Protein: DTX3L
E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2)

Gene: DTX3L
Organism: Homo sapiens
Interactions: 65
UniProt ID: Q8TDB6

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0002230 - positive regulation of defense response to virus by host
GO:0004842 - ubiquitin-protein transferase activity
GO:0004857 - enzyme inhibitor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

849380

UB2D1
Ubiquitin-conjugating enzyme E2 D1

5

20

Small-scale

0.922

High

1254701

DTX3L
E3 ubiquitin-protein ligase DTX3L

4

7

Small-scale

0.906

High

919797

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

20

Small-scale

0.854

High

895856

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.793

High

896339

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

20

High-throughput

0.783

High

1221258

PARP9
Protein mono-ADP-ribosyltransferase PARP9

10

5

Small-scale

0.757

High

851852

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.698

High

908860

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.698

High

930308

UBC9
SUMO-conjugating enzyme UBC9

1

20

High-throughput

0.698

High

1174513

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

16

High-throughput

0.698

High

1254705

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.698

High

1254706

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1254709

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

20

High-throughput

0.698

High

1254714

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

4

High-throughput

0.698

High

1254722

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

420861

H2B1J
Histone H2B type 1-J

1

0

Small-scale

0.687

High

1254718

SPG21
Maspardin

3

1

High-throughput

0.675

High

1175294

H2AV
Histone H2A.V

1

2

Small-scale

0.647

High

668847

PML
Protein PML

1

2

High-throughput

0.618

High

1170942

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.618

High

1205012

DTX1
E3 ubiquitin-protein ligase DTX1

1

7

Small-scale

0.618

High

1254721

DTX4
E3 ubiquitin-protein ligase DTX4

1

7

Small-scale

0.618

High

391807

H2A1B
Histone H2A type 1-B/E

1

0

Small-scale

0.614

High

786394

STAT1
Signal transducer and activator of transcription 1-alpha/beta

2

2

Small-scale

0.584

High

917636

H4
Histone H4

1

1

Small-scale

0.561

High

1254708

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

1

Small-scale

0.561

High

1169168

RN111
E3 ubiquitin-protein ligase Arkadia

1

1

High-throughput

0.541

High

1254713

PHF7
PHD finger protein 7

1

2

High-throughput

0.541

High

72147

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

1254720

DP13A
DCC-interacting protein 13-alpha

1

0

High-throughput

0.513

High

614396

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

0

High-throughput

0.493

High

160107

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

3

Small-scale

0.479

High

238423

JAK2
Tyrosine-protein kinase JAK2

1

8

Small-scale

0.479

High

487607

ANDR
Androgen receptor

1

1

Small-scale

0.479

High

553258

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

616842

JAK1
Tyrosine-protein kinase JAK1

1

7

Small-scale

0.479

High

651760

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

720983

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

941212

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

980467

NOTC2
Neurogenic locus notch homolog protein 2

1

7

Small-scale

0.479

High

1030374

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

1042112

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1115185

PAR14
Protein mono-ADP-ribosyltransferase PARP14

1

5

Small-scale

0.479

High

1146646

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

1254702

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1254703

HDAC2
Histone deacetylase 2

1

2

High-throughput

0.479

High

1254704

STAM1
Signal transducing adapter molecule 1

1

4

Small-scale

0.479

High

1254707

PDLI5
PDZ and LIM domain protein 5

1

1

Small-scale

0.479

High

1254710

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

1

Small-scale

0.479

High

1254716

ANTR1
Anthrax toxin receptor 1

1

0

Small-scale

0.460

High

204708

E41L2
Band 4.1-like protein 2

1

0

Small-scale

0.458

High

473438

UCRIL
Putative cytochrome b-c1 complex subunit Rieske-like protein 1

1

0

High-throughput

0.458

High

779782

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

1237425

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

1254712

CND3
Condensin complex subunit 3

1

0

Small-scale

0.458

High

1254715

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

0

Small-scale

0.458

High

1254719

DJB11
DnaJ homolog subfamily B member 11

1

0

High-throughput

0.458

High

708991

MCM7
DNA replication licensing factor MCM7

1

1

Small-scale

0.445

High

1254711

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

1254717

GLOD4
Glyoxalase domain-containing protein 4

1

1

Small-scale

0.437

High

677846

LCN1
Lipocalin-1

1

0

High-throughput

0.279

Low

1170312

RBM43
RNA-binding protein 43

1

0

High-throughput

0.279

Low

100993

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

546476

INGR1
Interferon gamma receptor 1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024