like 1

1

0

High-throughput

0.279

Low

611234

GABPA
GA-binding protein alpha chain

1

0

High-throughput

0.279

Low

611236

PP1R8
Nuclear inhibitor of protein phosphatase 1

1

0

High-throughput

0.279

Low

611238

CSTF3
Cleavage stimulation factor subunit 3

1

0

High-throughput

0.279

Low

611243

FASTK
Fas-activated serine/threonine kinase

1

0

High-throughput

0.279

Low

611250

QSER1
Glutamine and serine-rich protein 1

1

0

High-throughput

0.279

Low

611276

SFR1
Swi5-dependent recombination DNA repair protein 1 homolog

1

0

High-throughput

0.279

Low

611285

FNBP4
Formin-binding protein 4

1

0

High-throughput

0.279

Low

611317

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

0

High-throughput

0.279

Low

611320

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low

611321

FCRL5
Fc receptor-like protein 5

1

0

High-throughput

0.279

Low

611340

HES4
Transcription factor HES-4

1

0

High-throughput

0.279

Low

611343

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

0

High-throughput

0.279

Low

611351

RFOX1
RNA binding protein fox-1 homolog 1

1

0

High-throughput

0.279

Low

611352

GPT2L
G patch domain-containing protein 2-like

1

0

High-throughput

0.279

Low

611357

DKK2
Dickkopf-related protein 2

1

0

High-throughput

0.279

Low

611365

SCML2
Sex comb on midleg-like protein 2

1

0

High-throughput

0.279

Low

473243

F153B
Protein FAM153B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024