Protein: ROCK2
Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)

Gene: ROCK2
Organism: Homo sapiens
Interactions: 113
UniProt ID: O75116

Gene Ontology (top 5):
GO:0000281 - mitotic cytokinesis
GO:0001837 - epithelial to mesenchymal transition
GO:0001934 - positive regulation of protein phosphorylation
GO:0002020 - protease binding
GO:0002931 - response to ischemia

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

254459

KS6A3
Ribosomal protein S6 kinase alpha-3

3

10

High-throughput

0.871

High

254476

ROCK1
Rho-associated protein kinase 1

3

17

High-throughput

0.861

High

254520

DJB11
DnaJ homolog subfamily B member 11

3

6

High-throughput

0.861

High

182059

PDPK1
3-phosphoinositide-dependent protein kinase 1

3

19

High-throughput

0.839

High

254430

RASK
GTPase KRas

3

20

High-throughput

0.827

High

254428

RASN
GTPase NRas

2

20

High-throughput

0.754

High

254464

RHOA
Transforming protein RhoA

2

20

Small-scale

0.754

High

254466

RB11A
Ras-related protein Rab-11A

2

6

High-throughput

0.754

High

254467

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

254439

MLRV
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

1

16

Small-scale

0.724

High

254484

CDKN3
Cyclin-dependent kinase inhibitor 3

1

2

Small-scale

0.724

High

254437

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

2

Small-scale

0.713

High

254423

DNJC8
DnaJ homolog subfamily C member 8

1

3

High-throughput

0.691

High

254497

ZN444
Zinc finger protein 444

1

2

High-throughput

0.691

High

254499

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

4

High-throughput

0.691

High

254502

ANR49
Ankyrin repeat domain-containing protein 49

1

4

High-throughput

0.691

High

254504

SGK3
Serine/threonine-protein kinase Sgk3

1

17

High-throughput

0.691

High

254508

ZN641
Zinc finger protein 641

1

2

High-throughput

0.691

High

254510

DUS16
Dual specificity protein phosphatase 16

1

5

High-throughput

0.691

High

71046

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

10

High-throughput

0.665

High

254422

STK16
Serine/threonine-protein kinase 16

1

14

High-throughput

0.665

High

254480

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

20

High-throughput

0.665

High

169748

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

3

High-throughput

0.628

High

254452

ADDB
Beta-adducin

2

5

High-throughput

0.628

High

120238

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

226028

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.618

High

238319

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

254424

RHBT1
Rho-related BTB domain-containing protein 1

1

20

Small-scale

0.618

High

254427

EGFR
Epidermal growth factor receptor

1

8

High-throughput

0.618

High

254429

RASH
GTPase HRas

1

17

High-throughput

0.618

High

254431

NTRK1
High affinity nerve growth factor receptor

1

11

High-throughput

0.618

High

254433

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

254442

FGFR1
Fibroblast growth factor receptor 1

1

12

High-throughput

0.618

High

254445

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

254447

NUCL
Nucleolin

1

9

Small-scale

0.618

High

254456

MUC18
Cell surface glycoprotein MUC18

1

10

High-throughput

0.618

High

254460

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.618

High

254462

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

254463

RAB2A
Ras-related protein Rab-2A

1

9

High-throughput

0.618

High

254468

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

254472

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

254483

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

254493

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.618

High

254512

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

254513

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.618

High

254515

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

254449

AMRP
Alpha-2-macroglobulin receptor-associated protein

2

0

High-throughput

0.602

High

254441

LAMP1
Lysosome-associated membrane glycoprotein 1

2

7

High-throughput

0.584

High

254474

EP300
Histone acetyltransferase p300

2

9

Small-scale

0.584

High

254486

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.575

High

254491

FBX42
F-box only protein 42

2

3

High-throughput

0.574

High

254426

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

5

Small-scale

0.571

High

254434

LEG1
Galectin-1

1

1

High-throughput

0.536

High

254435

CLCB
Clathrin light chain B

1

2

High-throughput

0.536

High

254453

AHR
Aryl hydrocarbon receptor

1

5

High-throughput

0.536

High

254457

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

1

1

High-throughput

0.536

High

254475

AKP13
A-kinase anchor protein 13

1

11

High-throughput

0.536

High

254477

SMAD4
Mothers against decapentaplegic homolog 4

1

7

High-throughput

0.536

High

254478

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

254495

MILR1
Allergin-1

1

3

High-throughput

0.536

High

254498

RYBP
RING1 and YY1-binding protein

1

4

High-throughput

0.536

High

254500

BBS1
Bardet-Biedl syndrome 1 protein

1

2

High-throughput

0.536

High

254507

LURA1
Leucine rich adaptor protein 1

1

8

High-throughput

0.536

High

254509

CDC5L
Cell division cycle 5-like protein

1

6

High-throughput

0.536

High

254511

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.536

High

254514

SUV92
Histone-lysine N-methyltransferase SUV39H2

1

3

High-throughput

0.536

High

254518

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

High-throughput

0.536

High

254523

FBX2
F-box only protein 2

1

2

High-throughput

0.536

High

254454

STAT3
Signal transducer and activator of transcription 3

1

1

Small-scale

0.515

High

254485

H2B2E
Histone H2B type 2-E

1

14

High-throughput

0.515

High

254432

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

245924

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.513

High

254490

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

1

0

High-throughput

0.513

High

254494

PHF5A
PHD finger-like domain-containing protein 5A

1

0

High-throughput

0.513

High

254501

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

254505

PP14B
Protein phosphatase 1 regulatory subunit 14B

1

1

Small-scale

0.501

High

254471

HTRA3
Serine protease HTRA3

1

2

High-throughput

0.489

High

254492

TBCD9
TBC1 domain family member 9

1

1

High-throughput

0.489

High

254503

S39A7
Zinc transporter SLC39A7

1

2

High-throughput

0.489

High

254522

EGFL7
Epidermal growth factor-like protein 7

1

5

High-throughput

0.489

High

239434

MAGC1
Melanoma-associated antigen C1

1

4

Small-scale

0.481

High

204819

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

254438

TAU
Microtubule-associated protein tau

1

12

High-throughput

0.479

High

254440

HSP7C
Heat shock cognate 71 kDa protein

1

9

High-throughput

0.479

High

254443

LAMP2
Lysosome-associated membrane glycoprotein 2

1

7

High-throughput

0.479

High

254444

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

254446

CXA1
Gap junction alpha-1 protein

1

4

High-throughput

0.479

High

254448

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.479

High

254455

PERI
Peripherin

1

15

High-throughput

0.479

High

254465

ARF6
ADP-ribosylation factor 6

1

7

High-throughput

0.479

High

254469

KCNJ2
Inward rectifier potassium channel 2

1

1

Small-scale

0.479

High

254470

H31
Histone H3.1

1

8

High-throughput

0.479

High

254473

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

254479

CUL3
Cullin-3

1

5

High-throughput

0.479

High

254481

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

254482

TRIP4
Activating signal cointegrator 1

1

1

High-throughput

0.479

High

254488

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

254489

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

254506

OPTN
Optineurin

1

18

High-throughput

0.479

High

254517

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

5

High-throughput

0.479

High

254521

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

254524

MARE3
Microtubule-associated protein RP/EB family member 3

1

1

High-throughput

0.479

High

254525

LAMP3
Lysosome-associated membrane glycoprotein 3

1

7

High-throughput

0.479

High

254425

MRP6
ATP-binding cassette sub-family C member 6

1

0

Small-scale

0.458

High

254458

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.458

High

254487

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.458

High

254496

MGDP1
Magnesium-dependent phosphatase 1

1

0

High-throughput

0.458

High

254516

LZTL1
Leucine zipper transcription factor-like protein 1

1

0

High-throughput

0.458

High

254450

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.445

High

254519

SPHK1
Sphingosine kinase 1

1

1

Small-scale

0.445

High

254451

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

254436

GOG8G
Putative golgin subfamily A member 8G

1

18

High-throughput

0.407

High

254461

DEF1
Neutrophil defensin 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024