Protein: MRE11
Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)

Gene: MRE11
Organism: Homo sapiens
Interactions: 223
UniProt ID: P49959

Gene Ontology (top 5):
GO:0000014 - single-stranded DNA endodeoxyribonuclease activity
GO:0000019 - regulation of mitotic recombination
GO:0000723 - telomere maintenance
GO:0000724 - double-strand break repair via homologous recombination
GO:0000729 - DNA double-strand break processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

837057

RAD50
DNA repair protein RAD50

36

6

Small-scale

0.993

High

836974

MRE11
Double-strand break repair protein MRE11

4

4

Small-scale

0.895

High

246192

NBN
Nibrin

40

1

Small-scale

0.770

High

837016

MDC1
Mediator of DNA damage checkpoint protein 1

7

4

Small-scale

0.751

High

749235

BRCA1
Breast cancer type 1 susceptibility protein

10

1

Small-scale

0.750

High

837071

CTIP
DNA endonuclease RBBP8

10

0

Small-scale

0.722

High

837005

ATM
Serine-protein kinase ATM

5

6

Small-scale

0.712

High

650683

RFA1
Replication protein A 70 kDa DNA-binding subunit

5

1

Small-scale

0.702

High

801029

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.691

High

555354

H2AX
Histone H2AX

5

0

Small-scale

0.673

High

837023

TERF2
Telomeric repeat-binding factor 2

4

0

Small-scale

0.651

High

837044

SLX4
Structure-specific endonuclease subunit SLX4

3

2

Small-scale

0.640

High

802406

ATRX
Transcriptional regulator ATRX

3

3

Small-scale

0.633

High

523598

XRCC6
X-ray repair cross-complementing protein 6

2

1

Small-scale

0.631

High

836978

BLM
RecQ-like DNA helicase BLM

3

3

Small-scale

0.624

High

837082

FACD2
Fanconi anemia group D2 protein

2

0

Small-scale

0.623

High

386325

P53
Cellular tumor antigen p53

3

0

Small-scale

0.619

High

283179

RGS20
Regulator of G-protein signaling 20

2

1

High-throughput

0.611

High

836984

H4
Histone H4

3

0

Small-scale

0.604

High

836982

SUMO2
Small ubiquitin-related modifier 2

2

2

High-throughput

0.602

High

836975

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

3

High-throughput

0.601

High

837025

H31T
Histone H3.1t

2

1

Small-scale

0.601

High

837080

FANCJ
Fanconi anemia group J protein

2

0

Small-scale

0.598

High

150915

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.586

High

226871

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

244125

BRD4
Bromodomain-containing protein 4

2

4

High-throughput

0.584

High

282856

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

2

1

High-throughput

0.584

High

294540

RECQ4
ATP-dependent DNA helicase Q4

2

3

Small-scale

0.584

High

322344

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

1

High-throughput

0.584

High

552243

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.584

High

808403

YAP1
Transcriptional coactivator YAP1

2

1

Small-scale

0.584

High

837060

FBXW7
F-box/WD repeat-containing protein 7

2

1

Small-scale

0.584

High

837065

DCR1C
Protein artemis

2

1

Small-scale

0.584

High

837074

ANM1
Protein arginine N-methyltransferase 1

2

1

Small-scale

0.584

High

837095

UBQL4
Ubiquilin-4

2

1

Small-scale

0.584

High

369203

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

295509

RECQ5
ATP-dependent DNA helicase Q5

1

3

Small-scale

0.561

High

719981

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

837099

NALP2
NACHT, LRR and PYD domains-containing protein 2

2

0

Small-scale

0.559

High

837101

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

2

0

Small-scale

0.559

High

625238

CDK2
Cyclin-dependent kinase 2

1

1

Small-scale

0.552

High

837006

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

0

High-throughput

0.551

High

272520

OFD1
Centriole and centriolar satellite protein OFD1

2

0

High-throughput

0.547

High

559611

H12
Histone H1.2

1

0

Small-scale

0.537

High

836985

GRB2
Growth factor receptor-bound protein 2

1

0

Small-scale

0.537

High

836987

DYL1
Dynein light chain 1, cytoplasmic

1

0

Small-scale

0.537

High

837084

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

Small-scale

0.537

High

157018

AIM2
Interferon-inducible protein AIM2

1

1

High-throughput

0.536

High

161635

GAK
Cyclin-G-associated kinase

1

1

High-throughput

0.536

High

319142

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.536

High

836983

ERR3
Estrogen-related receptor gamma

1

2

High-throughput

0.536

High

837026

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.536

High

837068

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

624563

CCNE1
G1/S-specific cyclin-E1

1

1

Small-scale

0.515

High

71088

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.513

High

436687

GLI1
Zinc finger protein GLI1

1

0

High-throughput

0.513

High

449607

HMGB1
High mobility group protein B1

1

0

High-throughput

0.513

High

836990

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

837011

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

837019

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.513

High

837046

NECP1
Adaptin ear-binding coat-associated protein 1

1

0

High-throughput

0.513

High

837048

TDRD7
Tudor domain-containing protein 7

1

0

High-throughput

0.513

High

837085

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.513

High

837086

FOXP1
Forkhead box protein P1

1

0

High-throughput

0.513

High

837097

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

Small-scale

0.513

High

836986

SUMO1
Small ubiquitin-related modifier 1

1

2

High-throughput

0.501

High

279006

RAD17
Cell cycle checkpoint protein RAD17

1

1

Small-scale

0.500

High

836994

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.493

High

837064

NEK1
Serine/threonine-protein kinase Nek1

1

0

Small-scale

0.486

High

579460

DNLI1
DNA ligase 1

1

1

Small-scale

0.481

High

837070

CDX2
Homeobox protein CDX-2

1

0

Small-scale

0.480

High

837073

NKX31
Homeobox protein Nkx-3.1

1

0

Small-scale

0.480

High

620466

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

0

High-throughput

0.479

High

837000

ILF2
Interleukin enhancer-binding factor 2

1

0

Small-scale

0.479

High

837036

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

1

0

Small-scale

0.479

High

164362

TRI66
Tripartite motif-containing protein 66

1

2

High-throughput

0.479

High

169257

MDM4
Protein Mdm4

1

2

Small-scale

0.479

High

267958

EED
Polycomb protein EED

1

3

High-throughput

0.479

High

282578

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

Small-scale

0.479

High

340796

KAD1
Adenylate kinase isoenzyme 1

1

1

High-throughput

0.479

High

431660

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.479

High

487239

ANDR
Androgen receptor

1

3

High-throughput

0.479

High

532436

TCTP
Translationally-controlled tumor protein

1

1

High-throughput

0.479

High

569398

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

707558

H2B1B
Histone H2B type 1-B

1

1

High-throughput

0.479

High

740470

PPARG
Peroxisome proliferator-activated receptor gamma

1

3

Small-scale

0.479

High

779027

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

836981

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

1

High-throughput

0.479

High

836988

H31
Histone H3.1

1

1

High-throughput

0.479

High

836991

MDM2
E3 ubiquitin-protein ligase Mdm2

1

2

Small-scale

0.479

High

836995

ERCC6
DNA excision repair protein ERCC-6

1

2

Small-scale

0.479

High

836997

EP300
Histone acetyltransferase p300

1

2

Small-scale

0.479

High

836998

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

836999

TP53B
TP53-binding protein 1

1

2

High-throughput

0.479

High

837001

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

Small-scale

0.479

High

837002

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

837003

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

837008

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

837009

BIRC2
Baculoviral IAP repeat-containing protein 2

1

3

Small-scale

0.479

High

837012

CUL3
Cullin-3

1

1

High-throughput

0.479

High

837014

RAB32
Ras-related protein Rab-32

1

1

High-throughput

0.479

High

837018

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

837028

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

1

High-throughput

0.479

High

837030

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

837031

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.479

High

837034

PAXI1
PAX-interacting protein 1

1

1

Small-scale

0.479

High

837054

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

837055

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

837056

KAT2B
Histone acetyltransferase KAT2B

1

3

Small-scale

0.479

High

837063

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

4

Small-scale

0.479

High

837076

TINF2
TERF1-interacting nuclear factor 2

1

1

High-throughput

0.479

High

837077

PCGF1
Polycomb group RING finger protein 1

1

1

High-throughput

0.479

High

837083

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.479

High

837089

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

837091

DCR1B
5' exonuclease Apollo

1

1

Small-scale

0.479

High

837094

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

2

High-throughput

0.479

High

837096

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

Small-scale

0.479

High

837102

HDAC6
Histone deacetylase 6

1

1

Small-scale

0.479

High

837105

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

837107

FBW1B
F-box/WD repeat-containing protein 11

1

1

High-throughput

0.479

High

837108

BRPF3
Bromodomain and PHD finger-containing protein 3

1

3

High-throughput

0.479

High

837109

TRRAP
Transformation/transcription domain-associated protein

1

6

Small-scale

0.479

High

214147

SPOP
Speckle-type POZ protein

1

0

Small-scale

0.460

High

122567

MEN1
Menin

1

0

High-throughput

0.458

High

158760

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

Small-scale

0.458

High

161800

ZN263
Zinc finger protein 263

1

0

Small-scale

0.458

High

209784

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

232814

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

0

High-throughput

0.458

High

255600

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

264145

DPOLQ
DNA polymerase theta

1

0

Small-scale

0.458

High

298284

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

318937

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

346247

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

359766

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

360626

SPTA1
Spectrin alpha chain, erythrocytic 1

1

0

Small-scale

0.458

High

373887

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

384498

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

475491

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

503693

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

508878

TOP2A
DNA topoisomerase 2-alpha

1

0

Small-scale

0.458

High

521810

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

579673

XRCC1
DNA repair protein XRCC1

1

0

Small-scale

0.458

High

590147

CCNA2
Cyclin-A2

1

0

Small-scale

0.458

High

684522

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

823703

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

828961

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

836977

PLK1
Serine/threonine-protein kinase PLK1

1

0

Small-scale

0.458

High

836979

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

836980

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

836992

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

836993

SEMG2
Semenogelin-2

1

0

Small-scale

0.458

High

836996

RBBP4
Histone-binding protein RBBP4

1

0

Small-scale

0.458

High

837004

SKP2
S-phase kinase-associated protein 2

1

0

Small-scale

0.458

High

837007

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

0

High-throughput

0.458

High

837017

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

Small-scale

0.458

High

837020

CUL7
Cullin-7

1

0

High-throughput

0.458

High

837021

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

837022

PCBP1
Poly(rC)-binding protein 1

1

0

Small-scale

0.458

High

837024

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

837027

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

837029

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.458

High

837033

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

837035

ZN365
Protein ZNF365

1

0

Small-scale

0.458

High

837037

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

837038

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

837039

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

837042

SKA3
Spindle and kinetochore-associated protein 3

1

0

Small-scale

0.458

High

837043

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

837045

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

837047

RN169
E3 ubiquitin-protein ligase RNF169

1

0

Small-scale

0.458

High

837050

ATRIP
ATR-interacting protein

1

0

Small-scale

0.458

High

837051

DDX1
ATP-dependent RNA helicase DDX1

1

0

Small-scale

0.458

High

837052

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

837053

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

837058

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.458

High

837059

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

Small-scale

0.458

High

837062

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

Small-scale

0.458

High

837069

NECD
Necdin

1

0

High-throughput

0.458

High

837072

BARD1
BRCA1-associated RING domain protein 1

1

0

Small-scale

0.458

High

837075

SOSB1
SOSS complex subunit B1

1

0

Small-scale

0.458

High

837078

RN126
E3 ubiquitin-protein ligase RNF126

1

0

Small-scale

0.458

High

837079

CYREN
Cell cycle regulator of non-homologous end joining

1

0

Small-scale

0.458

High

837081

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

837087

TXNIP
Thioredoxin-interacting protein

1

0

Small-scale

0.458

High

837088

SENP3
Sentrin-specific protease 3

1

0

Small-scale

0.458

High

837090

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

837092

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

837093

ANLN
Anillin

1

0

High-throughput

0.458

High

837100

MCM9
DNA helicase MCM9

1

0

Small-scale

0.458

High

837104

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

837110

DUS10
Dual specificity protein phosphatase 10

1

0

High-throughput

0.458

High

401649

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

455224

PARP1
Poly [ADP-ribose] polymerase 1

1

1

Small-scale

0.445

High

794214

MSH2
DNA mismatch repair protein Msh2

1

2

Small-scale

0.445

High

836976

MSH6
DNA mismatch repair protein Msh6

1

2

Small-scale

0.445

High

837061

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

2

Small-scale

0.445

High

791385

HD
Huntingtin

1

0

High-throughput

0.438

High

217862

PRKY
Putative serine/threonine-protein kinase PRKY

1

0

High-throughput

0.426

High

371379

ANGI
Angiogenin

1

0

High-throughput

0.426

High

652783

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

Small-scale

0.426

High

722196

RFC1
Replication factor C subunit 1

1

0

Small-scale

0.426

High

776268

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.426

High

837103

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.426

High

831106

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

836989

PRKDC
DNA-dependent protein kinase catalytic subunit

1

6

Small-scale

0.408

High

837010

ATR
Serine/threonine-protein kinase ATR

1

6

Small-scale

0.408

High

72183

B3KSW4
Regulator of G protein signaling 20

1

1

High-throughput

0.407

High

437567

CEL2B
Chymotrypsin-like elastase family member 2B

3

0

High-throughput

0.347

High

837041

F219A
Protein FAM219A

3

0

High-throughput

0.347

High

528084

BMP1
Bone morphogenetic protein 1

2

0

High-throughput

0.328

High

837032

CF161
Cilia- and flagella-associated protein 161

2

0

High-throughput

0.318

High

672646

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.279

Low

837040

RAB43
Ras-related protein Rab-43

1

0

High-throughput

0.279

Low

837049

SCG3
Secretogranin-3

1

0

High-throughput

0.279

Low

837066

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

837106

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

0

High-throughput

0.279

Low

657664

LYOX
Protein-lysine 6-oxidase

1

0

Small-scale

0.261

Low

100598

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

837013

PTC1
Protein patched homolog 1

1

0

Small-scale

0.249

Low

837015

TRI29
Tripartite motif-containing protein 29

1

0

Small-scale

0.249

Low

837067

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low

837098

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024