Protein: DYR
Dihydrofolate reductase (EC 1.5.1.3)

Gene: DYR, DHFR
Organism: Homo sapiens
Interactions: 119
UniProt ID: P00374

Gene Ontology (top 5):
GO:0000900 - mRNA regulatory element binding translation repressor activity
GO:0003729 - mRNA binding
GO:0004146 - dihydrofolate reductase activity
GO:0005542 - folic acid binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

335281

DYR2
Dihydrofolate reductase 2, mitochondrial

1

2

High-throughput

0.665

High

335328

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

1

High-throughput

0.618

High

335231

P53
Cellular tumor antigen p53

2

0

Small-scale

0.569

High

335253

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.561

High

335237

CH60
60 kDa heat shock protein, mitochondrial

1

1

Small-scale

0.550

High

324972

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

0

High-throughput

0.547

High

217978

PEX1
Peroxisomal ATPase PEX1

1

2

High-throughput

0.536

High

320482

OXSR1
Serine/threonine-protein kinase OSR1

1

1

High-throughput

0.536

High

335258

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

1

High-throughput

0.536

High

335265

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

1

2

High-throughput

0.536

High

335274

TRI65
E3 ubiquitin-protein ligase TRIM65

1

1

High-throughput

0.536

High

335275

DNMBP
Dynamin-binding protein

1

1

High-throughput

0.536

High

335276

TBA1A
Tubulin alpha-1A chain

1

2

High-throughput

0.536

High

335288

CTF18
Chromosome transmission fidelity protein 18 homolog

1

1

High-throughput

0.536

High

335304

METH
Methionine synthase

1

1

High-throughput

0.536

High

335310

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

2

High-throughput

0.536

High

335314

SHRPN
Sharpin

1

1

High-throughput

0.536

High

335327

TBD2B
TBC1 domain family member 2B

1

2

High-throughput

0.536

High

127690

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.513

High

149814

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.513

High

176522

FANCA
Fanconi anemia group A protein

1

0

High-throughput

0.513

High

239452

PLPL9
85/88 kDa calcium-independent phospholipase A2

1

0

High-throughput

0.513

High

272834

KS6A4
Ribosomal protein S6 kinase alpha-4

1

0

High-throughput

0.513

High

300869

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.513

High

335240

GSTM3
Glutathione S-transferase Mu 3

1

0

High-throughput

0.513

High

335243

1433S
14-3-3 protein sigma

1

0

High-throughput

0.513

High

335247

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.513

High

335255

ARHG5
Rho guanine nucleotide exchange factor 5

1

0

High-throughput

0.513

High

335256

TRAF2
TNF receptor-associated factor 2

1

0

High-throughput

0.513

High

335267

PKHG4
Puratrophin-1

1

0

High-throughput

0.513

High

335270

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.513

High

335272

GPAT2
Glycerol-3-phosphate acyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

335273

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

1

0

High-throughput

0.513

High

335280

MTMRD
Myotubularin-related protein 13

1

0

High-throughput

0.513

High

335282

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

335283

TENS4
Tensin-4

1

0

High-throughput

0.513

High

335286

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.513

High

335295

HPS3
BLOC-2 complex member HPS3

1

0

High-throughput

0.513

High

335296

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

335299

SPTCS
Spatacsin

1

0

High-throughput

0.513

High

335312

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

335316

HAUS4
HAUS augmin-like complex subunit 4

1

0

High-throughput

0.513

High

335320

MA2C1
Alpha-mannosidase 2C1

1

0

High-throughput

0.513

High

335322

NALP2
NACHT, LRR and PYD domains-containing protein 2

1

0

High-throughput

0.513

High

335329

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

335249

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.501

High

335250

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

1

Small-scale

0.501

High

335257

FOXL1
Forkhead box protein L1

1

1

High-throughput

0.489

High

335266

TBB8
Tubulin beta-8 chain

1

1

High-throughput

0.489

High

335271

TBC9B
TBC1 domain family member 9B

1

2

High-throughput

0.489

High

335287

SHKB1
SH3KBP1-binding protein 1

1

1

High-throughput

0.489

High

335292

N42L2
NEDD4-binding protein 2-like 2

1

1

High-throughput

0.489

High

335306

FOXB1
Forkhead box protein B1

1

1

High-throughput

0.489

High

335307

KCD14
BTB/POZ domain-containing protein KCTD14

1

1

High-throughput

0.489

High

335313

DNAI2
Dynein axonemal intermediate chain 2

1

1

High-throughput

0.489

High

335315

KLK15
Kallikrein-15

1

1

High-throughput

0.489

High

335318

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

1

High-throughput

0.489

High

335326

AMFR
E3 ubiquitin-protein ligase AMFR

1

0

Small-scale

0.480

High

226190

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

274466

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

1

High-throughput

0.479

High

335229

RASN
GTPase NRas

1

1

High-throughput

0.479

High

335230

RASK
GTPase KRas

1

1

High-throughput

0.479

High

335234

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.479

High

335248

RND2
Rho-related GTP-binding protein RhoN

1

1

High-throughput

0.479

High

335263

CDC37
Hsp90 co-chaperone Cdc37

1

1

Small-scale

0.479

High

335277

RHOU
Rho-related GTP-binding protein RhoU

1

1

High-throughput

0.479

High

335317

RHOF
Rho-related GTP-binding protein RhoF

1

1

High-throughput

0.479

High

335232

PYGL
Glycogen phosphorylase, liver form

1

0

High-throughput

0.458

High

335235

ANDR
Androgen receptor

1

0

High-throughput

0.458

High

335242

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

335244

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

335264

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

335291

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.458

High

335297

OPTN
Optineurin

1

0

High-throughput

0.458

High

335319

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

335324

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

335269

GKAP1
G kinase-anchoring protein 1

1

1

High-throughput

0.439

High

335228

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.437

High

335236

H14
Histone H1.4

1

1

High-throughput

0.437

High

335239

H12
Histone H1.2

1

1

High-throughput

0.437

High

335259

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.437

High

335261

RHOH
Rho-related GTP-binding protein RhoH

1

1

High-throughput

0.437

High

335311

RHBT2
Rho-related BTB domain-containing protein 2

1

1

High-throughput

0.437

High

335245

HELZ
Probable helicase with zinc finger domain

1

0

High-throughput

0.426

High

335268

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

71063

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.279

Low

211339

PI15
Peptidase inhibitor 15

1

0

High-throughput

0.279

Low

278986

RAD17
Cell cycle checkpoint protein RAD17

1

0

High-throughput

0.279

Low

312770

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

0

High-throughput

0.279

Low

328206

LGI1
Leucine-rich glioma-inactivated protein 1

1

0

High-throughput

0.279

Low

335233

TSP1
Thrombospondin-1

1

0

High-throughput

0.279

Low

335238

EDN3
Endothelin-3

1

0

High-throughput

0.279

Low

335252

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.279

Low

335254

IL5RA
Interleukin-5 receptor subunit alpha

1

0

High-throughput

0.279

Low

335260

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.279

Low

335262

NAB2
NGFI-A-binding protein 2

1

0

High-throughput

0.279

Low

335279

BTLA
B- and T-lymphocyte attenuator

1

0

High-throughput

0.279

Low

335284

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.279

Low

335285

BANP
Protein BANP

1

0

High-throughput

0.279

Low

335289

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

0

High-throughput

0.279

Low

335290

MYO3B
Myosin-IIIb

1

0

High-throughput

0.279

Low

335293

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.279

Low

335294

RAD50
DNA repair protein RAD50

1

0

High-throughput

0.279

Low

335298

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.279

Low

335301

IF140
Intraflagellar transport protein 140 homolog

1

0

High-throughput

0.279

Low

335302

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

335303

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

0

High-throughput

0.279

Low

335305

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

335308

ELOV1
Very long chain fatty acid elongase 1

1

0

High-throughput

0.279

Low

335309

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.279

Low

335321

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.279

Low

335323

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

0

High-throughput

0.279

Low

335325

ZNHI2
Zinc finger HIT domain-containing protein 2

1

0

High-throughput

0.279

Low

335330

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

335241

NFYA
Nuclear transcription factor Y subunit alpha

1

0

Small-scale

0.249

Low

335246

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

335251

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

335278

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

335300

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024