Protein: RING1
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)

Gene: RING1
Organism: Homo sapiens
Interactions: 182
UniProt ID: Q06587

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0001739 - sex chromatin
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

717742

BMI1
Polycomb complex protein BMI-1

22

19

Small-scale

0.991

High

987991

RYBP
RING1 and YY1-binding protein

17

20

Small-scale

0.989

High

718393

PCGF2
Polycomb group RING finger protein 2

12

19

Small-scale

0.983

High

988024

CBX8
Chromobox protein homolog 8

8

20

Small-scale

0.980

High

987989

YAF2
YY1-associated factor 2

10

20

High-throughput

0.980

High

988015

PCGF1
Polycomb group RING finger protein 1

8

19

Small-scale

0.978

High

988012

RING2
E3 ubiquitin-protein ligase RING2

9

19

Small-scale

0.977

High

987986

PCGF5
Polycomb group RING finger protein 5

9

19

High-throughput

0.977

High

123243

CBX4
E3 SUMO-protein ligase CBX4

10

20

Small-scale

0.976

High

988016

PCGF6
Polycomb group RING finger protein 6

8

19

Small-scale

0.973

High

987982

BCOR
BCL-6 corepressor

7

20

Small-scale

0.970

High

987977

PCGF3
Polycomb group RING finger protein 3

6

19

High-throughput

0.953

High

327842

CBX7
Chromobox protein homolog 7

5

20

Small-scale

0.943

High

316019

CBX6
Chromobox protein homolog 6

5

20

High-throughput

0.940

High

987972

CBX2
Chromobox protein homolog 2

5

20

Small-scale

0.924

High

849312

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

20

Small-scale

0.898

High

919711

UB2D2
Ubiquitin-conjugating enzyme E2 D2

4

20

High-throughput

0.898

High

896302

UBE2K
Ubiquitin-conjugating enzyme E2 K

4

20

High-throughput

0.892

High

895781

UB2D3
Ubiquitin-conjugating enzyme E2 D3

3

20

Small-scale

0.868

High

988038

UB2D4
Ubiquitin-conjugating enzyme E2 D4

3

20

High-throughput

0.861

High

987979

BCORL
BCL-6 corepressor-like protein 1

2

20

High-throughput

0.811

High

851807

UB2E1
Ubiquitin-conjugating enzyme E2 E1

2

20

Small-scale

0.793

High

987956

RING1
E3 ubiquitin-protein ligase RING1

2

19

Small-scale

0.793

High

988008

UB2E2
Ubiquitin-conjugating enzyme E2 E2

2

20

High-throughput

0.791

High

586701

CSK22
Casein kinase II subunit alpha'

9

20

High-throughput

0.757

High

391666

H2A1B
Histone H2A type 1-B/E

2

20

Small-scale

0.755

High

934122

CSK21
Casein kinase II subunit alpha

6

20

High-throughput

0.738

High

943060

PHC1
Polyhomeotic-like protein 1

6

20

Small-scale

0.736

High

987988

PHC2
Polyhomeotic-like protein 2

5

20

Small-scale

0.718

High

988004

LMBL2
Lethal(3)malignant brain tumor-like protein 2

4

20

High-throughput

0.704

High

988002

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

4

15

Small-scale

0.704

High

987963

CBX3
Chromobox protein homolog 3

4

20

Small-scale

0.699

High

988005

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.698

High

903159

WDR5
WD repeat-containing protein 5

4

17

High-throughput

0.694

High

555425

H2AX
Histone H2AX

1

20

High-throughput

0.691

High

265636

E2F6
Transcription factor E2F6

3

20

Small-scale

0.681

High

928883

SKP1
S-phase kinase-associated protein 1

3

12

High-throughput

0.675

High

931602

CSK2B
Casein kinase II subunit beta

3

10

High-throughput

0.667

High

987993

PHC3
Polyhomeotic-like protein 3

3

20

High-throughput

0.667

High

898110

MAX
Protein max

3

17

Small-scale

0.656

High

386590

P53
Cellular tumor antigen p53

2

10

Small-scale

0.646

High

346606

MYC
Myc proto-oncogene protein

3

20

Small-scale

0.640

High

361753

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

2

3

High-throughput

0.628

High

361992

FIBG
Fibrinogen gamma chain

2

3

High-throughput

0.628

High

902886

DCAF7
DDB1- and CUL4-associated factor 7

2

20

High-throughput

0.628

High

949760

CBX1
Chromobox protein homolog 1

2

20

High-throughput

0.628

High

987966

HDAC1
Histone deacetylase 1

2

11

High-throughput

0.628

High

987969

TFDP1
Transcription factor Dp-1

2

5

High-throughput

0.628

High

987987

MGAP
MAX gene-associated protein

2

13

High-throughput

0.628

High

987996

KDM2B
Lysine-specific demethylase 2B

2

20

High-throughput

0.628

High

987999

AUTS2
Autism susceptibility gene 2 protein

2

20

Small-scale

0.628

High

475658

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

17

Small-scale

0.618

High

707600

H2B1B
Histone H2B type 1-B

1

19

High-throughput

0.618

High

918311

H2B1C
Histone H2B type 1-C/E/F/G/I

1

19

High-throughput

0.618

High

934691

H31
Histone H3.1

1

20

High-throughput

0.618

High

952292

H33
Histone H3.3

1

20

High-throughput

0.618

High

963597

E2F1
Transcription factor E2F1

2

17

Small-scale

0.611

High

987997

IKBD
NF-kappa-B inhibitor delta

2

12

High-throughput

0.606

High

988010

ZIM3
Zinc finger imprinted 3

2

10

High-throughput

0.606

High

556758

ACADS
Short-chain specific acyl-CoA dehydrogenase, mitochondrial

2

0

High-throughput

0.602

High

507407

ERG
Transcriptional regulator ERG

2

20

Small-scale

0.595

High

244333

BRD4
Bromodomain-containing protein 4

2

12

High-throughput

0.584

High

884138

KLF3
Krueppel-like factor 3

2

20

High-throughput

0.584

High

850010

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

20

Small-scale

0.578

High

828206

CENPA
Histone H3-like centromeric protein A

1

20

Small-scale

0.575

High

988039

R4GMX3
Polycomb complex protein BMI-1

1

19

High-throughput

0.575

High

361856

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

3

High-throughput

0.574

High

988023

FBRS
Probable fibrosin-1

2

20

High-throughput

0.574

High

987968

FHL1
Four and a half LIM domains protein 1

1

9

Small-scale

0.573

High

987981

FBX38
F-box only protein 38

1

2

High-throughput

0.541

High

988017

TRI55
Tripartite motif-containing protein 55

1

19

High-throughput

0.541

High

157031

AIM2
Interferon-inducible protein AIM2

1

4

High-throughput

0.536

High

296441

ACL6B
Actin-like protein 6B

1

14

High-throughput

0.536

High

518984

PIP
Prolactin-inducible protein

1

2

High-throughput

0.536

High

782334

KDM5C
Lysine-specific demethylase 5C

1

8

Small-scale

0.536

High

804218

NOTC1
Neurogenic locus notch homolog protein 1

1

5

High-throughput

0.536

High

987995

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.536

High

988007

SCMH1
Polycomb protein SCMH1

1

20

High-throughput

0.536

High

988028

RAB6B
Ras-related protein Rab-6B

1

5

High-throughput

0.536

High

988034

MTUS1
Microtubule-associated tumor suppressor 1

1

19

High-throughput

0.536

High

988035

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

High-throughput

0.536

High

988014

MESP1
Mesoderm posterior protein 1

1

0

Small-scale

0.529

High

72138

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

987976

H31T
Histone H3.1t

1

20

High-throughput

0.527

High

877021

CASP6
Caspase-6

1

4

High-throughput

0.515

High

987985

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

4

High-throughput

0.515

High

988001

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

10

High-throughput

0.508

High

726169

BASI
Basigin

1

8

Small-scale

0.504

High

174823

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

13

High-throughput

0.501

High

394593

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

890625

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

High-throughput

0.501

High

988025

MOV10
Helicase MOV-10

1

14

Small-scale

0.500

High

279527

FLOT1
Flotillin-1

1

4

High-throughput

0.489

High

344854

CYTS
Cystatin-S

1

1

High-throughput

0.489

High

344972

CYTN
Cystatin-SN

1

1

High-throughput

0.489

High

353406

PIGR
Polymeric immunoglobulin receptor

1

1

High-throughput

0.489

High

987965

MSLN
Mesothelin

1

1

High-throughput

0.489

High

987970

FLOT2
Flotillin-2

1

4

High-throughput

0.489

High

988026

FBSL
Fibrosin-1-like protein

1

20

High-throughput

0.489

High

987960

GRSF1
G-rich sequence factor 1

1

20

Small-scale

0.481

High

988003

TRI63
E3 ubiquitin-protein ligase TRIM63

1

18

High-throughput

0.481

High

148711

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

162658

XPO1
Exportin-1

1

11

High-throughput

0.479

High

171020

TBXT
T-box transcription factor T

1

13

High-throughput

0.479

High

177620

TYY2
Transcription factor YY2

1

20

Small-scale

0.479

High

211843

TLX3
T-cell leukemia homeobox protein 3

1

18

High-throughput

0.479

High

224414

RAD21
Double-strand-break repair protein rad21 homolog

1

4

Small-scale

0.479

High

262438

TULP3
Tubby-related protein 3

1

4

High-throughput

0.479

High

268040

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

294743

RECQ4
ATP-dependent DNA helicase Q4

1

18

High-throughput

0.479

High

316864

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

325702

LATS1
Serine/threonine-protein kinase LATS1

1

6

High-throughput

0.479

High

326602

SNAI1
Zinc finger protein SNAI1

1

14

Small-scale

0.479

High

374102

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.479

High

379317

MYCN
N-myc proto-oncogene protein

1

20

Small-scale

0.479

High

414256

RB
Retinoblastoma-associated protein

1

5

Small-scale

0.479

High

508958

TOP2A
DNA topoisomerase 2-alpha

1

5

Small-scale

0.479

High

554435

GATA1
Erythroid transcription factor

1

18

High-throughput

0.479

High

620334

GATA2
Endothelial transcription factor GATA-2

1

18

High-throughput

0.479

High

620485

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

18

High-throughput

0.479

High

631409

BRD2
Bromodomain-containing protein 2

1

19

High-throughput

0.479

High

632705

TYY1
Transcriptional repressor protein YY1

1

20

Small-scale

0.479

High

641384

PAX6
Paired box protein Pax-6

1

14

High-throughput

0.479

High

658489

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

679100

TLX1
T-cell leukemia homeobox protein 1

1

19

High-throughput

0.479

High

718495

NOS2
Nitric oxide synthase, inducible

1

1

Small-scale

0.479

High

727507

HNF1B
Hepatocyte nuclear factor 1-beta

1

15

High-throughput

0.479

High

727853

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

782525

HNF4A
Hepatocyte nuclear factor 4-alpha

1

9

High-throughput

0.479

High

830934

CTCF
Transcriptional repressor CTCF

1

9

Small-scale

0.479

High

839734

LHX2
LIM/homeobox protein Lhx2

1

5

High-throughput

0.479

High

869620

TERF1
Telomeric repeat-binding factor 1

1

8

High-throughput

0.479

High

917158

H4
Histone H4

1

7

High-throughput

0.479

High

959365

VIGLN
Vigilin

1

17

High-throughput

0.479

High

983423

MAD1
Max dimerization protein 1

1

18

Small-scale

0.479

High

985206

HME1
Homeobox protein engrailed-1

1

4

High-throughput

0.479

High

987957

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

987961

FOXI1
Forkhead box protein I1

1

7

High-throughput

0.479

High

987962

FOXL1
Forkhead box protein L1

1

7

High-throughput

0.479

High

987971

SMC1A
Structural maintenance of chromosomes protein 1A

1

12

Small-scale

0.479

High

987973

NFIX
Nuclear factor 1 X-type

1

15

High-throughput

0.479

High

987975

TERF2
Telomeric repeat-binding factor 2

1

8

High-throughput

0.479

High

987978

DCAF6
DDB1- and CUL4-associated factor 6

1

20

High-throughput

0.479

High

987984

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

12

High-throughput

0.479

High

987992

ZBT38
Zinc finger and BTB domain-containing protein 38

1

10

Small-scale

0.479

High

987994

CSK23
Casein kinase II subunit alpha 3

1

20

High-throughput

0.479

High

987998

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

988000

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

2

High-throughput

0.479

High

988009

ZFP42
Zinc finger protein 42 homolog

1

20

Small-scale

0.479

High

988011

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

988013

FEV
Protein FEV

1

20

High-throughput

0.479

High

988018

FOXQ1
Forkhead box protein Q1

1

10

High-throughput

0.479

High

988019

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

988020

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

20

High-throughput

0.479

High

988022

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

988030

HECW2
E3 ubiquitin-protein ligase HECW2

1

4

High-throughput

0.479

High

988031

LHX3
LIM/homeobox protein Lhx3

1

7

High-throughput

0.479

High

988032

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

988033

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.479

High

988036

SMC3
Structural maintenance of chromosomes protein 3

1

11

Small-scale

0.479

High

103726

G5E9A7
DM1 locus, WD repeat containing

1

20

High-throughput

0.470

High

527418

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.470

High

158611

RGS12
Regulator of G-protein signaling 12

1

0

Small-scale

0.458

High

545963

MYOD1
Myoblast determination protein 1

1

0

High-throughput

0.458

High

816505

MAOX
NADP-dependent malic enzyme

1

0

Small-scale

0.458

High

987959

MN1
Transcriptional activator MN1

1

0

Small-scale

0.458

High

987974

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.458

High

401886

JUN
Transcription factor Jun

1

18

High-throughput

0.445

High

987964

CTBP1
C-terminal-binding protein 1

1

10

High-throughput

0.445

High

987967

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.445

High

987980

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

819583

INAR2
Interferon alpha/beta receptor 2

1

1

Small-scale

0.437

High

987983

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.437

High

987990

ZDH23
Palmitoyltransferase ZDHHC23

1

8

Small-scale

0.437

High

988021

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.437

High

988027

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

10

High-throughput

0.437

High

988029

ZDH18
Palmitoyltransferase ZDHHC18

1

4

Small-scale

0.437

High

987958

LTOR4
Ragulator complex protein LAMTOR4

1

0

High-throughput

0.279

Low

988006

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.279

Low

988037

LTOR2
Ragulator complex protein LAMTOR2

1

0

High-throughput

0.279

Low

484816

AMY1B
Alpha-amylase 1B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024