Protein: MP2K3
Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)

Gene: MP2K3, MAP2K3
Organism: Homo sapiens
Interactions: 238
UniProt ID: P46734

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001817 - regulation of cytokine production
GO:0002931 - response to ischemia
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

805428

MK14
Mitogen-activated protein kinase 14

18

20

Small-scale

0.988

High

805461

M3K5
Mitogen-activated protein kinase kinase kinase 5

7

17

Small-scale

0.960

High

805367

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

5

17

High-throughput

0.929

High

805357

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

4

17

Small-scale

0.901

High

805435

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

3

20

Small-scale

0.870

High

805498

M3K4
Mitogen-activated protein kinase kinase kinase 4

2

17

Small-scale

0.818

High

160435

AURKA
Aurora kinase A

2

18

Small-scale

0.812

High

557066

PGFRA
Platelet-derived growth factor receptor alpha

2

13

Small-scale

0.812

High

607914

FGFR4
Fibroblast growth factor receptor 4

2

19

Small-scale

0.812

High

665169

EPHA2
Ephrin type-A receptor 2

2

16

Small-scale

0.812

High

805425

STK11
Serine/threonine-protein kinase STK11

2

17

Small-scale

0.812

High

805478

RASF1
Ras association domain-containing protein 1

2

19

Small-scale

0.812

High

805496

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

2

20

Small-scale

0.806

High

805485

TAOK2
Serine/threonine-protein kinase TAO2

1

20

Small-scale

0.785

High

805462

M3K3
Mitogen-activated protein kinase kinase kinase 3

2

17

Small-scale

0.778

High

243329

DNJA2
DnaJ homolog subfamily A member 2

2

18

High-throughput

0.737

High

312785

M3K6
Mitogen-activated protein kinase kinase kinase 6

2

20

High-throughput

0.737

High

658839

MK01
Mitogen-activated protein kinase 1

2

20

High-throughput

0.737

High

672029

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

9

High-throughput

0.737

High

681362

DNJA1
DnaJ homolog subfamily A member 1

2

18

High-throughput

0.737

High

805427

DDB1
DNA damage-binding protein 1

2

6

High-throughput

0.737

High

805429

CDC37
Hsp90 co-chaperone Cdc37

2

12

High-throughput

0.737

High

805441

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

15

High-throughput

0.737

High

805480

DJB11
DnaJ homolog subfamily B member 11

2

16

High-throughput

0.737

High

623868

KPCL
Protein kinase C eta type

1

18

High-throughput

0.691

High

686610

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.691

High

723281

APJ
Apelin receptor

1

2

High-throughput

0.691

High

734885

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

18

High-throughput

0.691

High

805444

CDK20
Cyclin-dependent kinase 20

1

20

High-throughput

0.691

High

805490

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

3

High-throughput

0.691

High

805497

ROBO1
Roundabout homolog 1

1

1

High-throughput

0.691

High

346180

MYC
Myc proto-oncogene protein

3

14

Small-scale

0.678

High

805426

PKN1
Serine/threonine-protein kinase N1

1

16

Small-scale

0.665

High

373854

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.647

High

383686

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

441468

MET
Hepatocyte growth factor receptor

1

15

High-throughput

0.647

High

488610

ARAF
Serine/threonine-protein kinase A-Raf

1

20

High-throughput

0.647

High

515369

CDK4
Cyclin-dependent kinase 4

1

20

High-throughput

0.647

High

542836

BRAF
Serine/threonine-protein kinase B-raf

1

20

High-throughput

0.647

High

647503

MK03
Mitogen-activated protein kinase 3

1

20

Small-scale

0.647

High

673039

CCND2
G1/S-specific cyclin-D2

1

19

High-throughput

0.647

High

681730

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

High-throughput

0.647

High

790917

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

19

High-throughput

0.647

High

790958

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

20

High-throughput

0.647

High

805371

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.647

High

805394

CDK6
Cyclin-dependent kinase 6

1

20

High-throughput

0.647

High

805405

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

17

High-throughput

0.647

High

805469

GLIS2
Zinc finger protein GLIS2

1

13

High-throughput

0.647

High

805477

LATS2
Serine/threonine-protein kinase LATS2

1

16

High-throughput

0.647

High

805494

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

16

Small-scale

0.647

High

397308

ADT2
ADP/ATP translocase 2

3

7

High-throughput

0.633

High

418019

NPM
Nucleophosmin

3

5

High-throughput

0.633

High

428081

TBB5
Tubulin beta chain

3

20

High-throughput

0.633

High

683890

1433S
14-3-3 protein sigma

3

20

High-throughput

0.633

High

649064

ARNT
Aryl hydrocarbon receptor nuclear translocator

2

14

Small-scale

0.629

High

805417

BECN1
Beclin-1

2

3

Small-scale

0.629

High

702201

CD70
CD70 antigen

2

1

High-throughput

0.628

High

71084

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

7

High-throughput

0.618

High

156804

FFAR1
Free fatty acid receptor 1

1

3

High-throughput

0.618

High

226787

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

338104

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

431636

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

805476

ANLN
Anillin

1

4

High-throughput

0.618

High

582120

NUCL
Nucleolin

1

7

High-throughput

0.618

High

641659

U2AF2
Splicing factor U2AF 65 kDa subunit

1

13

High-throughput

0.618

High

778978

CCNF
Cyclin-F

1

16

High-throughput

0.618

High

805364

CDK9
Cyclin-dependent kinase 9

1

20

High-throughput

0.618

High

805388

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.618

High

805397

RON
Macrophage-stimulating protein receptor

1

20

High-throughput

0.618

High

805398

DUS2
Dual specificity protein phosphatase 2

1

8

High-throughput

0.618

High

805404

TADBP
TAR DNA-binding protein 43

1

19

High-throughput

0.618

High

805437

CE170
Centrosomal protein of 170 kDa

1

14

High-throughput

0.618

High

805440

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.618

High

805457

ZFP42
Zinc finger protein 42 homolog

1

9

Small-scale

0.618

High

805458

SRPK1
SRSF protein kinase 1

1

19

High-throughput

0.618

High

805474

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

805475

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

642223

RL13
Large ribosomal subunit protein eL13

2

1

High-throughput

0.600

High

257579

ANR17
Ankyrin repeat domain-containing protein 17

1

0

High-throughput

0.586

High

805408

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

13

Small-scale

0.584

High

805363

ARRB1
Beta-arrestin-1

1

10

Small-scale

0.578

High

805395

PLCB2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

1

3

Small-scale

0.573

High

123876

SPT5H
Transcription elongation factor SPT5

2

4

High-throughput

0.571

High

131643

USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y

2

11

High-throughput

0.571

High

150030

IF1AY
Eukaryotic translation initiation factor 1A, Y-chromosomal

2

2

High-throughput

0.571

High

156246

PSA7
Proteasome subunit alpha type-7

2

11

High-throughput

0.571

High

271272

NPM3
Nucleoplasmin-3

2

6

High-throughput

0.571

High

320826

HS74L
Heat shock 70 kDa protein 4L

2

20

High-throughput

0.571

High

388294

HSPB1
Heat shock protein beta-1

2

10

High-throughput

0.571

High

437293

4F2
Amino acid transporter heavy chain SLC3A2

2

2

High-throughput

0.571

High

445310

RSSA
Small ribosomal subunit protein uS2

2

1

High-throughput

0.571

High

501801

BIP
Endoplasmic reticulum chaperone BiP

2

20

High-throughput

0.571

High

503636

HSP7C
Heat shock cognate 71 kDa protein

2

18

High-throughput

0.571

High

564030

HSP76
Heat shock 70 kDa protein 6

2

19

High-throughput

0.571

High

570982

PYRG1
CTP synthase 1

2

3

High-throughput

0.571

High

640708

CTNA2
Catenin alpha-2

2

7

High-throughput

0.571

High

653187

PYR1
Multifunctional protein CAD

2

7

High-throughput

0.571

High

676830

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

2

High-throughput

0.571

High

714130

HSP74
Heat shock 70 kDa protein 4

2

20

High-throughput

0.571

High

716617

CTNA1
Catenin alpha-1

2

7

High-throughput

0.571

High

716857

CTNB1
Catenin beta-1

2

11

High-throughput

0.571

High

751527

GRP75
Stress-70 protein, mitochondrial

2

20

High-throughput

0.571

High

805360

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

2

2

High-throughput

0.571

High

805365

BAP31
B-cell receptor-associated protein 31

2

1

High-throughput

0.571

High

805366

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

17

High-throughput

0.571

High

805375

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

2

20

High-throughput

0.571

High

805381

GRB2
Growth factor receptor-bound protein 2

2

20

High-throughput

0.571

High

805383

RS21
Small ribosomal subunit protein eS21

2

1

High-throughput

0.571

High

805384

RACK1
Small ribosomal subunit protein RACK1

2

17

High-throughput

0.571

High

805385

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

20

High-throughput

0.571

High

805386

TBA1B
Tubulin alpha-1B chain

2

20

High-throughput

0.571

High

805387

TBB4B
Tubulin beta-4B chain

2

20

High-throughput

0.571

High

805393

S25A3
Solute carrier family 25 member 3

2

15

High-throughput

0.571

High

805396

AKA12
A-kinase anchor protein 12

2

15

High-throughput

0.571

High

805401

RBBP4
Histone-binding protein RBBP4

2

4

High-throughput

0.571

High

805406

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

2

2

High-throughput

0.571

High

805407

MTA1
Metastasis-associated protein MTA1

2

3

High-throughput

0.571

High

805414

TBB2A
Tubulin beta-2A chain

2

20

High-throughput

0.571

High

805418

FAT1
Protocadherin Fat 1

2

4

High-throughput

0.571

High

805430

RBBP7
Histone-binding protein RBBP7

2

11

High-throughput

0.571

High

805433

TBB8
Tubulin beta-8 chain

2

20

High-throughput

0.571

High

805434

PDCD4
Programmed cell death protein 4

2

1

High-throughput

0.571

High

805438

DCAF8
DDB1- and CUL4-associated factor 8

2

9

High-throughput

0.571

High

805449

HS105
Heat shock protein 105 kDa

2

20

High-throughput

0.571

High

805450

HDAC2
Histone deacetylase 2

2

11

High-throughput

0.571

High

805452

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

11

High-throughput

0.571

High

805453

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

12

High-throughput

0.571

High

805460

MMS19
MMS19 nucleotide excision repair protein homolog

2

1

High-throughput

0.571

High

805463

TBA1C
Tubulin alpha-1C chain

2

20

High-throughput

0.571

High

805467

TBB6
Tubulin beta-6 chain

2

20

High-throughput

0.571

High

805492

RUVB2
RuvB-like 2

2

4

High-throughput

0.571

High

805493

RUVB1
RuvB-like 1

2

4

High-throughput

0.571

High

158754

HAT1
Histone acetyltransferase type B catalytic subunit

2

0

High-throughput

0.547

High

590694

BTF3
Transcription factor BTF3

2

0

High-throughput

0.547

High

805369

IF6
Eukaryotic translation initiation factor 6

2

0

High-throughput

0.547

High

805409

HAP28
28 kDa heat- and acid-stable phosphoprotein

2

0

High-throughput

0.547

High

805439

PNCB
Nicotinate phosphoribosyltransferase

2

0

High-throughput

0.547

High

805466

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.543

High

457139

ALDOC
Fructose-bisphosphate aldolase C

1

3

High-throughput

0.541

High

528363

MYH6
Myosin-6

1

20

High-throughput

0.536

High

805368

FOXA3
Hepatocyte nuclear factor 3-gamma

1

5

High-throughput

0.536

High

805403

FOXL1
Forkhead box protein L1

1

4

High-throughput

0.536

High

805411

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.536

High

805443

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

6

High-throughput

0.536

High

805446

SIR6
NAD-dependent protein deacylase sirtuin-6

1

10

High-throughput

0.536

High

805455

EFMT3
EEF1A lysine methyltransferase 3

1

5

High-throughput

0.536

High

805470

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

805483

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

2

High-throughput

0.536

High

805495

KLK5
Kallikrein-5

1

4

High-throughput

0.536

High

805479

HPBP1
Hsp70-binding protein 1

2

2

High-throughput

0.521

High

147977

UBFD1
Ubiquitin domain-containing protein UBFD1

1

0

High-throughput

0.517

High

805445

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

154006

TERT
Telomerase reverse transcriptase

1

2

High-throughput

0.501

High

386279

P53
Cellular tumor antigen p53

1

6

High-throughput

0.501

High

394304

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

555100

CD44
CD44 antigen

1

4

High-throughput

0.501

High

598441

NF1
Neurofibromin

1

13

High-throughput

0.501

High

708207

ERD22
ER lumen protein-retaining receptor 2

1

1

High-throughput

0.501

High

719408

MERL
Merlin

1

10

High-throughput

0.501

High

805370

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

High-throughput

0.501

High

805423

TEAD2
Transcriptional enhancer factor TEF-4

1

3

High-throughput

0.501

High

805424

SMAD1
Mothers against decapentaplegic homolog 1

1

17

High-throughput

0.501

High

805431

HIF1A
Hypoxia-inducible factor 1-alpha

1

14

High-throughput

0.501

High

805451

KAT2A
Histone acetyltransferase KAT2A

1

10

High-throughput

0.501

High

805486

CBLC
E3 ubiquitin-protein ligase CBL-C

1

2

High-throughput

0.501

High

805487

FZR1
Fizzy-related protein homolog

1

15

High-throughput

0.501

High

208900

FOXS1
Forkhead box protein S1

1

6

High-throughput

0.489

High

805472

DNAI2
Dynein axonemal intermediate chain 2

1

5

High-throughput

0.489

High

805473

KLK15
Kallikrein-15

1

4

High-throughput

0.489

High

443148

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.480

High

150683

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

13

High-throughput

0.479

High

167341

SMAD7
Mothers against decapentaplegic homolog 7

1

17

Small-scale

0.479

High

229642

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

20

Small-scale

0.479

High

244081

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

297726

MICA2
[F-actin]-monooxygenase MICAL2

1

14

High-throughput

0.479

High

322307

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

351299

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

1

High-throughput

0.479

High

499606

CH60
60 kDa heat shock protein, mitochondrial

1

12

High-throughput

0.479

High

532420

TCTP
Translationally-controlled tumor protein

1

5

High-throughput

0.479

High

567819

HXB9
Homeobox protein Hox-B9

1

3

High-throughput

0.479

High

571347

DDX5
Probable ATP-dependent RNA helicase DDX5

1

10

High-throughput

0.479

High

574958

RL7
Large ribosomal subunit protein uL30

1

3

High-throughput

0.479

High

650606

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

653141

DCK
Deoxycytidine kinase

1

1

High-throughput

0.479

High

736301

RL4
Large ribosomal subunit protein uL4

1

3

High-throughput

0.479

High

759921

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.479

High

776601

STAT3
Signal transducer and activator of transcription 3

1

6

Small-scale

0.479

High

801503

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

1

4

High-throughput

0.479

High

805359

RL28
Large ribosomal subunit protein eL28

1

3

High-throughput

0.479

High

805361

RL29
Large ribosomal subunit protein eL29

1

1

High-throughput

0.479

High

805362

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

7

High-throughput

0.479

High

805372

RS3A
Small ribosomal subunit protein eS1

1

2

High-throughput

0.479

High

805373

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

20

High-throughput

0.479

High

805374

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

9

High-throughput

0.479

High

805376

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

805377

H2B1C
Histone H2B type 1-C/E/F/G/I

1

15

High-throughput

0.479

High

805379

RS28
Small ribosomal subunit protein eS28

1

2

High-throughput

0.479

High

805380

RL30
Large ribosomal subunit protein eL30

1

3

High-throughput

0.479

High

805382

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

805389

RL24
Large ribosomal subunit protein eL24

1

2

High-throughput

0.479

High

805390

RL36A
Large ribosomal subunit protein eL42

1

1

High-throughput

0.479

High

805391

SMAD3
Mothers against decapentaplegic homolog 3

1

17

High-throughput

0.479

High

805392

RL19
Large ribosomal subunit protein eL19

1

2

High-throughput

0.479

High

805399

DHX9
ATP-dependent RNA helicase A

1

4

High-throughput

0.479

High

805400

GOGA2
Golgin subfamily A member 2

1

20

High-throughput

0.479

High

805402

ILF3
Interleukin enhancer-binding factor 3

1

8

High-throughput

0.479

High

805410

TBB3
Tubulin beta-3 chain

1

20

High-throughput

0.479

High

805412

CUL3
Cullin-3

1

10

High-throughput

0.479

High

805413

CUL4A
Cullin-4A

1

10

High-throughput

0.479

High

805416

SRC8
Src substrate cortactin

1

10

High-throughput

0.479

High

805419

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

18

High-throughput

0.479

High

805420

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

805421

PTPA
Serine/threonine-protein phosphatase 2A activator

1

2

Small-scale

0.479

High

805422

PCBP1
Poly(rC)-binding protein 1

1

19

High-throughput

0.479

High

805432

CL16A
Protein CLEC16A

1

4

High-throughput

0.479

High

805436

NU188
Nucleoporin NUP188

1

1

High-throughput

0.479

High

805442

ZN598
E3 ubiquitin-protein ligase ZNF598

1

6

High-throughput

0.479

High

805454

RL36L
Ribosomal protein eL42-like

1

1

High-throughput

0.479

High

805465

BUD13
BUD13 homolog

1

7

High-throughput

0.479

High

805468

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

5

High-throughput

0.479

High

805471

DDX24
ATP-dependent RNA helicase DDX24

1

13

High-throughput

0.479

High

805481

ZRAN1
Ubiquitin thioesterase ZRANB1

1

13

High-throughput

0.479

High

805482

TES
Testin

1

13

High-throughput

0.479

High

805484

AGO2
Protein argonaute-2

1

8

Small-scale

0.479

High

805489

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

20

Small-scale

0.479

High

805491

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

8

Small-scale

0.479

High

805358

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.458

High

805378

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.458

High

805447

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

805488

DIM1
Probable dimethyladenosine transferase

1

0

High-throughput

0.458

High

805415

DCTN1
Dynactin subunit 1

1

20

Small-scale

0.457

High

528735

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.445

High

126362

MATN2
Matrilin-2

1

3

High-throughput

0.437

High

805456

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.279

Low

805448

RM30
Large ribosomal subunit protein uL30m

1

0

High-throughput

0.249

Low

805459

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low

805464

PIGQ
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024