Protein: DTX3
Probable E3 ubiquitin-protein ligase DTX3 (EC 2.3.2.27) (Protein deltex-3) (Deltex3) (RING finger protein 154) (RING-type E3 ubiquitin transferase DTX3)

Gene: DTX3
Organism: Homo sapiens
Interactions: 103
UniProt ID: Q8N9I9

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0007219 - Notch signaling pathway
GO:0016567 - protein ubiquitination
GO:0046872 - metal ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

896336

UBE2K
Ubiquitin-conjugating enzyme E2 K

4

20

High-throughput

0.904

High

159075

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

3

20

High-throughput

0.861

High

849372

UB2D1
Ubiquitin-conjugating enzyme E2 D1

3

20

High-throughput

0.861

High

895846

UB2D3
Ubiquitin-conjugating enzyme E2 D3

3

20

High-throughput

0.861

High

1238399

TRAF4
TNF receptor-associated factor 4

3

1

High-throughput

0.861

High

1238409

UB2D4
Ubiquitin-conjugating enzyme E2 D4

3

20

High-throughput

0.861

High

1238411

RN114
E3 ubiquitin-protein ligase RNF114

3

3

High-throughput

0.861

High

1238397

CHFR
E3 ubiquitin-protein ligase CHFR

3

0

High-throughput

0.816

High

919787

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

High-throughput

0.800

High

932551

UB2L3
Ubiquitin-conjugating enzyme E2 L3

2

20

High-throughput

0.800

High

851847

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.698

High

1033121

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

High-throughput

0.698

High

1238392

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.698

High

1238393

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1078867

ITSN1
Intersectin-1

3

1

High-throughput

0.667

High

800919

MK09
Mitogen-activated protein kinase 9

4

0

High-throughput

0.663

High

271145

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

3

5

High-throughput

0.654

High

1238395

NMD3
60S ribosomal export protein NMD3

3

0

High-throughput

0.638

High

1238402

CIAO3
Cytosolic iron-sulfur assembly component 3

3

0

High-throughput

0.638

High

908825

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.625

High

1238398

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

20

High-throughput

0.625

High

585014

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

Small-scale

0.618

High

412265

FYN
Tyrosine-protein kinase Fyn

2

7

High-throughput

0.615

High

209117

NCK2
Cytoplasmic protein NCK2

2

7

High-throughput

0.606

High

883368

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

6

High-throughput

0.606

High

924709

GRB2
Growth factor receptor-bound protein 2

2

8

High-throughput

0.606

High

1046413

PTK6
Protein-tyrosine kinase 6

2

7

High-throughput

0.606

High

1075802

CIP4
Cdc42-interacting protein 4

2

2

High-throughput

0.606

High

1238388

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

2

6

High-throughput

0.606

High

1238403

PAR11
Protein mono-ADP-ribosyltransferase PARP11

2

3

High-throughput

0.606

High

1238404

SYFB
Phenylalanine--tRNA ligase beta subunit

2

0

High-throughput

0.585

High

324504

BAG3
BAG family molecular chaperone regulator 3

2

0

High-throughput

0.580

High

1238396

ZMY19
Zinc finger MYND domain-containing protein 19

2

0

High-throughput

0.580

High

433420

YES
Tyrosine-protein kinase Yes

2

7

High-throughput

0.553

High

1238387

IKBD
NF-kappa-B inhibitor delta

2

1

High-throughput

0.553

High

980453

NOTC2
Neurogenic locus notch homolog protein 2

1

7

Small-scale

0.552

High

957738

XIAP
E3 ubiquitin-protein ligase XIAP

1

1

High-throughput

0.541

High

1238400

RNF38
E3 ubiquitin-protein ligase RNF38

1

3

High-throughput

0.541

High

1238390

RAD50
DNA repair protein RAD50

1

4

High-throughput

0.536

High

1238406

PARP2
Poly [ADP-ribose] polymerase 2

1

3

High-throughput

0.536

High

72146

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

1218665

U2D2L
Putative ubiquitin-conjugating enzyme E2 D2-like protein

1

20

High-throughput

0.528

High

1238389

RN141
RING finger protein 141

1

0

High-throughput

0.518

High

1191469

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

1238401

GGNB2
Gametogenetin-binding protein 2

1

0

High-throughput

0.513

High

1216495

ZDH17
Palmitoyltransferase ZDHHC17

1

2

High-throughput

0.494

High

296324

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

5

High-throughput

0.481

High

1238407

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

4

High-throughput

0.481

High

261297

FLNB
Filamin-B

1

4

Small-scale

0.479

High

387116

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

432062

HS90A
Heat shock protein HSP 90-alpha

1

6

Small-scale

0.479

High

433897

LYN
Tyrosine-protein kinase Lyn

1

7

Small-scale

0.479

High

453480

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

3

Small-scale

0.479

High

455661

PARP1
Poly [ADP-ribose] polymerase 1

1

6

Small-scale

0.479

High

524985

XRCC5
X-ray repair cross-complementing protein 5

1

2

Small-scale

0.479

High

598231

FLNA
Filamin-A

1

4

Small-scale

0.479

High

682891

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

5

Small-scale

0.479

High

714978

PROF2
Profilin-2

1

1

Small-scale

0.479

High

736587

RL4
Large ribosomal subunit protein uL4

1

1

Small-scale

0.479

High

745228

RBMX
RNA-binding motif protein, X chromosome

1

1

Small-scale

0.479

High

929564

RACK1
Small ribosomal subunit protein RACK1

1

2

Small-scale

0.479

High

963368

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

1

Small-scale

0.479

High

1042049

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1052904

FLNC
Filamin-C

1

4

Small-scale

0.479

High

1238386

PDZD8
PDZ domain-containing protein 8

1

1

Small-scale

0.479

High

168951

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

Small-scale

0.458

High

313854

SVIL
Supervillin

1

0

Small-scale

0.458

High

531215

EF2
Elongation factor 2

1

0

Small-scale

0.458

High

575108

RL7
Large ribosomal subunit protein uL30

1

0

Small-scale

0.458

High

670846

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

Small-scale

0.458

High

671283

RL12
Large ribosomal subunit protein uL11

1

0

Small-scale

0.458

High

739190

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

Small-scale

0.458

High

809366

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

Small-scale

0.458

High

907401

RS8
Small ribosomal subunit protein eS8

1

0

Small-scale

0.458

High

911188

RS13
Small ribosomal subunit protein uS15

1

0

Small-scale

0.458

High

913630

RL7A
Large ribosomal subunit protein eL8

1

0

Small-scale

0.458

High

919167

RAN
GTP-binding nuclear protein Ran

1

0

Small-scale

0.458

High

944330

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

Small-scale

0.458

High

962214

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

Small-scale

0.458

High

999627

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

Small-scale

0.458

High

1238410

MYO5A
Unconventional myosin-Va

1

0

Small-scale

0.458

High

1238391

OSTF1
Osteoclast-stimulating factor 1

1

2

High-throughput

0.439

High

415415

ATPB
ATP synthase subunit beta, mitochondrial

1

2

Small-scale

0.437

High

636994

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

Small-scale

0.437

High

827487

EFTU
Elongation factor Tu, mitochondrial

1

2

Small-scale

0.437

High

959258

S25A3
Solute carrier family 25 member 3

1

1

Small-scale

0.437

High

960888

CLH1
Clathrin heavy chain 1

1

1

Small-scale

0.437

High

1238405

RRBP1
Ribosome-binding protein 1

1

4

Small-scale

0.437

High

1136717

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

4

0

Small-scale

0.362

High

1238408

GUAD
Guanine deaminase

2

0

High-throughput

0.328

High

261855

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

2

0

High-throughput

0.318

High

950657

ARF5
ADP-ribosylation factor 5

2

0

High-throughput

0.316

High

1185186

EPMIP
EPM2A-interacting protein 1

2

0

High-throughput

0.316

High

1205583

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

1237605

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

0

High-throughput

0.316

High

1220105

UEVLD
Ubiquitin-conjugating enzyme E2 variant 3

1

0

High-throughput

0.282

High

538688

MYL6B
Myosin light chain 6B

1

0

Small-scale

0.249

Low

545498

RAC2
Ras-related C3 botulinum toxin substrate 2

1

0

Small-scale

0.249

Low

587355

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

1

0

Small-scale

0.249

Low

1052441

FLOT2
Flotillin-2

1

0

Small-scale

0.249

Low

1058479

GANAB
Neutral alpha-glucosidase AB

1

0

Small-scale

0.249

Low

1088560

MIC60
MICOS complex subunit MIC60

1

0

Small-scale

0.249

Low

1238394

EFHD2
EF-hand domain-containing protein D2

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024