Protein: SRBP2
Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)]

Gene: SRBP2, SREBF2
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q12772

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000139 - Golgi membrane
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1016061

FHL2
Four and a half LIM domains protein 2

3

12

High-throughput

0.858

High

1016055

SRBP2
Sterol regulatory element-binding protein 2

2

18

Small-scale

0.778

High

150561

ABLM1
Actin-binding LIM protein 1

1

10

High-throughput

0.698

High

1016059

FHL3
Four and a half LIM domains protein 3

1

12

High-throughput

0.698

High

1016068

ZYX
Zyxin

1

12

High-throughput

0.698

High

1016076

ABLM2
Actin-binding LIM protein 2

1

12

High-throughput

0.698

High

1016089

CBP
CREB-binding protein

3

19

Small-scale

0.667

High

1016060

NFYC
Nuclear transcription factor Y subunit gamma

3

2

High-throughput

0.667

High

588766

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

3

4

High-throughput

0.667

High

970265

NRG1
Pro-neuregulin-1, membrane-bound isoform

3

3

High-throughput

0.667

High

1015971

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

3

16

Small-scale

0.656

High

647557

MK03
Mitogen-activated protein kinase 3

2

9

Small-scale

0.651

High

658912

MK01
Mitogen-activated protein kinase 1

2

9

Small-scale

0.651

High

738962

SRBP1
Sterol regulatory element-binding protein 1

1

19

Small-scale

0.647

High

782529

HNF4A
Hepatocyte nuclear factor 4-alpha

2

20

Small-scale

0.639

High

1016099

CGRF1
Cell growth regulator with RING finger domain protein 1

3

0

High-throughput

0.638

High

435073

SP1
Transcription factor Sp1

2

20

Small-scale

0.636

High

702758

CADH5
Cadherin-5

2

7

High-throughput

0.628

High

1016088

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

1

High-throughput

0.628

High

930177

UBC9
SUMO-conjugating enzyme UBC9

2

8

Small-scale

0.614

High

1016077

S39A4
Zinc transporter ZIP4

3

1

High-throughput

0.609

High

181099

INSI1
Insulin-induced gene 1 protein

2

2

Small-scale

0.584

High

989611

ACHD
Acetylcholine receptor subunit delta

2

2

High-throughput

0.574

High

1016069

S4A8
Electroneutral sodium bicarbonate exchanger 1

2

1

High-throughput

0.574

High

1016071

S39AC
Zinc transporter ZIP12

2

1

High-throughput

0.574

High

1016084

I17RC
Interleukin-17 receptor C

2

1

High-throughput

0.574

High

130321

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

20

Small-scale

0.561

High

579333

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

17

Small-scale

0.561

High

278069

PIAS1
E3 SUMO-protein ligase PIAS1

1

13

High-throughput

0.541

High

278272

PIAS2
E3 SUMO-protein ligase PIAS2

1

13

High-throughput

0.541

High

502025

BIP
Endoplasmic reticulum chaperone BiP

1

7

High-throughput

0.541

High

556852

CREB1
Cyclic AMP-responsive element-binding protein 1

1

9

High-throughput

0.541

High

575406

EGR1
Early growth response protein 1

1

8

High-throughput

0.541

High

617747

NFYA
Nuclear transcription factor Y subunit alpha

1

2

High-throughput

0.541

High

827180

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.541

High

868456

ATX1
Ataxin-1

1

6

High-throughput

0.541

High

874082

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

2

High-throughput

0.541

High

963302

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

4

High-throughput

0.541

High

1016057

ULA1
NEDD8-activating enzyme E1 regulatory subunit

1

1

High-throughput

0.541

High

1016064

GOGB1
Golgin subfamily B member 1

1

7

High-throughput

0.541

High

1016081

ZDH17
Palmitoyltransferase ZDHHC17

1

6

High-throughput

0.541

High

1016090

ARHG1
Rho guanine nucleotide exchange factor 1

1

1

High-throughput

0.541

High

1016091

CSN5
COP9 signalosome complex subunit 5

1

8

High-throughput

0.541

High

1016098

TTC1
Tetratricopeptide repeat protein 1

1

4

High-throughput

0.541

High

1016113

ZMYM2
Zinc finger MYM-type protein 2

1

6

High-throughput

0.541

High

1016115

C8AP2
CASP8-associated protein 2

1

1

High-throughput

0.541

High

1016123

PIAS3
E3 SUMO-protein ligase PIAS3

1

13

High-throughput

0.541

High

245230

RAMP2
Receptor activity-modifying protein 2

1

1

High-throughput

0.536

High

513738

CP19A
Aromatase

1

1

High-throughput

0.536

High

558719

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

1

High-throughput

0.536

High

1016063

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

1

High-throughput

0.536

High

1016072

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

1016085

KCNG4
Potassium voltage-gated channel subfamily G member 4

1

3

High-throughput

0.536

High

1016107

CP26B
Cytochrome P450 26B1

1

1

High-throughput

0.536

High

1016118

TMED5
Transmembrane emp24 domain-containing protein 5

1

2

High-throughput

0.536

High

1016056

OS9
Protein OS-9

1

0

High-throughput

0.518

High

386620

P53
Cellular tumor antigen p53

1

12

Small-scale

0.515

High

950156

SMAD3
Mothers against decapentaplegic homolog 3

1

14

Small-scale

0.515

High

380374

CD3D
T-cell surface glycoprotein CD3 delta chain

1

0

High-throughput

0.513

High

1016074

FAXC
Failed axon connections homolog

1

0

High-throughput

0.513

High

1016093

RN170
E3 ubiquitin-protein ligase RNF170

1

0

High-throughput

0.513

High

1016102

TMM59
Transmembrane protein 59

1

0

High-throughput

0.513

High

1016104

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

1016110

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.513

High

160534

AURKA
Aurora kinase A

1

3

Small-scale

0.501

High

788187

CASP3
Caspase-3

1

4

Small-scale

0.501

High

998613

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.501

High

1016065

IMB1
Importin subunit beta-1

1

5

Small-scale

0.501

High

1016117

KLF13
Krueppel-like factor 13

1

20

Small-scale

0.501

High

270497

MED6
Mediator of RNA polymerase II transcription subunit 6

1

1

Small-scale

0.500

High

826260

CDK8
Cyclin-dependent kinase 8

1

15

Small-scale

0.500

High

1016066

MED1
Mediator of RNA polymerase II transcription subunit 1

1

10

Small-scale

0.500

High

1016095

MED15
Mediator of RNA polymerase II transcription subunit 15

1

15

Small-scale

0.500

High

556438

ITB4
Integrin beta-4

1

4

High-throughput

0.494

High

1016083

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

5

High-throughput

0.494

High

1016122

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

1

High-throughput

0.494

High

171986

GP182
G-protein coupled receptor 182

1

3

High-throughput

0.489

High

540289

GPIX
Platelet glycoprotein IX

1

3

High-throughput

0.489

High

570836

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

2

High-throughput

0.489

High

1016073

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

3

High-throughput

0.489

High

1016075

TM268
Transmembrane protein 268

1

1

High-throughput

0.489

High

1016082

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

1

High-throughput

0.489

High

1016101

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.489

High

1016106

TMM9B
Transmembrane protein 9B

1

1

High-throughput

0.489

High

1016116

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

1

High-throughput

0.489

High

1016120

PCDB3
Protocadherin beta-3

1

1

High-throughput

0.489

High

1016121

PCDGL
Protocadherin gamma-C4

1

1

High-throughput

0.489

High

1016080

MCAF1
Activating transcription factor 7-interacting protein 1

1

17

High-throughput

0.481

High

177280

HDAC3
Histone deacetylase 3

1

12

Small-scale

0.479

High

199883

SPIT2
Kunitz-type protease inhibitor 2

1

5

High-throughput

0.479

High

239456

PLPL9
85/88 kDa calcium-independent phospholipase A2

1

4

Small-scale

0.479

High

299885

ERLN2
Erlin-2

1

2

Small-scale

0.479

High

603053

OSBP1
Oxysterol-binding protein 1

1

4

Small-scale

0.479

High

1016062

NPAT
Protein NPAT

1

2

Small-scale

0.479

High

1016094

NR1H4
Bile acid receptor

1

20

Small-scale

0.479

High

1016096

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

11

Small-scale

0.479

High

1016097

PARK7
Parkinson disease protein 7

1

2

Small-scale

0.479

High

1016100

HINFP
Histone H4 transcription factor

1

1

Small-scale

0.479

High

1016105

SPRNG
SREBP regulating gene protein

1

1

Small-scale

0.479

High

1016108

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

2

Small-scale

0.479

High

1016109

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

Small-scale

0.479

High

1016114

NPCL1
NPC1-like intracellular cholesterol transporter 1

1

3

Small-scale

0.479

High

1016119

TRRAP
Transformation/transcription domain-associated protein

1

11

Small-scale

0.479

High

825687

MTR1B
Melatonin receptor type 1B

1

3

High-throughput

0.464

High

844897

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.458

High

976326

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

1

0

High-throughput

0.458

High

1016079

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1016086

RN139
E3 ubiquitin-protein ligase RNF139

1

0

Small-scale

0.458

High

72110

B3KQF8
cDNA FLJ90387 fis, clone NT2RP2005391, highly similar to Homo sapiens activating transcription factor 7 interacting protein

1

19

High-throughput

0.457

High

791513

HD
Huntingtin

1

4

High-throughput

0.457

High

1016058

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

17

High-throughput

0.445

High

1016067

RB11B
Ras-related protein Rab-11B

1

0

High-throughput

0.438

High

353929

IGHM
Immunoglobulin heavy constant mu

1

3

High-throughput

0.407

High

771183

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.328

High

1016078

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

2

0

High-throughput

0.328

High

1016112

DKK3
Dickkopf-related protein 3

2

0

High-throughput

0.328

High

948425

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.282

High

1016070

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

0

High-throughput

0.279

Low

1016087

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.279

Low

1016092

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

1016103

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

1016111

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024