Protein: HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2)

Gene: HCN1
Organism: Mus musculus
Interactions: 51
UniProt ID: O88704

Gene Ontology (top 5):
GO:0003254 - regulation of membrane depolarization
GO:0005222 - intracellularly cAMP-activated cation channel activity
GO:0005248 - voltage-gated sodium channel activity
GO:0005249 - voltage-gated potassium channel activity
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

292103

HCN2
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

2

14

Small-scale

0.789

High

292110

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

14

Small-scale

0.716

High

292112

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

13

High-throughput

0.691

High

292113

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

17

High-throughput

0.691

High

292115

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

11

High-throughput

0.691

High

292118

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.691

High

292120

TNIK
Traf2 and NCK-interacting protein kinase

1

9

High-throughput

0.691

High

292125

PAK3
Serine/threonine-protein kinase PAK 3

1

11

High-throughput

0.691

High

292143

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed]

1

17

High-throughput

0.691

High

292149

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.691

High

292124

CSK21
Casein kinase II subunit alpha

1

4

High-throughput

0.618

High

71336

B2RY58
Hyperpolarization-activated, cyclic nucleotide-gated K+ 4

1

14

High-throughput

0.618

High

93682

E9Q6P9
Calcium channel, voltage-dependent, T type, alpha 1H subunit

1

5

Small-scale

0.618

High

103560

G5E884
non-specific serine/threonine protein kinase

1

9

High-throughput

0.618

High

292122

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

2

7

High-throughput

0.611

High

292137

PEX5R
PEX5-related protein

2

7

Small-scale

0.611

High

251014

HCN4
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

1

14

High-throughput

0.575

High

292038

PAK1
Serine/threonine-protein kinase PAK 1

1

10

High-throughput

0.575

High

292130

BRSK2
Serine/threonine-protein kinase BRSK2

1

8

High-throughput

0.553

High

292111

BSN
Protein bassoon

1

5

High-throughput

0.536

High

292117

RP3A
Rabphilin-3A

1

5

High-throughput

0.536

High

292121

NF1
Neurofibromin

1

3

High-throughput

0.536

High

292123

KCD16
BTB/POZ domain-containing protein KCTD16

1

6

High-throughput

0.536

High

292126

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

8

High-throughput

0.536

High

292128

GIT1
ARF GTPase-activating protein GIT1

1

9

High-throughput

0.536

High

292129

Q68FG2
Spectrin beta chain

1

8

High-throughput

0.536

High

292132

ASIC1
Acid-sensing ion channel 1

1

1

High-throughput

0.536

High

292133

KCD12
BTB/POZ domain-containing protein KCTD12

1

8

High-throughput

0.536

High

292135

DLG1
Disks large homolog 1

1

4

High-throughput

0.536

High

292140

MPDZ
Multiple PDZ domain protein

1

3

High-throughput

0.536

High

292144

DSCAM
Cell adhesion molecule DSCAM

1

7

High-throughput

0.536

High

292145

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

4

High-throughput

0.536

High

292146

ARHG7
Rho guanine nucleotide exchange factor 7

1

2

High-throughput

0.536

High

292147

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

6

High-throughput

0.536

High

292148

SHRM3
Protein Shroom3

1

5

High-throughput

0.536

High

292150

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

1

High-throughput

0.536

High

292134

GABR2
Gamma-aminobutyric acid type B receptor subunit 2

1

0

High-throughput

0.513

High

292136

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

0

High-throughput

0.513

High

292131

SPKAP
A-kinase anchor protein SPHKAP

1

1

High-throughput

0.489

High

292139

SH3K1
SH3 domain-containing kinase-binding protein 1

1

2

High-throughput

0.489

High

292141

SH319
SH3 domain-containing protein 19

1

10

High-throughput

0.489

High

192898

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

1

High-throughput

0.479

High

292116

SSR3
Somatostatin receptor type 3

1

2

High-throughput

0.479

High

292119

AP2S1
AP-2 complex subunit sigma

1

2

High-throughput

0.479

High

292142

CNTP2
Contactin-associated protein-like 2

1

5

High-throughput

0.479

High

102722

G3X9H5
Huntingtin

1

0

High-throughput

0.458

High

93373

TENS1
Tensin-1

1

3

High-throughput

0.445

High

292138

Q8C6V6
Phosphatase tensin-type domain-containing protein

1

1

High-throughput

0.437

High

292114

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.279

Low

292127

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024