Protein: MDM2
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)

Gene: MDM2
Organism: Mus musculus
Interactions: 54
UniProt ID: P23804

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001568 - blood vessel development
GO:0001974 - blood vessel remodeling
GO:0002027 - regulation of heart rate
GO:0002039 - p53 binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

356823

P53
Cellular tumor antigen p53

32

10

Small-scale

0.993

High

193156

MDM4
Protein Mdm4

7

5

Small-scale

0.958

High

620860

RL11
Large ribosomal subunit protein uL5

5

2

Small-scale

0.912

High

620825

MDM2
E3 ubiquitin-protein ligase Mdm2

2

5

Small-scale

0.778

High

620847

ARF
Tumor suppressor ARF

8

0

Small-scale

0.718

High

620831

RL5
Large ribosomal subunit protein uL18

4

1

Small-scale

0.666

High

620833

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

14

Small-scale

0.647

High

620834

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

14

Small-scale

0.647

High

620837

UBC9
SUMO-conjugating enzyme UBC9

1

15

Small-scale

0.647

High

620846

DLG4
Disks large homolog 4

3

3

Small-scale

0.640

High

193122

DAXX
Death domain-associated protein 6

2

2

Small-scale

0.611

High

620835

RL23
Large ribosomal subunit protein uL14

2

1

Small-scale

0.611

High

620858

RASF1
Ras association domain-containing protein 1

1

7

Small-scale

0.586

High

620848

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

8

Small-scale

0.584

High

103320

G3X9P9
SUMO/sentrin specific peptidase 2-like 2A

1

2

Small-scale

0.578

High

620828

CEBPB
CCAAT/enhancer-binding protein beta

1

2

Small-scale

0.561

High

620832

CCNG1
Cyclin-G1

1

2

Small-scale

0.561

High

620838

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

3

Small-scale

0.561

High

620856

SENP2
Sentrin-specific protease 2

1

2

Small-scale

0.561

High

292436

HIPK1
Homeodomain-interacting protein kinase 1

1

7

Small-scale

0.554

High

620841

RASF5
Ras association domain-containing protein 5

1

6

Small-scale

0.552

High

620826

PAX3
Paired box protein Pax-3

1

0

Small-scale

0.537

High

620865

DPOE1
DNA polymerase epsilon catalytic subunit A

1

0

Small-scale

0.504

High

70896

EP300
Histone acetyltransferase p300

1

3

Small-scale

0.479

High

140228

HDAC1
Histone deacetylase 1

1

3

Small-scale

0.479

High

292649

SP1
Transcription factor Sp1

1

3

Small-scale

0.479

High

486085

EF1A1
Elongation factor 1-alpha 1

1

1

Small-scale

0.479

High

617174

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.479

High

618883

IRF8
Interferon regulatory factor 8

1

2

Small-scale

0.479

High

620827

NECD
Necdin

1

5

Small-scale

0.479

High

620829

TBP
TATA-box-binding protein

1

1

Small-scale

0.479

High

620830

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

Small-scale

0.479

High

620836

SUMO1
Small ubiquitin-related modifier 1

1

2

Small-scale

0.479

High

620844

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

Small-scale

0.479

High

620845

MRE11
Double-strand break repair protein MRE11

1

2

Small-scale

0.479

High

620850

WDTC1
WD and tetratricopeptide repeats protein 1

1

1

High-throughput

0.479

High

620851

KS6B1
Ribosomal protein S6 kinase beta-1

1

6

Small-scale

0.479

High

620853

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

2

Small-scale

0.479

High

620855

ARRB2
Beta-arrestin-2

1

4

Small-scale

0.479

High

620857

ARBK1
Beta-adrenergic receptor kinase 1

1

5

Small-scale

0.479

High

620859

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

4

Small-scale

0.479

High

620861

EID1
EP300-interacting inhibitor of differentiation 1

1

1

Small-scale

0.479

High

620862

P73
Tumor protein p73

1

10

Small-scale

0.479

High

620863

NBN
Nibrin

1

2

Small-scale

0.479

High

620864

GSK3B
Glycogen synthase kinase-3 beta

1

1

Small-scale

0.479

High

620866

FOXO3
Forkhead box protein O3

1

4

Small-scale

0.479

High

620840

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.458

High

620852

ARRB1
Beta-arrestin-1

1

4

High-throughput

0.457

High

620839

1433T
14-3-3 protein theta

1

11

Small-scale

0.445

High

620842

Q5SV02
RAD50 double strand break repair protein

1

2

Small-scale

0.437

High

620843

IGF1R
Insulin-like growth factor 1 receptor

1

4

Small-scale

0.437

High

620854

DLG2
Disks large homolog 2

1

3

Small-scale

0.437

High

620849

PARP6
Protein mono-ADP-ribosyltransferase PARP6

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024