Protein: SRC
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)

Gene: SRC
Organism: Mus musculus
Interactions: 75
UniProt ID: P05480

Gene Ontology (top 5):
GO:0001545 - primary ovarian follicle growth
GO:0001819 - positive regulation of cytokine production
GO:0002102 - podosome
GO:0004672 - protein kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

403419

FAK1
Focal adhesion kinase 1

4

20

Small-scale

0.873

High

403406

SRC
Proto-oncogene tyrosine-protein kinase Src

3

20

Small-scale

0.845

High

403411

KPCE
Protein kinase C epsilon type

2

18

Small-scale

0.799

High

403408

CSF1R
Macrophage colony-stimulating factor 1 receptor

2

20

Small-scale

0.754

High

403422

STAT3
Signal transducer and activator of transcription 3

2

15

Small-scale

0.754

High

403463

FAK2
Protein-tyrosine kinase 2-beta

2

20

Small-scale

0.754

High

403415

CBL
E3 ubiquitin-protein ligase CBL

6

20

Small-scale

0.737

High

403410

INSR
Insulin receptor

1

20

Small-scale

0.691

High

403418

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.691

High

403434

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

16

High-throughput

0.691

High

403435

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

12

High-throughput

0.691

High

250949

DOK2
Docking protein 2

1

20

Small-scale

0.690

High

397197

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

16

Small-scale

0.647

High

403413

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

20

Small-scale

0.647

High

403442

TRPC6
Short transient receptor potential channel 6

1

8

Small-scale

0.647

High

403443

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

10

Small-scale

0.647

High

403448

EFS
Embryonal Fyn-associated substrate

1

20

Small-scale

0.647

High

403462

TRPC4
Short transient receptor potential channel 4

1

13

Small-scale

0.647

High

403465

TRPC5
Short transient receptor potential channel 5

1

6

Small-scale

0.647

High

403454

PAXI
Paxillin

2

20

Small-scale

0.624

High

403421

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

Small-scale

0.618

High

403423

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

403425

EPHB2
Ephrin type-B receptor 2

1

20

Small-scale

0.618

High

403430

SHC1
SHC-transforming protein 1

1

19

Small-scale

0.618

High

403432

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.618

High

403440

SHC3
SHC-transforming protein 3

1

19

Small-scale

0.618

High

403441

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

20

Small-scale

0.618

High

403445

DLG4
Disks large homolog 4

1

16

High-throughput

0.618

High

403446

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

403451

SHC2
SHC-transforming protein 2

1

19

Small-scale

0.618

High

403457

TLR3
Toll-like receptor 3

1

13

Small-scale

0.618

High

403459

TLR9
Toll-like receptor 9

1

12

Small-scale

0.618

High

403460

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.618

High

403461

TLR4
Toll-like receptor 4

1

13

Small-scale

0.618

High

403466

GAB1
GRB2-associated-binding protein 1

1

20

Small-scale

0.618

High

403412

ENOA
Alpha-enolase

2

4

Small-scale

0.602

High

403437

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

2

20

Small-scale

0.602

High

222493

ITB3
Integrin beta-3

2

11

Small-scale

0.584

High

403436

Q5U3L0
SH3-domain binding protein 2

1

5

Small-scale

0.579

High

403438

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

Small-scale

0.561

High

403420

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

6

High-throughput

0.536

High

403407

CSF1
Macrophage colony-stimulating factor 1

1

7

Small-scale

0.515

High

403427

WASP
Actin nucleation-promoting factor WAS

1

20

Small-scale

0.515

High

403458

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

3

Small-scale

0.515

High

403469

CHIP
E3 ubiquitin-protein ligase CHIP

1

10

Small-scale

0.515

High

403433

ENAH
Protein enabled homolog

1

18

Small-scale

0.501

High

403439

TRPC1
Short transient receptor potential channel 1

1

12

Small-scale

0.501

High

403453

FRS2
Fibroblast growth factor receptor substrate 2

1

20

Small-scale

0.501

High

403467

TRPC2
Short transient receptor potential channel 2

1

12

Small-scale

0.501

High

403416

CXA1
Gap junction alpha-1 protein

1

11

Small-scale

0.500

High

70886

EP300
Histone acetyltransferase p300

1

15

Small-scale

0.479

High

139009

S1PR1
Sphingosine 1-phosphate receptor 1

1

8

Small-scale

0.479

High

139938

DIAP1
Protein diaphanous homolog 1

1

11

Small-scale

0.479

High

250683

ATX2
Ataxin-2

1

12

Small-scale

0.479

High

292104

HCN2
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

1

8

Small-scale

0.479

High

403414

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

403417

SSR3
Somatostatin receptor type 3

1

9

High-throughput

0.479

High

403424

CAV3
Caveolin-3

1

8

Small-scale

0.479

High

403426

TRAF6
TNF receptor-associated factor 6

1

16

Small-scale

0.479

High

403428

5HT4R
5-hydroxytryptamine receptor 4

1

6

Small-scale

0.479

High

403429

DAB1
Disabled homolog 1

1

18

Small-scale

0.479

High

403431

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

6

High-throughput

0.479

High

403444

K1C14
Keratin, type I cytoskeletal 14

1

8

Small-scale

0.479

High

403447

ITA2
Integrin alpha-2

1

6

Small-scale

0.479

High

403449

Q6P7T9
Nuclear factor of activated T-cells c1 isoform IA-IXS

1

8

Small-scale

0.479

High

403450

RIGI
Antiviral innate immune response receptor RIG-I

1

6

High-throughput

0.479

High

403452

ARRB1
Beta-arrestin-1

1

8

Small-scale

0.479

High

403455

ARRB2
Beta-arrestin-2

1

8

Small-scale

0.479

High

403456

K2C5
Keratin, type II cytoskeletal 5

1

2

Small-scale

0.479

High

403468

PDC6I
Programmed cell death 6-interacting protein

1

8

Small-scale

0.479

High

403470

SKP2
S-phase kinase-associated protein 2

1

5

Small-scale

0.479

High

403471

K1C16
Keratin, type I cytoskeletal 16

1

9

Small-scale

0.479

High

403464

SRCN1
SRC kinase signaling inhibitor 1

1

8

Small-scale

0.445

High

403409

CASB
Beta-casein

1

0

Small-scale

0.261

Low


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Last updated: 15 Jul 2024