Protein: SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3)

Gene: SIR3, SIRT3
Organism: Homo sapiens
Interactions: 95
UniProt ID: Q9NTG7

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006476 - protein deacetylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

500148

CH60
60 kDa heat shock protein, mitochondrial

5

5

Small-scale

0.723

High

1345685

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

11

Small-scale

0.691

High

1031286

SKP2
S-phase kinase-associated protein 2

2

4

Small-scale

0.650

High

678088

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

2

2

High-throughput

0.628

High

1285828

TRI43
Tripartite motif-containing protein 43

2

3

High-throughput

0.628

High

440757

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

2

3

Small-scale

0.624

High

1345678

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

1

11

Small-scale

0.618

High

637076

ATPA
ATP synthase subunit alpha, mitochondrial

2

5

Small-scale

0.612

High

396505

ALDH2
Aldehyde dehydrogenase, mitochondrial

2

7

Small-scale

0.611

High

1055551

DMC1
Meiotic recombination protein DMC1/LIM15 homolog

2

1

High-throughput

0.611

High

258809

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

0

High-throughput

0.602

High

344021

ASSY
Argininosuccinate synthase

2

0

High-throughput

0.602

High

1345686

RM42
Large ribosomal subunit protein mL42

2

0

High-throughput

0.602

High

451973

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

3

2

High-throughput

0.599

High

832945

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

2

5

Small-scale

0.595

High

311294

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

2

0

High-throughput

0.585

High

524033

XRCC6
X-ray repair cross-complementing protein 6

1

5

Small-scale

0.578

High

687294

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

3

Small-scale

0.578

High

1345679

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

4

Small-scale

0.578

High

231167

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

5

Small-scale

0.561

High

671530

ECHM
Enoyl-CoA hydratase, mitochondrial

1

5

Small-scale

0.561

High

935287

H31
Histone H3.1

1

10

Small-scale

0.561

High

992203

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

2

Small-scale

0.561

High

1345677

ACS2L
Acetyl-coenzyme A synthetase 2-like, mitochondrial

1

1

Small-scale

0.561

High

840326

PEX5
Peroxisomal targeting signal 1 receptor

1

1

High-throughput

0.541

High

615847

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.537

High

646536

ANX13
Annexin A13

1

4

High-throughput

0.536

High

815453

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

High-throughput

0.536

High

885908

YBEY
Endoribonuclease YbeY

1

1

High-throughput

0.536

High

1204150

NIT1
Deaminated glutathione amidase

1

1

High-throughput

0.536

High

1217508

AHNK2
Protein AHNAK2

1

5

High-throughput

0.536

High

1289706

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

1

High-throughput

0.536

High

1292823

SYMM
Methionine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

1314905

SSBP3
Single-stranded DNA-binding protein 3

1

3

High-throughput

0.536

High

1331136

MTG2
Mitochondrial ribosome-associated GTPase 2

1

3

High-throughput

0.536

High

1334475

ELP3
Elongator complex protein 3

1

1

High-throughput

0.536

High

1345684

RT18B
Small ribosomal subunit protein mS40

1

1

High-throughput

0.536

High

206859

FOXO3
Forkhead box protein O3

1

13

Small-scale

0.515

High

238817

UGDH
UDP-glucose 6-dehydrogenase

1

2

Small-scale

0.515

High

320029

HERC2
E3 ubiquitin-protein ligase HERC2

1

11

Small-scale

0.515

High

415515

ATPB
ATP synthase subunit beta, mitochondrial

1

3

Small-scale

0.515

High

502598

BIP
Endoplasmic reticulum chaperone BiP

1

10

Small-scale

0.515

High

538420

ENPL
Endoplasmin

1

3

Small-scale

0.515

High

714080

HS71L
Heat shock 70 kDa protein 1-like

1

6

Small-scale

0.515

High

751853

GRP75
Stress-70 protein, mitochondrial

1

14

Small-scale

0.515

High

1137576

RIF1
Telomere-associated protein RIF1

1

10

Small-scale

0.515

High

1164672

MAP12
Methionine aminopeptidase 1D, mitochondrial

1

2

High-throughput

0.515

High

1232424

CMYA5
Cardiomyopathy-associated protein 5

1

8

Small-scale

0.515

High

1345681

TTF2
Transcription termination factor 2

1

17

Small-scale

0.515

High

261909

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.513

High

523172

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

High-throughput

0.513

High

602156

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.513

High

612061

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.513

High

671127

ATPD
ATP synthase subunit delta, mitochondrial

1

0

High-throughput

0.513

High

716571

CAH5A
Carbonic anhydrase 5A, mitochondrial

1

0

High-throughput

0.513

High

1124809

OXLD1
Oxidoreductase-like domain-containing protein 1

1

0

High-throughput

0.513

High

1219043

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1345680

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.513

High

489826

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

5

High-throughput

0.501

High

962990

MDM2
E3 ubiquitin-protein ligase Mdm2

1

4

Small-scale

0.501

High

433091

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

Small-scale

0.493

High

1255770

MICA1
[F-actin]-monooxygenase MICAL1

1

8

High-throughput

0.489

High

1345683

RT18C
Small ribosomal subunit protein bS18m

1

2

High-throughput

0.489

High

72092

B3KMS0
Condensin complex subunit 1

1

3

Small-scale

0.479

High

262991

CISY
Citrate synthase, mitochondrial

1

6

Small-scale

0.479

High

316530

ETHE1
Persulfide dioxygenase ETHE1, mitochondrial

1

1

Small-scale

0.479

High

325907

LATS1
Serine/threonine-protein kinase LATS1

1

4

Small-scale

0.479

High

335202

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

3

Small-scale

0.479

High

505911

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

2

Small-scale

0.479

High

714434

HSP74
Heat shock 70 kDa protein 4

1

13

Small-scale

0.479

High

822517

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

2

Small-scale

0.479

High

918008

H4
Histone H4

1

5

Small-scale

0.479

High

1046454

SNTB1
Beta-1-syntrophin

1

1

Small-scale

0.479

High

1063377

CND1
Condensin complex subunit 1

1

3

Small-scale

0.479

High

1068098

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

1068150

PDK2
[Pyruvate dehydrogenase

1

1

Small-scale

0.479

High

1087724

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

1

Small-scale

0.479

High

1171907

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1269722

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

1305837

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

Small-scale

0.479

High

1333371

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

5

Small-scale

0.479

High

1345682

RUVB1
RuvB-like 1

1

4

Small-scale

0.479

High

235001

SNX3
Sorting nexin-3

1

4

High-throughput

0.470

High

309534

MTMR5
Myotubularin-related protein 5

1

2

Small-scale

0.470

High

959141

PIPNA
Phosphatidylinositol transfer protein alpha isoform

1

0

Small-scale

0.458

High

1168128

HSDL2
Hydroxysteroid dehydrogenase-like protein 2

1

0

Small-scale

0.458

High

128650

DNM1L
Dynamin-1-like protein

1

4

High-throughput

0.457

High

1026837

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

8

Small-scale

0.437

High

1288533

ARHGQ
Rho guanine nucleotide exchange factor 26

1

1

High-throughput

0.437

High

1314951

LS14B
Protein LSM14 homolog B

3

0

High-throughput

0.347

High

1317650

REG4
Regenerating islet-derived protein 4

2

0

High-throughput

0.328

High

660722

GRN
Progranulin

2

0

Small-scale

0.319

High

892759

C1QT8
Complement C1q tumor necrosis factor-related protein 8

1

0

High-throughput

0.279

Low

1205560

TMM25
Transmembrane protein 25

1

0

High-throughput

0.279

Low

1176004

PGAP1
GPI inositol-deacylase

1

0

Small-scale

0.269

Low


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Last updated: 15 Jul 2024