Protein: P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)

Gene: P85A, Pik3r1
Organism: Mus musculus
Interactions: 86
UniProt ID: P26450

Gene Ontology (top 5):
GO:0001678 - intracellular glucose homeostasis
GO:0001784 - phosphotyrosine residue binding
GO:0001934 - positive regulation of protein phosphorylation
GO:0001953 - negative regulation of cell-matrix adhesion
GO:0002687 - positive regulation of leukocyte migration

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

643067

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

9

20

Small-scale

0.961

High

403533

KIT
Mast/stem cell growth factor receptor Kit

5

20

Small-scale

0.919

High

452179

CSF1R
Macrophage colony-stimulating factor 1 receptor

3

20

Small-scale

0.854

High

643091

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.834

High

193568

PK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

3

20

Small-scale

0.821

High

643106

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

3

20

Small-scale

0.821

High

643085

TIE2
Angiopoietin-1 receptor

2

20

Small-scale

0.808

High

643059

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

20

Small-scale

0.806

High

643099

CRK
Adapter molecule crk

2

20

Small-scale

0.789

High

610546

CBL
E3 ubiquitin-protein ligase CBL

16

20

Small-scale

0.759

High

643063

IRS1
Insulin receptor substrate 1

13

20

Small-scale

0.755

High

643064

BTK
Tyrosine-protein kinase BTK

2

20

Small-scale

0.754

High

643066

FYN
Tyrosine-protein kinase Fyn

2

20

Small-scale

0.754

High

643094

RASH
GTPase HRas

2

20

Small-scale

0.754

High

643096

JAK2
Tyrosine-protein kinase JAK2

2

20

Small-scale

0.754

High

384057

ARAF
Serine/threonine-protein kinase A-Raf

1

20

Small-scale

0.747

High

643107

ABI1
Abl interactor 1

1

20

Small-scale

0.747

High

411918

LCK
Proto-oncogene tyrosine-protein kinase LCK

1

20

Small-scale

0.724

High

643078

SHC1
SHC-transforming protein 1

1

19

Small-scale

0.724

High

540266

EPOR
Erythropoietin receptor

2

19

Small-scale

0.675

High

643113

GAB1
GRB2-associated-binding protein 1

3

20

Small-scale

0.664

High

643062

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

Small-scale

0.647

High

643068

CRKL
Crk-like protein

1

20

Small-scale

0.647

High

643109

SNX9
Sorting nexin-9

1

9

Small-scale

0.646

High

643075

IRS2
Insulin receptor substrate 2

3

20

Small-scale

0.640

High

404009

PGFRB
Platelet-derived growth factor receptor beta

1

20

Small-scale

0.618

High

546262

INSR
Insulin receptor

1

20

Small-scale

0.618

High

557349

BLK
Tyrosine-protein kinase Blk

1

20

Small-scale

0.618

High

639435

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.618

High

643057

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.618

High

643072

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.618

High

643074

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.618

High

643079

UFO
Tyrosine-protein kinase receptor UFO

1

20

Small-scale

0.618

High

643082

KPCT
Protein kinase C theta type

1

17

Small-scale

0.618

High

643087

EPS8
Epidermal growth factor receptor kinase substrate 8

1

20

Small-scale

0.618

High

643092

GRB10
Growth factor receptor-bound protein 10

1

20

Small-scale

0.618

High

643093

MERTK
Tyrosine-protein kinase Mer

1

20

Small-scale

0.618

High

643112

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

18

Small-scale

0.618

High

643055

CD28
T-cell-specific surface glycoprotein CD28

2

7

Small-scale

0.594

High

643097

SH3G1
Endophilin-A2

1

20

High-throughput

0.590

High

643065

THB
Thyroid hormone receptor beta

2

20

Small-scale

0.584

High

643089

Q3ZB59
Growth factor receptor bound protein 2-associated protein 2

1

20

Small-scale

0.578

High

643083

CTNB1
Catenin beta-1

2

10

Small-scale

0.576

High

643086

TIE1
Tyrosine-protein kinase receptor Tie-1

1

20

Small-scale

0.575

High

643060

CD22
B-cell receptor CD22

1

11

Small-scale

0.561

High

643054

NCKP1
Nck-associated protein 1

1

2

Small-scale

0.554

High

643101

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

10

Small-scale

0.554

High

643088

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

4

High-throughput

0.553

High

643108

WASF1
Actin-binding protein WASF1

1

19

Small-scale

0.536

High

70897

EP300
Histone acetyltransferase p300

1

7

Small-scale

0.515

High

501139

OSTP
Osteopontin

1

1

Small-scale

0.515

High

639482

CD19
B-lymphocyte antigen CD19

1

2

Small-scale

0.515

High

643090

MYO16
Unconventional myosin-XVI

1

14

Small-scale

0.515

High

643100

NYAP1
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

1

14

Small-scale

0.515

High

643105

NYAP2
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

1

14

Small-scale

0.515

High

643103

MAP6
Microtubule-associated protein 6

1

5

Small-scale

0.501

High

643073

WASP
Actin nucleation-promoting factor WAS

1

16

Small-scale

0.500

High

103593

ANK3
Ankyrin-3

1

11

Small-scale

0.479

High

192582

TNR11
Tumor necrosis factor receptor superfamily member 11A

1

13

Small-scale

0.479

High

345603

FOS
Protein c-Fos

1

6

Small-scale

0.479

High

454943

CADH1
Cadherin-1

1

16

Small-scale

0.479

High

544694

CADH2
Cadherin-2

1

17

Small-scale

0.479

High

603900

TAL1
T-cell acute lymphocytic leukemia protein 1 homolog

1

2

High-throughput

0.479

High

643053

TNR5
Tumor necrosis factor receptor superfamily member 5

1

13

Small-scale

0.479

High

643056

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.479

High

643058

IL2RG
Cytokine receptor common subunit gamma

1

20

Small-scale

0.479

High

643061

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

11

High-throughput

0.479

High

643069

PSN1
Presenilin-1

1

1

Small-scale

0.479

High

643076

DOK1
Docking protein 1

1

20

Small-scale

0.479

High

643077

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

18

Small-scale

0.479

High

643080

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

11

High-throughput

0.479

High

643084

PLAK
Junction plakoglobin

1

17

Small-scale

0.479

High

643110

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

1

Small-scale

0.479

High

643070

PA2G4
Proliferation-associated protein 2G4

1

0

Small-scale

0.458

High

643111

BCAP
Phosphoinositide 3-kinase adapter protein 1

1

0

Small-scale

0.458

High

292063

BRD7
Bromodomain-containing protein 7

1

15

High-throughput

0.457

High

643081

NDKB
Nucleoside diphosphate kinase B

1

2

High-throughput

0.457

High

643095

PCBP2
Poly(rC)-binding protein 2

1

14

High-throughput

0.457

High

643098

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

3

High-throughput

0.457

High

643114

ICOS
Inducible T-cell costimulator

1

1

Small-scale

0.457

High

222752

LAT
Linker for activation of T-cells family member 1

1

3

High-throughput

0.445

High

421445

CSF1
Macrophage colony-stimulating factor 1

1

4

Small-scale

0.445

High

222283

NKG2D
NKG2-D type II integral membrane protein

1

4

Small-scale

0.437

High

643071

GOGA3
Golgin subfamily A member 3

1

15

High-throughput

0.417

High

643102

BTLA
B- and T-lymphocyte attenuator

1

0

Small-scale

0.249

Low

643104

Q8BK32
Nuclear receptor corepressor 1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024